Cited by 2,543Bone health and osteoporosis researchBone Metabolism and DiseasesClassical Anatomy and Histology

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Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

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Dempster, David W, Compston, Juliet E, Drezner, Marc K, Glorieux, Francis H, Kanis, John A, Malluche, Hartmut, Meunier, Pierre J, Ott, Susan M, Recker, Robert R, Parfitt, A Michael·2013·Journal of Bone and Mineral Research

DOI 10.1002/jbmr.1805PMC PMC3672237

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Abstract

Before publication of the original version of this report in 1987, practitioners of bone histomorphometry communicated with each other in a variety of arcane languages, which in general were unintelligible to those outside the field. The need for standardization of nomenclature had been recognized for many years,1 during which there had been much talk but no action. To satisfy this need, B Lawrence Riggs (ASBMR President, 1985 to 1986) asked A Michael Parfitt to convene an ASBMR committee to develop a new and unified system of terminology, suitable for adoption by the Journal of Bone and Mineral Research (JBMR) as part of its Instructions to Authors. The resulting recommendations were published in 19872 and were quickly adopted not only by JBMR but also by all respected journals in the bone field. The recommendations improved markedly the ability of histomorphometrists to communicate with each other and with nonhistomorphometrists, leading to a broader understanding and appreciation of histomorphometric data. In 2012, 25 years after the development of the standardized nomenclature system, Thomas L Clemens (Editor in Chief of JBMR) felt that it was time to revise and update the recommendations. The original committee was reconvened by David W Dempster, who appointed one new member, Juliet E Compston. The original document was circulated to the committee members and was extensively revised according to their current recommendations. The key revisions include omission of terminology used before 1987, recommendations regarding the parameters and technical information that should be included in all histomorphometry articles, recommendations on how to handle dynamic parameters of bone formation in settings of low bone turnover, and updating of references. It is generally agreed that a bone is an individual organ of the skeletal system, but the term "bone" has at least three meanings. The first is mineralized bone matrix excluding osteoid; this usage conforms rigorously to the definition of bone as a hard tissue. Osteoid is bone matrix that will be (but is not yet) mineralized, and is sometimes referred to as pre-bone. The second meaning of "bone," and the one we have adopted, is bone matrix, whether mineralized or not, ie, including both mineralized bone and osteoid. The third meaning of "bone" is a tissue including bone marrow and other soft tissue, as well as bone as just defined. We refer to the combination of bone and associated soft tissue or marrow as "bone tissue." "Tissue" is defined3 as "an aggregation of similarly specialized cells united in the performance of a particular function." In this sense, bone, bone marrow, and the contents of osteonal canals are certainly not the same tissue, but in a more general sense, most textbooks of histology recognize only four fundamental tissues—epithelium, nerve, muscle, and connective tissue4—of which the last-named includes bone and all its accompanying nonmineralized tissue. In current clinical and radiologic parlance, "trabecular" and "cortical" refer to contrasting structural types of bone. But "trabecular" does not appear in any standard textbook of anatomy or histology as a name for a type of bone; rather, "spongy" or "cancellous" is used. "Spongiosa" (primary or secondary) is best restricted to the stages of endochondral ossification; "cancellous" is most commonly used in textbooks4, 5 and is the term we have chosen. We retain the noun "trabecula" and its associated adjective "trabecular" to refer to an individual structural element of cancellous bone, in accordance with current practice in histology,4 pathology,6 and biomechanics.7 Etymologically, a trabecula is a beam or rod, and in young people plates rather than rods are the predominant structural elements, both in the spine8 and in the ilium,9 but no convenient alternative is available. The size, shape, and orientation of trabeculae (as just defined) vary considerably between different types of cancellous bone.9, 10 "Density" is a frequent source of confusion in discussions about bone. We propose that the term should be restricted as far as possible to its primary meaning in physics of mass per unit volume,11, 12 with a subsidiary meaning analogous to population density, which is applied mainly to cells. This precludes the use of "density" in its stereologic sense, as will be discussed later. Corresponding to the definitions given earlier, the volume to which mass is referred can be of mineralized bone, bone, bone tissue (cortical or cancellous), or a whole bone. Mineralized bone density is slightly less than true bone density, which excludes the volume of osteocyte lacunae and canaliculi.11 This volume is small and generally ignored; lacunar volume can be readily measured,13 but canalicular volume is inaccessible to light microscopy. Bone density reflects the volumetric proportion of osteoid; bone matrix volume, excluding lacunar and canalicular volume, has been referred to as absolute bone volume.14 B

