Telomeres and telomerase in the clinical management of colorectal cancer
Abstract
Colorectal cancer (CRC) is the third most common cancer worldwide. Our aim is to describe the state of the art about the role of telomeres and telomerase in the clinical management of CRC and its potential utility as prognostic and diagnostic biomarkers and targets of new treatments. Telomere length could be a new diagnostic marker as an anomalous behavior is observed in peripheral blood cells when CRC patients and healthy people are compared. Moreover, telomeres and telomerase may be used as diagnostic markers considering that universal changes appear along the CRC process. Currently, new therapeutic cancer approaches are focused on inhibiting the maintenance of telomere length, choosing as targets telomerase -or its subunits- or the Shelterin complex. The goal of these therapies is the shortening of telomeres and the induction of cell senescence. Telomeres and telomerase emerge as useful molecular tools in the clinical management of CRC.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Telomerase activity has been found in normal mucosa samples at a lower frequency, ranging from 9% to 53%.
“In contrast, TA has been found in normal mucosa samples at a lower frequency, ranging from 9% to 53% [22,203].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [22]
During each cell cycle, telomerase activity seems to be concentrated primarily to telomeric ends whose length reaches a critically short length (telomeric prioritization).
“during each cell cycle, TA seems to be concentrated primarily to these telomeric ends whose length reaches a critically short length (telomeric prioritization) [22,189].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [22]
Cites
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works
International Agency for Research on Cancer
National Cancer Institute (2020) · Definitions · doi:10.32388/pfg7jq · Cited by 9,493 · see citing works
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596 · see citing works
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400 · see citing works
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056 · see citing works
Mammalian Telomeres End in a Large Duplex Loop
Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., & de Lange, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80760-6 · Cited by 2,447 · see citing works
Li, Y., Yang, Y., Lu, M., & Shen, L. (2011) · Hepatogastroenterology · doi:10.5754/hge11753 · Cited by 2,435 · see citing works
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200 · see citing works
Switching and Signaling at the Telomere
Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,097 · see citing works
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · cited 1× · see citing works
“This proliferation is followed by ulterior telomeric erosion until cells reach a second stage of mortality (M2), whereas the telomeres are critically short [49].”
BackgroundHow Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802 · see citing works
Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784 · see citing works
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works
Monovalent cation-induced structure of telomeric DNA: The G-quartet model
Williamson, J. R., Raghuraman, M. K., & Cech, T. R. (1989) · Cell · doi:10.1016/0092-8674(89)90610-7 · Cited by 1,228 · see citing works
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219 · see citing works
Telomere loss: mitotic clock or genetic time bomb?
Harley, C. B. (1991) · Mutation Research/DNAging · doi:10.1016/0921-8734(91)90018-7 · Cited by 1,139 · see citing works
Human Telomerase and Its Regulation
Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898 · see citing works
Control of Human Telomere Length by TRF1 and TRF2
Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., & de Lange, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1659-1668.2000 · Cited by 768 · see citing works
The rate of telomere sequence loss in human leukocytes varies with age
Frenck, R. W., Blackburn, E. H., & Shannon, K. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5607 · Cited by 675 · see citing works
Telomere length and replicative aging in human vascular tissues.
Chang, E., & Harley, C. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11190 · Cited by 635 · see citing works
Targeting telomeres and telomerase
Cian, A. D., Lacroix, L., Douarre, C., Temime‐Smaali, N., Trentesaux, C., Riou, J., & Mergny, J. (2007) · Biochimie · doi:10.1016/j.biochi.2007.07.011 · Cited by 571 · see citing works
The biology of replicative senescence
Campisi, J. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(96)00058-5 · Cited by 538 · see citing works
Shay, J. W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.677 · Cited by 517 · see citing works
Russo, A., Bazan, V., Iacopetta, B., Kerr, D., Soussi, T., & Gebbia, N. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.00.471 · Cited by 416 · see citing works
Evidence for a Critical Telomere Length in Senescent Human Fibroblasts
Allsopp, R., & Harley, C. B. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1213 · Cited by 391 · see citing works
Piatyszek, M. A., Kim, N. W., Weinrich, S. L., Hiyama, K., Hiyama, E., Wright, W. E., & Shay, J. W. (1995) · Methods in Cell Science · doi:10.1007/bf00981880 · Cited by 384 · see citing works
Telomerase activity associated with acquisition of malignancy in human colorectal cancer.
