Cited by 397Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated ReceptorsPluripotent Stem Cells Research

The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.

Retinoids regulate stem cell differentiation

Open access

Gudas, Lorraine J., Wagner, John A.·2011·Journal of Cellular Physiology

DOI 10.1002/jcp.22417PMC PMC3315372

Open this paper in CoChat — free account

Abstract

Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert profound effects on development, and complement cancer chemotherapeutic regimens. All‐trans retinoic acid (RA) and other active retinoids are generated from vitamin A (retinol), but key aspects of the signaling pathways required to produce active retinoids remain unclear. Retinoids generated by one cell type can affect nearby cells, so retinoids also function in intercellular communication. RA induces differentiation primarily by binding to RARs, transcription factors that associate with RXRs and bind RAREs in the nucleus. Binding of RA: (1) initiates changes in interactions of RAR/RXRs with co‐repressor and co‐activator proteins, activating transcription of primary target genes; (2) alters interactions with proteins that induce epigenetic changes; (3) induces transcription of genes encoding transcription factors and signaling proteins that further modify gene expression (e.g., FOX03A, Hoxa1, Sox9, TRAIL, UBE2D3); and (4) results in alterations in estrogen receptor α signaling. Proteins that bind at or near RAREs include Sin3a, N‐CoR1, PRAME, Trim24, NRIP1, Ajuba, Zfp423, and MN1/TEL. Interactions among retinoids, RARs/RXRs, and these proteins explain in part the powerful effects of retinoids on stem cell differentiation. Studies of this retinol signaling cascade enhance our ability to understand and regulate stem cell differentiation for therapeutic and scientific purposes. In cancer chemotherapeutic regimens retinoids can promote tumor cell differentiation and/or induce proteins that sensitize tumors to drug combinations. Mechanistic studies of retinoid signaling continue to suggest novel drug targets and will improve therapeutic strategies for cancer and other diseases, such as immune‐mediated inflammatory diseases. J. Cell. Physiol. 226: 322–330, 2011. © 2010 Wiley‐Liss, Inc.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/jcp.22417

Cites

133 of 133 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mechanisms of Polycomb gene silencing: knowns and unknowns
Simon, J. A., & Kingston, R. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2763 · Cited by 1,360
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
The Retinoids-Biology, Chemistry and Medicine
Wolf, G. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.5.796a · Cited by 1,000
Coactivator and corepressor complexes in nuclear receptor function
Xu, L., Glass, C. K., & Rosenfeld, M. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80021-5 · Cited by 909
An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
Yu, J., Yu, J., Mani, R.-S., Cao, Q., Brenner, C. J., Cao, X., Wang, X., Wu, L., Li, J., Hu, M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.018 · Cited by 850
A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A
Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., & Sun, H. (2007) · Science · doi:10.1126/science.1136244 · Cited by 836
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Schoenfelder, S., Sexton, T., Chakalova, L., Cope, N. F., Horton, A., Andrews, S., Kurukuti, S., Mitchell, J. A., Umlauf, D., Dimitrova, D. S., et al. (2009) · Nature Genetics · doi:10.1038/ng.496 · Cited by 735
Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism
Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 700
Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors
Schug, T. T., Berry, D. C., Shaw, N. S., Travis, S. N., & Noy, N. (2007) · Cell · doi:10.1016/j.cell.2007.02.050 · Cited by 680
Retinoids, Retinoic Acid Receptors, and Cancer
Tang, X.-H., & Gudas, L. J. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130303 · Cited by 596
Self-citation

