Mechanism of NLRP3 inflammasome activation

Sutterwala, Fayyaz S.; Haasken, Stefanie; Cassel, Suzanne L.

doi:10.1111/nyas.12458

Cited by 739Inflammasome and immune disordersImmune Response and InflammationIL-33, ST2, and ILC Pathways

Mechanism of NLRP3 inflammasome activation

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Sutterwala, Fayyaz S., Haasken, Stefanie, Cassel, Suzanne L.·2014·Annals of the New York Academy of Sciences

DOI 10.1111/nyas.12458PMC PMC4074217

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Abstract

Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1-dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. The NLRP3 inflammasome is the most thoroughly studied of the inflammasome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists. This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.

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This binding elicits activation of the NLRP3 inflammasome in LPS-stimulated macrophages, causing secretion of IL-18 and IL-1β, and may promote maintenance and function of the epithelial barrier.
“this has been shown to elicit activation of the NLRP3 inflammasome in LPS-stimulated macrophages, which causes secretion of IL-18 (but also of the pro-inflammatory cytokine IL-1β) and may thus promote maintenance and function of the epithelial barrier (Mariathasan et al., 2006; Sutterwala et al., 2014; 2006; Yaron et al., 2015).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Sutterwala et al., 2014

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The Inflammasome
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works
Two CD95 (APO‐1/Fas) signaling pathways
Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K., Krammer, P. H., & Peter, M. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1675 · Cited by 3,000 · see citing works
Activation and regulation of the inflammasomes
Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884 · see citing works
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Thornberry, N., Bull, H., Calaycay, J., Chapman, K., Howard, A., Kostura, M., Miller, D. K., Molineaux, S., Weidner, J., Auniņš, J., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,725 · see citing works
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627 · see citing works
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,020 · see citing works
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831 · see citing works
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,822 · see citing works
NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome
Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679 · see citing works
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
Zhao, Y., Yang, J., Shi, J., Gong, Y., Lu, Q., Xu, H., Liu, L., & Shao, F. (2011) · Nature · doi:10.1038/nature10510 · Cited by 1,273 · see citing works
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223
Johnnidis, J. B., Harris, M., Wheeler, R., Stehling-Sun, S., Lam, M. H., Kirak, O., Brummelkamp, T., Fleming, M., & Camargo, F. (2008) · Nature · doi:10.1038/nature06607 · Cited by 1,269 · see citing works
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., et al. (1997) · Science · doi:10.1126/science.275.5297.206 · Cited by 1,159 · see citing works
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
Fink, S. L., & Cookson, B. T. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00751.x · Cited by 1,114 · see citing works
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
Bürckstümmer, T., Baumann, C., Blüml, S., Dixit, E., Dürnberger, G., Jahn, H., Planyavsky, M., Bilban, M., Colinge, J., Bennett, K. L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1702 · Cited by 1,091 · see citing works
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
Lee, G., Subramanian, N., Kim, A. I., Aksentijevich, I. A., Goldbach‐Mansky, R. T., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012) · Nature · doi:10.1038/nature11588 · Cited by 1,077 · see citing works
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026 · see citing works
The NLR Gene Family: A Standard Nomenclature
Ting, J. P. ‐., Lovering, R. C., Alnemri, E. S., Bertin, J., Boss, J. M., Davis, B. K., Flavell, R. A., Girardin, S. E., Godzik, A., Harton, J. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.005 · Cited by 958 · see citing works
Cytochrome c release from mitochondria proceeds by a two-step process
Ott, M., Robertson, J. D., Gogvadze, V. G., Zhivotovsky, B., & Orrenius, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241655498 · Cited by 955 · see citing works
Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation
Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., Sadler, J. J., Knepper-Adrian, V., Han, R., Qiao, L., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.001 · Cited by 938 · see citing works
Inflammasomes and Their Roles in Health and Disease
Lamkanfi, M., & Dixit, V. M. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155745 · Cited by 935 · see citing works
Critical role for calcium mobilization in activation of the NLRP3 inflammasome
Murakami, T., Öckinger, J., Yu, J., Byles, V., McColl, A., Hofer, A. M., & Horng, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117765109 · Cited by 925 · see citing works
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
Guarda, G., Braun, M., Staehli, F., Tardivel, A., Mattmann, C., Förster, I., Farlik, M., Decker, T., Pasquier, R. D., Romero, P. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.006 · Cited by 924 · see citing works
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
Kofoed, E. M., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10394 · Cited by 894 · see citing works
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 861 · see citing works
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