Chadéneau, C., Hay, K. D., Hirte, H. W., Gallinger, S., & Bacchetti, S. (1995) · PubMed · Cited by 357 · see citing works
Kyo, S., Takakura, M., Fujiwara, T., & Inoue, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00878.x · Cited by 347 · see citing works
Telomere length in different tissues of elderly patients
Friedrich, U., Griese, E.-U., Schwab, M., Fritz, P., Thon, K.-P., & Klotz, U. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00173-1 · Cited by 325 · see citing works
Hug, N., & Lingner, J. (2006) · Chromosoma · doi:10.1007/s00412-006-0067-3 · Cited by 291 · see citing works
Prognostic and predictive factors in colorectal cancer
Zlobec, I., & Lugli, A. K. (2008) · Postgraduate Medical Journal · doi:10.1136/jcp.2007.054858 · Cited by 280 · see citing works
Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)
Poole, J. C., Andrews, L. G., & Tollefsbol, T. O. (2001) · Gene · doi:10.1016/s0378-1119(01)00440-1 · Cited by 275 · see citing works
Guilleret, I., Yan, P., Grange, F., Braunschweig, R., Bosman, F. T., & Benhattar, J. (2002) · International Journal of Cancer · doi:10.1002/ijc.10593 · Cited by 260 · see citing works
Telomerase regulation and stem cell behaviour
Flores, I., Benetti, R., & Blasco, M. A. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.03.003 · Cited by 232 · see citing works
Short Telomere Length, Cancer Survival, and Cancer Risk in 47102 Individuals
Weischer, M., Nordestgaard, B. G., Cawthon, R., Freiberg, J., Tybjærg‐Hansen, A., & Bojesen, S. E. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt016 · Cited by 228 · see citing works
The first molecular details of ALT in human tumor cells
Muntoni, A., & Reddel, R. R. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi266 · Cited by 226 · see citing works
Devereux, T. R., Horikawa, I., Anna, C. H., Annab, L. A., Afshari, C. A., & Barrett, J. C. (1999) · PubMed · Cited by 214 · see citing works
TIN2 Mediates Functions of TRF2 at Human Telomeres
Kim, S., Beausejour, C. M., Davalos, A. R., Kaminker, P. G., Heo, S., & Campisi, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408650200 · Cited by 212 · see citing works
Alternative lengthening of telomeres, telomerase, and cancer
Reddel, R. R. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00702-4 · Cited by 191 · see citing works
Hiyama, E., & Hiyama, K. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00709-7 · Cited by 191 · see citing works
Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
Artandi, S. E., & Attardi, L. D. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.211 · Cited by 190 · see citing works
Mechanisms of oncogenesis in colon versus rectal cancer
Kapiteijn, E., Liefers, G., Los, L., Kranenbarg, E. M., Hermans, J., Tollenaar, R. A. E. M., Moriya, Y., van de Velde, C. J. H., & van Krieken, J. H. J. M. (2001) · The Journal of Pathology · doi:10.1002/path.918 · Cited by 189 · see citing works
Engelhardt, M. M., Drullinsky, P. R., Guillem, J. G., & Moore, M. A. S. (1997) · PubMed · Cited by 189 · see citing works
Methylation of the human telomerase gene CpG island.