Flagged first, then by citations

Show all 133 references

Sorted by citations

Mechanisms of retinoic acid signalling and its roles in organ and limb development
Cunningham, T. J., & Duester, G. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3932 · Cited by 595
Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity
Carazo, A., Macáková, K., Matoušová, K., Krčmová, L. K., Protti, M., & Mladěnka, P. (2021) · Nutrients · doi:10.3390/nu13051703 · Cited by 418
Imidazoles as potential anticancer agents
Ali, I., Lone, M. N., & Aboul‐Enein, H. Y. (2017) · MedChemComm · doi:10.1039/c7md00067g · Cited by 416
Vitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408
Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer
Iclozan, C., Antonia, S. J., Chiappori, A., Chen, D., & Gabrilovich, D. I. (2013) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-013-1396-8 · Cited by 326
Retinoic acid synthesis and functions in early embryonic development
Kin Ting Kam, R., Deng, Y., Chen, Y., & Zhao, H. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-11 · Cited by 283
Retinoic acid signaling pathways in development and diseases
Das, B. C., Thapa, P., Karki, R., Das, S., Mahapatra, S., Liu, T.-C., Torregroza, I., Wallace, D. P., Kambhampati, S., Van Veldhuizen, P., et al. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.11.025 · Cited by 276
A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells
Shen, S., Xu, X., Lin, S., Zhang, Y., Liu, H., Zhang, C., & Mo, R. (2021) · Nature Nanotechnology · doi:10.1038/s41565-020-00793-0 · Cited by 266
Biodegradable Hollow Mesoporous Silica Nanoparticles for Regulating Tumor Microenvironment and Enhancing Antitumor Efficiency
Kong, M., Tang, J., Qiao, Q., Wu, T., Qi, Y., Tan, S., Gao, X., & Zhang, Z. (2017) · Theranostics · doi:10.7150/thno.19987 · Cited by 197
Enzymology of retinoic acid biosynthesis and degradation
Kedishvili, N. Y. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r037028 · Cited by 196
Vitamin A Metabolism, Action, and Role in Skeletal Homeostasis
Conaway, H. H., Henning, P., & Lerner, U. H. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1071 · Cited by 189
Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells
Semrau, S., Goldmann, J. E., Soumillon, M., Mikkelsen, T. S., Jaenisch, R., & van Oudenaarden, A. (2017) · Nature Communications · doi:10.1038/s41467-017-01076-4 · Cited by 182
Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells
Sun, R., Liu, Y., Li, S.-Y., Shen, S., Du, X.-J., Xu, C.-F., Cao, Z.-T., Bao, Y., Zhu, Y.-H., Li, Y.-P., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.018 · Cited by 172
An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis
Zhang, F. S., Guo, X. Q., Xia, Y., & Mao, L. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04079-z · Cited by 174
Retinoid Signaling in Progenitors Controls Specification and Regeneration of the Urothelium
Gandhi, D., Molotkov, A., Batourina, E., Schneider, K., Dan, H., Reiley, M., Laufer, E., METZGER, D., Liang, F., Liao, Y., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.07.017 · Cited by 165
Pathophysiology of ocular surface squamous neoplasia
Gichuhi, S., Ohnuma, S., Sagoo, M. S., & Burton, M. J. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.10.015 · Cited by 169
A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis
Lesch, B. J., Dokshin, G. A., Young, R. A., McCarrey, J. R., & Page, D. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315204110 · Cited by 161
Emerging roles for retinoids in regeneration and differentiation in normal and disease states
Gudas, L. J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.08.002 · Cited by 158
Self-citation
ALDH as a Stem Cell Marker in Solid Tumors
Toledo-Guzmán, M. E., Ibáñez-Hernández, M. Á., Gallegos, A. A. G., & Ortíz-Sánchez, E. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x13666180810120012 · Cited by 152
3D graphene oxide-encapsulated gold nanoparticles to detect neural stem cell differentiation
Kim, T. P., Lee, K., & Choi, J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.101 · Cited by 142
Ovarian cancer stem cells and targeted therapy
Keyvani, V., Farshchian, M., Esmaeili, S., Yari, H., Moghbeli, M., Nezhad, S. R. K., & Abbaszadegan, M. R. (2019) · Journal of Ovarian Research · doi:10.1186/s13048-019-0588-z · Cited by 140
Proteinuria Impairs Podocyte Regeneration by Sequestering Retinoic Acid
Peired, A. J., Angelotti, M. L., Ronconi, E., la Marca, G., Mazzinghi, B., Sisti, A., Lombardi, D., Giocaliere, E., Bona, M. D., Villanelli, F., et al. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012090950 · Cited by 139
