Bile Formation and Secretion

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

Gottesman, M. M., & PASTAN, I. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.002125 · Cited by 3,569

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

Juliano, R. L., & Ling, V. W. T. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90160-7 · Cited by 3,317

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M., Pastan, I., & Willingham, M. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.21.7735 · Cited by 2,823

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Schinkel, A. H., Smit, J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., Riele, H. T., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90212-7 · Cited by 2,284

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I. H., & Gottesman, M. M. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.361 · Cited by 2,059

Membrane Fusion: Grappling with SNARE and SM Proteins

Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

Bull, P. C., Thomas, G. R., Rommens, J. M., Forbes, J., & Cox, D. W. (1993) · Nature Genetics · doi:10.1038/ng1293-327 · Cited by 1,939

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819

Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption

Altmann, S. W., Davis, H. R., Zhu, L.-J., Yao, X., Hoos, L. M., Tetzloff, G. G., Iyer, S. P. N., Maguire, M., Golovko, A., Zeng, M., et al. (2004) · Science · doi:10.1126/science.1093131 · Cited by 1,818

Molecular Regulation of Canalicular ABC Transporters

Saad, A. B., Bruneau, A., Mareux, E., Lapalus, M., Delaunay, J.-L., Gonzales, E. M., Jacquemin, E., Aït‐Slimane, T., & Falguières, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042113 · Cited by 33

Intestinal microbiota drives cholestasis-induced specific hepatic gene expression patterns

Juanola, O., Hassan, M., Kumar, P., Yılmaz, B., Keller, I., Simillion, C., Engelmann, C., Tacke, F., Dufour, J., Gottardi, A. D., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1911534 · Cited by 33

A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis

Pan, Q., Luo, G., Qu, J., Chen, S., Zhang, X., Zhao, N., Ding, J., Yang, H., Li, M., Li, L., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114563 · Cited by 33

Mechanism of anti-hyperuricemia of isobavachin based on network pharmacology and molecular docking

Luo, J., Chen, X., Liang, P.-Y., Zhao, Z., Wu, T., Li, Z., Wan, S., Luo, J. F., Pang, J., Zhang, J., et al. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106637 · Cited by 33

Viability Assessment During Normothermic Machine Liver Perfusion: A Literature Review

Jeddou, H., Tzedakis, S., Chaouch, M. A., Sulpice, L., Samson, M., & Boudjéma, K. (2025) · Liver International · doi:10.1111/liv.16244 · Cited by 32

Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway

Shi, M., Tang, J., Zhang, T., & Han, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115164 · Cited by 32

Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution

Wu, B., Xu, W., Wu, K., Li, Y., Hu, M., Feng, C., Zhu, C., Zheng, J., Cui, X., Li, J., et al. (2024) · Nature Ecology & Evolution · doi:10.1038/s41559-024-02510-9 · Cited by 31

Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis

Zhang, T., Hasegawa, Y., & Waldor, M. K. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01862-z · Cited by 31

PPAR agonists for the treatment of cholestatic liver diseases: Over a decade of clinical progress

Hayes, C. M., Gallucci, G. M., Boyer, J. L., Assis, D. N., & Ghonem, N. S. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000612 · Cited by 31

Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends

Bernardino, R. L., Marinelli, R., Maggio, A., Gena, P., Cataldo, I., Alves, M. G., Svelto, M., Oliveira, P. F., & Calamita, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071096 · Cited by 31

Biophysical Control of Bile Duct Epithelial Morphogenesis in Natural and Synthetic Scaffolds

Funfak, A., Bouzhir-Sima, L., Gontran, E., Minier, N., Dupuis‐Williams, P., & Gobaa, S. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00417 · Cited by 31

Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing

Donoghue, L., Nguyen, K. T. V., Graham, C., & Sethu, P. (2021) · Micromachines · doi:10.3390/mi12020139 · Cited by 31

The Inside-Out of End-Stage Liver Disease: Hepatocytes are the Keystone

Haep, N., Florentino, R. M., Squires, J. E., Bell, A. W., & Soto–Gutiérrez, A. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1725023 · Cited by 31

Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics

Huang, G., Wallace, D. F., Powell, E. E., Rahman, T. M., Clark, P. J., & Subramaniam, V. N. (2023) · Biomedicines · doi:10.3390/biomedicines11102809 · Cited by 31

Hepatotoxicity and metabolic effects of cellular extract of cyanobacterium Radiocystis fernandoi containing microcystins RR and YR on neotropical fish (Hoplias malabaricus)

Paulino, M. G., Rossi, P. A., Venturini, F. P., Tavares, D., de Souza, N. E. D. S., Sakuragui, M. M., Moraes, G., Terezan, A. P., Fernandes, J. B., Giani, A., et al. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.02.089 · Cited by 31

D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress

Zhao, S., Li, N., Zhao, W., Liu, H., Ge, M., Zhang, Y., Zhao, L.-Y., You, X., He, H., & Shao, R. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.98 · Cited by 31

Bile acid metabolism and signaling: potential therapeutic target for nonalcoholic fatty liver disease

Lin, C.-H., & Kohli, R. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/s41424-018-0034-3 · Cited by 31

A continuous fluorescence assay for simple quantification of bile salt hydrolase activity in the gut microbiome

Brandvold, K. R., Weaver, J., Whidbey, C., & Wright, A. (2019) · Scientific Reports · doi:10.1038/s41598-018-37656-7 · Cited by 31

In vitro models to evaluate ingestible devices: Present status and current trends

O’Farrell, C., Stamatopoulos, K., Simmons, M. J. H., & Batchelor, H. K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113924 · Cited by 31

High Starch Induces Hematological Variations, Metabolic Changes, Oxidative Stress, Inflammatory Responses, and Histopathological Lesions in Largemouth Bass (Micropterus salmoides)

Xie, Y., Shao, X., Zhang, P., Zhang, H., Yu, J., Yao, X., Fu, Y., Wei, J., & Wu, C. (2024) · Metabolites · doi:10.3390/metabo14040236 · Cited by 30

Consensus classification of biliary complications after liver transplantation: guidelines from the BileducTx meeting

Esser, H., de Jong, I. E. M., Roos, F. M., Bogensperger, C., Brunner, S. M., Cardini, B., Dutkowski, P., Eker, H. H., Ferreira-González, S., Forbes, S. J., et al. (2024) · British journal of surgery · doi:10.1093/bjs/znae321 · Cited by 30

Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14

Prajapati, M., Conboy, H. L., Hojyo, S., Fukada, T., Budnik, B., & Bartnikas, T. B. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100835 · Cited by 30

Role of Immune Cells in Biliary Repair

Lan, T., Qian, S., Tang, C., & Gao, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.866040 · Cited by 31

Withholding Parenteral Nutrition During Critical Illness Increases Plasma Bilirubin but Lowers the Incidence of Biliary Sludge

Vanwijngaerden, Y.-M., Langouche, L., Brunner, R., Debaveye, Y. A., Gielen, M., Casaer, M. P., Liddle, C., Coulter, S., Wouters, P. J., Wilmer, A. P., et al. (2013) · Hepatology · doi:10.1002/hep.26928 · Cited by 30

The bile–gut axis and metabolic consequences of cholecystectomy

Lange, A. H., Pedersen, M. G., Ellegaard, A., Nerild, H. H., Brønden, A., Sonne, D. P., & Knop, F. K. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae034 · Cited by 29

Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems

Fernández-Murga, M. L., Petrov, P., Conde, I., Castell, J. V., Gómez‐Lechón, M. J., & Jover, R. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.07.017 · Cited by 29

Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens

Valestrand, L., Zheng, F., Hansen, S. H., Øgaard, J., Hov, J. R., Björkström, N. K., Karlsen, T. H., Jiang, X., & Melum, E. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.12.008 · Cited by 31

Complementary Gene Regulation by NRF1 and NRF2 Protect Against Hepatic Cholesterol Overload

