The DOI matches its Crossref record.
Heritable and life-style determinants of bone mineral density
Abstract
Familial resemblance in bone mineral density at five skeletal sites was measured among 160 adult members of 40 families. Each family included a postmenopausal mother, one premenopausal daughter, one son, and the children's father. Similarities in selected life-style factors thought to influence bone density, such as physical activity, smoking, alcohol use, and diet, were also evaluated. Bone density was measured by dual-energy (total body, femoral neck, and lumbar spine) or single-photon (radius and os calcis) absorptiometry. Correlation coefficients between the midparent Z score and offspring Z scores of bone mineral density ranged from 0.22 to 0.52 among daughters and from 0.27 to 0.58 among sons. Adjustment of bone density for age, height, weight, and significant life-style or environmental factors yielded heritability estimates for the five skeletal sites between 0.46 and 0.62. That is, 46–62% of variance in bone density was attributable to heredity. Most estimates derived from the group of daughters were similar to those from the sons. These observations provide support for a significant contribution of heredity to bone density. However, an individual's life-style may account for a potentially large proportion of the nonheritable variance in bone density.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Weaver, C. M., Gordon, C. M., Janz, K. F., Kalkwarf, H. J., Lappe, J. M., Lewis, R., O’Karma, M., Wallace, T. C., & Zemel, B. S. (2016) · Osteoporosis International · doi:10.1007/s00198-015-3440-3 · Cited by 1,378
Wolff, I., van Croonenborg, J. J., Kemper, H. C. G., Kostense, P. J., & Twisk, J. W. R. (1999) · Osteoporosis International · doi:10.1007/s001980050109 · Cited by 589
A meta-analysis of the effects of cigarette smoking on bone mineral density
Ward, K. D., & Klesges, R. C. (2001) · Calcified Tissue International · doi:10.1007/bf02390832 · Cited by 530
Risk factors for fractures of the proximal humerus: results from the EPIDOS prospective study
Lee, S. H., Dargent-Molina, P., & Bréart, G. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.5.817 · Cited by 251
Gender Specificity in the Genetic Determinants of Peak Bone Mass
Orwoll, E. S., Belknap, J. K., & Klein, R. F. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.11.1962 · Cited by 194
Chesi, A., Wagley, Y., Johnson, M. E., Manduchi, E., Su, C., Lu, S., Leonard, M. E., Hodge, K. M., Pippin, J. A., Hankenson, K. D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09302-x · Cited by 158
Cross-sex pattern of bone mineral density in early onset gender identity disorder
Haraldsen, I. R., Haug, E., Falch, J., Egeland, T., & Opjordsmoen, S. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.012 · Cited by 113
Physical Activity, Calcium Intake and Bone Health in Children and Adolescents
Ondrak, K. S., & Morgan, D. W. (2007) · Sports Medicine · doi:10.2165/00007256-200737070-00003 · Cited by 97
Heritability of BMD of Femoral Neck and Lumbar Spine: A Multivariate Twin Study of Finnish Men
Videman, T., Levälahti, E., Battié, M. C., Simonen, R., Vanninen, E., & Kaprio, J. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070606 · Cited by 68
Roshandel, D., Holliday, K. L., Pye, S. R., Boonen, S., Borghs, H., Vanderschueren, D., Huhtaniemi, I. T., Adams, J. E., Ward, K. A., Bartfai, G., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.78 · Cited by 66
Rautava, E., Lehtonen-Veromaa, M., Kautiainen, H., Kajander, S., Heinonen, O. J., Viikari, J., & Möttönen, T. (2007) · Osteoporosis International · doi:10.1007/s00198-006-0312-x · Cited by 40
The roles of adulthood behavioural factors and familial influences in bone density among men
Videman, T., Battié, M. C., Gibbons, L. E., Vanninen, E., Kaprio, J., & Koskenvuo, M. (2002) · Annals of Medicine · doi:10.1080/078538902321012388 · Cited by 15
Metadata
- Authors
- Krall, E. A., & Dawson-Hughes, B.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-01-01
- Volume
- 8
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2079887487
- Cited by
- 574
- References
- 0
- FWCI
- 16.90
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
