The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Glucocorticoid induced autophagy in osteocytes
Open accessAbstract
Glucocorticoid (GC) therapy is the most frequent cause of secondary osteoporosis. In this study we have demonstrated that GC treatment induced the development of autophagy, preserving osteocyte viability. GC treatment resulted in an increase in autophagy markers and the accumulation of autophagosome vacuoles in vitro and in vivo promoted the onset of the osteocyte autophagy, as determined by expression of autophagy markers in an animal model of GC-induced osteoporosis. An autophagy inhibitor reversed the protective effects of GCs. The effects of GCs on osteocytes were in contrast to tumor necrosis factor α (TNF-α), which induced apoptosis but not autophagy. Together this study reveals a novel mechanism for the effect of GC on osteocytes, shedding new insight into mechanisms responsible for bone loss in patients receiving GC therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We have reported that osteocyte autophagy is crucial to the regulation of bone structure and plays a role in GC induced bone fragility [44, 68].”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,638
How to Interpret LC3 Immunoblotting
Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595 · cited 1×
“induced upregulation of autophagy is facilitated primarily through biosynthesis but not through the blockage of LC3-II degradation.((24))”
BackgroundGuidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230
Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,105
Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753 · cited 2×
“A previous study reported that GCs induce apoptosis of osteocytes, reporting nearly 15% to 20% apoptotic cells in GCtreated mice.((3)) Interestingly, Lane and colleagues((8)) reported increased osteocyte lacunar size and loss of mineral around the osteocytes, suggesting that a metabolic change had occurred in the pres…”
BackgroundUse of Inhaled Corticosteroids and Risk of Fractures
van Staa, T. P., Leufkens, H. G. M., & Cooper, C. C. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.3.581 · Cited by 1,297
Use of oral corticosteroids and risk of fractures
Van Staa, T. P., Leufkens, H. G. M., Abenhaim, L., Zhang, B., & Cooper, C. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.993 · Cited by 1,263
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
Kanzawa, T., Germano, I. M., Komata, T., Ito, H., Kondo, Y., & Kondo, S. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401359 · Cited by 995
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–192 of 192
Dexamethasone Stimulates Hepatitis B Virus (HBV) Replication Through Autophagy
He, Q., Song, X., Huang, Y., Huang, W., Ye, B., Luo, H., Luo, H., Wu, L., Wang, Z., Chen, W., et al. (2018) · Medical Science Monitor · doi:10.12659/msm.906250 · Cited by 26
“Some reported that dexamethasone could induce autophagy in lymphocyte and osteocytes [12,13].”
BackgroundLiang, X., Luo, D., Chen, Y.-R., Li, J., Yan, B., Guo, Y., Wen, M., Xu, B., & Li, G. (2022) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-022-02977-x · Cited by 25
“and regulates the negative effects of GC on osteoblasts, osteoclasts and osteocytes [25].”
BackgroundDevelopment of broiler chickens after treatment with thymulin 5cH: a zoo technical approach
Sato, C., Galha, V., & Bonamin, L. V. (2012) · Homeopathy · doi:10.1016/j.homp.2011.09.004 · Cited by 24
Osteocytes are not only mechanoreceptive cells
Rochefort, G. Y., & Benhamou, C.-L. (2013) · International Journal for Numerical Methods in Biomedical Engineering · doi:10.1002/cnm.2561 · Cited by 26
Lee, K. I.-R., Chen, J.-H., & Chen, K.-H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020641 · Cited by 26
“This depletion of bone-forming cells disrupts the osteocytic network, which is essential for mechanosensation and coordination of bone turnover [90,91].”
