Cited by 397Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated ReceptorsPluripotent Stem Cells Research

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Retinoids regulate stem cell differentiation

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Gudas, Lorraine J., Wagner, John A.·2011·Journal of Cellular Physiology

DOI 10.1002/jcp.22417PMC PMC3315372

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Abstract

Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert profound effects on development, and complement cancer chemotherapeutic regimens. All‐trans retinoic acid (RA) and other active retinoids are generated from vitamin A (retinol), but key aspects of the signaling pathways required to produce active retinoids remain unclear. Retinoids generated by one cell type can affect nearby cells, so retinoids also function in intercellular communication. RA induces differentiation primarily by binding to RARs, transcription factors that associate with RXRs and bind RAREs in the nucleus. Binding of RA: (1) initiates changes in interactions of RAR/RXRs with co‐repressor and co‐activator proteins, activating transcription of primary target genes; (2) alters interactions with proteins that induce epigenetic changes; (3) induces transcription of genes encoding transcription factors and signaling proteins that further modify gene expression (e.g., FOX03A, Hoxa1, Sox9, TRAIL, UBE2D3); and (4) results in alterations in estrogen receptor α signaling. Proteins that bind at or near RAREs include Sin3a, N‐CoR1, PRAME, Trim24, NRIP1, Ajuba, Zfp423, and MN1/TEL. Interactions among retinoids, RARs/RXRs, and these proteins explain in part the powerful effects of retinoids on stem cell differentiation. Studies of this retinol signaling cascade enhance our ability to understand and regulate stem cell differentiation for therapeutic and scientific purposes. In cancer chemotherapeutic regimens retinoids can promote tumor cell differentiation and/or induce proteins that sensitize tumors to drug combinations. Mechanistic studies of retinoid signaling continue to suggest novel drug targets and will improve therapeutic strategies for cancer and other diseases, such as immune‐mediated inflammatory diseases. J. Cell. Physiol. 226: 322–330, 2011. © 2010 Wiley‐Liss, Inc.

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Mechanisms of Polycomb gene silencing: knowns and unknowns
Simon, J. A., & Kingston, R. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2763 · Cited by 1,360
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
The Retinoids-Biology, Chemistry and Medicine
Wolf, G. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.5.796a · Cited by 1,000
Coactivator and corepressor complexes in nuclear receptor function
Xu, L., Glass, C. K., & Rosenfeld, M. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80021-5 · Cited by 909
An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
Yu, J., Yu, J., Mani, R.-S., Cao, Q., Brenner, C. J., Cao, X., Wang, X., Wu, L., Li, J., Hu, M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.018 · Cited by 850
A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A
Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., & Sun, H. (2007) · Science · doi:10.1126/science.1136244 · Cited by 836
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Schoenfelder, S., Sexton, T., Chakalova, L., Cope, N. F., Horton, A., Andrews, S., Kurukuti, S., Mitchell, J. A., Umlauf, D., Dimitrova, D. S., et al. (2009) · Nature Genetics · doi:10.1038/ng.496 · Cited by 735
Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism
Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 700
Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors
Schug, T. T., Berry, D. C., Shaw, N. S., Travis, S. N., & Noy, N. (2007) · Cell · doi:10.1016/j.cell.2007.02.050 · Cited by 680
Retinoids, Retinoic Acid Receptors, and Cancer
Tang, X.-H., & Gudas, L. J. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130303 · Cited by 596
Self-citation
The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structuresPreprint
Abu–Abed, S., Dollé, P., METZGER, D., Beckett, B., Chambon, P., & Petkovich, M. P. (2001) · Genes & Development · doi:10.1101/gad.855001 · Cited by 572
Transcriptional control of preadipocyte determination by Zfp423
Gupta, R. K., Arany, Z. P., Seale, P., Mepani, R. J., Li, Y., Conroe, H. M., Roby, Y. A., Kulaga, H. M., Reed, R. R., & Spiegelman, B. M. (2010) · Nature · doi:10.1038/nature08816 · Cited by 555
Deconstructing repression: evolving models of co-repressor action
Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2736 · Cited by 532
EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance
Suvà, M.-L., Riggi, N., Janiszewska, M., Radovanovic, I., Provero, P., Stehle, J., Baumer, K., Bitoux, M. L., Marino, D., Cironi, L., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1622 · Cited by 466
The Human Tumor Antigen PRAME Is a Dominant Repressor of Retinoic Acid Receptor Signaling
Epping, M. T., Wang, L., Edel, M. J., Carlée, L., Hernandez, M., & Bernards, R. (2005) · Cell · doi:10.1016/j.cell.2005.07.003 · Cited by 432
Retinoic acid from the meninges regulates cortical neuron generation.