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Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,344
Self-citation
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258
Self-citation
A Textbook of Histology
Bloom, W., & Fawcett, D. W. (1962) · Cited by 2,210
Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.
Gundersen, H. J. G. (1986) · PubMed · Cited by 1,658
Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.
PARFITT, A. M., Mathews, C. H. E., Villanueva, A. R., Kleerekoper, M., Frame, B., & Rao, D. S. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111096 · Cited by 1,542
Self-citation
Stereology of arbitrary particles*
Gundersen, H. J. G. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb02764.x · Cited by 1,444
Dorland??s Illustrated Medical Dictionary
Arey, L. B., Burrows, W. O., Greenhill, J. P., & Hewitt, R. M. (1957) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195712000-00043 · Cited by 1,347
Tetracycline-based histological analysis of bone remodeling
Frost, H. M. (1969) · Calcified Tissue Research · doi:10.1007/bf02058664 · Cited by 1,111
Estimation of surface area from vertical sections
Baddeley, A. J., Gundersen, H. J. G., & Cruz-Orive, L. M. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb04282.x · Cited by 1,057
Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
Zebaze, R., Ghasemzadeh, A., Bohte, A., Iuliano-Burns, S., Mirams, M., Price, R. I., Mackie, E. J., & Seeman, E. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60320-0 · Cited by 870

Flagged first, then by citations

Show all 85 references

Research works printed but not linked: 14

Robinson, 1960, Bone as a tissue, 186
Courpron, 1976, Bone histomorphometry. Second international workshop, 39
Vaughan, 1976, The physiology of bone
Parfitt, 1983, Bone histomorphometry. Techniques and interpretations, 53
Aherne, 1982, Morphometry
Schenk, 1976, Proceedings of the First Workshop on Bone Morphometry, 336
Frost, 1983, Bone histomorphometry. Techniques and interpretations, 109
Duncan, 1973, First Workshop on Bone Histomorphometry, 78
Parfitt, 1981, Bone histomorphometry. Third International Workshop, 213
Lindsay, Letter to the editor: double and quadruple tetracycline labeling of bone, J Bone Miner Res
Parfitt, 1983, Bone histomorphometry. Techniques and interpretations, 143
Jaworski, 1983, Skeletal research. Vol 2, 237
Frost, 1983, Bone histomorphometry. Techniques and interpretations, 133
Riggs, 1963, The mathematical approach to physiologic problems