Dessain, S. K., Yu, H., Reddel, R. R., Beijersbergen, R. L., & Weinberg, R. A. (2000) · PubMed · Cited by 185 · see citing works
Gertler, R., Rosenberg, R., Stricker, D., Friederichs, J., Hoos, A., Werner, M., Ulm, K., Holzmann, B., Nekarda, H., & Siewert, J.-R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.160 · Cited by 180 · see citing works
Telomere maintenance by telomerase and by recombination can coexist in human cells
Cerone, M. A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1945 · Cited by 171 · see citing works
Telomerase and cancer: revisiting the telomere hypothesis
Autexier, C., & Greider, C. W. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10042-6 · Cited by 166 · see citing works
Telomere shortening and ageing of the immune system.
Kaszubowska, L. (2008) · PubMed · Cited by 161 · see citing works
The Role of Telomere Biology in Cancer
Xu, L., Li, S., & Stohr, B. A. (2013) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164030 · Cited by 160 · see citing works
[Telomerase as a tumor marker?].
Hummel, M., Heine, B., Demel, G., & Stein, H. (1997) · PubMed · Cited by 149 · see citing works
Telomere structure and telomerase in health and disease
Gomez, D. E., Armando, R. G., Fariña, H. G., Menna, P. L., Cerrudo, C. S., Ghiringhelli, P. D., & Alonso, D. F. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1611 · Cited by 145 · see citing works
CTCF binds the proximal exonic region of hTERT and inhibits its transcription
Renaud, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki989 · Cited by 137 · see citing works
Cancer and aging: the importance of telomeres in genome maintenance
Rodier, F., Kim, S.-H., Nijjar, T., Yaswen, P., & Campisi, J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.012 · Cited by 132 · see citing works
Tatsumoto, N., Hiyama, E., Murakami, Y., Imamura, Y., Shay, J. W., Matsuura, Y., & Yokoyama, T. (2000) · PubMed · Cited by 132 · see citing works
Telomeres: The silence is broken
Azzalin, C. M., & Lingner, J. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5836 · Cited by 123 · see citing works
Clinical significance of tumor markers and an emerging perspective on colorectal cancer
Yamashita, K., & Watanabe, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.01022.x · Cited by 118 · see citing works
Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor
Goueli, B. S., & Janknecht, R. (2003) · Oncogene · doi:10.1038/sj.onc.1206847 · Cited by 115 · see citing works
Garcia‐Aranda, C., de Juan, C., Diaz‐Lopez, A., Sanchez‐Pernaute, A., Torres, A., Diaz‐Rubio, E., Balibrea, J., Benito, M., & Iniesta, P. (2006) · Cancer · doi:10.1002/cncr.21625 · Cited by 105 · see citing works
Review The diagnostics of colorectal cancer
Świderska, M., Choromańska, B., Dąbrowska, E., Duchnowska, E., Choromańska, K., Szczurko, G., Myśliwiec, P., Dadan, J., Ładny, J. R., & Zwierz, K. (2014) · Współczesna Onkologia · doi:10.5114/wo.2013.39995 · Cited by 96 · see citing works
Telomerase efficiently elongates highly transcribing telomeres in human cancer cells
Farnung, B. O., Brun, C. M., Arora, R., Lorenzi, L. E., & Azzalin, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035714 · Cited by 91 · see citing works
Terrin, L., Rampazzo, E., Pucciarelli, S., Agostini, M., Bertorelle, R., Esposito, G., DelBianco, P., Nitti, D., & De Rossi, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0478 · Cited by 91 · see citing works
Role of TERRA in the regulation of telomere length
Wang, C., Zhao, L., & Lu, S. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.10528 · Cited by 89 · see citing works
Telomeres, telomerase and colorectal cancer
Bertorelle, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i8.1940 · Cited by 82 · see citing works
Bertorelle, R., Briarava, M., Rampazzo, E., Biasini, L., Agostini, M., Maretto, I., Lonardi, S., Friso, M. L., Mescoli, C., Zagonel, V, et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2012.602 · Cited by 77 · see citing works
