Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?
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Skeletal mass is regulated by two key activities: bone removal (resorption) by hematopoietic lineage osteoclasts and bone matrix formation by mesenchymal lineage osteoblasts. During adult life, these activities occur sequentially on the same surface: a process termed as remodeling. Tiny packets of bone are removed by osteoclasts and replaced by new bone matrix produced by osteoblasts. This continual renewal process allows repair of mechanical imperfections and calcium homeostasis.
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Because TGF-β1 and IGF1 do not remain accessible long enough to affect complete refilling of the resorption cavity, their action might be limited to the early phases of remodeling when osteoclasts are still actively resorbing bone matrix.
“Since TGF-β1 and IGF1 do not remain accessible long enough to affect the complete refilling of the resorption cavity,220 their action might be limited to the early phases of remodeling, when osteoclasts are still actively resorbing the bone matrix.”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [220]
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- Authors
- Sims, N. A., & Martin, T. J.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Sims, Natalie A.
- ORCID
- Sims, Natalie A.
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2015-03-24
- Volume
- 6
- Pages
- 41-41
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC4371744
- OpenAlex
- W2053586178
- Cited by
- 184
- References
- 63
- Citations by year
- 2026: 14 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 19 · 2021: 19 · 2020: 19 · 2019: 27 · 2018: 17 · 2017: 19 · 2016: 13 · 2015: 9
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- bone remodeling, osteoclasts, osteoblasts, bone resorption, bone matrix formation, calcium homeostasis, bone turnover
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