Siegenthaler, J. A., Ashique, A. M., Zarbalis, K., Patterson, K. P., Hecht, J. H., Kane, M. A., Folias, A. E., Choe, Y., May, S. R., Kume, T., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.004 · Cited by 402
Function of retinoic acid receptors during embryonic development
Mark, M., Ghyselinck, N. B., & Chambon, P. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07002 · Cited by 363
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Nasr, R., Guillemin, M.-C., Ferhi, O., Soilihi, H., Pérès, L., Berthier, C., Rousselot, P. H., Robledo-Sarmiento, M., Lallemand-Breitenbach, V., Gourmel, B., et al. (2008) · Nature Medicine · doi:10.1038/nm.1891 · Cited by 354
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ developmentPreprint
Sandell, L. J., Sanderson, B. W., Moiseyev, G. P., Johnson, T., Mushegian, A. R., Young, K., Rey, J., Ma, J., Staehling‐Hampton, K., & Trainor, P. A. (2007) · Genes & Development · doi:10.1101/gad.1533407 · Cited by 341
Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL
Altucci, L., Rossin, A., Raffelsberger, W., Reitmair, A., Chomienne, C., & Gronemeyer, H. (2001) · Nature Medicine · doi:10.1038/89050 · Cited by 340
Retinoic Acid Receptor β Mediates the Growth-Inhibitory Effect of Retinoic Acid by Promoting Apoptosis in Human Breast Cancer Cells
Liu, Y., Lee, M., Wang, H., Li, Y., Hashimoto, Y., Klaus, M., Reed, J. C., & Zhang, X.-K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1138 · Cited by 329
Retinoid therapy of high-risk neuroblastoma
Reynolds, C. P., Matthay, K. K., Villablanca, J. G., & Maurer, B. J. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00108-3 · Cited by 329
Retinoids and vertebrate development.
Gudas, L. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40689-2 · Cited by 319
Self-citation
Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines
Sidell, N., Altman, A., Haussler, M. R., & Seeger, R. C. (1983) · Experimental Cell Research · doi:10.1016/0014-4827(83)90184-2 · Cited by 318
Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells
Campos, B., Wan, F., Farhadi, M. R., Ernst, A., Zeppernick, F. A., Tagscherer, K. E., Ahmadi, R., Lohr, J., Dictus, C., Gdynia, G., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1800 · Cited by 310
Genomic Antagonism between Retinoic Acid and Estrogen Signaling in Breast Cancer
Hua, S., Kittler, R., & White, K. P. (2009) · Cell · doi:10.1016/j.cell.2009.04.043 · Cited by 301
PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia
Martens, J. H. A., Brinkman, A. B., Simmer, F., Françoijs, K., Nebbioso, A., Ferrara, F., Altucci, L., & Stunnenberg, H. G. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.042 · Cited by 293
The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification
Pijnappel, W. W. M. P., Hendriks, H., Folkers, G. E., Brink, C. E. V. D., Dekker, E.-J., Edelenbosch, C., van der Saag, P. T., & Durston, A. J. (1993) · Nature · doi:10.1038/366340a0 · Cited by 285
Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6
Langston, A. W., & Gudas, L. J. (1992) · Mechanisms of Development · doi:10.1016/0925-4773(92)90055-o · Cited by 268
Self-citation
Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
Rochette‐Egly, C., & Germain, P. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07005 · Cited by 263
Cooperative interaction between retinoic acid receptor-α and estrogen receptor in breast cancerPreprint
Ross-Innes, C. S., Stark, R., Holmes, K. A., Schmidt, D., Spyrou, C., Russell, R., Massie, C. E., Vowler, S. L., Eldridge, M., & Carroll, J. S. (2010) · Genes & Development · doi:10.1101/gad.552910 · Cited by 260
Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells
Matt, N., Dupé, V., Garnier, J., Dennefeld, C., Chambon, P., Mark, M. P., & Ghyselinck, N. B. (2005) · Development · doi:10.1242/dev.02031 · Cited by 256
Ligand-Dependent Nuclear Receptor Corepressor LCoR Functions by Histone Deacetylase-Dependent and -Independent Mechanisms
Fernandes, I., Bastien, Y., Wai, T., Nygard, K. L., Lin, R., Cormier, O., Lee, H. S., Eng, F., Bertos, N., Pelletier, N., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00014-5 · Cited by 252
Role of the Polycomb Repressive Complex 2 in Acute Promyelocytic Leukemia
Villa, R., Pasini, D., Gutiérrez, A., Morey, L., Occhionorelli, M., Viré, E. A., Nomdedeu, J. F., Jenuwein, T., Pelicci, P. G., Minucci, S., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.009 · Cited by 247
Sin3: Master scaffold and transcriptional corepressor
Grzenda, A. L., Lomberk, G. A., Zhang, J., & Urrutia, R. A. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.05.007 · Cited by 241
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development
Niederreither, K., Abu–Abed, S., Schuhbaur, B., Petkovich, M. P., Chambon, P., & Dollé, P. (2002) · Nature Genetics · doi:10.1038/ng876 · Cited by 235
Rex-1, a Gene Encoding a Transcription Factor Expressed in the Early Embryo, Is Regulated via Oct-3/4 and Oct-6 Binding to an Octamer Site and a Novel Protein, Rox-1, Binding to an Adjacent Site
Ben-Shushan, E., Thompson, J. R., Gudas, L. J., & Bergman, Y. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.1866 · Cited by 235
Self-citation
NF1 Is a Tumor Suppressor in Neuroblastoma that Determines Retinoic Acid Response and Disease Outcome
Hölzel, M., Huang, S., Köster, J., Øra, I., Lakeman, A., Caron, H. N., Nijkamp, W., Xie, J., Callens, T., Asgharzadeh, S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.004 · Cited by 225
Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu
Zhou, X., Kong, N., Wang, J., Fan, H., Zou, H., Horwitz, D. A., Brand, D. D., Liu, Z., & Zheng, S. G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000598 · Cited by 218
Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein
Bouillet, P., Sapin, V., Chazaud, C., Messaddeq, N., Décimo, D., Dollé, P., & Chambon, P. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00039-7 · Cited by 209
RARγ is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation
Purton, L. E., Dworkin, S., Olsen, G. H., Walkley, C. R., Fabb, S. A., Collins, S. J., & Chambon, P. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052105 · Cited by 209
Physical and Functional Interactions between Cellular Retinoic Acid Binding Protein II and the Retinoic Acid-Dependent Nuclear Complex
Delva, L., Bastie, J.-N., Rochette-Egly, C., Kraïba, R., Balitrand, N., Despouy, G., Chambon, P., & Chomienne, C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7158 · Cited by 208
The promise of TRAIL—potential and risks of a novel anticancer therapy
Koschny, R., Walczak, H., & Ganten, T. M. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0194-1 · Cited by 195
Between Death and Survival: Retinoic Acid in Regulation of Apoptosis
Noy, N. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155509 · Cited by 192
Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells.
Seewaldt, V. L., Johnson, B. S., Parker, M. B., Collins, S., & Swisshelm, K. L. (1995) · PubMed · Cited by 192
Orphan Nuclear Receptor GCNF Is Required for the Repression of Pluripotency Genes during Retinoic Acid-Induced Embryonic Stem Cell Differentiation
Gu, P., Menuet, D. L., Chung, A. C.-K., Mancini, M. A., Wheeler, D. A., & Cooney, A. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8507-8519.2005 · Cited by 186
Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells.
