PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development
Abstract
Protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) is one of the regulatory subunits of the protein phosphatase 2A (PP2A), which is a major member of protein serine/threonine phosphatases in cells. PPP2R5A can regulate the cellular location, substrate specification and protein phosphatase function of PP2A, through which PPP2R5A plays an important role in many cellular activities. It has been reported that PPP2R5A relates with many diseases including some kinds of cancers, but the related mechanisms have a lot remaining to be discovered or demonstrated. This review arms to summarize PPP2R5A and its relationships with the occurrence and progression of tumors, helping us to further understand its significance in the prevention, early diagnosis, targeted therapy and prognosis improvement of tumors.
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PP2A trimers with B56 subunits are predominantly human tumour suppressors.
“Among the PP2A complexes, PP2A trimers with B56 subunits are predominantly human tumour suppressors4–7.”
From Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A (2023) · cites this paper as [5]
PP2A-B56α is a human tumour suppressor.
“The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor.”
From Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A (2023) · cites this paper as [5]
Among oncogenic CIP2A-regulated PP2A targets, the best-known is MYC.
“Among the oncogenic CIP2A-regulated PP2A targets, the best-known is MYC5,21,25.”
From Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A (2023) · cites this paper as [5]
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A B56 regulatory subunit of protein phosphatase 2A localizes to nuclear speckles in cardiomyocytes
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CIP2A promotes T-cell activation and immune response to Listeria monocytogenes infection
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Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae
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Role of "oncogenic nexus" of CIP2A in breast oncogenesis: how does it work?
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Screening and identification of proteins interacting with nucleostemin
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PP2A/B56 and GSK3/Ras suppress PKB activity duringDictyosteliumchemotaxis
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Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
Pavic, K., Gupta, N., Omella, J. D., Derua, R., Aakula, A., Huhtaniemi, R., Määttä, J. A., Höfflin, N., Okkeri, J., Wang, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36693-9 · Cited by 36 · see citing works
- Authors
- Mao, Z., Liu, C., Lin, X., Sun, B., & Su, C.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- Su, Changqing
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 414
- Pages
- 222-229
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2769585367
- Semantic Scholar
- 718a6b97895081f19b704bd8da2fdaee732da57c
- Cited by
- 30
- References
- 104
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 2
- FWCI
- 0.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81773251, 81702735)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- protein phosphatase 2A, tumor progression, carcinogenesis, serine/threonine phosphatase, cancer prognosis, targeted therapy, early diagnosis
- MeSH terms
- Animals, Cell Physiological Phenomena, Humans, Lymphocyte Activation, Mitosis, Models, Biological, Neoplasms, Phosphorylation, Signal Transduction, Protein Phosphatase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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