αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt‐dependent NF‐κB activation
Open accessAbstract
Controlling macrophage responses to pathogenic stimuli is critical for prevention of and recovery from the inflammatory state associated with the pathogenesis of many diseases. The adhesion receptor αVβ3 integrin is thought to be an important receptor that regulates macrophage differentiation and macrophage responses to external signaling, but it has not been previously identified as a contributor to macrophage‐related inflammation. Using an in vitro model of human blood monocytes (Mo) and monocyte‐derived macrophages (MDMs) we demonstrate that αVβ3 ligation results in sustained increases of the transcription factor NF‐κB DNA‐binding activity, as compared with control isotype‐matched IgG 1. Activation of NF‐κB parallels the increase of NF‐κB‐dependent pro‐inflammatory cytokine mRNA expression in MDMs isolated from individual donors, for example, TNF‐α (8‐ to 28‐fold), IL‐1β (15‐ to 30‐fold), IL‐6 (2‐ to 4‐fold), and IL‐8 (5‐ to 15‐fold) whereas there is more than a 10‐fold decrease in IL‐10 mRNA level occurs. Upon ligation of the αVβ3 receptor, treatment with TNF‐α (10 ng/ml) or LPS (200 ng/ml, 1,000 EU) results in the enhanced and synergistic activation of NF‐κB and LPS‐induced TNF‐α secretion. As additional controls, an inhibitor of αVβ3 integrin, cyclic RGD (10 µg/ml; IC 50 = 7.6 µM), attenuates the effects of αVβ3 ligation, and the natural ligand of αVβ3 integrin, vitronectin, reproduces the effects of αVβ3 activation by an immobilizing anti‐αVβ3 integrin mAb. We hypothesize that αVβ3 activation can maintain chronic inflammatory processes in pathological conditions and that the loss of αVβ3 ligation will allow macrophages to escape from the inflammatory state. J. Cell. Physiol. 226: 469–476, 2011. © 2010 Wiley‐Liss, Inc.
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RGD tethers provide a mechanism by which macrophages directly interacting with the hydrogel can sense substrate stiffness through integrin-mediated events.
“the RGD tethers provide a mechanism by which macrophages, directly interacting with the hydrogel, can sense substrate stiffness via integrin-mediated events.28”
From Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the <i>in vitro</i> activation of macrophages and <i>in vivo</i> host response to poly(ethylene glycol)‐based hydrogels (2012) · cites this paper as [28]
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- Authors
- Antonov, A. S., Antonova, G. N., Munn, D. H., Mivechi, N., Lucas, R., Catravas, J. D., & Verin, A. D.
- Affiliations
- Augusta University (US)
- Corresponding author
- Verin, Alexander D.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2010-11-26
- Volume
- 226
- Issue
- 2
- Pages
- 469-476
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC3235728
- OpenAlex
- W1998325568
- Cited by
- 128
- References
- 52
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 4 · 2023: 15 · 2022: 10 · 2021: 14 · 2020: 8 · 2019: 14 · 2018: 5 · 2017: 5 · 2016: 12 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 10
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA132640, R01CA062130)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- integrin αvβ3, macrophage inflammation, NF-κB activation, PI3K/Akt signaling, monocyte-derived macrophages, inflammatory cytokines, TNF-α, IL-1β, interleukin-6, interleukin-8, IL-10, lipopolysaccharide, vitronectin, cyclic RGD peptide, chronic inflammation
- MeSH terms
- Animals, Enzyme Inhibitors, Humans, Inflammation, Macrophages, Monocytes, Tumor Necrosis Factor-alpha, Signal Transduction, Cytokines, NF-kappa B, Phosphatidylinositol 3-Kinases, Integrin alphaVbeta3, Proto-Oncogene Proteins c-akt
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