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Cited by 92Wound Healing and TreatmentsTissue Engineering and Regenerative MedicineImmune cells in cancer

Biomaterials-Mediated Regulation of Macrophage Cell Fate

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Liu, Yining, Segura, Tatiana·2020·Frontiers in Bioengineering and Biotechnology
DOI 10.3389/fbioe.2020.609297PMC PMC7759630
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Abstract

Endogenous regeneration aims to rebuild and reinstate tissue function through enlisting natural self-repairing processes. Promoting endogenous regeneration by reducing tissue-damaging inflammatory responses while reinforcing self-resolving inflammatory processes is gaining popularity. In this approach, the immune system is recruited as the principal player to deposit a pro-reparative matrix and secrete pro-regenerative cytokines and growth factors. The natural wound healing cascade involves many immune system players (neutrophils, macrophages, T cells, B cells, etc.) that are likely to play important and indispensable roles in endogenous regeneration. These cells support both the innate and adaptive arms of the immune system and collectively orchestrate host responses to tissue damage. As the early responders during the innate immune response, macrophages have been studied for decades in the context of inflammatory and foreign body responses and were often considered a cell type to be avoided. The view on macrophages has evolved and it is now understood that macrophages should be directly engaged, and their phenotype modulated, to guide the timely transition of the immune response and reparative environment. One way to achieve this is to design immunomodulating biomaterials that can be placed where endogenous regeneration is desired and actively direct macrophage polarization. Upon encountering these biomaterials, macrophages are trained to perform more pro-regenerative roles and generate the appropriate environment for later stages of regeneration since they bridge the innate immune response and the adaptive immune response. This new design paradigm necessitates the understanding of how material design elicits differential macrophage phenotype activation. This review is focused on the macrophage-material interaction and how to engineer biomaterials to steer macrophage phenotypes for better tissue regeneration.

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Cited by

Sorted by citations

Authors
Liu, Y., & Segura, T.
Affiliations
Duke University (US)
Corresponding author
Segura, Tatiana
ORCID
Venue
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Published
2020-12-11
Volume
8
Pages
609297-609297
ISSN
2296-4185 (ISSN-L)
DOI
10.3389/fbioe.2020.609297
PMC
PMC7759630
OpenAlex
W3112713493
Cited by
92
References
32
Citations by year
2026: 16 · 2025: 16 · 2024: 21 · 2023: 15 · 2022: 16 · 2021: 8
FWCI
1.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R01AI152568)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
macrophage polarization, biomaterials, endogenous regeneration, tissue regeneration, wound healing, innate immune response

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