The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
MicroRNA‐223 triggers inflammation in porcine aorta by activating NLRP3 inflammasome under selenium deficiency
Abstract
Selenium (Se) is an essential trace element in organism. Se deficiency can cause many diseases, including vascular disease. Studies have shown that inflammation is the main inducement of vascular disease, microRNA (miRNA) can influence inflammation in various ways, and Se deficiency can affect miRNAs expression. To study the mechanism of aorta damage caused by Se deficiency, we constructed a Se deficiency porcine aorta model and found that Se deficiency can significantly inhibit miR‐223, which downregulates the expression of nucleotide‐binding oligomerization domain‐like receptor family 3 (NLRP3). Subsequently, we found that in Se deficiency group, NLRP3, and its downstream (caspase‐1, apoptosis‐related spot‐like protein [ASC], IL‐18, IL‐1β) expression was significantly increased. In vitro, we cultured pig iliac endothelium cell lines, and constructed miR‐223 knockdown and overexpression models. NLRP3 messenger RNA and protein levels were significant increased in the knockdown group, and decreased in the overexpression group. The results of this study show that Se deficiency in porcine arteries can induce inflammation through miR‐223/NLRP3.
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“In an endothelial cell study in pigs, miR-223 targeting NLRP3 alleviated inflammation development in porcine endothelial cells and triggered the aorta inflammatory injury 58.”
From miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation (2021) · cites this paper as [58]
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Cited by
miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation
Jiao, P., Wang, X.-P., Luoreng, Z.-M., Yang, J., Jia, L., Ma, Y., & Wei, D.-W. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59876 · Cited by 151
Metadata
- Authors
- Qing, Z., Kaixin, Z., Yanfei, H., Yiming, Z., Hua, X., Ling, Z., Guangliang, S., & Shu, L.
- Affiliations
- Department of Basic Veterinary Medicine, College of Veterinary Medicine Northeast Agricultural University Harbin People's Republic of China
- National Selenium‐Rich Product Quality Supervision and Inspection Center Enshi People's Republic of China
- ORCID
- Shu, Li
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2020-11-25
- Volume
- 236
- Issue
- 6
- Pages
- 4555-4564
- ISSN
- 0021-9541
- 1097-4652
- Cited by
- 20
- References
- 5
- Language
- en
- Funders
- Earmarked Fund for China Agriculture Research System (CARS‐35)
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- Qing, Z., Kaixin, Z., Yanfei, H., Yiming, Z., Hua, X., Ling, Z., Guangliang, S., & Shu, L. (2021). MicroRNA‐223 triggers inflammation in porcine aorta by activating NLRP3 inflammasome under selenium deficiency. Journal of Cellular Physiology. https://doi.org/10.1002/jcp.30178
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