Cited by 30Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development

Mao, Ziming, Liu, Chunying, Lin, Xuejing, Sun, Bin, Su, Changqing·2018·Cancer Letters

Abstract

Protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) is one of the regulatory subunits of the protein phosphatase 2A (PP2A), which is a major member of protein serine/threonine phosphatases in cells. PPP2R5A can regulate the cellular location, substrate specification and protein phosphatase function of PP2A, through which PPP2R5A plays an important role in many cellular activities. It has been reported that PPP2R5A relates with many diseases including some kinds of cancers, but the related mechanisms have a lot remaining to be discovered or demonstrated. This review arms to summarize PPP2R5A and its relationships with the occurrence and progression of tumors, helping us to further understand its significance in the prevention, early diagnosis, targeted therapy and prognosis improvement of tumors.

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Crossref · 10.1016/j.canlet.2017.11.024

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Authors
Mao, Z., Liu, C., Lin, X., Sun, B., & Su, C.
Affiliations
Second Military Medical University (CN)
Corresponding author
Su, Changqing
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2018-02
Volume
414
Pages
222-229
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2769585367
Cited by
30
References
104
Citations by year
2026: 2 · 2025: 6 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 2
FWCI
0.10
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81773251, 81702735)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
protein phosphatase 2A, tumor progression, carcinogenesis, serine/threonine phosphatase, cancer prognosis, targeted therapy, early diagnosis
MeSH terms
Animals, Cell Physiological Phenomena, Humans, Lymphocyte Activation, Mitosis, Models, Biological, Neoplasms, Phosphorylation, Signal Transduction, Protein Phosphatase 2

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