Effect of adrenal steroids on testosterone and luteinizing hormone secretion in the ram
Open accessAbstract
The effects of adrenal steroids on testosterone and LH secretion and changes in serum cortisol levels in response to treatments were studied in the ram. Acute administration of synthetic ACTH (10 micrograms/kg BW) elevated (P less than 0.01) serum cortisol and transiently suppressed (P less than 0.05) serum testosterone and LH. Acute dexamethasone treatment suppressed (P less than 0.01) serum cortisol, testosterone and LH. Administration of vehicle had no effect (P greater than 0.10) on serum hormone levels. These data support the contention that adrenal steroids inhibit testicular endocrine function indirectly by acting at the hypothalamic or pituitary level because both ACTH and dexamethasone treatments suppressed serum LH. To differentiate between hypothalamic and pituitary sites of action, the pituitary and testicular responses to an LHRH challenge (100 micrograms) were examined in rams chronically treated with dexamethasone (5 mg i.m., twice daily for 5 days). This treatment regimen suppressed (P less than 0.01) serum cortisol levels. Compared with controls, basal testosterone levels were suppressed (P less than 0.05) in dexamethasone-treated rams; however, no effect (P greater than 0.10) on the magnitude of the testosterone response to LHRH or on either basal or LHRH-stimulated LH secretion was observed. Thus, although a direct testicular effect cannot be eliminated, these data suggest that, in the ram, adrenal steroids inhibit testicular endocrine function by action at the level of the hypothalamus.
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In bulls and rams, administration of the synthetic glucocorticoid dexamethasone induces lowering effects on circulating LH and testosterone by acting at the hypothalamic level.
“In bulls and rams, administration of the synthetic glucocorticoid dexamethasone has induced lowering effects on circulating LH and testosterone by acting at the hypothalamic level [84,85].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [85]
The paper reports that acute dexamethasone suppressed circulating LH and testosterone in rams and says similar responses had been observed in bulls (Discussion, p. 195). It suggests a hypothalamic site of action in rams, but does not establish that mechanism in bulls; it also reports that chronic dexamethasone did not lower basal LH in rams. (LLM, conf=0.86)
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- Authors
- JUNIEWICZ, P. E., JOHNSON, B. H., & BOLT, D. J.
- Affiliations
- United States Department of Agriculture (US)
- Corresponding author
- JUNIEWICZ, PAUL E.
- ORCID
- JOHNSON, BRYAN H.
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 1987-05-06
- Volume
- 8
- Issue
- 3
- Pages
- 190-196
- ISSN
- 0196-3635 (ISSN-L)
- 1939-4640
- OpenAlex
- W1538063711
- Cited by
- 43
- References
- 32
- Citations by year
- 2024: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Andrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- adrenal steroids, testosterone secretion, luteinizing hormone secretion, rams, ACTH, dexamethasone, cortisol, hypothalamic regulation, pituitary regulation, testicular endocrine function, glucocorticoid feedback
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Dexamethasone, Drug Administration Schedule, Hydrocortisone, Kinetics, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Sheep, Testosterone
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