Disruption of protein–protein interactions: Towards new targets for chemotherapy
Abstract
Protein–protein interactions play a key role in various mechanisms of cellular growth and differentiation, and in the replication of pathogen organisms in host cells. Thus, inhibition of these interactions is a promising novel approach for rational drug design against a wide number of cellular and microbial targets. In the past few years, attempts to inhibit protein–protein interactions using antibodies, peptides, and synthetic or natural small molecules have met with varying degrees of success, and these will be the focus of this review. © 2005 Wiley‐Liss, Inc.
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PPIs play a crucial role in numerous biological processes, including signal transduction, cell proliferation, growth, differentiation, apoptosis.
“Protein–protein interactions (PPIs) play a crucial role in numerous biological processes, including signal transduction, cell proliferation, growth, differentiation, apoptosis.303–305”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [304]
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- Authors
- Loregian, A., & Palù, G.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Loregian, Arianna
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2005-05-05
- Volume
- 204
- Issue
- 3
- Pages
- 750-762
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2156698976
- Cited by
- 108
- References
- 160
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Keywords
- protein-protein interaction, drug design, chemotherapeutic target, immunoglobulins, peptides, small molecules, host-pathogen interaction
- MeSH terms
- Animals, Humans, Ligands, Protein Binding, Proteins, Drug Design, Apoptosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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