Effect of In vitro degradation of poly(D,L‐lactide)/β‐tricalcium composite on its shape‐memory properties
Abstract
The in vitro degradation characteristic and shape-memory properties of poly(D,L-lactide) (PDLLA)/beta-tricalcium phosphate (beta-TCP) composites were investigated because of their wide application in biomedical fields. In this article, PDLLA and crystalline beta-TCP were compounded and interesting shape-memory behaviors of the composite were first investigated. Then, in vitro degradation of the PDLLA/beta-TCP composites with weight ratios of 1:1, 2:1, and 3:1 was performed in phosphate buffer saline solution (PBS) (154 mM, pH 7.4) at 37 degrees C. The effect of in vitro degradation time for PDLLA/beta-TCP composites on shape-memory properties was studied by scanning electron microscopy, differential scanning calorimetry, gel permeation chromatography, X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The changes of structural morphology, glass transition temperature (T(g)), molecular weight, and weight loss of composites matrix and pH change of degradation medium indicated that shape-memory effects at different degradation time were nonlinearly influenced because of the breaking down of polymer chain and the formation of degradation products. Furthermore, the results from XRD and FTIR implied that the degradation products, for example, hydroxyapatite (HA), calcium hydrogen phosphate (CaHPO(4)), and calcium pyrophosphate (Ca(2)P(2)O(7)) phases also had some effects on shape-memory properties during the degradation.
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In PDLLA/β-TCP composites, stress recovery ratios decreased within 56 d from about 98% to values between 56 and 67% during in vitro degradation.
“In the course of degradation, the stress recovery ratios decreased within 56 d from about 98% to values in between 56 and 67%.”
From Review on the Functional Determinants and Durability of Shape Memory Polymers (2010) · cites this paper as [232]
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Self-citation
- Authors
- Zheng, X., Zhou, S., Yu, X., Li, X., Feng, B., Qu, S., & Weng, J.
- Affiliations
- Southwest Jiaotong University (CN)
- Corresponding author
- Zhou, Shaobing
- Venue
- Journal of Biomedical Materials Research Part B Applied Biomaterials
- Publisher
- Wiley
- Published
- 2007-12-27
- Volume
- 86B
- Issue
- 1
- Pages
- 170-180
- ISSN
- 1552-4973 (ISSN-L)
- 1552-4981
- OpenAlex
- W1987823837
- Cited by
- 35
- References
- 54
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 1 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
- Keywords
- poly(D,L-lactide), beta-tricalcium phosphate, polymer composites, shape memory effect, in vitro degradation, degradation products, hydroxyapatite, dicalcium phosphate, calcium pyrophosphate, glass transition temperature, molecular weight reduction, biodegradable polymers
- MeSH terms
- Biocompatible Materials, Body Weight, Calcium Phosphates, Calorimetry, Differential Scanning, Hydrogen-Ion Concentration, Materials Testing, Models, Chemical, Molecular Weight, Polyesters, Polymers, Temperature, X-Ray Diffraction, Spectroscopy, Fourier Transform Infrared, Bone Substitutes, Lactic Acid, In Vitro Techniques
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