Yu, W. H., Zhu, C., Xu, W., Jiang, L., & Jiang, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122150 · Cited by 22
Autophagy: A Promising Target for Age-related Osteoporosis
Wang, T., He, H., Liu, S., Jia, C., Fan, Z., Zhong, C., Yu, J., Liu, H., & He, C. (2018) · Current Drug Targets · doi:10.2174/1389450119666180626120852 · Cited by 24
Zhang, Q., & Zhang, X. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9622 · Cited by 21
Yamamoto, H., Saito, M., Goto, T., Ueshima, K., Ishida, M., Hayashi, S., Ikoma, K., Mazda, O., & Kubo, T. (2019) · Medical Molecular Morphology · doi:10.1007/s00795-018-00215-0 · Cited by 20
PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes
Yuan, J., Gao, Y., Liu, D., Tai, A. C. P., Zhou, H., Papadimitriou, J. M., Zhang, C., Zheng, M., & Gao, J. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.11.003 · Cited by 21
“Intriguingly, osteocytes are suggested to respond to stressful conditions including GC treatment by the mean of autophagy [17,18], suggesting that autophagy in osteocytes could be a new target for preventing GC-induced osteoporosis.”
BackgroundMa, B., Guan, G., Lv, Q., & Yang, L. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5563660 · Cited by 20
Jähn, K., & Zimmermann, E. A. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00686-8 · Cited by 18
Dungan, C. M., Li, J., & Williamson, D. L. (2016) · Lipids · doi:10.1007/s11745-016-4168-3 · Cited by 20
“In addition to upregulating REDD1 protein expression while consuming a HF diet, glucocorticoidinduced REDD1 expression can promote apoptosis [42] and autophagy [43], which is consistent with the observed increase in cleaved caspase 3 and the LC3-II/I ratio, markers of apoptosis and autophagy, respectively.”
BackgroundPreventive effects of Polygonum multiflorum on glucocorticoid-induced osteoporosis in rats
Zhou, M., Li, J., Wu, J., Yang, Y., Zeng, X., Lv, X., Cui, L., Yao, W., & Liu, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4802 · Cited by 20
“Glucocorticoids are effective anti-inflammatory and immunomodulatory agents, which secondarily contribute to dysfunction of bone metabolism, increases of bone fragility and the ultimate consequence of bone fractures (2).”
Sun, Q., Yang, Y., Li, X., He, B., Jia, Y., Zhang, N., & Zhao, R. (2016) · Steroids · doi:10.1016/j.steroids.2016.04.010 · Cited by 19
Jia, J., Yao, W., Amugongo, S. K., Shahnazari, M., Dai, W., Lay, Y.-A. E., Olvera, D., Zimmermann, E. A., Ritchie, R. O., Li, C., et al. (2012) · Bone · doi:10.1016/j.bone.2012.10.017 · Cited by 19
“Ale treatment increased serum TGF-β1 levels and the numbers of TGF-β1-positive osteocytes and periosteal cells in cortical bone.”
BackgroundDuarte, M., Pedrosa, S. S., Khusial, P. R., & Madureira, A. R. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111956 · Cited by 23
“…bone marrow (leukemic cells)) by increasing the transcription of autophagy genes such as ATG5, LC-3, and Beclin1 (Gao et al., 2016; Grand ´ er et al., 2009; Jung et al., 2020; Shi et al., 2015; Sinha et al., 2017; Swerdlow et al., 2008; Troncoso et al., 2014; Xia et al., 2010; Yao et al., 2013).”
Research progresses on mitochondrial-targeted biomaterials for bone defect repair
Wang, S., Liu, J., Zhou, L., Xu, H., Zhang, D., Zhang, X., Wang, Q., & Zhou, Q. H. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae082 · Cited by 18
Kenanidis, E. I., Potoupnis, M. E., Kakoulidis, P., Leonidou, A. O., Sakellariou, G. T., Sayegh, F. E., & Tsiridis, E. E. (2015) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2015.1040387 · Cited by 20
“In addition even direct osteocyte autophagy could be induced by specific GC like dexamethasone [42].”