Boyden, E. D., & Dietrich, W. F. (2006) · Nature Genetics · doi:10.1038/ng1724 · Cited by 860 · see citing works
HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
Roberts, T. L., Idris, A., Dunn, J. A., Kelly, G., Burnton, C. M., Hodgson, S., Hardy, L., Garceau, V., Sweet, M. J., Ross, I. L., et al. (2009) · Science · doi:10.1126/science.1169841 · Cited by 830 · see citing works
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820 · see citing works
Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
Juliana, C. A., Fernandes‐Alnemri, T., Kang, S., Farias, A., Qin, F., & Alnemri, E. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407130 · Cited by 771 · see citing works
Chronic Infantile Neurological Cutaneous and Articular Syndrome Is Caused by Mutations in CIAS1, a Gene Highly Expressed in Polymorphonuclear Cells and Chondrocytes
Feldmann, J., Prieur, A., Quartier, P., Berquin, P. C., Dogniaux, S., Cortis, E., Hamel‐Teillac, D., Fischer, A., & Basile, G. D. S. (2002) · The American Journal of Human Genetics · doi:10.1086/341357 · Cited by 737 · see citing works
Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
Py, B. F., Kim, M.-S., Vakifahmetoglu-Norberg, H., & Yuan, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.009 · Cited by 718 · see citing works
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases
Aksentijevich, I. A., Nowak, M., Mallah, M., Chae, J. J., Watford, W. T., Hofmann, S. R., Stein, L. D., Russo, R. A. G., Goldsmith, D. P., Dent, P. B., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10688 · Cited by 707 · see citing works
IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., & Chandran, B. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.008 · Cited by 702 · see citing works
The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.02.054 · Cited by 675 · see citing works
Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., & Hornung, V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100613 · Cited by 617 · see citing works
Signaling by ROS drives inflammasome activation
Martinon, F. (2010) · European Journal of Immunology · doi:10.1002/eji.200940168 · Cited by 604 · see citing works
Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation
Franchi, L., Eigenbrod, T., & Núñez, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900173 · Cited by 574 · see citing works
Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β
Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2474 · Cited by 571 · see citing works
Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis
Rasola, A., & Bernardi, P. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.04.007 · Cited by 563 · see citing works
NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223
Bauernfeind, F. G., Rieger, A., Schildberg, F. A., Knolle, P. A., Schmid-Burgk, J. L., & Hornung, V. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201516 · Cited by 531 · see citing works
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
Poeck, H., Bscheider, M., Groß, O., Finger, K., Roth, S., Rebsamen, M., Hannesschläger, N., Schlee, M., Rothenfußer, S., Barchet, W., et al. (2009) · Nature Immunology · doi:10.1038/ni.1824 · Cited by 518 · see citing works
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
Rossol, M., Pierer, M., Raulien, N., Quandt, D., Meusch, U., Rothe, K., Schubert, K. A., Schöneberg, T., Schaefer, M., Krügel, U., et al. (2012) · Nature Communications · doi:10.1038/ncomms2339 · Cited by 492 · see citing works
Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice
Chae, J. J., Cho, Y.-H., Lee, G., Cheng, J., Liu, P. P., Feigenbaum, L., Katz, S. I., & Kastner, D. L. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.020 · Cited by 473 · see citing works
Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1
Groß, O., Yazdi, A. S., Thomas, C. J., Masin, M., Heinz, L. X., Guarda, G., Quadroni, M., Drexler, S. K., & Tschopp, J. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.018 · Cited by 460 · see citing works
Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production
Haneklaus, M., Gerlic, M., Kurowska‐Stolarska, M., Rainey, A., Pich, D., McInnes, I. B., Hammerschmidt, W., O'Neill, L. A. J., & Masters, S. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200312 · Cited by 450 · see citing works
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
Mayor, A., Martinon, F., Smedt, T. D., Pétrilli, V., & Tschopp, J. (2007) · Nature Immunology · doi:10.1038/ni1459 · Cited by 438 · see citing works
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
Mao, K., Chen, S., Chen, M., Ma, Y., Wang, Y., Huang, B., He, Z., Zeng, Y., Hu, Y., Sun, S., et al. (2013) · Cell Research · doi:10.1038/cr.2013.6 · Cited by 397 · see citing works
Cell Volume Regulation Modulates NLRP3 Inflammasome Activation
Compan, V., Baroja‐Mazo, A., López‐Castejón, G., Gomez, A. I., Martínez, C. M., Angosto-Bazarra, D., Montero, M. T., Herranz, A. S., Bazán, E., Reimers, D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.013 · Cited by 390 · see citing works
TRPM2 links oxidative stress to NLRP3 inflammasome activation
Zhong, Z., Zhai, Y., Liang, S., Mori, Y., Han, R., Sutterwala, F. S., & Qiao, L. (2013) · Nature Communications · doi:10.1038/ncomms2608 · Cited by 374 · see citing works
Intracellular DNA recognition
Hornung, V., & Latz, E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2690 · Cited by 366 · see citing works
The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation
Triantafilou, K., Hughes, T. R., Triantafilou, M., & Morgan, B. P. (2013) · Journal of Cell Science · doi:10.1242/jcs.124388 · Cited by 361 · see citing works
An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
Khare, S., Dorfleutner, A., Bryan, N. B., Yun, C., Radian, A. D., de Almeida, L., Rojanasakul, Y., & Stehlik, C. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.001 · Cited by 340 · see citing works
Is mPTP the gatekeeper for necrosis, apoptosis, or both?