The molecular physiology of nuclear retinoic acid receptors. From health to disease
Duong, V., & Rochette‐Egly, C. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.10.007 · Cited by 137
Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling
Marcato, P., Dean, C. A., Liu, R., Coyle, K. M., Bydoun, M., Wallace, M., Clements, D. R., Turner, C., Mathenge, E. G., Gujar, S. A., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.07.010 · Cited by 132
Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity
Melnik, B. C. (2017) · Acta Dermato Venereologica · doi:10.2340/00015555-2535 · Cited by 131
Stem cell mechanobiology: diverse lessons from bone marrow
Ivanovska, I. L., Shin, J., Swift, J., & Discher, D. E. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.04.003 · Cited by 128
A sensitive and specific method for measurement of multiple retinoids in human serum with UHPLC-MS/MS
Arnold, S. L. M., Amory, J. K., Walsh, T. J., & Isoherranen, N. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d019745 · Cited by 119
p53: emerging roles in stem cells, development and beyond
Jain, A. K., & Barton, M. C. (2018) · Development · doi:10.1242/dev.158360 · Cited by 130
Retinoid Receptors in Bone and Their Role in Bone Remodeling
Henning, P., Conaway, H. H., & Lerner, U. H. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00031 · Cited by 116
Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development
Samarut, É., & Rochette‐Egly, C. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.03.025 · Cited by 126
Vitamin A and the epigenome
Dadon, S. B.-E., & Reifen, R. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1060940 · Cited by 107
Targeting the Epigenome with Bioactive Food Components for Cancer Prevention
Ong, T. P., Moreno, F. S., & Ross, S. A. (2011) · Lifestyle Genomics · doi:10.1159/000334585 · Cited by 99
Smooth Muscle Cell Differentiation In Vitro
Xie, C., Ritchie, R. P., Huang, H., Zhang, J., & Chen, Y. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221101 · Cited by 101
Smooth Muscle Cell Differentiation: Model Systems, Regulatory Mechanisms, and Vascular Diseases
Shi, N., & Chen, S. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25208 · Cited by 99
Retinoic acid signaling and mouse embryonic stem cell differentiation: Cross talk between genomic and non-genomic effects of RA
Rochette‐Egly, C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.04.003 · Cited by 102
Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer
Stevison, F., Jing, J., Tripathy, S., & Isoherranen, N. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.006 · Cited by 98
Vitamin A Deficiency Causes Hyperglycemia and Loss of Pancreatic β-Cell Mass
Trasino, S. E., Benoit, Y. D., & Gudas, L. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616763 · Cited by 94
Self-citation
Environmental relevant concentrations of benzophenone-3 induced developmental neurotoxicity in zebrafish
Tao, J., Bai, C., Chen, Y., Zhou, H., Liu, Y., Shi, Q., Pan, W., Dong, H., Li, L., Xu, H., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137686 · Cited by 92
Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies
Hunsu, V. O., Facey, C. O. B., Fields, J. Z., & Boman, B. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147731 · Cited by 92
Sex Determination in the Mammalian Germline
Spiller, C. M., Koopman, P. A., & Bowles, J. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120215-035449 · Cited by 92
Current Trends in ATRA Delivery for Cancer Therapy
Giuli, M. V., Hanieh, P. N., Giuliani, E., Rinaldi, F., Marianecci, C., Screpanti, I., Checquolo, S., & Carafa, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080707 · Cited by 92
Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
Akdemir, K. C., Jain, A. K., Allton, K. L., Aronow, B. J., Xu, X., Cooney, A. J., Li, W., & Barton, M. C. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt866 · Cited by 90
Retinoids and their biological effects against cancer
Alizadeh, F., Bolhassani, A., Khavari, A., Bathaie, S. Z., Naji, T., & Bidgoli, S. A. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.10.027 · Cited by 90
Retinoids induce stem cell differentiation via epigenetic changes
Gudas, L. J. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.08.002 · Cited by 85
Self-citation
Integrated Module and Gene-Specific Regulatory Inference Implicates Upstream Signaling Networks
