Increased presence of capillaries next to remodeling sites in adult human cancellous bone
Abstract
Vascularization is a prerequisite for osteogenesis in a number of situations, including bone development, fracture healing, and cortical bone remodeling. It is unknown whether a similar link exists between cancellous bone remodeling and vascularization. Here, we show an association between remodeling sites, capillaries, proliferative cells, and putative osteoblast progenitors. Iliac crest biopsies from normal human individuals were subjected to histomorphometry and immunohistochemistry to identify the respective positions of bone remodeling sites, CD34-positive capillaries, smooth muscle actin (SMA)-positive putative osteoblast progenitors, including pericytes, Ki67-positive proliferative cells, and bone remodeling compartment (BRC) canopies. The BRC canopy is a recently described structure separating remodeling sites from the bone marrow, consisting of CD56-positive osteoblasts at an early differentiation stage. We found that bone remodeling sites were associated with a significantly increased presence of capillaries, putative osteoblast progenitors, and proliferative cells in a region within 50 µm of the bone or the canopy surface. The increases were the highest above eroded surfaces and at the level of the light-microscopically assessed contact of these three entities with the bone or canopy surfaces. Between 51 and 100 µm, their densities leveled to that found above quiescent surfaces. Electron microscopy asserted the close proximity between BRC canopies and capillaries lined by pericytes. Furthermore, the BRC canopy cells were found to express SMA. These ordered distributions support the existence of an osteogenic-vascular interface in adult human cancellous bone. The organization of this interface fits the current knowledge on the mode of action of vasculature on osteogenesis, and points to the BRC canopy as a central player in this mechanism. We propose a model where initiation of bone remodeling coincides with the induction of proximity of the vasculature to endosteal surfaces, thereby allowing capillary-BRC canopy interactions that activate marrow events, including recruitment of osteoblast progenitors to bone remodeling sites. © 2013 American Society for Bone and Mineral Research.
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An increased presence of capillaries covering human cancellous bone is found at remodeling sites within 50 μm from the canopy surface.
“an increased presence of capillaries covering human cancellous bone has been found at remodeling sites in an area within 50 µm from the canopy surface.124”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [124]
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- Authors
- Kristensen, H. B., Andersen, T. L., Marcussen, N., Rolighed, L., & Delaisse, J.-M.
- Affiliations
- Department of Clinical Cell Biology, Lillebaelt/Vejle Hospital, IRS, University of Southern Denmark, Vejle, Denmark
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-09-18
- Volume
- 28
- Issue
- 3
- Pages
- 574-585
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2158079848
- Cited by
- 97
- References
- 54
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 13 · 2019: 10 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 10 · 2014: 9 · 2013: 11
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- bone remodeling, trabecular bone, bone vascularization, capillaries, osteoblast progenitors, pericytes, CD34, smooth muscle actin, Ki-67, CD56, bone marrow, bone formation
- MeSH terms
- Adult, Bone and Bones, Capillaries, Humans, Immunohistochemistry, Microscopy, Electron
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