Bile Formation and Secretion

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

Gottesman, M. M., & PASTAN, I. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.002125 · Cited by 3,569

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

Juliano, R. L., & Ling, V. W. T. (1976) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(76)90160-7 · Cited by 3,317

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M., Pastan, I., & Willingham, M. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.21.7735 · Cited by 2,823

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Schinkel, A. H., Smit, J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., Riele, H. T., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90212-7 · Cited by 2,284

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I. H., & Gottesman, M. M. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.361 · Cited by 2,059

Membrane Fusion: Grappling with SNARE and SM Proteins

Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

Bull, P. C., Thomas, G. R., Rommens, J. M., Forbes, J., & Cox, D. W. (1993) · Nature Genetics · doi:10.1038/ng1293-327 · Cited by 1,939

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819

Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption

Altmann, S. W., Davis, H. R., Zhu, L.-J., Yao, X., Hoos, L. M., Tetzloff, G. G., Iyer, S. P. N., Maguire, M., Golovko, A., Zeng, M., et al. (2004) · Science · doi:10.1126/science.1093131 · Cited by 1,818

Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid

Gregor, A., Pignitter, M., Trajanoski, S., Auernigg‐Haselmaier, S., Somoza, V., König, J. S., & Duszka, K. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1992236 · Cited by 19

Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice

Thibaut, M. M., Gillard, J., Dolly, A., Roumain, M., Leclercq, I. A., Delzenne, N. M., Muccioli, G. G., & Bindels, L. B. (2021) · Cancers · doi:10.3390/cancers13246389 · Cited by 19

Adenovirus‐mediated human aquaporin‐1 expression in hepatocytes improves lipopolysaccharide‐induced cholestasis

Marrone, J., Danielli, M., Gaspari, C. I., & Marinelli, R. A. (2017) · IUBMB Life · doi:10.1002/iub.1689 · Cited by 19

Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection

Ma, Q., 中国科学院生物物理研究所脑与认知科学国家重点实验室, 北., Ma, W., Song, T., Wu, Z., Liu, Z., Hu, Z., Han, J.-B., Xu, L., Zeng, B., et al. (2022) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.443 · Cited by 18

Bile acids and bile acid activated receptors in the treatment of Covid-19

Fiorucci, S., Urbani, G., Biagioli, M., Sepe, V., Distrutti, E., & Zampella, A. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115983 · Cited by 18

Microbial metabolites as modulators of host physiology

Joyce, S. A., & Clarke, D. J. (2024) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2023.12.001 · Cited by 20

Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa)

Mosedale, M., Button, D. C., Jackson, J. P., Freeman, K., Brouwer, K. R., Caggiano, A. O., Eisen, A., Iaci, J. F., Parry, T. J., Stanulis, R., et al. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx222 · Cited by 18

Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied

Duan, R. (2018) · World Journal of Hepatology · doi:10.4254/wjh.v10.i2.246 · Cited by 18

Metformin Preconditioning Improves Hepatobiliary Function and Reduces Injury in a Rat Model of Normothermic Machine Perfusion and Orthotopic Transplantation

Westerkamp, A. C., Fujiyoshi, M., Ottens, P. J., Nijsten, M. W., Touw, D. J., de Meijer, V. E., Lisman, T., Leuvenink, H. G. D., Moshage, H. J., Berendsen, T., et al. (2020) · Transplantation · doi:10.1097/tp.0000000000003216 · Cited by 18

MicroRNA in cardio-metabolic disorders

Su, X., Nie, M., Zhang, G., & Wang, B. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.03.024 · Cited by 18

On the Mechanisms of Biliary Flux

Vartak, N., Drasdo, D., Geisler, F., Itoh, T., Elferink, R. P. J. O., van de Graaf, S. F. J., Chiang, J. Y. L., Keitel, V., Trauner, M., Jansen, P. L. M., et al. (2021) · Hepatology · doi:10.1002/hep.32027 · Cited by 18

Smooth muscle cells, interstitial cells and neurons in the gallbladder (GB): Functional syncytium of electrical rhythmicity and GB motility (Review)