BackgroundTrabecular Bone Score Significantly Influences Treatment Decisions in Secondary Osteoporosis
Al-Hashimi, L., Klotsche, J., Ohrndorf, S., Gaber, T., & Hoff, P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12124147 · Cited by 18
Fenton, C. G., Crastin, A., Martin, C., Suresh, S., Montagna, I., Hussain, B., Naylor, A. J., Jones, S. W., Hansen, M. S., Gorvin, C. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137334 · Cited by 16
Bisphosphonates and glucocorticoid-induced osteoporosis: Efficacy and tolerability
Lespessailles, É. (2012) · Joint Bone Spine · doi:10.1016/j.jbspin.2012.08.005 · Cited by 16
Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia
Ueda, S., Ichiseki, T., Yoshitomi, Y., Yonekura, H., Ueda, Y., Kaneuji, A., & Matsumoto, T. (2014) · Medical Molecular Morphology · doi:10.1007/s00795-014-0077-9 · Cited by 16
“Cells were exposed under normoxia (20 % O2) or hypoxia (1 % O2) [23, 24] in the presence or absence of 1 lM dexamethasone (Dex) (MSD, Tokyo, Japan) for 24 h [25, 26].”
MethodHigh-throughput screening approaches to identify regulators of mammalian autophagy
Joachim, J., Jiang, M., McKnight, N. C., Howell, M. T., & Tooze, S. A. (2015) · Methods · doi:10.1016/j.ymeth.2015.02.002 · Cited by 16
Dexamethasone Exposure Accelerates Endochondral Ossification of Chick EmbryosViaAngiogenesis
Cheng, X., Yan, Y., Chen, J., Ma, Z.-L., Yang, R.-H., Wang, G., Chuai, M., Lee, K. K., & Yang, X. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv227 · Cited by 16
Dexamethasone reduces ATDC5 chondrocyte cell viability by inducing autophagy
Zhao, Y., Zuo, Y., Huo, H., Xiao, Y.-L., Yang, X., & Xin, D. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1915 · Cited by 16
β‑ecdysterone promotes autophagy and inhibits apoptosis in osteoporotic rats
Tang, Y., Yue, Z., Xin, D., Zeng, L., Xiong, Z., Hu, Z., & Xu, C. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8053 · Cited by 17
“A previous study revealed that dexamethasone, in contrast to PRED, induced osteocyte apoptosis, resulted in an increase in autophagy markers and promoted the accumulation of autophagosome vacuoles in vitro and in vivo , thus promoting the onset of osteocyte autophagy (10).”
Xing, W., Hao, L., Yang, X., Li, F., & Huo, H. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2253 · Cited by 14
New insights into the biology of glucocorticoid-induced osteoporosis
Lane, N. E., & Yao, W. (2011) · IBMS BoneKEy · doi:10.1138/20110511 · Cited by 15
“, we have found that dexamethasone treatment of an osteocytic cell line increased autophagic activity as detected by several standard approaches based on recently published guidelines that included fluorescent GFPLC3 dots, MDC fluorescence, LC3 lipidation and electron microscopy imaging in addition to conventional acr…”
MethodDore, R. K. (2013) · Patient Preference and Adherence · doi:10.2147/ppa.s31067 · Cited by 15
“Based on these data, long-term treatment with glucocorticoids leads to apoptosis, and subsequently a reduction in bone strength and bone loss.(29)”
Factors affecting bone strength other than osteoporosis
Ratti, C., Vulcano, E., Canton, G., Marano, M., Murena, L., & Cherubino, P. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0098-6 · Cited by 13
“This increased excretion of calcium leads to an increase in PTH secretion and a net increase in bone loss [7].”
BackgroundNeurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse models
Kühnisch, J., Seto, J., Lange, C., Stumpp, S., Kobus, K., Grohmann, J., Elefteriou, F., Fratzl, P., Mundlos, S., & Kolanczyk, M. (2014) · Bone · doi:10.1016/j.bone.2014.06.012 · Cited by 13
Yuze, M., Hu, J., Lv, J., Cheng, X., Tianwen, X., & Junqiang, Z. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1629273 · Cited by 12
Zhao, Z., Liu, W., Guo, S., Bai, R., & Yan, J. (2020) · Orthopaedic Surgery · doi:10.1111/os.12630 · Cited by 10
“In the current study, we detected increased Beclin 1 expression in the femoral head tissues of a rabbit model of SANFH, indicating that autophagy is also a pathological basis of SANFH.”
