Cited by 184Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

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Sims, Natalie A., Martin, T. John·2015·Frontiers in Endocrinology

Abstract

Skeletal mass is regulated by two key activities: bone removal (resorption) by hematopoietic lineage osteoclasts and bone matrix formation by mesenchymal lineage osteoblasts. During adult life, these activities occur sequentially on the same surface: a process termed as remodeling. Tiny packets of bone are removed by osteoclasts and replaced by new bone matrix produced by osteoblasts. This continual renewal process allows repair of mechanical imperfections and calcium homeostasis.

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Crossref · 10.3389/fendo.2015.00041

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  • Because TGF-β1 and IGF1 do not remain accessible long enough to affect complete refilling of the resorption cavity, their action might be limited to the early phases of remodeling when osteoclasts are still actively resorbing bone matrix.

    “Since TGF-β1 and IGF1 do not remain accessible long enough to affect the complete refilling of the resorption cavity,220 their action might be limited to the early phases of remodeling, when osteoclasts are still actively resorbing the bone matrix.”

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Authors
Sims, N. A., & Martin, T. J.
Affiliations
The University of Melbourne (AU)
Corresponding author
Sims, Natalie A.
Venue
Frontiers in Endocrinology
Published
2015-03-24
Volume
6
Pages
41-41
ISSN
1664-2392 (ISSN-L)
OpenAlex
W2053586178
Cited by
184
References
63
Citations by year
2026: 14 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 19 · 2021: 19 · 2020: 19 · 2019: 27 · 2018: 17 · 2017: 19 · 2016: 13 · 2015: 9
FWCI
1.87
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords
bone remodeling, osteoclasts, osteoblasts, bone resorption, bone matrix formation, calcium homeostasis, bone turnover

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