The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Efficacy and Safety of Sildenafil Citrate for Treatment of Erectile Dysfunction in a Population With Associated Organic Risk Factors
Abstract
ABSTRACT: The objective of this study was to determine the efficacy and safety of sildenafil in patients with erectile dysfunction (ED) and associated organic risk factors in a multispecialty clinic. Patients (n = 521) were diagnosed with ED based on self‐assessment. Associated risk factors were managed by medication or lifestyle modifications, or both, before treatment with sildenafil for ED. Patients received a 50‐mg dose of sildenafil that could be adjusted to 100 mg or 25 mg based on tolerability and efficacy. Patients recorded the number of successful intercourse encounters for 6 to 8 weeks, and the number of adverse events. Overall, there was an 82% successful intercourse rate with sildenafil treatment. The predominant associated risk factors for ED were hypertension (39%), hypogonadism (37%), and multiple medications (34%). Common adverse events due to sildenafil treatment were mild to moderate in nature and resulted in <2% patient discontinuation. Clinicians should be particularly careful to evaluate patients presenting with ED because the condition can be accompanied by a wide spectrum of risk factors requiring monitoring and treatment. However, with adequate treatment and control of these risk factors, the use of sildenafil in a representative population of men with ED in a multispecialty clinic can achieve a higher efficacy rate than previous studies have indicated.
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“Testosterone deficiency seems to predict a poor response to sildenafil10-12 or tadalafil13 and the addition of testosterone seemed helpful in five uncontrolled studies.12-14”
From Treatment Strategy for Non-Responders to PDE5 Inhibitors (2013) · cites this paper as [10]
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Cites
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
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Oral Sildenafil in the Treatment of Erectile Dysfunction
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Self-citation
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Cited by
Shamloul, R., & Ghanem, H. (2013) · The Lancet · doi:10.1016/s0140-6736(12)60520-0 · Cited by 1,091
Aversa, A., Isidori, A. M., Spera, G., Lenzi, A., & Fabbri, A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01764.x · Cited by 343
Porst, H., Padma-Nathan, H., Giuliano, F., Anglin, G., Varanese, L., & Rosen, R. (2003) · Urology · doi:10.1016/s0090-4295(03)00359-5 · Cited by 320
Traish, A. M., & Guay, A. T. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00245.x · Cited by 196
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Metadata
- Authors
- GUAY, A. T., PEREZ, J. B., JACOBSON, J., & NEWTON, R. A.
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 2001-09-10
- Volume
- 22
- Issue
- 5
- Pages
- 793-797
- ISSN
- 0196-3635
- 1939-4640
- Cited by
- 103
- References
- 3
- Language
- en
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- GUAY, A. T., PEREZ, J. B., JACOBSON, J., & NEWTON, R. A. (2001). Efficacy and Safety of Sildenafil Citrate for Treatment of Erectile Dysfunction in a Population With Associated Organic Risk Factors. Journal of Andrology. https://doi.org/10.1002/j.1939-4640.2001.tb02582.x
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