BackgroundLithium prevents glucocorticoid‐induced osteonecrosis of the femoral head by regulating autophagy
Wang, Q., Yang, Z., Li, Q., Zhang, W., & Kang, P. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18385 · Cited by 10
Shibayama, Y., Alkhoury, C., Nemazanyy, I., Henneman, N. F., Cagnard, N., Girard, M., Atsumi, T., & Panasyuk, G. (2022) · Acta Physiologica · doi:10.1111/apha.13793 · Cited by 9
Chang, Y.-S., Hou, S.-Y., Yu, S.-S., Tsai, S.-Y., Chen, Y., Hsu, L., Tsai, P.-J., Lin, H., Lin, C.-H., & Tsai, Y.-S. (2022) · Theranostics · doi:10.7150/thno.70752 · Cited by 10
“Dex was reported to induce autophagy in a variety of cells [58-60], yet its effect on autophagy in BAT is still unclear.”
BackgroundBonewald, L. F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00010-8 · Cited by 14
Rendina-Ruedy, E., Graef, J. L., Lightfoot, S. A., Ritchey, J. W., Clarke, S. L., Lucas, E. A., & Smith, B. J. (2016) · Bone Reports · doi:10.1016/j.bonr.2016.08.001 · Cited by 10
Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic Patients
Eizadi, M., Taghi, G. M., Mirakhori, Z., & Ashraf, A. (2018) · Research in Molecular Medicine · doi:10.18502/rmm.v5i4.3064 · Cited by 10
“(2010) reported a 50% decrease in the number of osteocytes in rats treated with steroids [23].”
BackgroundBonewald, L. F. (2013) · Primer on the metabolic bone diseases and disorders of mineral metabolism · doi:10.1002/9781118453926.ch4 · Cited by 10
Effect of β‑ecdysterone on glucocorticoid‑induced apoptosis and autophagy in osteoblasts
Tang, Y., Yue, Z., Li, G., Zeng, L., Xin, D., Hu, Z., & Xu, C. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7840 · Cited by 36
“GCs have been shown to induce autophagy in an animal model of osteoporosis through decreasing the ratio ofmicrotubule-associated protein 1 light chain 3 (LC3)-”
InfluentialRelić, B., Charlier, E., Deroyer, C., Malaise, O., Neuville, S., Desoroux, A., Gillet, P., de Seny, D., & Malaise, M. (2016) · Oncotarget · doi:10.18632/oncotarget.8042 · Cited by 9
“In addition dexamethasone induces autophagy in osteocytes [41].”
BackgroundImmune complexes suppressed autophagy in glomerular endothelial cells
Wang, L., & Law, H. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.02.013 · Cited by 9
Liu, S., Huang, Y., Wang, C., Tian, S., Xu, Y., & Ge, J. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6827 · Cited by 9
“Studies have shown that glucocorticoids cannot only induce osteoblast apoptosis, but also lead to the occurrence of bone autophagy (12).”
BackgroundGlucocorticoid-Induced Autophagy in Osteocytes
SCHTEINGART, D. E. (2011) · Yearbook of Endocrinology · doi:10.1016/j.yend.2011.05.007 · Cited by 9
Establishment and evaluation of the primary cultured tibial osteoblast model of broiler chicks
Cao, S., Li, T., Shao, Y., Yu-zhen, Z. H. A. O., ZHANG, L.-Y., Lü, L., ZHANG, R.-J., Hou, S., Liao, X., Xu-gang, L. U. O., et al. (2022) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2022.08.051 · Cited by 8
Pulsed electromagnetic fields as a promising therapy for glucocorticoid-induced osteoporosis
Zhang, T., Zhao, Z., & Wang, T. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1103515 · Cited by 9
“GCs induce osteocyte autophagy during the initial period (Xia et al., 2010), while prolonged usage of GCs causes osteocyte death, resulting in a decrease in osteocyte number, accompanied by significantly impaired bone quality.”
