Cited by 397Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated ReceptorsPluripotent Stem Cells Research

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Retinoids regulate stem cell differentiation

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Gudas, Lorraine J., Wagner, John A.·2011·Journal of Cellular Physiology

DOI 10.1002/jcp.22417PMC PMC3315372

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Abstract

Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert profound effects on development, and complement cancer chemotherapeutic regimens. All‐trans retinoic acid (RA) and other active retinoids are generated from vitamin A (retinol), but key aspects of the signaling pathways required to produce active retinoids remain unclear. Retinoids generated by one cell type can affect nearby cells, so retinoids also function in intercellular communication. RA induces differentiation primarily by binding to RARs, transcription factors that associate with RXRs and bind RAREs in the nucleus. Binding of RA: (1) initiates changes in interactions of RAR/RXRs with co‐repressor and co‐activator proteins, activating transcription of primary target genes; (2) alters interactions with proteins that induce epigenetic changes; (3) induces transcription of genes encoding transcription factors and signaling proteins that further modify gene expression (e.g., FOX03A, Hoxa1, Sox9, TRAIL, UBE2D3); and (4) results in alterations in estrogen receptor α signaling. Proteins that bind at or near RAREs include Sin3a, N‐CoR1, PRAME, Trim24, NRIP1, Ajuba, Zfp423, and MN1/TEL. Interactions among retinoids, RARs/RXRs, and these proteins explain in part the powerful effects of retinoids on stem cell differentiation. Studies of this retinol signaling cascade enhance our ability to understand and regulate stem cell differentiation for therapeutic and scientific purposes. In cancer chemotherapeutic regimens retinoids can promote tumor cell differentiation and/or induce proteins that sensitize tumors to drug combinations. Mechanistic studies of retinoid signaling continue to suggest novel drug targets and will improve therapeutic strategies for cancer and other diseases, such as immune‐mediated inflammatory diseases. J. Cell. Physiol. 226: 322–330, 2011. © 2010 Wiley‐Liss, Inc.

