Cited by 300Bone health and osteoporosis researchBody Composition Measurement TechniquesMedical Imaging and Analysis

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Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT

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Yu, Elaine W, Thomas, Bijoy J, Brown, J Keenan, Finkelstein, Joel S·2012·Journal of Bone and Mineral Research

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Abstract

Major alterations in body composition, such as with obesity and weight loss, have complex effects on the measurement of bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA). The effects of altered body fat on quantitative computed tomography (QCT) measurements are unknown. We scanned a spine phantom by DXA and QCT before and after surrounding with sequential fat layers (up to 12 kg). In addition, we measured lumbar spine and proximal femur BMD by DXA and trabecular spine BMD by QCT in 13 adult volunteers before and after a simulated 7.5 kg increase in body fat. With the spine phantom, DXA BMD increased linearly with sequential fat layering at the normal (p < 0.01) and osteopenic (p < 0.01) levels, but QCT BMD did not change significantly. In humans, fat layering significantly reduced DXA spine BMD values (mean ± SD: −2.2 ± 3.7%, p = 0.05) and increased the variability of measurements. In contrast, fat layering increased QCT spine BMD in humans (mean ± SD: 1.5 ± 2.5%, p = 0.05). Fat layering did not change mean DXA BMD of the femoral neck or total hip in humans significantly, but measurements became less precise. Associations between baseline and fat-simulation scans were stronger for QCT of the spine (r2 = 0.97) than for DXA of the spine (r2 = 0.87), total hip (r2 = 0.80), or femoral neck (r2 = 0.75). Bland-Altman plots revealed that fat-associated errors were greater for DXA spine and hip BMD than for QCT trabecular spine BMD. Fat layering introduces error and decreases the reproducibility of DXA spine and hip BMD measurements in human volunteers. Although overlying fat also affects QCT BMD measurements, the error is smaller and more uniform than with DXA BMD. Caution must be used when interpreting BMD changes in humans whose body composition is changing. © 2012 American Society for Bone and Mineral Research

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Authors: Yu, E. W., Thomas, B. J., Brown, J. K., & Finkelstein, J. S.
Affiliations: Massachusetts General Hospital (US)
The University of Texas at Austin (US)
Corresponding author: Yu, Elaine W
ORCID: Yu, Elaine W
Brown, J Keenan
Finkelstein, Joel S
Venue: Journal of Bone and Mineral Research
Publisher: Oxford University Press (OUP)
Published: 2011-09-13
Volume: 27
Issue: 1
Pages: 119-124
ISSN: 0884-0431 (ISSN-L)
1523-4681
DOI: 10.1002/jbmr.506
PMC: PMC3864640
OpenAlex: W2069043426
Cited by: 300
References: 26
Citations by year: 2026: 22 · 2025: 25 · 2024: 36 · 2023: 25 · 2022: 29 · 2021: 18 · 2020: 26 · 2019: 13 · 2018: 9 · 2017: 16 · 2016: 19 · 2015: 19 · 2014: 22 · 2013: 14 · 2012: 5
FWCI: 14.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Journal of Bone and Mineral Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (K23DK093713, T32DK007028)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Physical Sciences › Engineering › Biomedical Engineering › Medical Imaging and Analysis
Keywords: dual-energy X-ray absorptiometry, quantitative computed tomography, fat mass, body composition, obesity, weight loss, spine phantom, lumbar spine, proximal femur, trabecular bone, measurement reproducibility, osteopenia
MeSH terms: Adipose Tissue, Adult, Computer Simulation, Female, Femur, Humans, Male, Spine, Tomography, X-Ray Computed, Absorptiometry, Photon, Bone Density, Phantoms, Imaging

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Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT

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