Farahati, J., Demidchik, E. P., Biko, J., & Reiners, C. (2000) · Cancer · doi:10.1002/(sici)1097-0142(20000315)88:6 · Cited by 76 · see citing works
Masutomi, K., & Hahn, W. C. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00703-6 · Cited by 74 · see citing works
Tang, R., Cheng, A., Wang, J., & Wang, T. V. (1998) · PubMed · Cited by 69 · see citing works
Telomere Length Maintenance, Shortening, and Lengthening
Zhao, Z., Pan, X., Liu, L., & Liu, N. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24537 · Cited by 66 · see citing works
Recent Patents on Anti-Telomerase Cancer Therapy
Agrawal, A., Dang, S., & Gabrani, R. (2012) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489212798357958 · Cited by 61 · see citing works
Cui, Y., Gao, Y., Cai, Q., Qu, S., Cai, H., Li, H., Wu, J., Ji, B., Yang, G., Chow, W., et al. (2013) · Obesity · doi:10.1002/oby.20321 · Cited by 58 · see citing works
Molecular pathology of colorectal cancer
Bosman, F. T., & Yan, P. (2015) · Polish Journal of Pathology · doi:10.5114/pjp.2014.48094 · Cited by 55 · see citing works
Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
Fernández‐Marcelo, T., Sánchez-Pernaute, A., Pascua, I. P., de Juan, C., Head, J., Torres, A.-J., & Iniesta, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149626 · Cited by 49 · see citing works
Self-citationPrognostic and predictive factors in colorectal cancer.
Bolocan, A., Ion, D., Ciocan, D. N., & Paduraru, D. N. (2012) · PubMed · Cited by 48 · see citing works
Queisser, A., Heeg, S., Thaler, M., von Werder, A., & Opitz, O. G. (2013) · Cancer Genetics · doi:10.1016/j.cancergen.2013.10.001 · Cited by 46 · see citing works
Telomere length is a prognostic factor for overall survival in colorectal cancer
Valls, C., Piñol, C., Reñé, J. M., Buenestado, J., & Viñas, J. (2010) · Colorectal Disease · doi:10.1111/j.1463-1318.2010.02433.x · Cited by 44 · see citing works
Lopez (2002) · doi:10.1002/cncr.10911 · Cited by 36 · see citing works
Evaluation of telomerase in the development and progression of colon cancer
Boldrini, L., Faviana, P., Gisfredi, S., Zucconi, Y., Quirico, D. D., Donati, V. L., Berti, P., Spisni, R., Galleri, D., Materazzi, G., et al. (2002) · International Journal of Molecular Medicine · doi:10.3892/ijmm.10.5.589 · Cited by 36 · see citing works
Merkel cells in the human oesophagus
Harmse, J. L., Carey, F. A., Baird, A., Craig, S., Christie, K. N., Hopwood, D., & Lucocq, J. M. (1999) · Journal of Pathology · doi:10.1002/(sici)1096-9896(199910)189:2 · Cited by 33 · see citing works
Telomere Length Changes in Colorectal Cancers and Polyps
Kim, H. R., Kim, Y. J., Kim, H. J., Kim, S. K., & Lee, J. H. (2002) · Journal of Korean Medical Science · doi:10.3346/jkms.2002.17.3.360 · Cited by 32 · see citing works
The telomerase cycle: normal and pathological aspects
Brunori, M., Luciano, P., Gilson, É., & G�li, V. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0616-2 · Cited by 31 · see citing works
The association between telomerase, p53, and clinical staging in colorectal cancer
Brown, T. A., Aldous, W. K., Lance, R., Bläser, J., Baker, T., Williard, W., & Washington, F. L. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00057-9 · Cited by 30 · see citing works
Telomerase Activity as a Prognostic Factor in Colorectal Cancer
Casla, M. T. S., Vidaurreta, M., Sanchez-Rueda, D., Maestro, M. L., Arroyo, M., & Cerdán, F. J. (2005) · Oncology Research and Treatment · doi:10.1159/000088525 · Cited by 29 · see citing works
Telomerase Activity is a Prognostic Factor for Recurrence and Survival in Rectal Cancer
Valls, C., Felis, C. P., Espinet, J. M. R., García, J. B., & Salas, J. V. (2007) · Diseases of the Colon & Rectum · doi:10.1007/s10350-006-0820-y · Cited by 29 · see citing works
Prognostic biomarkers in colorectal cancer: where do we stand?
