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Cited by 440

The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.

Tumor associated macrophages and neutrophils in tumor progression

Galdiero, Maria R., Garlanda, Cecilia, Jaillon, Sébastien, Marone, Gianni, Mantovani, Alberto·2013·Journal of Cellular Physiology

Abstract

Tumor‐associated macrophages (TAMs) are a key component of the tumor microenvironment and orchestrate various aspects of cancer. Diversity and plasticity are hallmarks of cells of the monocyte–macrophage lineage. In response to distinct signals macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a spectrum of activation states. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity and inflammation. Generally, TAMs acquire an M2‐like phenotype that plays important roles in many aspects of tumor growth and progression. There is now evidence that also neutrophils can be driven towards distinct phenotypes in response to microenvironmental signals. The identification of mechanisms and molecules associated with macrophage and neutrophil plasticity and polarized activation provides a basis for new diagnostic and therapeutic strategies. J. Cell. Physiol. 228: 1404–1412, 2013. © 2012 Wiley Periodicals, Inc.

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Metadata

Authors
Galdiero, M. R., Garlanda, C., Jaillon, S., Marone, G., & Mantovani, A.
Venue
Journal of Cellular Physiology
Publisher
Wiley
Published
2013-03-21
Volume
228
Issue
7
Pages
1404-1412
ISSN
  • 0021-9541 (ISSN-L)
  • 1097-4652
OpenAlex
W2125884672
Cited by
440
References
141
FWCI
10.72
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Tumor associated macrophages and neutrophils in tumor progression. https://app.cochat.ai/papers/10.1002/jcp.24260
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Galdiero, M. R., Garlanda, C., Jaillon, S., Marone, G., & Mantovani, A. (2013). Tumor associated macrophages and neutrophils in tumor progression. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.24260

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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