Hosler, B. A., LaRosa, G. J., Grippo, J. F., & Gudas, L. J. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.12.5623 · Cited by 184
Self-citation
Diverse actions of retinoid receptors in cancer prevention and treatment
Mongan, N. P., & Gudas, L. J. (2007) · Differentiation · doi:10.1111/j.1432-0436.2007.00206.x · Cited by 182
Self-citation
Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to Vitamin A deficiency
Liu, L., & Gudas, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509643200 · Cited by 181
Self-citation
Non-cell-autonomous retinoid signaling is crucial for renal development
Rosselot, C., Spraggon, L., Chia, I. V., Batourina, E., Riccio, P., Lu, B., Niederreither, K., Dollé, P., Duester, G., Chambon, P., et al. (2010) · Development · doi:10.1242/dev.040287 · Cited by 181
Activation of Retinoic Acid Receptor-dependent Transcription by All-trans-retinoic Acid Metabolites and Isomers
Idres, N., Marill, J., Flexor, M., & Chabot, G. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205016200 · Cited by 181
An early effect of retinoic acid: cloning of an mRNA (Era-1) exhibiting rapid and protein synthesis-independent induction during teratocarcinoma stem cell differentiation.
LaRosa, G. J., & Gudas, L. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.2.329 · Cited by 170
Self-citation
All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis
Bai, A., Lü, N., Guo, Y., Liu, Z., Jiang, C., & Peng, Z. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0109006 · Cited by 167
Hyaluronan Mixed Esters of Butyric and Retinoic Acid Drive Cardiac and Endothelial Fate in Term Placenta Human Mesenchymal Stem Cells and Enhance Cardiac Repair in Infarcted Rat Hearts
Ventura, C., Cantoni, S., Bianchi, F., Lionetti, V., Cavallini, C., Scarlata, I., Foroni, L., Maioli, M., Bonsi, L., Alviano, F., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609350200 · Cited by 166
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
le Maire, A., Teyssier, C., Erb, C., Grimaldi, M., Álvarez, S., de Lera, Á. R., Balaguer, P., Gronemeyer, H., Royer, C. A., Germain, P., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1855 · Cited by 163
Loss of Trim24 (Tif1α) gene function confers oncogenic activity to retinoic acid receptor alpha
Khetchoumian, K., Teletin, M., Tisserand, J., Mark, M. P., Herquel, B., Ignat, M., Zucman‐Rossi, J., Cammas, F. M., Lerouge, T., Thibault-Carpentier, C., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.15 · Cited by 155
Developmental expression of retinoic acid receptors (RARs)
Dollé, P. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07006 · Cited by 152
Role of Retinoic Acid in the Differentiation of Embryonal Carcinoma and Embryonic Stem Cells
Soprano, D. R., Teets, B. W., & Soprano, K. J. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)75003-8 · Cited by 150
ZNF423 Is Critically Required for Retinoic Acid-Induced Differentiation and Is a Marker of Neuroblastoma Outcome
Huang, S., Laoukili, J., Epping, M. T., Köster, J., Hölzel, M., Westerman, B. A., Nijkamp, W., Hata, A., Asgharzadeh, S., Seeger, R. C., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.023 · Cited by 145
Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.