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Shen, G., Ren, H. J., Shang, Q., Zhao, W., Zhang, Z., Yu, X., Tang, K., Tang, J., Yang, Z., Liang, D., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102626 · Cited by 158
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Liu, W., Zhou, L., Zhou, C., Zhang, S., Jing, J., Xie, L., Sun, N., Duan, X., Jing, W., Liang, X., et al. (2016) · Nature Communications · doi:10.1038/ncomms12794 · Cited by 159
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Delaisse, J.-M., Andersen, T. L., Kristensen, H. B., Jensen, P. R., Andreasen, C. M., & Søe, K. (2020) · Bone · doi:10.1016/j.bone.2020.115628 · Cited by 152
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Holguin, N., Brodt, M. D., & Silva, M. J. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2900 · Cited by 153
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Iyer, S. V., Han, L., Bartell, S. M., Kim, H., Gubrij, I. B., de Cabo, R., O’Brien, C. A., Manolagas, S. C., & Almeida, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.561803 · Cited by 151
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Yu, M., Malik Tyagi, A., Li, J.-Y., Adams, J., Denning, T. L., Weitzmann, M. N., Jones, R. M., & Pacifici, R. (2020) · Nature Communications · doi:10.1038/s41467-019-14148-4 · Cited by 148
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Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F., et al. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3978 · Cited by 138
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Kim, S. P., Li, Z., Zoch, M. L., Frey, J. L., Bowman, C. E., Kushwaha, P., Ryan, K. A., Goh, B. C. K., Scafidi, S., Pickett, J. E., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92704 · Cited by 144
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Jiang, L., Su, D., Ding, S., Zhang, Q., Li, Z., Chen, F., Ding, W., Zhang, S., & Dong, J. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901314 · Cited by 140
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Xu, P., Lin, B., Deng, X., Huang, K., Zhang, Y., & Wang, N. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.013 · Cited by 135
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Chen, W., Foo, S., Taylor, A., Lulla, A., Merits, A., Hueston, L., Forwood, M. R., Walsh, N. C., Sims, N. A., Herrero, L. J., et al. (2014) · Journal of Virology · doi:10.1128/jvi.02034-14 · Cited by 132
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Komaba, H., Kaludjerovic, J., Hu, D. Z., Nagano, K., Amano, K., Ide, N., Sato, T., Densmore, M., Hanai, J.-I., Olauson, H., et al. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.014 · Cited by 128
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Novince, C. M., Whittow, C. R., Aartun, J. D., Hathaway, J. D., Poulides, N., Chavez, M. B., Steinkamp, H. M., Kirkwood, K. A., Huang, E., Westwater, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06126-x · Cited by 121
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Chang, M.-K., Krämer, I., Huber, T., Kinzel, B., Guth, S., Leupin, O., & Kneissel, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413828111 · Cited by 124
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Javaheri, B., Stern, A. R., Lara, N., Dallas, M., Zhao, H. L., Liu, Y., Bonewald, L. F., & Johnson, M. L. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2064 · Cited by 124
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Ni, R., Song, G., Fu, X., Song, R., Li, L., Pu, W., Gao, J., Hu, J., Liu, Q., He, F., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119730 · Cited by 118
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Xu, C., Ochi, H., Fukuda, T., Sato, S., Sunamura, S., Takarada, T., Hinoi, E., Okawa, A., & Takeda, S. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2803 · Cited by 117
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Authors: Dempster, D. W., Compston, J. E., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., Recker, R. R., & Parfitt, A. M.
Affiliations: Helen Hayes Hospital (US)
Cambridge University Hospitals NHS Foundation Trust (GB)
University of Wisconsin–Madison (US)
Shriners Hospitals for Children - Canada (CA)
Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, United Kingdom
University of Kentucky (US)
Inserm (FR)
University of Washington (US)
Creighton University (US)
University of Arkansas for Medical Sciences (US)
Corresponding author: Dempster, David W
ORCID: Dempster, David W
Compston, Juliet E
Drezner, Marc K
Glorieux, Francis H
Malluche, Hartmut
Meunier, Pierre J
Ott, Susan M
Recker, Robert R
Venue: Journal of Bone and Mineral Research
Publisher: Oxford University Press (OUP)
Published: 2012-11-29
Volume: 28
Issue: 1
Pages: 2-17
ISSN: 0884-0431 (ISSN-L)
1523-4681
DOI: 10.1002/jbmr.1805
PMC: PMC3672237
OpenAlex: W2096425957
Cited by: 2,543
References: 85
Citations by year: 2026: 122 · 2025: 158 · 2024: 205 · 2023: 163 · 2022: 184 · 2021: 227 · 2020: 267 · 2019: 225 · 2018: 220 · 2017: 202 · 2016: 182 · 2015: 175 · 2014: 155 · 2013: 53 · 2012: 1
FWCI: 21.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Bone and Mineral Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Research Bank (Australian Catholic University) (submittedVersion)
Funders: American Society for Bone and Mineral Research
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR027032)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Anatomy › Classical Anatomy and Histology
Keywords: bone histomorphometry, terminology standardization, terminology, bone formation, bone resorption, bone turnover, osteoid, bone matrix, low bone turnover
MeSH terms: Animals, Bone and Bones, Humans, Terminology as Topic, Reference Standards, Guidelines as Topic, Research Report

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Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

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