Ding, F., Hu, Q., Wang, Y., Jiang, M., Cui, Z.-Y., Guo, R., Liu, L., Chen, F., HU, H. X., & Zhao, G. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5236 · Cited by 17

MALDI Mass Spectral Imaging of Bile Acids Observed as Deprotonated Molecules and Proton-Bound Dimers from Mouse Liver Sections

Rzagalinski, I., Hainz, N., Meier, C., Tschernig, T., & Volmer, D. A. (2018) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-017-1886-6 · Cited by 17

Evaluation of acute and subacute toxicity of sodium taurodeoxycholate in rats

Choi, H.-J., Yun, J.-W., Kim, Y.-H., Kwon, E., Hyon, M.-K., Kim, J. Y., Che, J., Kim, W. H., Seong, S., & Kang, B.-C. (2019) · Drug and Chemical Toxicology · doi:10.1080/01480545.2019.1609493 · Cited by 17

Anatomy and Cellular Functions of the Liver

Qin, L., & Crawford, J. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-37591-7.00001-x · Cited by 17

Drug-Induced Dynamics of Bile Colloids

Hanio, S., Schlauersbach, J., Lenz, B., Spiegel, F., Böckmann, R. A., Schweins, R., Nischang, I., Schubert, U. S., Endres, S., Pöppler, A., et al. (2021) · Langmuir · doi:10.1021/acs.langmuir.0c02282 · Cited by 17

Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants

Saad, A. B., Vauthier, V., Tóth, Á., Janaszkiewicz, A., Durand‐Schneider, A., Bruneau, A., Delaunay, J., Lapalus, M., Mareux, E., Garcin, I., et al. (2021) · Liver International · doi:10.1111/liv.14839 · Cited by 17

Biallelic Mutations in Ubiquitin-Specific Peptidase 53 ( USP53 ) Causing Progressive Intrahepatic Cholestasis. Report of a Case With Review of Literature

Vij, M., & Sankaranarayanan, S. (2021) · Pediatric and Developmental Pathology · doi:10.1177/10935266211051175 · Cited by 17

New Insights Into the Persistent Effects of Acute Exposure to AFB1 on Rat Liver

Yan, J., Chen, L., Zhang, L., Zhang, Z., Zhao, Y., Wang, Y., & Ou, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.911757 · Cited by 17

Biochemical Characterization and Comparison of Pancreatic Lipases from the Pacific Bluefin Tuna, Thunnus orientalis; Totoaba, Totoaba macdonaldi; and Striped Bass, Morone saxatilis

Rueda‐López, S., Montaño, E. M., & Viana, M. T. (2016) · Journal of the World Aquaculture Society · doi:10.1111/jwas.12372 · Cited by 17

Contamination of dried blood spots – an underestimated risk in newborn screening

Winter, T., Lange, A. E., Hannemann, A., Nauck, M. A., & Muller, C. E. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0270 · Cited by 17

The role of the microbiome in liver disease

Schöler, D., & Schnabl, B. (2024) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000001013 · Cited by 16

Bile acids in liver and gastrointestinal cancer

Monte, M. J., Fàbrega, L., Romero, M. R., Temprano, Á. G., Kaplowitz, N., García‐Ruiz, C., Marı́n, J. J. G., & Fernández-Checa, J. C. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.09.002 · Cited by 16

Bile promotes Lactobacillus johnsonii N6.2 extracellular vesicle production with conserved immunomodulatory properties

Beliakoff, R., González, C. F., & Lorca, G. L. (2024) · Scientific Reports · doi:10.1038/s41598-024-62843-0 · Cited by 16

Bile Acids as a New Type of Steroid Hormones Regulating Nonspecific Energy Expenditure of the Body (Review)

Загоскин, П. П., & Erlykina, E. I. (2020) · Современные технологии в медицине · doi:10.17691/stm2020.12.5.13 · Cited by 16

Activity‐Based Protein Profiling of Bile Salt Hydrolysis in the Human Gut Microbiome with Beta‐Lactam or Acrylamide‐Based Probes

Brandvold, K. R., Miller, C. J., Volk, R. F., Killinger, B., Whidbey, C., & Wright, A. (2020) · ChemBioChem · doi:10.1002/cbic.202000748 · Cited by 16