Boylan, J. F., Lohnes, D., Taneja, R., Chambon, P., & Gudas, L. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9601 · Cited by 144
Self-citation
Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis
Zhang, L., Ren, X., Alt, E., Bai, X., Huang, S., Xu, Z., Lynch, P. M., Moyer, M. P., Wen, X.-F., & Wu, X. (2010) · Nature · doi:10.1038/nature08871 · Cited by 141
Retinoid Regulated Association of Transcriptional Co-regulators and the Polycomb Group Protein SUZ12 with the Retinoic Acid Response Elements of Hoxa1, RARβ2, and Cyp26A1 in F9 Embryonal Carcinoma Cells
Gillespie, R. F., & Gudas, L. J. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.06.079 · Cited by 132
Self-citation
Rere controls retinoic acid signalling and somite bilateral symmetry
Vilhais-Neto, G. C., Maruhashi, M., Smith, K. T., Vasseur-Cognet, M., Peterson, A. S., Workman, J. L., & Pourquié, O. (2010) · Nature · doi:10.1038/nature08763 · Cited by 129
Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster
Sessa, L., Breiling, A., Lavorgna, G., Silvestri, L., Casari, G., & Orlando, V. (2006) · RNA · doi:10.1261/rna.266707 · Cited by 122
Retinoids signal directly to zebrafish endoderm to specify insulin -expressing β-cells
Stafford, D. A., White, R. J., Kinkel, M. D., Linville, A., Schilling, T. F., & Prince, V. (2006) · Development · doi:10.1242/dev.02263 · Cited by 118
Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid
Passeron, T., Valencia, J. C., Namiki, T., Vieira, W. D., Passeron, H. J., Miyamura, Y., & Hearing, V. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci34015 · Cited by 116
Retinoids in biological control and cancer
Fields, A. L., Soprano, D., & Soprano, K. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21530 · Cited by 116
4-Oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors.
Achkar, C. C., Derguini, F., Blumberg, B., Langston, A., Levin, A. A., Speck, J., Evans, R. M., Bolado, J., Nakanishi, K., Buck, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4879 · Cited by 113
Self-citation
A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARα to target promoters
Bruck, N., Vitoux, D., Ferry, C., Duong, V., Bauer, A., de Thé, H., & Rochette‐Egly, C. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.256 · Cited by 108
Novel retinoic acid receptor ligands in Xenopus embryos.
Blumberg, B., Bolado, J., Derguini, F., Craig, A. G., Moreno, T. A., Chakravarti, D., Heyman, R. A., Buck, J., & Evans, R. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4873 · Cited by 106
Wnt/β-Catenin and Retinoic Acid Receptor Signaling Pathways Interact to Regulate Chondrocyte Function and Matrix Turnover
Yasuhara, R., Yuasa, T., Williams, J. A., Byers, S. W., Shah, S., Pacifici, M., Iwamoto, M., & Enomoto‐Iwamoto, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053926 · Cited by 101
Isx Participates in the Maintenance of Vitamin A Metabolism by Regulation of β-Carotene 15,15′-Monooxygenase (Bcmo1) Expression
Seino, Y., Miki, T., Kiyonari, H., Abe, T., Fujimoto, W., Kimura, K., Takeuchi, A., Takahashi, Y., Oiso, Y., Iwanaga, T., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707928200 · Cited by 100
Highly Compacted Chromatin Formed In Vitro Reflects the Dynamics of Transcription Activation In Vivo
Li, G., Margueron, R., Hu, G., Stokes, D. L., Wang, Y.-H., & Reinberg, D. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.042 · Cited by 96
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation
Hahn, C. K., Ross, K. N., Warrington, I. M., Mazitschek, R., Kanegai, C. M., Wright, R. D., Kung, A. L., Golub, T. R., & Stegmaier, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710413105 · Cited by 91
Epigenetic Regulatory Mechanisms Distinguish Retinoic Acid-mediated Transcriptional Responses in Stem Cells and Fibroblasts
Kashyap, V., & Gudas, L. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.115345 · Cited by 91
Self-citation
Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells.
