Cited by 108Chemical Synthesis and AnalysisProtein Degradation and InhibitorsComputational Drug Discovery Methods

Disruption of protein–protein interactions: Towards new targets for chemotherapy

Loregian, Arianna, Palù, Giorgio·2005·Journal of Cellular Physiology

Abstract

Protein–protein interactions play a key role in various mechanisms of cellular growth and differentiation, and in the replication of pathogen organisms in host cells. Thus, inhibition of these interactions is a promising novel approach for rational drug design against a wide number of cellular and microbial targets. In the past few years, attempts to inhibit protein–protein interactions using antibodies, peptides, and synthetic or natural small molecules have met with varying degrees of success, and these will be the focus of this review. © 2005 Wiley‐Liss, Inc.

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Crossref · 10.1002/jcp.20356

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160 of 160 references verified0 citation errors · 0 not checkable

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Authors
Loregian, A., & Palù, G.
Affiliations
University of Padua (IT)
Corresponding author
Loregian, Arianna
Venue
Journal of Cellular Physiology
Publisher
Wiley
Published
2005-05-05
Volume
204
Issue
3
Pages
750-762
ISSN
  • 0021-9541 (ISSN-L)
  • 1097-4652
OpenAlex
W2156698976
Cited by
108
References
160
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 5
FWCI
0.59
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cellular Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
Keywords
protein-protein interaction, drug design, chemotherapeutic target, immunoglobulins, peptides, small molecules, host-pathogen interaction
MeSH terms
Animals, Humans, Ligands, Protein Binding, Proteins, Drug Design, Apoptosis

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