Quantitative modeling identifies critical cell mechanics driving bile duct lumen formation

Liedekerke, P. V., Gannoun, L., Loriot, A. E., Johann, T., Lemaigre, F. P., & Drasdo, D. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009653 · Cited by 16

Inspissated bile syndrome in an infant with citrin deficiency and congenital anomalies of the biliary tract and esophagus: Identification and pathogenicity analysis of a novel SLC25A13 mutation with incomplete penetrance

Zeng, H.-S., Zhao, S., DENG, M., ZHANG, Z.-H., Cai, X., Chen, F., & Song, Y. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1929 · Cited by 16

Calcium signaling and secretion in cholangiocytes

Guerra, M. T., & Nathanson, M. H. (2015) · Pancreatology · doi:10.1016/j.pan.2015.05.477 · Cited by 16

Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs

Tardelli, M., Claudel, T., Bruschi, F. V., & Trauner, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061777 · Cited by 16

Bile formation in long-term ex situ perfused livers

Eshmuminov, D., Schuler, M. J., Becker, D., Borrego, L. B., Mueller, M., Hagedorn, C., Häusler, S., Steiger, J., Tibbitt, M. W., Dutkowski, P., et al. (2021) · Surgery · doi:10.1016/j.surg.2020.11.042 · Cited by 16

The neonatal liver: Normal development and response to injury and disease

Tanimizu, N. (2021) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2021.101229 · Cited by 15

Gallstone and Gallbladder Disease: Biliary Tract and Cholangiopathies

Ceci, L., Han, Y., Krutsinger, K., Baiocchi, L., Wu, N., Kundu, D., Kyritsi, K., Zhou, T., Gaudio, E., Francis, H., et al. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220028 · Cited by 17

Bile Acids in Pancreatic Carcinogenesis

Sharma, B., Twelker, K., Nguyen, C., Ellis, S., Bhatia, N. D., Kuschner, Z. D., Agriantonis, A., Agriantonis, G., Arnold, M., Dave, J., et al. (2024) · Metabolites · doi:10.3390/metabo14070348 · Cited by 15

Aquaporins in Biliary Function: Pathophysiological Implications and Therapeutic Targeting

Khalil, M., Gena, P., Ciaula, A. D., Portincasa, P., & Calamita, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212133 · Cited by 15

Gut Microbiome and Bile Acid Interactions

Wu, N., Bayatpour, S., Hylemon, P. B., Aseem, S. O., Brindley, P. J., & Zhou, H. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.11.004 · Cited by 15

Unveiling the Pharmacological Mechanisms of Eleutheroside E Against Postmenopausal Osteoporosis Through UPLC-Q/TOF-MS-Based Metabolomics

Ma, Y., Hou, Z.-J., Li, Y., Zheng, B.-B., Wang, J., & Wang, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01316 · Cited by 15

3D Printed Model of Extrahepatic Biliary Ducts for Biliary Stent Testing

Thomas, J. L., Patel, S., Troop, L., Guru, R., Faist, N., Bellott, B. J., & Esterlen, B. A. (2020) · Materials · doi:10.3390/ma13214788 · Cited by 15

Metabolomic profiles in relation to benchmark polycyclic aromatic compounds (PACs) and trace elements in two seabird species from Arctic Canada

Sarma, S. N., Thomas, P. J., Naz, S., Pauli, B. D., Crump, D., Zahaby, Y., O’Brien, J. M., Mallory, M. L., Franckowiak, R. P., Gendron, M., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.112022 · Cited by 15

A triple combination strategy of UHPLC-MSn, hypolipidemic activity and transcriptome sequencing to unveil the hypolipidemic mechanism of Nelumbo nucifera alkaloids

Yang, J., Zhang, Y., Jiang, L., Li, C., Sun, Z., Yan, Z., Lin, T., Jiang, Y., & Liu, B. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114608 · Cited by 15

Univariate or multivariate approaches for histopathological biomarkers in the context of environmental quality assessments?