BackgroundShi, H., Li, B., Zhang, D., Han, H., He, H., Zhu, J., Wang, H., & Chen, L. (2023) · The FASEB Journal · doi:10.1096/fj.202300022rr · Cited by 8
Pharmacological Interventions for Glucocorticoid-Induced Osteoporosis: An Umbrella Review
Liang, H.-D., Zhao, J., & Tian, T. (2023) · Hormone and Metabolic Research · doi:10.1055/a-2112-1596 · Cited by 8
“Introduction Glucocorticoids (GCs) are widely used in clinical work due to their effectiveness in achieving immunosuppression, an anti-inflammatory response, and other pharmacological effects [1, 2]; in fact, GCs are used to treat many types of diseases.”
BackgroundUpdated recommendations on the management of glucocorticoid-induced osteoporosis
Orcel, P. (2014) · Joint Bone Spine · doi:10.1016/j.jbspin.2014.08.004 · Cited by 8
Suwanjang, W., Ruankham, W., Chetsawang, B., Mukda, S., Ngampramuan, S., Srisung, S., Prachayasittikul, V., & Prachayasittikul, S. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105083 · Cited by 8
[Role of autophagy in the pathogenesis of periodontitis].
Mo, L., Jia, X.-Y., Liu, C., Zhou, X., & Xu, X. (2019) · PubMed Central · doi:10.7518/hxkq.2019.04.016 · Cited by 5
Pang, K., Wang, S., Li, M., & Zhou, Z. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.746087 · Cited by 5
“MP treatment increased the incidence of FHN substantially, while co-treatment with 3-MA reduced the occurrence of FHN.”
BackgroundInfluentialZhou, C., Hu, X., Jing, Y., Zhang, J., Tao, J., Ouyang, X., Tang, J., Zhang, G., & Liu, H. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1698404 · Cited by 5
“Glucocorticoid (GC) exposure induces autophagosome accumulation and upregulates LC3A/LC3B, ATG2, ATG7, and other key components, re fl ecting robust activation of the lysosome-dependent autophagy pathway (165).”
Fleischhauer, L., López-Delgado, A. C., Geurtzen, K., & Knopf, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1122351 · Cited by 4
“Studies on mice documented an induction of autophagy and partially even apoptosis of osteoblasts and terminally differentiated osteoblasts (osteocytes) in the presence of GCs (12, 13).”
BackgroundBonewald, L. F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00007-1 · Cited by 8
SCHTEINGART, D. E. (2012) · Yearbook of Medicine · doi:10.1016/s0084-3873(12)00333-1 · Cited by 3
Suwanjang, W., Sirisuwat, C., Srisung, S., Isarankura‐Na‐Ayudhya, C., Pannengpetch, S., & Prachayasittikul, S. (2022) · Rejuvenation Research · doi:10.1089/rej.2021.0002 · Cited by 3
“6,7 Recent evidence demonstrates that high dose of dexamethasone induced neurotoxicity via impairment of mitochondrial dynamics in SH-SY5Y cells.”
Ostéoporose secondaire à la corticothérapie systémique
Bouvard, B., Legrand, É., Audran, M., & Chappard, D. (2011) · Revue du Rhumatisme Monographies · doi:10.1016/j.monrhu.2011.02.005 · Cited by 3
Aftab, O., Fryknäs, M., Zhang, X., Milito, A. D., Hammerling, U., Linder, S., Larsson, R. L., & Gustafsson, M. G. (2013) · Autophagy · doi:10.4161/auto.26678 · Cited by 3
“In the current literature, there are several recent reports from independent researchers showing that the top hits analyzed by us are indeed modulating the autophagic process.(12,15-17,24) Moreover, we provided biochemical evidence that many of the top hits identified induced accumulation of autophagosomes and/or incr…”
BackgroundKneissel, M. (2011) · IBMS BoneKEy · doi:10.1138/20110490 · Cited by 3
The Osteocyte Network as a Source and Reservoir of Signaling Factors
Bonewald, L. F. (2010) · Endocrinology and Metabolism · doi:10.3803/enm.2010.25.3.161 · Cited by 3
Schteingart, D. E. (2012) · Yearbook of Endocrinology · doi:10.1016/j.yend.2012.05.015 · Cited by 3
[Effects of icariin on autophagy and exosome production of bone microvascular endothelial cells].