Kinnally, K. W., Peixoto, P. M. V., Ryu, S.-Y., & Dejean, L. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.013 · Cited by 339 · see citing works
Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1
Bruey, J., Bruey-Sédano, N., Luciano, F., Zhai, D., Balpai, R., Xu, C., Kress, C. L., Bailly‐Maitre, B., Li, X., Osterman, A. L., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.045 · Cited by 319 · see citing works
Critical functions of priming and lysosomal damage for NLRP3 activation
Hornung, V., & Latz, E. (2010) · European Journal of Immunology · doi:10.1002/eji.200940185 · Cited by 297 · see citing works
Cardiolipin provides an essential activating platform for caspase-8 on mitochondria
Gonzalvez, F., Schug, Z. T., Houtkooper, R. H., MacKenzie, E. D., Brooks, D. G., Wanders, R. J. A., PETIT, P. X., Vaz, F. M., & Gottlieb, E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803129 · Cited by 297 · see citing works
IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
Lin, K.-M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S. K., Cohen, P., Thomas, J. A., & Pasare, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320294111 · Cited by 288 · see citing works
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection
Ichinohe, T., Yamazaki, T., Koshiba, T., & Yanagi, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312571110 · Cited by 284 · see citing works
The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity
Park, S., Juliana, C. A., Hong, S., Datta, P., Hwang, I., Fernandes‐Alnemri, T., Yu, J., & Alnemri, E. S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301170 · Cited by 266 · see citing works
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
Guarda, G., Dostert, C., Staehli, F., Cabalzar, K., Castillo, R., Tardivel, A., Schneider, P., & Tschopp, J. (2009) · Nature · doi:10.1038/nature08100 · Cited by 250 · see citing works
Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome
Fernandes‐Alnemri, T., Kang, S., Anderson, C., Sagara, J., Fitzgerald, K. A., & Alnemri, E. S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301681 · Cited by 235 · see citing works
NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate ofToxoplasma gondii-Infected Monocytic Cells
Witola, W. H., Mui, E. J., Hargrave, A. C., Liu, S., Hypolite, M., Montpetit, A., Cavaillès, P., Bisanz, C., Cesbron‐Delauw, M., Fournié, G. J., et al. (2010) · Infection and Immunity · doi:10.1128/iai.00898-10 · Cited by 194 · see citing works
BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane
Schug, Z. T., Gonzalvez, F., Houtkooper, R. H., Vaz, F. M., & Gottlieb, E. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.135 · Cited by 191 · see citing works
Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein
Rayamajhi, M., Zak, D. E., Chavarría‐Smith, J., Vance, R. E., & Miao, E. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301549 · Cited by 185 · see citing works
Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction
Schroder, K., Sagulenko, V., Zamoshnikova, A., Richards, A. A., Cridland, J. A., Irvine, K. M., Stacey, K. J., & Sweet, M. J. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.020 · Cited by 182 · see citing works
Early changes in intramitochondrial cardiolipin distribution during apoptosis.
Garcia‐Fernandez, M. I., Troiano, L., Moretti, L., Nasi, M., Pinti, M., Salvioli, S., Dobrucki, J. W., & Cossarizza, A. (2002) · PubMed · Cited by 181 · see citing works
Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome
Labbè, K., McIntire, C. R., Doiron, K., LeBlanc, P. M., & Saleh, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.10.016 · Cited by 169 · see citing works
Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
López‐Castejón, G., Luheshi, N., Compan, V., High, S., Whitehead, R. C., Flitsch, S. L., Kirov, A., Prudovsky, I. A., Swanton, E., & Brough, D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.422238 · Cited by 166 · see citing works
An Interaction between Bcl-xL and the Voltage-dependent Anion Channel (VDAC) Promotes Mitochondrial Ca2+ Uptake
Huang, H., Hu, X., Eno, C. O., Zhao, G., Li, C., & White, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.448290 · Cited by 147 · see citing works
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
Ratsimandresy, R. A., Dorfleutner, A., & Stehlik, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00440 · Cited by 109 · see citing works
Cyclic‐di‐GMP and cyclic‐di‐AMP activate the NLRP3 inflammasome
Sater, A. A. A., Tattoli, I., Jin, L., Grajkowski, A., Levi, A., Koller, B. H., Allen, I. C., Beaucage, S. L., Fitzgerald, K. A., Ting, J. P. ‐., et al. (2013) · EMBO Reports · doi:10.1038/embor.2013.132 · Cited by 83 · see citing works
Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease
Clayton, R., Clark, J. B., & Sharpe, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02918.x · Cited by 64 · see citing works
Role of Phospholipid Scramblase 3 in the Regulation of Tumor Necrosis Factor-α-Induced Apoptosis
Liu, J., Epand, R. F., Durrant, D., Grossman, D., Chi, N., Epand, R. M., & Lee, R. M. (2008) · Biochemistry · doi:10.1021/bi701962c · Cited by 58 · see citing works

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NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791 · see citing works
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works
Molecular mechanisms regulating NLRP3 inflammasome activation
Jo, E.-K., Kim, J. K., Shin, D.-M., & Sasakawa, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.95 · Cited by 1,378 · see citing works
Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies
Tang, Y., Liu, J., Zhang, D., Xu, Z., Ji, J., & Wen, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01708 · Cited by 1,094 · see citing works
Single-cell immune landscape of human atherosclerotic plaques
Fernandez, D. M., Rahman, A. H., Fernandez, N. F., Chudnovskiy, A., Amir, E.-A. D., Amadori, L., Khan, N. S., Wong, C. K., Shamailova, R., Hill, C. A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0590-4 · Cited by 970 · see citing works
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
“…of the NLRP3 inflammasome in LPS-stimulated macrophages, which causes secretion of IL-18 (but also of the pro-inflammatory cytokine IL-1b) and may thus promote maintenance and function of the epithelial barrier (Mariathasan et al., 2006; Sutterwala et al., 2006, 2014; Yaron et al., 2015).”