Gusso‐Choueri, P. K., Choueri, R. B., de Araújo, G. S., Cruz, A. C. F., Stremel, T. R. D. O., de Campos, S. X., Abessa, D. M. D. S., & Ribeiro, C. A. D. O. (2022) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2022.113828 · Cited by 15

Current strategies to generate mature human induced pluripotent stem cells derived cholangiocytes and future applications

Cervantes‐Alvarez, E., Wang, Y., de l’Hortet, A. C., Guzman‐Lepe, J., Zhu, J., & Takeishi, K. (2017) · Organogenesis · doi:10.1080/15476278.2016.1278133 · Cited by 15

Metabolomics analysis of time-series human small intestine lumen samples collected in vivo

Folz, J. S., Shalon, D., & Fiehn, O. (2021) · Food & Function · doi:10.1039/d1fo01574e · Cited by 15

Genetic loss of the muscarinic M3 receptor markedly alters bile formation and cholestatic liver injury in mice

Durchschein, F., Krones, E., Pollheimer, M. J., Zollner, G., Wagner, M., Raufman, J., & Fickert, P. (2017) · Hepatology Research · doi:10.1111/hepr.12928 · Cited by 15

Flexible Microtube Plasma for the Consecutive-Ionization of Cholesterol in Nano-Electrospray Mass Spectrometry

Foest, D., Knodel, A., Ahrends, R., Coman, C., Franzke, J., & Brandt, S. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04052 · Cited by 14

Gallstone Disease and Its Correlation With Thyroid Disorders: A Narrative Review

Ravi, P. C., Thugu, T. R., Singh, J., Dasireddy, R. R., Kumar, S. A., Isaac, N. V., Oladimeji, A., DeTrolio, V. R., Abdalla, R., Mohan, V., et al. (2023) · Cureus · doi:10.7759/cureus.45116 · Cited by 14

Normothermic machine perfusion for liver transplantation: current state and future directions

Lindemann, J. D., Yu, J. S., & Doyle, M. M. (2024) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000001141 · Cited by 14

Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes

Zobir, S. Z. M., Fauzi, F. M., Liggi, S., Drakakis, G., Fu, X., Fan, T.-P., & Bender, A. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/2106465 · Cited by 14

Analysis of the Bile Salt Export Pump (ABCB11) Interactome Employing Complementary Approaches

Przybylla, S., Stindt, J., Kleinschrodt, D., Esch, J. S. A., Häussinger, D., Keitel, V., Smits, S. H. J., & Schmitt, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159778 · Cited by 14

Feasibility of discrimination of gall bladder (GB) stone and GB polyp using voltage-applied SERS measurement of bile juice samples in conjunction with two-trace two-dimensional (2T2D) correlation analysis

Vu, T. D., Sohng, W., Jang, E., Choi, D., & Chung, H. (2020) · The Analyst · doi:10.1039/d0an02115f · Cited by 14

Impact of hypoxia and AMPK on CFTR-mediated bicarbonate secretion in human cholangiocyte organoids

Roos, F. J. M., Bijvelds, M. J. C., Verstegen, M. M. A., Roest, H. P., Metselaar, H. J., Polak, W. G., de Jonge, H. R., IJzermans, J. N. M., & van der Laan, L. J. W. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00389.2020 · Cited by 14

Prophylactic Inhibition of Colonization by Streptococcus pneumoniae with the Secondary Bile Acid Metabolite Deoxycholic Acid

Vidal, J. E., Wier, M. N., Angulo-Zamudio, U., McDevitt, E., Vidal, A. G. J., Alibayov, B., Scasny, A., Wong, S. M., Akerley, B. J., & McDaniel, L. S. (2021) · Infection and Immunity · doi:10.1128/iai.00463-21 · Cited by 14

Importance of Conjugation of the Bile Salt on the Mechanism of Lipolysis

Łozińska, N., & Jungnickel, C. (2021) · Molecules · doi:10.3390/molecules26195764 · Cited by 14

Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway

Xue, S., He, W., Zeng, X., Tang, Z., Feng, S., Zhong, Z., Xiong, Y., Wang, Y., & Ye, Q. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9065 · Cited by 14

Predicting drug-induced cholestasis: preclinical models

Petrov, P., Fernández-Murga, M. L., López-Riera, M., Gómez-Lechón, M. J., Castell, J. V., & Jover, R. (2018) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1487399 · Cited by 14