Sagaert, X. (2014) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-013-1532-z · Cited by 28 · see citing works
Guillermo Bannura, C., G, M. A. C., P, J. C., E, A. B., Carlos Melo, L., & C, D. S. (2004) · Revista médica de Chile · doi:10.4067/s0034-98872004000600005 · Cited by 27 · see citing works
Augustine, T. A., Baig, M., Sood, A., Budagov, T., Atzmon, G., Mariadason, J. M., Aparo, S., Maitra, R., & Goel, S. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.561 · Cited by 27 · see citing works
Relationship between microsatellite instability and telomere shortening in colorectal cancer
Takagi, S., Kinouchi, Y., Hiwatashi, N., Nagashima, F., Chida, M., Takahashi, S., Negoro, K., Shimosegawa, T., & Toyota, T. (2000) · Diseases of the Colon & Rectum · doi:10.1007/bf02237220 · Cited by 24 · see citing works
Differences in telomerase activity between colon and rectal cancer
Ayiomamitis, G. D., Notas, G., Zaravinos, A., Zizi-Sermpetzoglou, A., Γεωργιάδου, Μ., Sfakianaki, O., & Kouroumallis, E. (2014) · Canadian Journal of Surgery · doi:10.1503/cjs.031312 · Cited by 24 · see citing works
Is telomerase a novel target for metastatic colon cancer?
Roig, A. I., Wright, W. E., & Shay, J. W. (2009) · Current Colorectal Cancer Reports · doi:10.1007/s11888-009-0028-3 · Cited by 21 · see citing works
Riegert‐Johnson, D. L., Boardman, L. A., Crook, J. E., Thomas, C. S., Johnson, R., & Roberts, M. E. (2012) · The International Journal of Biological Markers · doi:10.5301/jbm.2012.9347 · Cited by 20 · see citing works
Vidaurreta, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i28.3868 · Cited by 19 · see citing works
Ghori, A., Usselmann, B., Ferryman, S. R., Morris, A. G., & Fraser, I. A. (2002) · Colorectal Disease · doi:10.1046/j.1463-1318.2002.00378.x · Cited by 17 · see citing works
Telomerase activity and telomere length in the colorectal polyp-carcinoma sequence
Valls, C., Felis, C. P., Espinet, J. M. R., García, J. B., & Salas, J. V. (2009) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082009000300004 · Cited by 16 · see citing works
In colon cancer, normal colon tissue and blood cells have altered telomere lengths
Valls, C., Piñol, C., Reñé‐Espinet, J. M., Buenestado, J., & Salas, J. V. (2015) · Journal of Surgical Oncology · doi:10.1002/jso.23894 · Cited by 11 · see citing works
Quantitative analysis of telomerase activity: a potential diagnostic tool for colorectal carcinoma.
Abe, N., Watanabe, T., Nakashima, M., Masaki, T., Mori, T., Sugiyama, M., & Atomi, Y. (2001) · PubMed · Cited by 9 · see citing works
Telomerase activity in different clinical staging of colorectal adenocarcinoma.