Akl, M. G., Li, L., Baccetto, R., Phanse, S., Zhang, Q., Trites, M. J., McDonald, S., Aoki, H., Babu, M., & Widenmaier, S. B. (2022) · Cell Reports · doi:10.1016/j.celrep.2023.112399 · Cited by 29

Targeting PCSK9 as a promising new mechanism for lowering low-density lipoprotein cholesterol

Badia, L. A. D., Elshourbagy, N. A., & Mousa, S. A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.011 · Cited by 29

Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities

Hussein, K. H., Ahmadzada, B., Correa, J. C., Sultan, A., Wilken, S., Amiot, B., & Nyberg, S. L. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.06.001 · Cited by 28

Tissue engineering of the biliary tract and modelling of cholestatic disorders

Brevini, T., Tysoe, O., & Sampaziotis, F. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.049 · Cited by 28

Circulating Extracellular Vesicles Contain Liver-Derived RNA Species as Indicators of Severe Cholestasis-Induced Early Liver Fibrosis in Mice

Fagoonee, S., Arigoni, M., Manco, M., Olivero, M., Bizzaro, F., Magagnotti, C., Andolfo, A., Miniscalco, B., Forni, M., Todeschi, S., et al. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0023 · Cited by 28

Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion

de Jong, I. E. M., Bodewes, S. B., van Leeuwen, O. B., Oosterhuis, D., Lantinga, V. A., Thorne, A. M., Lascaris, B., van den Heuvel, M. C., Wells, R. G., Olinga, P., et al. (2023) · Transplantation · doi:10.1097/tp.0000000000004531 · Cited by 28

Bile Acids and Microbiota Interplay in Pancreatic Cancer

Malhotra, P., Palanisamy, R., Caparros-Martin, J. A., & Falasca, M. (2023) · Cancers · doi:10.3390/cancers15143573 · Cited by 28

Hepatic‐Accumulated Obeticholic Acid and Atorvastatin Self‐Assembled Nanocrystals Potentiate Ameliorative Effects in Treatment of Metabolic‐Associated Fatty Liver Disease

Lu, H., Ban, Z., Xiao, K., Sun, M., Liu, Y., Chen, F., Shi, T., Chen, L., Shao, D., Zhang, M., et al. (2024) · Advanced Science · doi:10.1002/advs.202308866 · Cited by 28

Changes in Protein Expression in Two Cholangiocarcinoma Cell Lines Undergoing Formation of Multicellular Tumor Spheroids In Vitro

Mischiati, C., Ura, B., Roncoroni, L., Elli, L., Cervellati, C., Squerzanti, M., Conte, D., Doneda, L., de Laureto, P. P., Franceschi, G. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118906 · Cited by 28

Structure, Function, and Responses to Injury

Crawford, J. M., Bioulac‐Sage, P., & Hytiroglou, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6697-9.00001-7 · Cited by 28

Benefits and challenges to therapeutic targeting of bile acid circulation in cholestatic liver disease

Trauner, M., Karpen, S. J., & Dawson, P. A. (2025) · Hepatology · doi:10.1097/hep.0000000000001438 · Cited by 27

Iron overload reduces synthesis and elimination of bile acids in rat liver

Prašnická, A., Laštůvková, H., Faradonbeh, F. A., Cermanová, J., Hroch, M., Mokrý, J., Doleželová, E., Pávek, P., Žížalová, K., Vı́tek, L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46150-7 · Cited by 27

Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets

Wang, L., Hou, W.-T., Wang, J., Xu, D., Guo, C., Sun, L., Ruan, K., Zhou, C., & Chen, Y. (2022) · Cell Research · doi:10.1038/s41422-021-00611-9 · Cited by 27

Development of 3D Hepatic Constructs Within Polysaccharide-Based Scaffolds with Tunable Properties

Labour, M.-N., Guilcher, C. L., Aid, R., Samad, N. E., Lanouar, S., Simón‐Yarza, T., & Letourneur, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103644 · Cited by 27

Distinct bile acid alterations in response to a single administration of PFOA and PFDA in mice

Yu, X., Zhang, Y., Cogliati, B., Klaassen, C. D., Kumar, S., Cheng, X., & Bu, P. (2024) · Toxicology · doi:10.1016/j.tox.2023.153719 · Cited by 26