Background
NLRP3 inflammasome and its inhibitors: a review
Shao, B.-Z., Xu, Z.-Q., Han, B.-Z., Su, D.-F., & Liu, C. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00262 · Cited by 836 · see citing works
“Activation of the NLRP3 inflammasome appears to occur in two steps (Zhong et al., 2013a; Sutterwala et al., 2014; Ozaki et al., 2015; Figure 1).”
Background
Initiation and perpetuation of <scp>NLRP</scp> 3 inflammasome activation and assembly
Elliott, E. I., & Sutterwala, F. S. (2015) · Immunological Reviews · doi:10.1111/imr.12286 · Cited by 821 · see citing works
Self-citation
The NLRP3 inflammasome in acute myocardial infarction
Toldo, S. A., & Abbate, A. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.161 · Cited by 673 · see citing works
Pharmacological Inhibitors of the NLRP3 Inflammasome
Zahid, A., Li, B., Kombe, A. J. K., Jin, T., & Tao, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02538 · Cited by 671 · see citing works
Mitochondria in health, disease, and aging
Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 622 · see citing works
The role of mitochondria in NLRP3 inflammasome activation
Liu, Q., Zhang, D., Hu, D., Zhou, X., & Zhou, Y. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.010 · Cited by 475 · see citing works
Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy
Yu, J.-J., Nagasu, H., Murakami, T., Hoang, H., Broderick, L., Hoffman, H., & Horng, T. (2014) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1414859111 · Cited by 449 · see citing works
Inflammation – Cause or Consequence of Heart Failure or Both?
Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 475 · see citing works
The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease
Wang, S., Yuan, Y., Chen, N., & Wang, H. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.019 · Cited by 447 · see citing works
Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury
Toldo, S. A., Mauro, A. G., Cutter, Z., & Abbate, A. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00158.2018 · Cited by 373 · see citing works
NLRP3 Inflammasome Activation‐Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats
Qiu, Z., Lei, S., Zhao, B., Wu, Y., Su, W., Liu, M., Meng, Q., Zhou, B., Leng, Y., & Xia, Z. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9743280 · Cited by 351 · see citing works
Candida parapsilosis: from genes to the bedside
Tóth, R., Nosek, J., Mora-Montes, H. M., Gabaldon, T., Bliss, J. M., Nosanchuk, J. D., Turner, S. A., Butler, G., Vágvölgyi, C., & Gácser, A. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00111-18 · Cited by 327 · see citing works
Mitochondria, Oxidative Stress and Innate Immunity
Chen, Y., Zhou, Z., & Min, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01487 · Cited by 315 · see citing works
“NLRs, including the NLRP1, NLRP3 and NLR family caspase recruitment domain (CARD) domain containing 4 (NLRC4) inflammasomes, are characterized by a central located NOD domain that is flanked at N-terminal CARD, pyrin domain (PYD), acidic transactivating domain, or baculovirus inhibitor repeat (BIR) (Franchi et al., 20…”
Background
Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation
Chen, X., Zhou, Y., & Yu, J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00246 · Cited by 320 · see citing works
Focus on the Role of NLRP3 Inflammasome in Diseases
Fusco, R., Siracusa, R., Genovese, T., Cuzzocrea, S., & Paola, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124223 · Cited by 292 · see citing works
Management of Myocarditis-Related Cardiomyopathy in Adults
Tschöpe, C., Cooper, L. T., Torre‐Amione, G., & Linthout, S. V. (2019) · Circulation Research · doi:10.1161/circresaha.118.313578 · Cited by 280 · see citing works
Spotlight on the NLRP3 inflammasome pathway
Groslambert, M., & Py, B. F. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141220 · Cited by 267 · see citing works
Multiple cathepsins promote pro-IL-1β synthesis and NLRP3-mediated IL-1β activation
Orlowski, G. M., Colbert, J. D., Sharma, S., Bogyo, M., Robertson, S. A., & Rock, K. L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500509 · Cited by 268 · see citing works
The peri-menopause in a woman’s life: a systemic inflammatory phase that enables later neurodegenerative disease
McCarthy, M., & Raval, A. P. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01998-9 · Cited by 282 · see citing works
Targeting the Microglial NLRP3 Inflammasome and Its Role in Parkinson's Disease
Haque, M. E., Akther, M., Jakaria, M., Kim, I., Azam, S., & Choi, D. (2019) · Movement Disorders · doi:10.1002/mds.27874 · Cited by 248 · see citing works
Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases
Lu, F., Lan, Z., Xin, Z., He, C., Guo, Z., Xia, X., & Hu, T. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29268 · Cited by 248 · see citing works
World Journal of Pharmaceutical Sciences
(2021) · World Journal of Pharmaceutical Sciences · doi:10.54037/wjps · Cited by 246 · see citing works
The NLRP3 Inflammasome and Its Role in Sepsis Development
Danielski, L. G., Giustina, A. D., Bonfante, S., Barichello, T., & Petronilho, F. C. (2019) · Inflammation · doi:10.1007/s10753-019-01124-9 · Cited by 237 · see citing works
K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells
Yaron, J. R., Gangaraju, S., Rao, M. Y., Kong, X., Zhang, L., Su, F., Tian, Y., Glenn, H. L., & Meldrum, D. R. (2015) · Cell Death & Disease · doi:10.1038/cddis.2015.277 · Cited by 212 · see citing works
“Proposed mechanisms for regulating the activation of the NLRP3 inflammasome pathway are varied and controversial.(1) Among the most popular proposed mechanisms is the flux of cellular ions.”
BackgroundInfluential
Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets
Kouba, B. R., Borba, L. A., de Souza, P. B., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2024) · Cells · doi:10.3390/cells13050423 · Cited by 232 · see citing works
Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome
Yin, H., Guo, Q., Li, X., Tang, T., Li, C., Wang, H., Sun, Y., Feng, Q., Ma, C., Gao, C., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701495 · Cited by 210 · see citing works
Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF‐kB/NLRP3 pathway
Luo, M., Yan, D., Sun, Q., Tao, J., Xu, L., Sun, H., & Zhao, H. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29556 · Cited by 211 · see citing works
Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment
Wang, Z., Meng, S., Cao, L., Chen, Y., Zuo, Z., & Peng, S. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1137-1 · Cited by 209 · see citing works
HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation
Chivero, E. T., Guo, M., Periyasamy, P., Liao, K., Callen, S. E., & Buch, S. J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3045-16.2017 · Cited by 202 · see citing works
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease
Mukherjee, T., Kumar, N., Chawla, M., Philpott, D. J., & Basak, S. (2024) · Science Signaling · doi:10.1126/scisignal.adh1641 · Cited by 204 · see citing works
The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia
Liao, J., Kapadia, V., Brown, L. S., Cheong, N., Longoria, C., Mija, D., Ramgopal, M., Mirpuri, J., McCurnin, D., & Savani, R. C. (2015) · Nature Communications · doi:10.1038/ncomms9977 · Cited by 193 · see citing works
Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death
Sanman, L. E., Yu, Q., Eisele, N. A., Ng, T. M., van der Linden, W. A., Monack, D. M., Weerapana, E., & Bogyo, M. S. (2016) · eLife · doi:10.7554/elife.13663 · Cited by 193 · see citing works
Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis
Wang, C., Xu, Y., Wang, X., Guo, C., Wang, T., & Wang, Z. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7440 · Cited by 189 · see citing works
NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages
Liu, Y.-G., Chen, J., Zhang, Z.-T., Ma, X., Chen, Y., Du, X.-M., Liu, H., Zong, Y., & Lu, G. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.460 · Cited by 190 · see citing works
Role of inflammatory signaling in atrial fibrillation
Scott, L., Li, N., & Dobrev, D. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.10.020 · Cited by 188 · see citing works
Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects
Traba, J., Kwarteng-Siaw, M., Okoli, T. C., Li, J., Huffstutler, R. D., Bray, A., Waclawiw, M. A., Han, K., Pelletier, M., Sauve, A. A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83260 · Cited by 180 · see citing works
Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders
Zhou, K., Shi, L., Wang, Y., Chen, S., & Zhang, J. (2016) · Journal of Immunology Research · doi:10.1155/2016/9238290 · Cited by 175 · see citing works
Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy
Rojas, J., Bermúdez, V., Palmar, J., Martínez, M. S., Olivar, L. C., Nava, M., Tomey, D., Rojas, M., Salazar, J. J., Garicano, C., et al. (2018) · Journal of Diabetes Research · doi:10.1155/2018/9601801 · Cited by 177 · see citing works
Macrophages in the Aging Liver and Age-Related Liver Disease
Stahl, E. C., Haschak, M. J., Popovic, B., & Brown, B. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02795 · Cited by 171 · see citing works
Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis.