Lukman, K., Am, M., Th, A., Hanafi, B., & Karnadihardja, W. (2000) · PubMed · Cited by 8 · see citing works
Boldrini, L., Faviana, P., Gisfredi, S., Zucconi, Y., Quirico, D. D., Donati, Berti, P., Spisni, R., Galleri, D., Materazzi, G., et al. (2002) · International Journal of Molecular Medicine · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chen, M., Gu, Y.-Y., Zhang, A. L., Sze, D., Mo, S., & May, B. H. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105778 · Cited by 83 · see citing works
Role of telomere length in human carcinogenesis (Review)
Tsatsakis, A. M., Oikonomopoulou, T., Νikolouzakis, Τ. Κ., Vakonaki, E., Tzatzarakis, M. N., Flamourakis, M., Renieri, E. A., Fragkiadaki, P., Iliaki, E., Bachlitzanaki, M., et al. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5526 · Cited by 58 · see citing works
Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review
Peluso, G., Incollingo, P., Calogero, A., Tammaro, V., Rupealta, N., Chiacchio, G., Sotelo, M. L. S., Minieri, G., Pisani, A., Riccio, E., et al. (2017) · BioMed Research International · doi:10.1155/2017/2605628 · Cited by 40 · see citing works
Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works
Link between risk of colorectal cancer and serum vitamin E levels
Dong, Y., Liu, Y., Shu, Y., Chen, X., Hu, J.-L., Zheng, R., Ma, D., Yang, C., & Guan, X. (2017) · Medicine · doi:10.1097/md.0000000000007470 · Cited by 28 · see citing works
Measurement of Telomere Length in Colorectal Cancers for Improved Molecular Diagnosis
Balc’h, E. L., Grandin, N., Demattei, M.-V., Guyétant, S., Tallet, A., Pagès, J., Ouaïssi, M., Lecomte, T., & Charbonneau, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091871 · Cited by 21 · see citing works
Maimaiti, A., Aizezi, A., Anniwaer, J., Ayitula, A., Ali, B., & Dilixiati, M. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.89677 · Cited by 19 · see citing works
López‐Doriga, A., Valle, L., Alonso, M. H., Aussó, S., Closa, A., Sanjuán, X., Barquero, D., Rodríguez‐Moranta, F., Pamplona, R. S., & Moreno, V. R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.06.010 · Cited by 18 · see citing works
Nanoparticles and colon cancer
Shrivastava, P., Sharma, R. K., Gautam, L., Vyas, S., & Vyas, S. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819793-6.00009-6 · Cited by 10 · see citing works
Telomere in colorectal cancer associated with distant metastases and predicted a poor prognosis
Ye, X., Li, J., Song, C., & Chen, W. (2021) · Translational Cancer Research · doi:10.21037/tcr-20-3341 · Cited by 8 · see citing works
Tao, H., He, S., Zhao, C., Wang, Y., Sheng, W., & Zhen, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.225 · Cited by 6 · see citing works
Hippo Signaling Pathway in Cancer Stem CellPreprint
Shen, W., Zhao, W., Xu, H., & Xiao, X. (2023) · doi:10.22541/au.169985524.44850361/v1
Common genetic variants in telomere genetics in colorectal cancer: a Mendelian randomisation studyPreprint
Huang, Y., Min, G., Wang, H., Liu, T., & Jiang, L. (2025) · Research Square · doi:10.21203/rs.3.rs-5738729/v1
- Authors
- Piñol-Felis, C., Fernández-Marcelo, T., Viñas-Salas, J., & Valls-Bautista, C.
- Venue
- Clinical and Translational Oncology
- Published
- 2016-10-19
- Volume
- 19
- Issue
- 4
- Pages
- 399-408
- ISSN
- 1699-048X (ISSN-L)
- 1699-3055
- OpenAlex
- W2539337557
- Cited by
- 13
- References
- 99
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical & Translational Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- telomeres, telomerase, colorectal cancer, prognostic factors, diagnostic biomarkers, telomere length, peripheral blood cells, shelterin complex, telomerase inhibitors, cellular senescence, cancer therapy targets
- MeSH terms
- Humans, Biomarkers, Tumor, Colorectal Neoplasms, Telomere, Telomerase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
