Histochemical and Morphological Characteristics of the Vastus Lateralis Muscle in Patients with Chronic Obstructive Pulmonary Disease
Abstract
Purpose and methods In this study, we examined the fiber-type proportions, cross-sectional areas (CSA), and capillarization from needle biopsies of the vastus lateralis muscle in 20 patients with chronic obstructive pulmonary disease (COPD) (FEV1 = 37 +/- 11% predicted, peak VO2 = 13 +/- 4 mL.min-1.kg-1) and nine age-matched normal subjects (peak VO2 = 33 +/- 7 mL.min-1.kg-1). The effects of endurance training on these parameters were also evaluated in 11 of the 20 patients with COPD. Results The proportion of Type I fiber was smaller in COPD than normals (34 +/- 14% vs 58 +/- 16 in normals, P Conclusions We conclude that in COPD, 1) the vastus lateralis muscle is characterized by a marked decrease in Type I fiber proportion, an increase in Type IIb fiber proportion, a decrease in Type I, IIa, and IIab fiber CSA and by a relatively preserved capillarization; and 2) a 12-wk training program induces a significant increase in Type I and IIa CSA.
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Capillarization has been found impaired specifically in type I muscle fibers in COPD, which has a deep impact on the muscle's oxidative capacity.
“Capillarization has notably been found impaired specifically in type I muscle fibers, which has a deep impact on the muscle’s oxidative capacity [14,15]”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [15]
Cites
Muscle respiratory capacity and fiber type as determinants of the lactate threshold
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Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938 · see citing works
Self-citationAmerican Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
Nici, L., Donner, C., Wouters, E., Zuwallack, R., Ambrosino, N., Bourbeau, J., Carone, M., Celli, B., Engelen, M., Fahy, B., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1211st · Cited by 1,966 · see citing works
Self-citationSkeletal muscle dysfunction in patients with chronic obstructive pulmonary disease
Hussain, S., Cheol, K., & Mofarrahi, M. (2008) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s4480 · Cited by 224 · see citing works
Muscle Wasting and Changes in Muscle Protein Metabolism in Chronic Obstructive Pulmonary Disease
Jagoe, R. T., & Engelen, M. P. K. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004608 · Cited by 134 · see citing works
Tang, K., Wagner, P. D., & Breen, E. C. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.21955 · Cited by 125 · see citing works
“…and animal models exposed to cigarette smoke present a decrease in skeletal muscle fiber size, reduced oxidative enzyme activity, capillary regression and a shift in muscle fiber composition from oxidative to glycolytic fiber types (Jobin et al., 1998; Whittom et al., 1998; Gosker et al., 2008).”
BackgroundThe Mitochondrial Phenotype of Peripheral Muscle in Chronic Obstructive Pulmonary Disease
Picard, M., Godin, R., Sinnreich, M., Baril, J., Bourbeau, J., Perrault, H., Taivassalo, T., & Burelle, Y. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200807-1005oc · Cited by 95 · see citing works
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
“Capillarization has notably been found impaired specifically in type I muscle fibers, which has a deep impact on the muscle’s oxidative capacity [14,15].”
BackgroundEliason, G., Abdel-Halim, S. M., Piehl-Aulin, K., & Kadi, F. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-97 · Cited by 57 · see citing works
Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD
Latimer, L. E., Constantin-Teodosiu, D., Popat, B., Constantin, D., Houchen-Wolloff, L., Bolton, C. E., Steiner, M. C., & Greenhaff, P. L. (2022) · European Respiratory Journal · doi:10.1183/13993003.01507-2021 · Cited by 14 · see citing works
- Authors
- WHITTOM, F., JOBIN, J., SIMARD, P.-M., LEBLANC, P., SIMARD, C., BERNARD, S., BELLEAU, R., & MALTAIS, F.
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 1998-10
- Volume
- 30
- Issue
- 10
- Pages
- 1467-1474
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2030972258
- Cited by
- 447
- References
- 1
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 17 · 2020: 11 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 18 · 2015: 7 · 2014: 31 · 2013: 28 · 2012: 21
- FWCI
- 18.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- chronic obstructive pulmonary disease, vastus lateralis, skeletal muscle fiber type composition, muscle fiber cross-sectional area, capillarization, capillary-to-fiber ratio, endurance training, peak oxygen uptake, muscle histology
- MeSH terms
- Aged, Analysis of Variance, Biopsy, Needle, Capillaries, Exercise Test, Exercise Therapy, Female, Forced Expiratory Volume, Heart Rate, Histocytochemistry, Humans, Lactates, Lung Diseases, Obstructive, Male, Oxygen, Oxygen Consumption, Physical Endurance, Anaerobic Threshold, Case-Control Studies, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Anatomy, Cross-Sectional
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