Zhang, Q., Gao, F., Cheng, L., Liu, L., Sun, W., & Li, Z. (2019) · Europe PMC (PubMed Central) · doi:10.7507/1002-1892.201811009 · Cited by 3
Novel immunological targets in rheumatic diseases: clues from current therapies
D’Acquisto, F., Rattazzi, L., Piras, G., & Galuppo, M. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.06.021 · Cited by 2
Bisphosphonates and implants in the jaw bone
Abtahi, J. (2013) · DiVA (Linkoping University) · Cited by 2
Rendina-Ruedy, E. (2015) · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University) · doi:10.13140/rg.2.1.5090.3208 · Cited by 2
Bonewald, L. F. (2018) · Primer on the metabolic bone diseases and disorders of mineral metabolism · doi:10.1002/9781119266594.ch5 · Cited by 2
Regulatory signaling pathways of osteoblast autophagy in periprosthetic osteolysis
Gu, Y., Wu, Z., Xie, H., Fang, T., Wang, Q., & Gu, Y. (2024) · Frontiers in Cell Death · doi:10.3389/fceld.2024.1337724 · Cited by 1
“Xia et al. showed that certain metabolic stressors can activate autophagy in osteoblasts.”
Xie, A., Wang, L., Zhang, Y., Zhang, S., Cao, J., Wang, C., Wu, H., & Dai, W. (2025) · Steroids · doi:10.1016/j.steroids.2025.109693 · Cited by 1
Basic and clinical aspects of glucocorticoid action in bone
Zhou, H., Cooper, M. S., & Seibel, M. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00039-7 · Cited by 1
Cell Biology of Craniofacial Bone: Osteocytes
Bonewald, L. F. (2012) · doi:10.1002/9781118704868.ch8 · Cited by 1
Verhees, K. J. P. (2013) · Research Publications (Maastricht University) · doi:10.26481/dis.20130619kv
Toscani, D. (2015) · DSpaceUnipr (University of Parma)
WITHDRAWN: Novel Immunological Targets in Rheumatic Diseases: Clues from Current Therapies
D’Acquisto, F., Rattazzi, L., Piras, G., & Galuppo, M. L. (2014) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.09.002
Actualisation des recommandations pour la prise en charge de l’ostéoporose cortisonique
Orcel, P. (2014) · Revue du Rhumatisme · doi:10.1016/j.rhum.2014.08.004
Les bisphosphonates dans l’ostéoporose cortico-induite : efficacité et tolérance
Lespessailles, É. (2013) · Revue du Rhumatisme · doi:10.1016/j.rhum.2012.09.006
dysfunctionof autophagy in COPD skeletal muscle
Hussain, S. N. A., & Sandri, M. (2015)
Glucocorticoid-Induced Osteoporosis Management Among Seniors
Albaun, M. J. (2014) · TSpace (University of Toronto)
Yamakura, M. U. F. (2012)
Role of autophagy in building and maintaining the skeletal system
Camuzard, O., Trojani, M.-C., Carle, G. F., & Pierrefite‐Carle, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822003-0.00015-2
Kim, S., Munshi, L. B., Alamoush, B., Zaidi, M., & Epstein, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11237-1
Akbarzadeh, J., & Godoy, C. (2021) · Springer eBooks · doi:10.1007/978-3-030-75750-2_1
Kirk, A., James, B., Feltbower, R. G., Mushtaq, T., Whitehead, E., Kraft, J. K., Motwani, J., Parkin, H., Guest, J., Gray, J. C., et al. (2025) · British Journal of Haematology · doi:10.1111/bjh.70286
“…also reduce bone turnover and promote bone fragility through direct action on all bone cell types, having been shown to induce osteoblast apoptosis, 9–11 increase osteocyte autophagy 12,13 and suppress osteoclast precursor proliferation and impair osteoclast function with prolonged use.”