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Simon, J. A., & Kingston, R. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2763 · Cited by 1,360
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Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
The Retinoids-Biology, Chemistry and Medicine
Wolf, G. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.5.796a · Cited by 1,000
Coactivator and corepressor complexes in nuclear receptor function
Xu, L., Glass, C. K., & Rosenfeld, M. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80021-5 · Cited by 909
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Yu, J., Yu, J., Mani, R.-S., Cao, Q., Brenner, C. J., Cao, X., Wang, X., Wu, L., Li, J., Hu, M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.018 · Cited by 850
A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A
Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., & Sun, H. (2007) · Science · doi:10.1126/science.1136244 · Cited by 836
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Siedenburg, J. S., Weiß, S. I., Molnár, V., Tünsmeier, J., Shamir, M. H., Stein, V. M., & Tipold, A. (2024) · Journal of Zoo and Wildlife Medicine · doi:10.1638/2021-0107 · Cited by 4
Association of vitamin deficiency with the progression of anaemia
Urwa, H., Waheed, A., Naz, H., Shoaib, A. M., Saleem, K. M., & Muhammad, W. (2024) · The Egyptian Journal of Haematology · doi:10.4103/ejh.ejh_80_23 · Cited by 4
Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review.
Fayezi, S., Fayyazpour, P., Norouzi, Z., & Mehdizadeh, A. (2022) · PubMed Central · doi:10.22074/cellj.2022.8087 · Cited by 4
Glial cell derived neurotrophic factor induces spermatogonial stem cell marker genes in chicken mesenchymal stem cells
Boozarpour, S., Matin, M. M., Momeni‐Moghaddam, M., Dehghani, H., Mahdavi-Shahri, N., Sisakhtnezhad, S., Heirani‐Tabasi, A., Irfan‐Maqsood, M., & Bahrami, A. R. (2016) · Tissue and Cell · doi:10.1016/j.tice.2016.03.003 · Cited by 4
Analysis of Promyelocytic Leukemia in Human Embryonic Carcinoma Stem Cells During Retinoic Acid-Induced Neural Differentiation
Karbalaie, K., Vallian, S., Lachinani, L., Tanhaei, S., Baharvand, H., & Nasr‐Esfahani, M. H. (2016) · Iranian Journal of Biotechnology · doi:10.15171/ijb.1358 · Cited by 4
Administration of All-Trans Retinoic Acid to Pregnant Sows Improves the Developmental Defects of Hoxa1−/− Fetal Pigs
Zhou, H., Chen, Y., Hu, Y., Gao, S., Lu, W., & He, Y. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.618660 · Cited by 5
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Identification of prognostic biomarkers related to retinoic acid metabolism in gliomas and analysis of their impact on the immune microenvironment
Xu, S., Gao, Y., Xu, F., Yang, Y., & Wang, J. (2024) · Medicine · doi:10.1097/md.0000000000039836 · Cited by 3
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Butey, S. P., Brown, M. L., Julson, J. R., Marayati, R., Atigadda, V. R., Shaikh, M. G., Nazam, N., Quinn, C. H., Shirley, S., Stafman, L. L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093933 · Cited by 3
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Gires, O. (2013) · Springer eBooks · doi:10.1007/978-94-007-6211-4_20 · Cited by 3
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McArdle, A., Lo, D. D., Hyun, J. S., Senarath-Yapa, K., Chung, M. T., Wan, D. C., & Longaker, M. T. (2013) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e318278d88c · Cited by 3
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Zeng, X., Yin, L., Zhang, Y., Wang, Q., Li, J., Yin, Y., Wang, Q., Li, J., & Yang, H. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04546-9 · Cited by 2
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Ye, Q., Zhong, Q., Huang, G., & Zhang, W. (2024) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.25074 · Cited by 2
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Lemke, K. A., Sarkar, C. A., & Azarin, S. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-68952-0 · Cited by 2
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Simándi, Z., & Nagy, L. (2011) · InTech eBooks · doi:10.5772/24947 · Cited by 2
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Sakti, M., Nakasa, T., Shoji, T., Usman, M. A., Kawanishi, Y., Hamanishi, M., Yusuf, I., & Ochi, M. (2015) · Asia-Pacific Journal of Sports Medicine Arthroscopy Rehabilitation and Technology · doi:10.1016/j.asmart.2015.08.001 · Cited by 2
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Carrier, M., & Rochette‐Egly, C. (2015) · doi:10.1002/9781118628003.ch5 · Cited by 1
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Rane, J. K. (2012) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
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Gruszkaa, A. M., & Alcalay, M. (2020) · doi:10.1201/9781003159469-10
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Kedishvili, N. Y. (2013)
Combating malignant melanoma with the multifaceted soy-dervied peptide lunasin.
Shidal, C. (2017) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2713
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Leite, S. B. P. (2018) · doi:10.11606/t.17.2018.tde-26042018-113121
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Chen, X., Cao, B., Huo, Y., Niu, G., Zhang, M. Q., Mai, Z.-L., Lu, X., Niu, H., Chen, D.-N., & Ni, Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/520106
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Yao, W., Wang, L., Huang, H., Li, X., Wang, P., Mi, K., Cheng, J., Liu, H. X., Gu, C., Huang, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12135357
Additional file 1 of Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner
Tilsed, C. M., Morales, M. L. O., Zemek, R. M., Gordon, B. A., Piggott, M., Nowak, A. K., Fisher, S. A., Lake, R., & Lesterhuis, W. J. (2024) · Figshare · doi:10.6084/m9.figshare.25216824
Additional file 1 of All-trans retinoic acid reduces cancer stem cell-like cell-mediated resistance to gefitinib in NSCLC adenocarcinoma cells
Yao, W., Wang, L., Huang, H., Li, X., Wang, P., Mi, K., Cheng, J., Liu, H. X., Gu, C., Huang, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12135351
Additional file 3 of All-trans retinoic acid reduces cancer stem cell-like cell-mediated resistance to gefitinib in NSCLC adenocarcinoma cells
Yao, W., Wang, L., Huang, H., Li, X., Wang, P., Mi, K., Cheng, J., Liu, H. X., Gu, C., Huang, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12135366
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BindingDB Entry 50045454: Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1).
BindingDB (2016) · UC San Diego · doi:10.7270/q2416zqg
BindingDB Entry 50033900: Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).
BindingDB (2012) · UC San Diego · doi:10.7270/q2wm1dsj
BindingDB Entry 50021162: Small-molecule agents for treating skin diseases.
BindingDB (2025) · UC San Diego · doi:10.7270/q2zg6xvs
BindingDB Entry 50002577: Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids.
BindingDB (2020) · UC San Diego · doi:10.7270/q2wq06f7
BindingDB Entry 50046587: Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors.
BindingDB (2016) · UC San Diego · doi:10.7270/q2668g0c
Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer : expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models
Cosentino, L. (2012) · Bradford Scholars (University of Bradford)
Small cell lung cancer and cancer stem cell-like cells
Sarvi, S. (2014) · ERA

Authors: Gudas, L. J., & Wagner, J. A.
Affiliations: Cornell University (US)
Corresponding author: Gudas, Lorraine J.
ORCID: Gudas, Lorraine J.
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 2010-11-26
Volume: 226
Issue: 2
Pages: 322-330
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.22417
PMC: PMC3315372
OpenAlex: W2108254285
Cited by: 395
References: 133
Citations by year: 2026: 7 · 2025: 18 · 2024: 26 · 2023: 25 · 2022: 29 · 2021: 20 · 2020: 28 · 2019: 21 · 2018: 22 · 2017: 31 · 2016: 27 · 2015: 29 · 2014: 22 · 2013: 40 · 2012: 25
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA043796)
National Institute of Dental and Craniofacial Research (R01DE010389)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: retinoids, all-trans retinoic acid, stem cell differentiation, retinoic acid receptor, retinoid X receptor, epigenetic regulation, drug sensitization, therapeutic target
MeSH terms: Animals, Cell Differentiation, Retinoids, Stem Cells, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured, Signal Transduction, beta Catenin, TNF-Related Apoptosis-Inducing Ligand

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