Roy, S., Lagree, S., Hou, Z., Thomson, J. A., Stewart, R. M., & Gasch, A. P. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003252 · Cited by 89
OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation
Simándi, Z., Horváth, A., Wright, L. C., Cuaranta‐Monroy, I., Luca, I. D., Károlyi, K., Sauer, S., Deleuze, J., Gudas, L. J., Cowley, S. M., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.039 · Cited by 85
Self-citation
Combination of chemotherapy and cancer stem cell targeting agents: Preclinical and clinical studies
Li, Y., Atkinson, K., & Zhang, T. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.03.008 · Cited by 80
Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy
Kgatle, M. M., Kalla, A. A., Islam, M. M., Sathekge, M. M., & Moorad, R. (2016) · Prostate Cancer · doi:10.1155/2016/5653862 · Cited by 84
Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation
Ng-Blichfeldt, J.-P., Schrik, A., Kortekaas, R. K., Noordhoek, J. A., Heijink, I. H., Hiemstra, P. S., Stolk, J. N., Königshoff, M., & Gosens, R. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.002 · Cited by 80
Retinoid metabolism: new insights
Gudas, L. J. (2022) · Journal of Molecular Endocrinology · doi:10.1530/jme-22-0082 · Cited by 80
Self-citation
The use of natural products to target cancer stem cells.
Taylor, W. F., & Jabbarzadeh, E. (2017) · PubMed Central · Cited by 78
Aldehyde dehydrogenase in solid tumors and other diseases: Potential biomarkers and therapeutic targets
Xia, J. L., Li, S., Liu, S., & Zhang, L. (2023) · MedComm · doi:10.1002/mco2.195 · Cited by 80
Therapeutic Potential of the Inhibition of the Retinoic Acid Hydroxylases CYP26A1 and CYP26B1 by Xenobiotics
Nelson, C., Buttrick, B., & Isoherranen, N. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611313120004 · Cited by 79
Untangling Cortical Complexity During Development
Mukhtar, T., & Taylor, V. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518759332 · Cited by 81
Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression
Sissaoui, S., Yu, J., Yan, A.-M., Li, R., Yukselen, O., Kucukural, A., Zhu, L., & Lawson, N. (2020) · Circulation Research · doi:10.1161/circresaha.119.316075 · Cited by 66
Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
Bocker, M., Tuorto, F., Raddatz, G., Musch, T., Yang, F., Xu, M., Lyko, F., & Breiling, A. (2012) · Nature Communications · doi:10.1038/ncomms1826 · Cited by 72
Isotretinoin and FoxO1
Melnik, B. C. (2011) · Dermato-Endocrinology · doi:10.4161/derm.15331 · Cited by 94
Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment
Melnik, B. C. (2023) · Cells · doi:10.3390/cells12222600 · Cited by 86
Induction of CYP26A1 by Metabolites of Retinoic Acid: Evidence That CYP26A1 Is an Important Enzyme in the Elimination of Active Retinoids
Topletz, A. R., Tripathy, S., Foti, R., Shimshoni, J. A., Nelson, W. L., & Isoherranen, N. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.096784 · Cited by 79
circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation
Hollensen, A. K., Thomsen, H. S., Lloret-Llinares, M., Kamstrup, A. B., Jensen, J. M., Luckmann, M., Birkmose, N., Palmfeldt, J., Jensen, T. H., Hansen, T. B., et al. (2020) · eLife · doi:10.7554/elife.58478 · Cited by 68
Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention
Romani, M., Pistillo, M. P., & Banelli, B. (2015) · BioMed Research International · doi:10.1155/2015/587983 · Cited by 71
Ovarian Cancer Stem Cells: A New Target for Cancer Therapy
Zhan, Q., Wang, C., & Ngai, S. M. (2013) · BioMed Research International · doi:10.1155/2013/916819 · Cited by 67
Mesenchymal Stromal Cell Mutations and Wound Healing Contribute to the Etiology of Desmoid Tumors
Carothers, A. M., Rizvi, H. A., Hasson, R. M., Heit, Y. I., Davids, J. S., Bertagnolli, M. M., & Cho, N. L. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2819 · Cited by 67
RARγ is Essential for Retinoic Acid Induced Chromatin Remodeling and Transcriptional Activation in Embryonic Stem Cells
Kashyap, V., Laursen, K. B., Brenet, F. A., Viale, A. J., Scandura, J. M., & Gudas, L. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.119701 · Cited by 68
Self-citation
Proteomic characterization of adipose tissue constituents, a necessary step for understanding adipose tissue complexity
Peinado, J. R., Pardo, M., de la Rosa, O., & Malagón, M. M. (2012) · PROTEOMICS · doi:10.1002/pmic.201100355 · Cited by 67
Cancer stem cell impact on clinical oncology
Toledo-Guzmán, M. E., Ordóñez, G. D. B., Ibáñez-Hernández, M. Á., & Ortíz-Sánchez, E. (2018) · World Journal of Stem Cells · doi:10.4252/wjsc.v10.i12.183 · Cited by 67
Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling
Ghaffari, P., Mardinoğlu, A., Asplund, A., Shoaie, S., Kampf, C., Uhlén, M., & Nielsen, J. (2015) · Scientific Reports · doi:10.1038/srep08183 · Cited by 66
Lessons from common markers of tumor-initiating cells in solid cancers
Gires, O. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0772-9 · Cited by 63
All-trans retinoic acid modulates Wnt3A-induced osteogenic differentiation of mesenchymal stem cells via activating the PI3K/AKT/GSK3β signalling pathway
Zhang, S., Chen, X., Hu, Y., Wu, J., Cao, Q., Chen, S., & Gao, Y. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.018 · Cited by 64
An Overview of Neural Differentiation Potential of Human Adipose Derived Stem Cells
Salehi, H., Amirpour, N., Niapour, A., & Razavi, S. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9631-7 · Cited by 65
Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone
Alcorta-Sevillano, N., Macías, I., Rodrı́guez, C. I., & Infante, A. (2020) · Cells · doi:10.3390/cells9061330 · Cited by 61
Targeting breast cancer stem cells through retinoids: A new hope for treatment
Jan, N., Sofi, S., Qayoom, H., Haq, B. U., Shabir, A., & Mir, M. A. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104156 · Cited by 62
Retinoic Acid Suppresses the Canonical Wnt Signaling Pathway in Embryonic Stem Cells and Activates the Noncanonical Wnt Signaling Pathway
Osei-Sarfo, K., & Gudas, L. J. (2014) · Stem Cells · doi:10.1002/stem.1706 · Cited by 62
Self-citation
All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy
Yan, Y., Li, Z., Xu, X. D., Chen, C., Wei, W., Fan, M., Chen, X., Li, J. J., Wang, Y., & Huang, J. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1088-y · Cited by 62
Isotretinoin and FoxO1: A scientific hypothesis.
Melnik, B. C. (2011) · Europe PMC (PubMed Central) · doi:10.4161/derm.3.3.15331 · Cited by 62
Mechanisms of Feedback Regulation of Vitamin A Metabolism
O'Connor, C. M., Varshosaz, P., & Moise, A. R. (2022) · Nutrients · doi:10.3390/nu14061312 · Cited by 66
Evolving Strategies for Therapeutically Targeting Cancer Stem Cells
Talukdar, S., Emdad, L., Das, S. K., Sarkar, D., & Fisher, P. B. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.04.003 · Cited by 59
Molecular Signaling Mechanisms of Natural and Synthetic Retinoids for Inhibition of Pathogenesis in Alzheimer’s Disease
Chakrabarti, M., McDonald, A. J., Will Reed, J., Moss, M. A., Das, B. C., & Ray, S. K. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150450 · Cited by 57
Role of vitamins A, C, D, E in cancer prevention and therapy: therapeutic potentials and mechanisms of action
Talib, W. H., Jum'Ah, D., Attallah, Z. S., Jallad, M. S., Kury, L. T. A., Hadi, R. W., & Mahmod, A. I. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1281879 · Cited by 57
Effect of vitamin A deficiency on the immune response in obesity
García, O. P. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000079 · Cited by 62
Retinoic Acid Negatively Impacts Proliferation and MCTC Specific Attributes of Human Skin Derived Mast Cells, but Reinforces Allergic Stimulability
Babina, M., Artuc, M., Guhl, S., & Zuberbier, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030525 · Cited by 54
Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases
Velikic, G. S., Maric, D. M., Marić, D., Šupić, G., Puletić, M., Dulić, O., & Vojvodić, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020993 · Cited by 62
Are therapeutic effects of antiacne agents mediated by activation of F ox O 1 and inhibition of m TORC 1?
Melnik, B. C., & Schmitz, G. (2013) · Experimental Dermatology · doi:10.1111/exd.12172 · Cited by 56
Retinoid signaling in control of progenitor cell differentiation during mouse development
Duester, G. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.08.001 · Cited by 59
Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma
Liu, R., Li, S., Garcia, E., Glubrecht, D. D., Poon, H. Y., Easaw, J. C., & Godbout, R. (2016) · Glia · doi:10.1002/glia.22976 · Cited by 55
Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse
Velte, E. K., Niedenberger, B. A., Serra, N. D., Singh, A., la Cruz, L. R.-D., Hermann, B. P., & Geyer, C. B. (2019) · Development · doi:10.1242/dev.173088 · Cited by 55
Effects of Diet and Strain on Mouse Serum and Tissue Retinoid Concentrations
Obrochta, K. M., Kane, M. A., & Napoli, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099435 · Cited by 58
Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells
Kawano, Y., Kikukawa, Y., Fujiwara, S., Wada, N. A., Okuno, Y., Mitsuya, H., & Hata, H. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2134 · Cited by 56
Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner
Arnold, S. L. M., Kent, T., Hogarth, C. A., Griswold, M. D., Amory, J. K., & Isoherranen, N. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.03.001 · Cited by 53
Bladder Cancer Stem-Like Cells: Their Origin and Therapeutic Perspectives
Ohishi, T., Koga, F., & Migita, T. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010043 · Cited by 53
All-Trans Retinoic Acid Modulates DNA Damage Response and the Expression of the VEGF-A and MKI67 Genes in ARPE-19 Cells Subjected to Oxidative Stress
Tokarz, P., Piastowska‐Ciesielska, A. W., Kaarniranta, K., & Błasiak, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060898 · Cited by 53
Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris
Agamia, N., Roshdy, O. H., Abdelmaksoud, R., Abdalla, D., Talaat, I. M., Zaki, E. I., Tawdy, A. E., & Melnik, B. C. (2018) · Experimental Dermatology · doi:10.1111/exd.13787 · Cited by 54
All-trans retinoic acid reduces cancer stem cell-like cell-mediated resistance to gefitinib in NSCLC adenocarcinoma cells
Yao, W., Wang, L., Huang, H., Li, X., Wang, P., Mi, K., Cheng, J. Z., Liu, H., Gu, C., Huang, L., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-06818-0 · Cited by 54
Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis
Cunningham, T. J., Brade, T., Sandell, L. J., Lewandoski, M. B., Trainor, P. A., Colas, A. R., Mercola, M. A., & Duester, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137894 · Cited by 52
NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma
Hu, P.-S., Xia, Q.-S., Wu, F., Li, D.-K., Qi, Y.-J., Hu, Y., Wei, Z.-Z., Ss, L., Tian, N.-Y., Qf, W., et al. (2017) · Oncogene · doi:10.1038/onc.2017.34 · Cited by 51
HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation
Steens, J., & Klein, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1002909 · Cited by 50
Reduced retinoids and retinoid receptors' expression in pancreatic cancer: A link to patient survival
Bleul, T., Rühl, R., Bulashevska, S., Karakhanova, S., Werner, J., & Bazhin, A. V. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22158 · Cited by 50
Epigenetic regulation by RARα maintains ligand-independent transcriptional activity
Laursen, K. B., Wong, P., & Gudas, L. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr637 · Cited by 50
Self-citation
Derivation of male germ cells from ram bone marrow mesenchymal stem cells by three different methods and evaluation of their fate after transplantation into the testis
Ghasemzadeh-Hasankolaei, M., Eslaminejad, M., & Sedighi-Gilani, M. (2015) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-015-9945-4 · Cited by 44
PRAME expression in head and neck cancer correlates with markers of poor prognosis and might help in selecting candidates for retinoid chemoprevention in pre-malignant lesions
Szczepański, M. J., DeLeo, A. B., Łuczak, M. W., Molińska-Glura, M., Misiak, J., Szarzynska, B., Dworacki, G., Zagor, M., Rozwadowska, N., Kurpisz, M. K., et al. (2012) · Oral Oncology · doi:10.1016/j.oraloncology.2012.08.005 · Cited by 49

Authors: Gudas, L. J., & Wagner, J. A.
Affiliations: Cornell University (US)
Corresponding author: Gudas, Lorraine J.
ORCID: Gudas, Lorraine J.
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 2010-11-26
Volume: 226
Issue: 2
Pages: 322-330
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.22417
PMC: PMC3315372
OpenAlex: W2108254285
Cited by: 395
References: 133
Citations by year: 2026: 7 · 2025: 18 · 2024: 26 · 2023: 25 · 2022: 29 · 2021: 20 · 2020: 28 · 2019: 21 · 2018: 22 · 2017: 31 · 2016: 27 · 2015: 29 · 2014: 22 · 2013: 40 · 2012: 25
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA043796)
National Institute of Dental and Craniofacial Research (R01DE010389)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: retinoids, all-trans retinoic acid, stem cell differentiation, retinoic acid receptor, retinoid X receptor, epigenetic regulation, drug sensitization, therapeutic target
MeSH terms: Animals, Cell Differentiation, Retinoids, Stem Cells, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured, Signal Transduction, beta Catenin, TNF-Related Apoptosis-Inducing Ligand

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Retinoids regulate stem cell differentiation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks