Molecular regulation of androgen action in prostate cancer.
Abstract
Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This review will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. We will also summarize several recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer.
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As a transcription factor, the AR regulates the expression of thousands of both coding and noncoding RNA targets.
“As a transcription factor, the AR regulates the expression of thousands of both coding and noncoding RNA targets (4,7).”
From Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer (2011) · cites this paper as [7]
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Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer
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Self-citationAndrogen regulation of gene expression.
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- Authors
- Dehm, S. M., & Tindall, D. J.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Tindall, Donald J.
- ORCID
- Dehm, Scott M.
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2006-03-03
- Volume
- 99
- Issue
- 2
- Pages
- 333-344
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2049481073
- Cited by
- 336
- References
- 63
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 11 · 2023: 20 · 2022: 13 · 2021: 16 · 2020: 12 · 2019: 15 · 2018: 17 · 2017: 17 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 19 · 2012: 24
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA 91956, P50CA091956)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065236, DK65236, DK60920, R01DK060920)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- androgen action, prostate cancer, androgen receptor, androgen-regulated genes, gene expression profiling, androgen deprivation therapy, prostate cancer progression, castration-resistant prostate cancer
- MeSH terms
- Adult, Androgens, Animals, Cell Survival, Humans, Male, Models, Biological, Neoplasms, Hormone-Dependent, Prostate, Prostatic Neoplasms, Receptors, Androgen, Signal Transduction, Apoptosis, Gene Expression Profiling, Cell Line, Tumor, Cell Proliferation
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