Hepatic complications of oral contraceptive pills and estrogen on MRI: Controversies and update - Adenoma and beyond

Ponnatapura, J., Kielar, A. Z., Burke, L. M. B., Lockhart, M. E., Abualruz, A. R., Tappouni, R. F. R., & Lalwani, N. (2019) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2019.04.010 · Cited by 26

Design by Nature: Emerging Applications of Native Liver Extracellular Matrix for Cholangiocyte Organoid-Based Regenerative Medicine

Willemse, J., van der Laan, L. J. W., de Jonge, J., & Verstegen, M. M. A. (2022) · Bioengineering · doi:10.3390/bioengineering9030110 · Cited by 26

Viability testing during liver preservation

Patrono, D., Lonati, C., & Romagnoli, R. (2022) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000001004 · Cited by 26

Boldine enhances bile production in rats via osmotic and Farnesoid X receptor dependent mechanisms

Cermanová, J., Kadová, Z., Zagorova, M., Hroch, M., Tomšík, P., Nachtigal, P., Kudláčková, Z., Pávek, P., Dubecka, M., Čečková, M., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.03.004 · Cited by 26

Molecular regulation of mammalian hepatic architecture

Huppert, S. S., & Iwafuchi, M. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.12.003 · Cited by 26

Current insights in the complexities underlying drug-induced cholestasis

Deferm, N., Vocht, T. D., Qi, B., Brantegem, P. V., Gijbels, E., Vinken, M., de Witte, P. A. M., Bouillon, T. W., & Annaert, P. (2019) · Critical Reviews in Toxicology · doi:10.1080/10408444.2019.1635081 · Cited by 26

Some more about dogs: Proteomics of neglected biological fluids

Miller, I., Schlosser, S., Palazzolo, L., Veronesi, M. C., Eberini, I., & Gianazza, E. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103724 · Cited by 26

The food-borne pathogen Campylobacter jejuni depends on the AddAB DNA repair system to defend against bile in the intestinal environment

Gourley, C. R., Negretti, N. M., & Konkel, M. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-14646-9 · Cited by 25

Bile cast nephropathy: when the kidneys turn yellow

Chediak, A. E., Janom, K., & Koubar, S. H. (2020) · Renal Replacement Therapy · doi:10.1186/s41100-020-00265-0 · Cited by 25

Human Bile Contains Cholangiocyte Organoid-Initiating Cells Which Expand as Functional Cholangiocytes in Non-canonical Wnt Stimulating Conditions

Roos, F. J. M., Verstegen, M. M. A., Albarinos, L. M., Roest, H. P., Poley, J., Tetteroo, G. W. M., IJzermans, J. N. M., & van der Laan, L. J. W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.630492 · Cited by 25

Biological evidence to define a vitamin A deficiency cutoff using total liver vitamin A reserves

Tanumihardjo, S. A. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221992731 · Cited by 25

Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease

Zhou, T., Kundu, D., Robles-Linares, J., Meadows, V., Sato, K., Baiocchi, L., Ekser, B., Glaser, S. S., Alpini, G. D., Francis, H., et al. (2021) · Cells · doi:10.3390/cells10082072 · Cited by 25

Aquaporins and Gland Secretion

Delporte, C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1057-0_4 · Cited by 25

Fish oil alleviates circadian bile composition dysregulation in male mice with NAFLD

Liu, Y., Li, Q., Wang, H., Zhao, X.-J. G., Li, N., Zhang, H., Chen, G., & Liu, Z. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.03.005 · Cited by 25

FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression

Wang, S., Feng, R., Wang, S., Liu, H., Shao, C., Li, Y., Link, F., Munker, S., Liebe, R., Meyer, C., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-326987 · Cited by 24

Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy

Karolczak, S., Deshwar, A. R., Aristegui, E., Kamath, B. M., Lawlor, M. W., Andreoletti, G., Volpatti, J. R., Ellis, J. L., Yin, C., & Dowling, J. J. (2023) · Journal of Clinical Investigation · doi:10.1172/jci166275 · Cited by 24

Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats

Prašnická, A., Cermanová, J., Hroch, M., Doleželová, E., Rozkydalová, L., Smutný, T., Carazo, A., Chládek, J., Leníček, M., Nachtigal, P., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.09.003 · Cited by 24

Functional and Genomic Characterization of Ligilactobacillus salivarius TUCO-L2 Isolated From Lama glama Milk: A Promising Immunobiotic Strain to Combat Infections

Quilodrán-Vega, S., Albarracín, L., Mansilla, F. I., Arce, L. P., Zhou, B., Islam, M. A., Tomokiyo, M., Kassaa, I. A., Suda, Y., Kitazawa, H., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.608752 · Cited by 24

Current status and new directions for hepatocellular carcinoma diagnosis

Tu, J., Wang, B., Wang, X., Huo, K., Hu, W., Zhang, R., Li, J., Zhu, S., Liang, Q., & Han, S. (2024) · Liver Research · doi:10.1016/j.livres.2024.12.001 · Cited by 23

Absolute protein quantification allows differentiation of cell‐specific metabolic routes and functions

Wiśniewski, J. R., Koepsell, H., Gizak, A., & Rakus, D. (2014) · PROTEOMICS · doi:10.1002/pmic.201400456 · Cited by 23

Bile liquid biopsy in biliary tract cancer

Liu, F., Hao, X., Liu, B., Liu, S., & Yuan, Y. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117593 · Cited by 23

The bile salt/phospholipid ratio determines the extent of in vitro intestinal lipolysis of triglycerides: Interfacial and emulsion studies

Kłosowska, K., del Castillo-Santaella, T., Maldonado‐Valderrama, J., & Macierzanka, A. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114421 · Cited by 23

Immaturity of Bile Canalicular–Ductule Networks in the Future Liver Remnant While Associating Liver Partition and Portal Vein Occlusion for Staged Hepatectomy (ALPPS)

Matsuo, K., Hiroshima, Y., Yamazaki, K., Kasahara, K., Kikuchi, Y., Kawaguchi, D., Murakami, T., Ishida, Y., & Tanaka, K. (2017) · Annals of Surgical Oncology · doi:10.1245/s10434-017-5922-3 · Cited by 23

Recent advances in understanding the molecular mechanisms of cholestatic pruritus: A review

Sanjel, B., & Shim, W. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165958 · Cited by 23

The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease

Tsomidis, I., Tsakou, A., Voumvouraki, A., & Kouroumalis, E. (2026) · Biomedicines · doi:10.3390/biomedicines14010151 · Cited by 22

Bile Acids—A Peek Into Their History and Signaling

Nguyen, J. T., Shaw, R. P. H., & Anakk, S. (2022) · Endocrinology · doi:10.1210/endocr/bqac155 · Cited by 22

GPCR-mediated effects of fatty acids and bile acids on glucose homeostasis

Oteng, A., & Liu, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1206063 · Cited by 22

Cellular heterogeneity and plasticity during NAFLD progression

Park, H., Choi, J., Kim, H.-M., Yang, D.-Y., An, T. H., Lee, E., Han, B., Lee, S. C., Kim, W. K., Bae, K., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1221669 · Cited by 22

Geometrical and Structural Dynamics of Imatinib within Biorelevant Colloids

Wiest, J. M., Saedtler, M., Böttcher, B., Grüne, M., Reggane, M., Galli, B., Holzgrabe, U., & Meinel, L. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00469 · Cited by 22

Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models

Vauthier, V., Saad, A. B., Elie, J., Oumata, N., Durand‐Schneider, A., Bruneau, A., Delaunay, J.-L., Housset, C., Aït‐Slimane, T., Meijer, L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43111-y · Cited by 22

Development and validation of an LC-MS/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and apigenin-glucuronide) in the bile and blood samples: Application to a portal vein infusion study

Tu, Y., Zhou, L., Li, L., Wang, L., Gao, S., & Hu, M. (2020) · Analytical Biochemistry · doi:10.1016/j.ab.2020.113723 · Cited by 22

Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats

Doleželová, E., Prašnická, A., Cermanová, J., Carazo, A., Hyršová, L., Hroch, M., Mokrý, J., Adamcová, M., Mrkvicová, A., Pávek, P., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i43.7678 · Cited by 22

The Genetics of Inherited Cholestatic Disorders in Neonates and Infants: Evolving Challenges

Jeyaraj, R., Bounford, K. M., Ruth, N. D., Lloyd, C., MacDonald, F., Hendriksz, C. J., Baumann, U., Gissen, P., & Kelly, D. A. (2021) · Genes · doi:10.3390/genes12111837 · Cited by 21

Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells

Yuan, Y., Zhu, Y., Li, Y., Li, X., Jiao, R., & Bai, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043301 · Cited by 21

The Pan-liver Network Theory

Zhang, Y., & Fang, X.-M. (2023) · The Chinese Journal of Physiology · doi:10.4103/cjop.cjop-d-22-00131 · Cited by 22

3-D EM exploration of the hepatic microarchitecture – lessons learned from large-volume in situ serial sectioning

Shami, G. J., Cheng, D., Huynh, M. T. D., Vreuls, C. P. H., Wisse, E., & Braet, F. (2016) · Scientific Reports · doi:10.1038/srep36744 · Cited by 21

A Change in Bile Flow: Looking Beyond Transporter Inhibition in the Development of Drug-induced Cholestasis

Garzel, B., Zhang, L., Huang, S. M., & Wang, H. (2019) · Current Drug Metabolism · doi:10.2174/1389200220666190709170256 · Cited by 21

Presence of small resistant peptides from new in vitro digestion assays detected by liquid chromatography tandem mass spectrometry: An implication of allergenicity prediction of novel proteins?

Wang, R., Wang, Y., Edrington, T. C., Liu, Z., Lee, T. C., Silvanovich, A., Moon, H. S., Liu, Z. L., & Li, B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233745 · Cited by 21

Hepatobiliary acid-base homeostasis: Insights from analogous secretory epithelia

Trampert, D. C., van de Graaf, S. F. J., Jongejan, A., Elferink, R. P. J. O., & Beuers, U. H. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.10.010 · Cited by 21

Monitoring food structure in plant protein gels during digestion: Rheometry and Small Angle Neutron Scattering studies

Napieraj, M., Brûlet, A., Lutton, É., Randrianarisoa, U., Boire, A., & Boué, F. (2022) · Food Structure · doi:10.1016/j.foostr.2022.100270 · Cited by 21

Macro Histone Variants: Emerging Rheostats of Gastrointestinal Cancers

Giallongo, S., Re, O. L., & Vinciguerra, M. (2019) · Cancers · doi:10.3390/cancers11050676 · Cited by 21

The bile salt content of human bile impacts on simulated intestinal proteolysis of β-lactoglobulin

Dulko, D., Staroń, R., Krupa, Ł., Rigby, N. M., Mackie, A. R., Gutkowski, K., Wasik, A., & Macierzanka, A. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110413 · Cited by 20

Boldine Attenuates Cholestasis Associated With Nonalcoholic Fatty Liver Disease in Hereditary Hypertriglyceridemic Rats Fed by High-Sucrose Diet

Zagorova, M., Prašnická, A., Kadová, Z., Doleželová, E., Kazdová, L., Cermanová, J., Rozkydalová, L., Hroch, M., Mokrý, J., & Mičuda, S. (2015) · Physiological Research · doi:10.33549/physiolres.933206 · Cited by 20

Manganese transport and toxicity in polarized WIF-B hepatocytes

Thompson, K., Hein, J., Baez, A. S., Sosa, J. C., & Wessling‐Resnick, M. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00103.2018 · Cited by 20

The role of cellular interactions in the induction of hepatocyte polarity and functional maturation in stem cell-derived hepatic cells

Blau, B. J., & Miki, T. (2019) · Differentiation · doi:10.1016/j.diff.2019.02.006 · Cited by 20

