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Cited by 78Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsMenopause: Health Impacts and Treatments

Relation of serum levels of sex hormone binding globulin to coronary heart disease in postmenopausal women

Reinecke, Holger, Bogdanski, Janina, Woltering, Anne, Breithardt, G.ünter, Assmann, Gerd, Kerber, Sebastian, von Eckardstein, Arnold·2002·The American Journal of Cardiology
DOI 10.1016/s0002-9149(02)02490-6
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Abstract

Hyperandrogenemia and low levels of sex hormone binding globulin (SHBG) are frequently found in women with metabolic syndrome, which is characterized by low high-density lipoprotein cholesterol, hypertriglyceridemia, obesity, and hyperinsulinemia. The specific contribution of these various factors to coronary heart disease (CHD) is controversial. The coronary angiograms of 87 consecutive postmenopausal women were evaluated using 2 semiquantitative scoring systems to estimate the extent of focal and diffuse vessel wall alterations. Fasting sera were analyzed for levels of glucose, lipids, insulin, leptin, dehydroepiandrosterone sulfate, testosterone, and SHBG. Obesity was assessed by measuring body mass index, waist-to-hip ratio, skinfold thicknesses, and body impedance. After adjusting for age, there were significant differences in 55 women with CHD compared with 32 women without CHD: higher levels of low-density lipoprotein cholesterol (159 +/- 51 vs 132 +/- 39 mg/dl), apolipoprotein B (121 +/- 33 vs 102 +/- 29 mg/dl), triglycerides (115 vs 91 mg/dl), and basal insulin (7.5 vs 4.6 mU/L), as well as lower levels of high-density lipoprotein cholesterol (59.9 +/- 18.0 vs 69.0 +/- 17.1 mg/dl), SHBG (44.6 vs 68.1 nmol/L) and the quantitative insulin sensitivity check index (0.66 +/- 0.41 vs 0.93 +/- 0.73). Multivariate analysis by logistic regression identified age (odds ratio [OR] 1.22, 95% confidence intervals [CI] 1.09 to 1.37), smoking (OR 11.46, 95% CI 2.56 to 51.39), SHBG (…

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  • Low SHBG levels contribute to long term consequences of METS; associations between low SHBG and higher risk of coronary and peripheral artery disease have been found, independent of other cardiovascular risk factors.

    “Furthermore, low SHBG levels also contribute to long term consequences of METS. Associations between low SHBG and higher risk of coronary and peripheral artery disease have been found, independent of other cardiovascular risk factors [137, 138].”

    From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [138]

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Authors
Reinecke, H., Bogdanski, J., Woltering, A., Breithardt, G. Ü., Assmann, G., Kerber, S., & von Eckardstein, A.
Affiliations
  • University of Münster (DE)
  • University Hospital Münster (DE)
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2002-08
Volume
90
Issue
4
Pages
364-368
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/s0002-9149(02)02490-6
OpenAlex
W2050941311
Cited by
78
References
31
Citations by year
2026: 2 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 7
FWCI
2.47
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
sex hormone-binding globulin, coronary artery disease, postmenopausal women, metabolic syndrome, hyperandrogenemia, apolipoprotein B, dyslipidemia, insulin resistance, obesity, hypertriglyceridemia, low HDL cholesterol, coronary angiography, risk factors, smoking, dehydroepiandrosterone sulfate, testosterone, leptin
MeSH terms
Androgens, Apolipoproteins, Blood Glucose, Body Composition, Coronary Artery Disease, Female, Humans, Insulin, Lipids, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Obesity, Radiography, Regression Analysis, Sex Hormone-Binding Globulin, Triglycerides, Postmenopause

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