The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Real‐Time Fine Morphology of Motile Human Sperm Cells is Associated With IVF‐ICSI Outcome
Abstract
ABSTRACT: The aim of the present prospective study was to determine whether subtle sperm morphological characteristics affect the outcome of intracytoplasmic sperm injection (ICSI), and if so, to identify those that are relevant. For this purpose, we developed a new method, the motile sperm organelle morphology examination (MSOME). The examination is performed in real time using an inverted light microscope equipped with high‐power Nomarski optics enhanced by digital imaging to achieve a magnification up to 6300x. MSOME was applied to the leftover sperm fraction selected for microinjection in 100 random couples referred for ICSI treatment at 3 major in vitro fertilization centers. We found that the morphological normalcy of the entire sperm cell, according to MSOME criteria, was positively associated with ICSI fertilization rate (area under the receiver operating characteristics [ROC] curve, 88%) but not with pregnancy outcome. The morphological normalcy of the sperm nucleus, defined by MSOME, was significantly and positively associated with both fertilization rate and pregnancy outcome (areas under the ROC curve, 72% and 74%, respectively). These findings indicate that ICSI‐associated pregnancy rate may be affected by subtle morphological malformations of the sperm nucleus, which may remain undetected by the embryologist during the routine selection procedure.
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Cites
Predictive value of abnormal sperm morphology in in vitro fertilization
Kruger, T. F., Acosta, A. A., Simmons, K. F., Swanson, R. J., Matta, J. F., & Oehninger, S. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59660-5 · Cited by 1,159
Liu, J., Nagy, Z., Joris, H., Tournaye, H., Devroey, P., & Van Steirteghem, A. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136000 · Cited by 138
Cited by
Bartoov, B., Berkovitz, A., Eltes, F., Kogosovsky, A., Yagoda, A., Lederman, H., Artzi, S., Gross, M., & Barak, Y. (2003) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.05.016 · Cited by 375
Self-citationBerkovitz, A., Eltes, F., Yaari, S., Katz, N., Barr, I., Fishman, A., & Bartoov, B. (2005) · Human Reproduction · doi:10.1093/humrep/deh545 · Cited by 299
Self-citationParmegiani, L., Cognigni, G. E., Bernardi, S., Troilo, E., Ciampaglia, W., & Filicori, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.033 · Cited by 264
Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients.
Cohen-Bacrie, P., Belloc, S., Ménézo, Y. J. R., Clement, P., Hamidi, J., & Benkhalifa, M. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.01.086 · Cited by 170
Assessment of acrosome and nuclear abnormalities in human spermatozoa with large vacuoles
Perdrix, A., Travers, A., Chelli, M. H., Escalier, D., Do Rego, J. L., Milazzo, J. P., Mousset-Simeon, N., Mace, B., & Rives, N. (2011) · Human Reproduction · doi:10.1093/humrep/deq297 · Cited by 137
Metadata
- Authors
- BARTOOV, B., BERKOVITZ, A., ELTES, F., KOGOSOWSKI, A., MENEZO, Y., & BARAK, Y.
- Venue
- Journal of Andrology
- Publisher
- Wiley
- Published
- 2002-01-02
- Volume
- 23
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0196-3635 (ISSN-L)
- 1939-4640
- OpenAlex
- W1900989753
- Cited by
- 428
- References
- 2
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Real‐Time Fine Morphology of Motile Human Sperm Cells is Associated With IVF‐ICSI Outcome. https://app.cochat.ai/papers/10.1002/j.1939-4640.2002.tb02595.x
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- BARTOOV, B., BERKOVITZ, A., ELTES, F., KOGOSOWSKI, A., MENEZO, Y., & BARAK, Y. (2002). Real‐Time Fine Morphology of Motile Human Sperm Cells is Associated With IVF‐ICSI Outcome. Journal of Andrology. https://doi.org/10.1002/j.1939-4640.2002.tb02595.x
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