Physicochemical Characterization, Toxicity and In Vivo Biodistribution Studies of a Discoidal, Lipid-Based Drug Delivery Vehicle: Lipodisq Nanoparticles Containing Doxorubicin

Torgersen, M. L., Judge, P. J., Juarez, J. F. B., Pandya, A. D., Fußer, M., Davies, C. W., Maciejewska, M., Yin, D. J., Mælandsmo, G. M., Skotland, T., et al. (2020) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2020.2911 · Cited by 14

A metabolomic-based study on disturbance of bile acids metabolism induced by intratracheal instillation of nickel oxide nanoparticles in rats

Zhang, Q., Chang, X., Wang, X., Zhan, H., Gao, Q., Yang, M., Liu, H., Li, S., & Sun, Y. (2021) · Toxicology Research · doi:10.1093/toxres/tfab039 · Cited by 14

Two Novel Pathogenic Variants of TJP2 Gene and the Underlying Molecular Mechanisms in Progressive Familial Intrahepatic Cholestasis Type 4 Patients

Tang, J., Tan, M., Deng, Y., Tang, H., Shi, H., Li, M., Ma, W., Li, J., Dai, H., Li, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661599 · Cited by 14

Coupling paper spray ionization with the flexible microtube plasma for the determination of low polar biomarkers in mass spectrometry

Foest, D., Knodel, A., Brandt, S., & Franzke, J. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339619 · Cited by 14

Bile Acid-Induced Liver Injury in Cholestasis

Li, T., & Chiang, J. Y. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-53774-0_7 · Cited by 14

Model and methods to assess hepatic function from indocyanine green fluorescence dynamical measurements of liver tissue

Audebert, C., & Vignon-Clementel, I. E. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.01.008 · Cited by 14

A bioinformatics investigation into the pharmacological mechanisms of javanica oil emulsion injection in non-small cell lung cancer based on network pharmacology methodologies

Ni, M., Liu, X., Meng, Z., Liu, S., Jia, S., Liu, Y., Zhou, W., Wu, J., Zhang, J., Guo, S., et al. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02939-y · Cited by 14

Ocular manifestations of liver disease: an important diagnostic aid

Patel, R., Nair, S., Choudhry, H. S., Jaffry, M., & Dastjerdi, M. H. (2024) · International Ophthalmology · doi:10.1007/s10792-024-03103-y · Cited by 13

Emerging Strategies to Overcome Chemoresistance: Structural Insights and Therapeutic Targeting of Multidrug Resistance-Linked ATP-Binding Cassette Transporters

Nagampalli, R. S. K., Vadla, G. P., & Nadendla, E. K. (2025) · International Journal of Translational Medicine · doi:10.3390/ijtm5010006 · Cited by 13

Cellular Evidence and Source of Exosomes in the Biliary System of the Chinese Soft-Shelled Turtle, Pelodiscus sinensis

Zhu, X., Wang, S., Tarique, I., An, T., Yang, H., Bai, X., Wang, X., Chen, Q., & Yang, P. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01097 · Cited by 13

Herbal supplements interactions with oral oestrogen‐based contraceptive metabolism and transport

Hlengwa, N., Muller, C. J. F., Basson, A. K., Bowles, S., Louw, J., & Awortwe, C. (2020) · Phytotherapy Research · doi:10.1002/ptr.6623 · Cited by 13

Alcohol exposure increases manganese accumulation in the brain and exacerbates manganese-induced neurotoxicity in mice

Han, M., Böhlke, M., Maher, T. J., & Kim, J. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03166-1 · Cited by 13

Mild hypoxia exposure impacts peripheral serotonin uptake and degradation in Gulf toadfish (Opsanus beta)

Sebastiani, J., Sabatelli, A., & McDonald, M. D. (2022) · Journal of Experimental Biology · doi:10.1242/jeb.244064 · Cited by 13

Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs

Parrow, A., Larsson, P., Augustijns, P., & Bergström, C. A. S. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00710 · Cited by 13

Secondary bile acids and the biliary epithelia: The good and the bad

Lenci, I., Milana, M., Signorello, A., Grassi, G. B., & Baiocchi, L. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i2.357 · Cited by 13