Sun, S., Yue, P., Hong, W. K., & Lotan, R. (2000) · PubMed · Cited by 90
RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition
Afonja, O., Raaka, B. M., Huang, A. J., Das, S., Zhao, X., Helmer, E., Juste, D., & Samuels, H. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205985 · Cited by 86
Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation
Mohammad, H. P., Cai, Y., McGarvey, K. M., Easwaran, H., Neste, L. V., Ohm, J. E., O’Hagan, H. M., & Baylin, S. B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0065 · Cited by 86
Retinoic acid directs neuronal differentiation of human pluripotent stem cell lines in a non-cell-autonomous manner
Tonge, P. D., & Andrews, P. W. (2010) · Differentiation · doi:10.1016/j.diff.2010.04.001 · Cited by 85
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Lee, E. R., Murdoch, F. E., & Fritsch, M. K. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0203 · Cited by 82
The atRA‐responsive gene neuron navigator 2 functions in neurite outgrowth and axonal elongation
Muley, P. D., McNeill, E. M., Marzinke, M. A., Knobel, K. M., Barr, M. M., & Clagett‐Dame, M. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20670 · Cited by 81
Retinyl Ester Formation by Lecithin:Retinol Acyltransferase Is a Key Regulator of Retinoid Homeostasis in Mouse Embryogenesis
Kim, Y.-K., Wassef, L., Hamberger, L., Piantedosi, R., Palczewski, K., Blaner, W. S., & Quadro, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708885200 · Cited by 80
Zfp423 Is Required for Normal Cerebellar Development
Warming, S., Rachel, R. A., Jenkins, N. A., & Copeland, N. G. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02255-05 · Cited by 80
Transcription Factor Smad3 Is Required for the Inhibition of Adipogenesis by Retinoic Acid
Marchildon, F., St‐Louis, C., Akter, R., Roodman, V., & Wiper‐Bergeron, N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.054536 · Cited by 79
Discovery and Design of Retinoic Acid Receptor and Retinoid X Receptor Class- and Subtype-Selective Synthetic Analogs of All-trans-retinoic Acid and 9-cis-Retinoic Acid
Dawson, M. I., & Zhang, X.-K. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023370789 · Cited by 76
Retinoic Acid Synthesis Promotes Development of Neural Progenitors from Mouse Embryonic Stem Cells by Suppressing Endogenous, Wnt-Dependent Nodal Signaling
Engberg, N., Kahn, M., Petersen, D. R., Hansson, M. D., & Serup, P. (2010) · Stem Cells · doi:10.1002/stem.479 · Cited by 76
Phosphorylation by PKA potentiates retinoic acid receptor α activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7
Gaillard, E., Bruck, N., Brelivet, Y., Bour, G., Lalevée, S., Bauer, A., Poch, O., Moras, D., & Rochette-Egly, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509717103 · Cited by 76
ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription
Qin, Z., Ren, F., Xu, X., Ren, Y., Li, H., Wang, Y., Zhai, Y., & Chang, Z. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00362-09 · Cited by 76
Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.
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Self-citation
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Self-citation
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Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation
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Kinetic Analysis of Human Enzyme RDH10 Defines the Characteristics of a Physiologically Relevant Retinol Dehydrogenase
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An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells.
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Authors: Gudas, L. J., & Wagner, J. A.
Affiliations: Cornell University (US)
Corresponding author: Gudas, Lorraine J.
ORCID: Gudas, Lorraine J.
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 2010-11-26
Volume: 226
Issue: 2
Pages: 322-330
ISSN: 0021-9541 (ISSN-L)
1097-4652
DOI: 10.1002/jcp.22417
PMC: PMC3315372
OpenAlex: W2108254285
Cited by: 395
References: 133
Citations by year: 2026: 7 · 2025: 18 · 2024: 26 · 2023: 25 · 2022: 29 · 2021: 20 · 2020: 28 · 2019: 21 · 2018: 22 · 2017: 31 · 2016: 27 · 2015: 29 · 2014: 22 · 2013: 40 · 2012: 25
FWCI: 2.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Cellular Physiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA043796)
National Institute of Dental and Craniofacial Research (R01DE010389)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: retinoids, all-trans retinoic acid, stem cell differentiation, retinoic acid receptor, retinoid X receptor, epigenetic regulation, drug sensitization, therapeutic target
MeSH terms: Animals, Cell Differentiation, Retinoids, Stem Cells, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured, Signal Transduction, beta Catenin, TNF-Related Apoptosis-Inducing Ligand

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Retinoids regulate stem cell differentiation

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