Targeted Analysis of 46 Bile Acids to Study the Effect of Acetaminophen in Rat by LC-MS/MS

Prinville, V., Ohlund, L. B., & Sleno, L. (2020) · Metabolites · doi:10.3390/metabo10010026 · Cited by 21

Hepatocytes and Their Role in Metabolism

Dutta, S., Mishra, S. P., Sahu, A. K., Mishra, K. K., Kashyap, P. K., & Sahu, B. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99083 · Cited by 21

Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier

Yu, J., Meng, Z., Liu, X., Zheng, Y., Xue, D., Hao, C., & Wang, L. (2024) · ImmunoTargets and Therapy · doi:10.2147/itt.s495095 · Cited by 19

Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency

Li, C. Z., Ogawa, H., Ng, S. S., Chen, X., Kishimoto, E., Sakabe, K., Fukami, A., Hu, Y., Mayhew, C. N., Hellmann, J., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100446 · Cited by 19

Important roles of transporters in the pharmacokinetics of anti-viral nucleoside/nucleotide analogs

Yang, M., & Xu, X. (2022) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2022.2112175 · Cited by 19

Multi-transcriptomics reveals RLMF axis-mediated signaling molecules associated with bovine feed efficiency

Yang, C., Ding, Y., Dan, X., Shi, Y., & Kang, X. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1090517 · Cited by 19

Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations

Maddirevula, S., Shagrani, M. A., Ji, A., Horne, C. R., Young, S. N., Mather, L. J., Alqahtani, M. F., McKerlie, C., Wood, G. A., Potter, P. K., et al. (2024) · Genetics in Medicine · doi:10.1016/j.gim.2024.101231 · Cited by 19

A Critical Evaluation of Liver Pathology in Humans with Danon Disease and Experimental Correlates in a Rat Model of LAMP-2 Deficiency

Wang, L., Wang, J., Cai, W., Shi, Y., Zhou, X., Guo, G., Guo, C., Huang, X., Han, Z., Zhang, S., et al. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-017-8598-3 · Cited by 19

Model Systems for Studying the Role of Canalicular Efflux Transporters in Drug-Induced Cholestatic Liver Disease

Stieger, B., & Mahdi, Z. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.03.023 · Cited by 19

Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury

Min, J., Chen, H., Gong, Z., Liu, X., Wu, T., Li, W., Fang, J., Huang, T., Zhang, Y., Zhao, W., et al. (2018) · Molecules · doi:10.3390/molecules23092287 · Cited by 19

Clearance of transaminases during normothermic ex situ liver perfusion

Bral, M., Aboelnazar, N. S., Hatami, S., Thiesen, A., Bigam, D. L., Freed, D. H., & Shapiro, A. M. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215619 · Cited by 19

Feasibility of Voltage-Applied SERS Measurement of Bile Juice as an Effective Analytical Scheme to Enhance Discrimination between Gall Bladder (GB) Polyp and GB Cancer

Vu, T. D., Jang, E., Lee, J., Choi, D., Chang, J., & Chung, H. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00275 · Cited by 19

Resilience of three-dimensional sinusoidal networks in liver tissue

Karschau, J., Scholich, A., Wise, J. L., Morales-Navarrete, H. A., Kalaidzidis, Y. L., Zerial, M., & Friedrich, B. M. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007965 · Cited by 19

Cellular Mechanisms of Hepatic Fluid and Electrolyte Transport

Dyke, R. W. V., Lake, J. R., & Scharschmidt, B. F. (1989) · Comprehensive physiology · doi:10.1002/j.2040-4603.1989.tb01392.x

THE MECHANISM OF BILIARY LIPID SECRETION AND ITS DEFECTS

Elferink, R. P. J. O., & Groen, A. K. (1999) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70043-1 · Cited by 27

Bile secretion

Erlinger, S. (1992) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072582 · Cited by 19

Cellular mechanisms of bile formation

Blitzer, B. L., & Boyer, J. L. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90027-0 · Cited by 140

Molecular Mechanisms in Bile Formation

Meier, P. J., & Stieger, B. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.2.89 · Cited by 51