Bile Composition - which Components Can Have Clinical Significance? A Review of the Literature

Podgórski, P., Przybyłkowski, A. M., & Nehring, P. (2023) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-4634 · Cited by 13

Review: Fish bile, a highly versatile biomarker for different environmental pollutants

de Souza, H. M., de Almeida, R. F., Lopes, A. P., & Hauser‐Davis, R. A. (2024) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2024.109845 · Cited by 13

Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice

Bertolini, A., Nguyen, M., Zehra, S. A., Taleb, S. A., Bauer-Pisani, T., Palm, N., Strazzabosco, M., & Fiorotto, R. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.03.041 · Cited by 13

Maternal copeptin levels in intrahepatic cholestasis of pregnancy

Tayyar, A., Yüksel, İ. T., Köroğlu, N., Tayyar, A. T., Davutoğlu, E. A., Fırat, A. A., & Çetin, B. A. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1335708 · Cited by 13

Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites

Dopico, A. M., & Bukiya, A. N. (2017) · Current topics in membranes · doi:10.1016/bs.ctm.2017.07.001 · Cited by 13

Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices

Zivko, C., Fuhrmann, G., & Luciani, P. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129559 · Cited by 13

Tubular bile duct structure mimicking bile duct morphogenesis for prospective in vitro liver metabolite recovery

Rizki-Safitri, A., Shinohara, M., Tanaka, M., & Sakai, Y. (2020) · Journal of Biological Engineering · doi:10.1186/s13036-020-0230-z · Cited by 13

Bile Goes Viral

Tenge, V. R., Murakami, K., Salmen, W., Lin, S., Crawford, S. E., Neill, F. H., Prasad, B. V. V., Atmar, R. L., & Estes, M. K. (2021) · Viruses · doi:10.3390/v13060998 · Cited by 13

Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure

Bebelman, M. P., Bovyn, M. J., Mayer, C., Delpierre, J., Naumann, R., Martins, N. P., Honigmann, A., Kalaidzidis, Y. L., Haas, P. A., & Zerial, M. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202208002 · Cited by 13

Effects of Hepatic Ischemia–Reperfusion Injuries and NRF2 on Transcriptional Activities of Bile Transporters in Rats

Kim, J., Martin, A., Yee, J., Fojut, L., Geurts, A. M., Oshima, K., Zimmerman, M. A., & Hong, J. C. (2018) · Journal of Surgical Research · doi:10.1016/j.jss.2018.09.057 · Cited by 13

Low polarity fraction of Radix Bupleuri alleviates chronic unpredictable mild stress-induced depression in rats through FXR modulating bile acid homeostasis in liver, gut, and brain

Wang, W., Bai, X., Li, J., Wang, S., Zhao, F., Qin, X., & Gao, X. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116523 · Cited by 12

Proteomic response of Turicibacter bilis MMM721 to chicken bile and its bile acids

Maki, J. J., Lippolis, J. D., & Looft, T. P. (2022) · BMC Research Notes · doi:10.1186/s13104-022-06127-8 · Cited by 12

Normal Gastrointestinal Tract Physiology

Shahsavari, D., & Parkman, H. P. (2022) · Springer eBooks · doi:10.1007/978-3-030-94953-2_1 · Cited by 12

Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells

Foo, W., Cseresnyés, Z., Rössel, C., Teng, Y., Ramoji, A., Chi, M., Hauswald, W., Huschke, S., Hoeppener, S., Popp, J., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122016 · Cited by 12

Expression of mediators of purinergic signaling in human liver cell lines

Goree, J. R., Lavoie, É. G., Fausther, M., & Dranoff, J. A. (2014) · Purinergic Signalling · doi:10.1007/s11302-014-9425-4 · Cited by 12

Generation of Organoids from Mouse Extrahepatic Bile Ducts

Shiota, J., Zaki, N. H. M., Merchant, J. L., Samuelson, L. C., & Razumilava, N. (2019) · Journal of Visualized Experiments · doi:10.3791/59544 · Cited by 12

Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells

Valestrand, L., Berntsen, N. L., Zheng, F., Schrumpf, E., Hansen, S. H., Karlsen, T. H., Blumberg, R. S., Hov, J. R., Jiang, X., & Melum, E. (2020) · Clinical & Experimental Immunology · doi:10.1111/cei.13541 · Cited by 12

The effect of Crocin on TFAM and PGC-1α expression and Catalase and Superoxide dismutase activities following cholestasis-induced neuroinflammation in the striatum of male Wistar rats

Eteghadi, M.-R., Nasehi, M., Vaseghi, S., & Hesami-Tackallou, S. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00748-x · Cited by 12

Etiopathogenesis and pathophysiology of cholestasis

Asensio, M., Ortiz-Rivero, S., Morente-Carrasco, A., & Marı́n, J. J. G. (2022) · Exploration of Digestive Diseases · doi:10.37349/edd.2022.00008 · Cited by 11

Predictive value of bile acids as metabolite biomarkers for gallstone disease: A systematic review and meta-analysis

Han, X., Wang, J., Wu, Y., Gu, H., Zhao, N., Liao, X., & Jiang, M. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305170 · Cited by 11

Bile salt induced aggregation and nanostructure formation of β-lactoglobulin in gastrointestinal environments

Takkella, D., Sharma, S., Vishwakarma, J., & Gavvala, K. (2024) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2024.110944 · Cited by 11

Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice

Jiang, J., Fan, M., Yuan, W., Yue, D., Wang, Z., Yang, L., Huang, W., Jin, L., Wang, X., & Ding, L. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00387.2024 · Cited by 11

Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish

Chiang, K.-Y., Li, Y., Li, Y.-H., Huang, S.-J., Wu, C.-L., Gong, H., & Wu, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011217 · Cited by 11

Modulation of Disordered Bile Acid Homeostasis and Hepatic Tight Junctions Using Salidroside against Hepatocyte Apoptosis in Furan-Induced Mice

Wang, Z., Liu, H., Li, L., Li, Y., Yan, H., & Yuan, Y. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04654 · Cited by 11

Human microbiome and cardiovascular diseases

Alam, J., Puppala, V., Uppulapu, S. K., Das, B., & Banerjee, S. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.07.012 · Cited by 11

Hereditary spherocytosis complicated by intrahepatic cholestasis: two case reports

Han, N., Huang, W., Wang, J., Bai, L., Yan, L., & Tang, H. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5076 · Cited by 11

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition

Beaudoin, J. J., Yang, K., Adiwidjaja, J., Taneja, G., Watkins, P. B., Siler, S. Q., Howell, B. A., & Woodhead, J. L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1085621 · Cited by 11

Establishment and Validation of a Novel Risk Score for Hepatocellular Carcinoma Based on Bile Acid and Bile Salt Metabolism-Related Genes

Shi, Q., Yuan, X. H., Xue, C., Gu, X., & Li, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108597 · Cited by 11

ABC transporters involved in respiratory and cholestatic diseases: From rare to very rare monogenic diseases

Lakli, M., Onnée, M., Carrez, T., Becq, F., Falguières, T., & Fanen, P. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116468 · Cited by 11

Deoxycholic acid inhibited proliferation and induced apoptosis and necrosis by regulating the activity of transcription factors in rat pancreatic acinar cell line AR42J

Zhang, G., Zhang, J., Shang, D., Qi, B., & Chen, H. (2015) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-015-9907-x · Cited by 11

Cellular Mechanisms of Hepatic Fluid and Electrolyte Transport

Dyke, R. W. V., Lake, J. R., & Scharschmidt, B. F. (1989) · Comprehensive physiology · doi:10.1002/j.2040-4603.1989.tb01392.x

THE MECHANISM OF BILIARY LIPID SECRETION AND ITS DEFECTS

Elferink, R. P. J. O., & Groen, A. K. (1999) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70043-1 · Cited by 27

Bile secretion

Erlinger, S. (1992) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072582 · Cited by 19

Cellular mechanisms of bile formation

Blitzer, B. L., & Boyer, J. L. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90027-0 · Cited by 140

Molecular Mechanisms in Bile Formation

Meier, P. J., & Stieger, B. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.2.89 · Cited by 51