Autophagy: A Novel Therapeutic Target for Osteoporosis
Meng, L., Zhang, Z., Huang, Y., Zheng, C., Wang, L., Li, Z., Wang, Y., Li, Y., Liu, M., Zhao, B., et al. (2026) · Phenomics · doi:10.1007/s43657-025-00244-7
SLC29A1 /ENT1 and SLC29A3 /ENT3 differentially regulate autophagy
Bissa, B., Kaur, T., Joshi, A., & Govindarajan, R. (2026) · Autophagy · doi:10.1080/15548627.2026.2639407
“However, excessive auto-phagy has detrimental effects on bone health [84,85], consistent with the ectopic spinal mineralization observed in aged slc29a1 − /− mice, resembling diffuse idiopathic skeletal hyperostosis in humans.”
Rong, Y., Zhang, L., Xu, M., Chen, Y., Wang, X., Li, S., Yang, G., & Chen, G. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1750464
“These fi ndings were corroborated by in vivo studies, collectively indicating that GCs induce osteocyte autophagy and apoptosis (67, 68).”
Rôle de l’autophagie dans l’ostéosarcome
Camuzard, O. (2019) · theses.fr (ABES) · doi:10.70675/db9b0551zd9a2z4cf6z8dc4zdfbbe6b4e208
Bioprinted bonoid-on-a-chip model for studying drug effects on human osteocyte differentiation
Scheinpflug, J., Höfer, C. T., Steinfath, M., Thomas, A., Schmerbeck, S. S., John, T., Schneider, M. R., Schönfelder, G., Schulze, F., & Barenys, M. (2026) · Biofabrication · doi:10.1088/1758-5090/ae7ed2
“In our study we exposed the cells to 1.5 µ m DEXA a concentration that lies above the physiological range and approaches the lower therapeutic threshold used in clinical settings [77–81], without being so high to have fast and direct cytotoxic effects.”
InfluentialThe complexity of skeletal fragility in overt endogenous Cushing’s syndrome: how much do we know?
Voltan, G., Mogno, C., Contini, G., Tizianel, I., Ferrarese, M., & Camozzi, V. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1918392
Wang, X., Mao, L., Li, Y., & Wang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1924727
Metadata
- Authors
- Xia, X., Kar, R., Gluhak-Heinrich, J., Yao, W., Lane, N. E., Bonewald, L. F., Biswas, S. K., Lo, W.-K., & Jiang, J. X.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Department of Orthodontics, University of Texas Health Science Center, San Antonio, TX, USA
- University of California Davis Medical Center (US)
- University of Missouri–Kansas City (US)
- Morehouse School of Medicine (US)
- Corresponding author
- Jiang, Jean X
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10-25
- Volume
- 25
- Issue
- 11
- Pages
- 2479-2488
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- PMC
- PMC3179284
- OpenAlex
- W2004485238
- Cited by
- 193
- References
- 33
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 12 · 2019: 13 · 2018: 16 · 2017: 11 · 2016: 12 · 2015: 18 · 2014: 22 · 2013: 21 · 2012: 16
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Tokyo Medical and Dental University
- National Institutes of Health (AQ‐1507, and K24, AR46798)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K24-AR04884, R01AR043052, K24AR048841, P01AR046798, P01AR46798)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12 HD05195801, K12HD051958)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- glucocorticoids, autophagy, osteocytes, glucocorticoid-induced osteoporosis, autophagosomes, osteocyte viability, autophagy inhibition, TNF-α, apoptosis, bone loss
- MeSH terms
- Adenine, Animals, Autophagy, Cell Count, Cell Line, Chickens, Dexamethasone, Glucocorticoids, Microtubule-Associated Proteins, Osteocytes, Phagosomes, Biomarkers, Apoptosis, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
