The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Ferritinophagy/ferroptosis: Iron‐related newcomers in human diseases
Abstract
Nuclear receptor coactivator 4 mediated ferritinophagy is an autophagic phenomenon that specifically involves ferritin to release intracellular free iron. Ferritinophagy is implicated in maintaining efficient erythropoiesis. Notably, ferritinophagy also plays a central role in driving some pathological processes, including Parkinson’s disease (PD) and urinary tract infections. Some evidence has demonstrated that ferritinophagy is critical to induce ferroptosis. Ferroptosis is a newly nonapoptotic form of cell death, characterized by the accumulation of iron‐based lipid reactive oxygen species. Ferroptosis plays an important role in inhibiting some types of cancers, such as hepatocellular carcinoma, pancreatic carcinoma, prostate cancer, and breast cancer. Conversely, the activation of ferroptosis accelerates neurodegeneration diseases, including PD and Alzheimer’s disease. Therefore, in this review, we summarize the regulatory mechanisms related to ferritinophagy and ferroptosis. Moreover, the distinctive effects of ferritinophagy in human erythropoiesis and some pathologies, coupled with the promotive or inhibitory role of tumorous and neurodegenerative diseases mediated by ferroptosis, are elucidated. Obviously, activating or inhibiting ferroptosis could be exploited to achieve desirable therapeutic effects on diverse cancers and neurodegeneration diseases. Interrupting ferritinophagy to control iron level might provide a potentially therapeutic avenue to suppress urinary tract infections.
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Cites
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“Ferritin, the substrate of ferritinophagy, represents the major form of stored iron via its iron‐filled cage structure (Arosio, Ingrassia, & Cavadini, 2009; Harrison & Arosio, 1996).”
BackgroundAutophagy promotes ferroptosis by degradation of ferritin
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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
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Cited by
The interaction between ferroptosis and inflammatory signaling pathways
Chen, Y., Fang, Z.-M., Yi, X., Wei, X., & Jiang, D.-S. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05716-0 · Cited by 567
FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease
Tian, Y., Lu, J., Hao, X., Li, H., Zhang, G., Liu, X., Li, X., Zhao, C., Kuang, W., Chen, D., et al. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00929-z · Cited by 422
The role of NCOA4-mediated ferritinophagy in health and disease
Santana-Codina, N., & Mancias, J. D. (2018) · Pharmaceuticals · doi:10.3390/ph11040114 · Cited by 410
Ashraf, A., Jeandriens, J., Parkes, H. G., & So, P.-W. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101494 · Cited by 300
Wang, Y., Yu, L., Ding, J., & Chen, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010095 · Cited by 294
Metadata
- Authors
- Tang, M., Chen, Z., Wu, D., & Chen, L.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2018-08-04
- Volume
- 233
- Issue
- 12
- Pages
- 9179-9190
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2886498462
- Cited by
- 290
- References
- 36
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- closed
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