He, X., Fan, X.-H., Bai, B., Lu, N., Zhang, S., & Zhang, L.-M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105447 · Cited by 153 · see citing works
NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease
Zeller, M. V., Dias, D., Sebastião, A. M., & Valente, C. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210268 · Cited by 173 · see citing works
Advances in mechanisms and signaling pathways of carbon nanotube toxicity
Dong, J., & Ma, Q. (2015) · Nanotoxicology · doi:10.3109/17435390.2015.1009187 · Cited by 169 · see citing works
Apoptosis, Necrosis, and Necroptosis in the Gut and IntestinalHomeostasis
Negroni, A., Cucchiara, S., & Stronati, L. (2015) · Mediators of Inflammation · doi:10.1155/2015/250762 · Cited by 163 · see citing works
Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis
Rimessi, A., Bezzerri, V., Patergnani, S., Marchi, S., Cabrini, G., & Pinton, P. (2015) · Nature Communications · doi:10.1038/ncomms7201 · Cited by 161 · see citing works
ACT001 attenuates microglia-mediated neuroinflammation after traumatic brain injury via inhibiting AKT/NFκB/NLRP3 pathway
Cai, L., Gong, Q., Qi, L., Xu, T., Suo, Q., Li, X., Wang, W., Yao, J., Yang, D., Xu, Z., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00862-y · Cited by 161 · see citing works
Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential
Saha, S., Sadhukhan, P., & Sil, P. C. (2016) · BioFactors · doi:10.1002/biof.1292 · Cited by 159 · see citing works
NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy
Nakanishi, H., Kawashima, Y., Kurima, K., Chae, J. J., Ross, A. M., Pinto-Patarroyo, G. P., Patel, S. K., Muskett, J. A., Ratay, J. S., Chattaraj, P., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702946114 · Cited by 154 · see citing works
A noncanonical function of cGAMP in inflammasome priming and activation
Swanson, K. V., Junkins, R. D., Kurkjian, C. J., Holley-Guthrie, E., Pendse, A. A., Morabiti, R. E., Petrucelli, A., Barber, G. N., Benedict, C. A., & Ting, J. P. ‐. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171749 · Cited by 148 · see citing works
NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias
Scott, L., Fender, A. C., Saljic, A., Li, L., Chen, X., Wang, X., Linz, D., Lang, J., Hohl, M., Twomey, D. J., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab024 · Cited by 154 · see citing works
USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome
Lin, M., Zhao, Z., Yang, Z., Meng, Q., Tan, P., Xie, W., Qin, Y., Wang, R., & Cui, J. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.029 · Cited by 145 · see citing works
The Importance of NLRP3 Inflammasome in Heart Failure
Butts, B., GARY, R. A., Dunbar, S. B., & Butler, J. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.04.014 · Cited by 142 · see citing works
A novel “complement–metabolism–inflammasome axis” as a key regulator of immune cell effector function
Arbore, G., & Kemper, C. (2016) · European Journal of Immunology · doi:10.1002/eji.201546131 · Cited by 141 · see citing works
Therapeutic roles of polysaccharides from Dendrobium Officinaleon colitis and its underlying mechanisms
Liang, J., Chen, S., Chen, J., Lin, J., Xiong, Q., Yang, Y., Yuan, J. J., Zhou, L., He, L., Hou, S., et al. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.01.013 · Cited by 140 · see citing works
Inflammasomes: Their Role in Normal and Complicated Pregnancies
Gomez‐Lopez, N., Motomura, K., Miller, D., Garcia‐Flores, V., Galaz, J., & Romero, R. J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900901 · Cited by 134 · see citing works
Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis
Angeletti, A., Cantarelli, C., Petrosyan, A., Andrighetto, S., Budge, K., D’Agati, V. D., Hartzell, S., Malvi, D., Donadei, C., Thurman, J. M., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191699 · Cited by 139 · see citing works
Advanced glycation end products regulate anabolic and catabolic activities via NLRP3‐inflammasome activation in human nucleus pulposus cells
Song, Y., Wang, Y., Zhang, Y., Geng, W., Liu, W., Gao, Y., Li, S., Wang, K., Wu, X., Kang, L., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13067 · Cited by 134 · see citing works
Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease
Lee, S., Suh, G. Y., Ryter, S. W., & Choi, A. M. K. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0231tr · Cited by 129 · see citing works
Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases
Liu, B., Li, X., Yu, H. V., Shi, X., Zhou, Y., Alvarez, S., Naldrett, M. J., Kachman, S. D., Ro, S., Sun, X., et al. (2021) · Theranostics · doi:10.7150/thno.60265 · Cited by 133 · see citing works
NLRP3 Inflammasome in Acute Myocardial Infarction
Mauro, A. G., Bonaventura, A., Mezzaroma, E., Quader, M. A., & Toldo, S. A. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000717 · Cited by 129 · see citing works
Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease
Wu, X., Dong, L., Lin, X., & Li, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01728 · Cited by 122 · see citing works
Principles of inflammasome priming and inhibition: implications for psychiatric disorders
Herman, F. J., & Pasinetti, G. M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.010 · Cited by 115 · see citing works
A Comparative Overview of the Intracellular Guardians of Plants and Animals: NLRs in Innate Immunity and Beyond
Duxbury, Z., Wu, C., & Ding, P. (2021) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-080620-104948 · Cited by 117 · see citing works
Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain
Lammerding, L., Slowik, A., Johann, S., Beyer, C., & Zendedel, A. (2015) · Neuroendocrinology · doi:10.1159/000439435 · Cited by 115 · see citing works
SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome
Reitz, C. J., Alibhai, F. J., Khatua, T. N., Rasouli, M., Bridle, B. W., Burris, T. P., & Martino, T. A. (2019) · Communications Biology · doi:10.1038/s42003-019-0595-z · Cited by 120 · see citing works
Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
Satoh, T., Trudler, D., Oh, C.-K., & Lipton, S. (2022) · Antioxidants · doi:10.3390/antiox11010124 · Cited by 103 · see citing works
Deletion of Nlrp3 Augments Survival during Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis
Jin, L., Batra, S., & Jeyaseelan, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601745 · Cited by 118 · see citing works
Intra-amniotic inflammation induces preterm birth by activating the NLRP3 inflammasome†
Faro, J. P., Romero, R. J., Schwenkel, G., Garcia‐Flores, V., Arenas‐Hernandez, M., Leng, Y., Xu, Y., Miller, D., Hassan, S. S., & Gomez‐Lopez, N. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy261 · Cited by 114 · see citing works
Known unknowns of cardiolipin signaling: The best is yet to come
Maguire, J. J., Tyurina, Y. Y., Mohammadyani, D., Kapralov, A. A., Anthonymuthu, T. S., Qu, F., Amoscato, A. A., Sparvero, L. J., Tyurin, V. A., Planas-Iglesias, J., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.08.001 · Cited by 116 · see citing works
Inflammasomes in host response to protozoan parasites
Zamboni, D. S., & Lima-Junior, D. S. (2015) · Immunological Reviews · doi:10.1111/imr.12291 · Cited by 113 · see citing works
NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis
Chung, H., Vilaysane, A., Lau, A. N., Stahl, M., Morampudi, V., Bondzi‐Simpson, A., Platnich, J. M., Bracey, N. A., French, M.-C., Beck, P., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.14 · Cited by 114 · see citing works
Targeting NLRP3 Inflammasome Activation in Severe Asthma
Theofani, E., Semitekolou, M., Morianos, I., Samitas, Κ., & Xanthou, G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101615 · Cited by 118 · see citing works
Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca2+/NF-κB pathway
Sun, Y., Leng, P., Song, M., Li, D., Guo, P., Xu, X., Gao, H., Li, Z., Li, C., & Zhang, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106681 · Cited by 113 · see citing works
Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye
Chi, W., Hua, X., Chen, X., Bian, F., Yuan, X., Zhang, L., Wang, X., Chen, D., Deng, R., Li, Z., et al. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.02.006 · Cited by 112 · see citing works
Immunomodulation of the NLRP3 Inflammasome in Atherosclerosis, Coronary Artery Disease, and Acute Myocardial Infarction
Silvis, M. J. M., Demkes, E. J., Fiolet, A. T. L., Dekker, M., Bosch, L., van Hout, G. P. J., Timmers, L., & de Kleijn, D. P. V. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-10049-w · Cited by 113 · see citing works
Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice
Shao, S., Xu, C.-B., Chen, C.-J., Shi, G.-N., Guo, Q.-L., Zhou, Y., Wei, Y.-Z., Wu, L., Shi, J.-G., & Zhang, T.-T. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02178-z · Cited by 112 · see citing works
Activation of NLRP3 inflammasome by crystalline structures via cell surface contact
Hari, A., Zhang, Y., Tu, Z., Detampel, P., Stenner, M. D., Ganguly, A., & Shi, Y. (2014) · Scientific Reports · doi:10.1038/srep07281 · Cited by 111 · see citing works
The sensing of mitochondrial DAMPs by non-immune cells
Rodríguez‐Nuevo, A., & Antonio Zorzano, A. (2019) · Cell Stress · doi:10.15698/cst2019.06.190 · Cited by 113 · see citing works
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Plazyo, O., Romero, R. J., Unkel, R., Balancio, A., Mial, T. N., Xu, Y., Dong, Z., Hassan, S. S., & Gomez‐Lopez, N. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.116.144139 · Cited by 109 · see citing works
The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis
Li, J.-Y., Wang, Y.-Y., Shao, T., Fan, D., Lin, A., Xiang, L., & Shao, J.-Z. (2020) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)49920-0 · Cited by 109 · see citing works
A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis
Gomez‐Lopez, N., Romero, R. J., Xu, Y., Plazyo, O., Unkel, R., Leng, Y., Than, N. G., Chaiworapongsa, T., Panaitescu, B., Dong, Z., et al. (2017) · Reproductive Sciences · doi:10.1177/1933719116687656 · Cited by 107 · see citing works
Extracellular mitochondrial DNA promote NLRP3 inflammasome activation and induce acute lung injury through TLR9 and NF-κB
Wu, G., Zhu, Q., Zeng, J., Gu, X., Miao, Y., Xu, W., Lv, T., & Song, Y. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.10.26 · Cited by 108 · see citing works
TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells
Huang, P., Zhang, Z., Zhang, P., Feng, J., Xie, J., Zheng, Y., Liang, X., Zhu, B., Chen, Z., Feng, S., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03713-0 · Cited by 111 · see citing works
A Role for the Inflammasome in Spontaneous Labor at Term
Romero, R. J., Xu, Y., Plazyo, O., Chaemsaithong, P., Chaiworapongsa, T., Unkel, R., Than, N. G., Chiang, P. J., Dong, Z., Xu, Z., et al. (2016) · American Journal of Reproductive Immunology · doi:10.1111/aji.12440 · Cited by 106 · see citing works
PCSK9 Promotes Endothelial Dysfunction During Sepsis Via the TLR4/MyD88/NF-κB and NLRP3 Pathways
Huang, L., Li, Y., Cheng, Z., Lv, Z., Luo, S., & Xia, Y. (2022) · Inflammation · doi:10.1007/s10753-022-01715-z · Cited by 105 · see citing works
Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases
Pellegrini, C., Fornai, M., Antonioli, L., Blandizzi, C., & Calderone, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122876 · Cited by 110 · see citing works
Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s Disease
Shukla, P. K., Delotterie, D. F., Xiao, J., Pierre, J. F., Rao, R., McDonald, M. P., & Khan, M. M. (2021) · Cells · doi:10.3390/cells10040779 · Cited by 103 · see citing works
NLRP3 Inflammasome: Activation and Regulation in Age‐Related Macular Degeneration
Gao, J., Liu, R. T., Cao, S., Cui, J. Z., Wang, A., To, E. C., & Matsubara, J. A. (2015) · Mediators of Inflammation · doi:10.1155/2015/690243 · Cited by 102 · see citing works
Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
Piippo, N., Korhonen, E., Hytti, M., Skottman, H., Kinnunen, K., Josifovska, N., Petrovski, G., Kaarniranta, K., & Kauppinen, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-25123-2 · Cited by 102 · see citing works
Targeting NLRP3 Inflammasome in the Treatment of CNS Diseases
Shao, B., Cao, Q., & Chong, L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00320 · Cited by 102 · see citing works
SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts
Park, S., Shin, J., Bae, J., Han, D., Park, S., Shin, J., Lee, S. K., & Park, H. (2020) · Cells · doi:10.3390/cells9030728 · Cited by 98 · see citing works
NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine
Cai, J., Guan, H., Xing, J., Yang, J., Chen, X., Zhang, H., Zheng, Y., Zhu, Y., Liu, Q., & Zhang, Z. (2021) · Toxicology · doi:10.1016/j.tox.2021.152720 · Cited by 99 · see citing works
Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation
Li, N., & Brundel, B. J. J. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.316364 · Cited by 97 · see citing works
Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing
Yadav, J. P., Verma, A., Pathak, P., Dwivedi, A. R., Singh, A. K., Kumar, P., Khalilullah, H., Jaremko, M., Emwas, A.-H., & Patel, D. K. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117058 · Cited by 98 · see citing works
MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
Zhang, X., Fan, C., Zhang, H., Zhao, Q., Liu, Y., Xu, C., Xie, Q., Wu, X., Yu, X., Zhang, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.103 · Cited by 93 · see citing works

NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma
McKee, C. M., & Coll, R. C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0720-513r · Cited by 236 · see citing works
The inflammasome: an integrated view
Gross, O., Thomas, C. J., Guarda, G., & Tschopp, J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01046.x · Cited by 778 · see citing works
Molecular Mechanism of NLRP3 Inflammasome Activation
Jin, C., & Flavell, R. A. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9440-3 · Cited by 440 · see citing works
The NLRP3 inflammasome: Mechanisms of activation, regulation, and role in diseases
Dadkhah, M., & Sharifi, M. (2024) · International Reviews of Immunology · doi:10.1080/08830185.2024.2415688 · Cited by 40 · see citing works
Critical functions of priming and lysosomal damage for NLRP3 activation
Hornung, V., & Latz, E. (2010) · European Journal of Immunology · doi:10.1002/eji.200940185 · Cited by 297 · see citing works

Authors: Sutterwala, F. S., Haasken, S., & Cassel, S. L.
Affiliations: University of Iowa (US)
Corresponding author: Sutterwala, Fayyaz S.
ORCID: Sutterwala, Fayyaz S.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2014-05-19
Volume: 1319
Issue: 1
Pages: 82-95
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/nyas.12458
PMC: PMC4074217
OpenAlex: W1636793459
Cited by: 736
References: 82
Citations by year: 2026: 25 · 2025: 54 · 2024: 58 · 2023: 68 · 2022: 85 · 2021: 88 · 2020: 81 · 2019: 52 · 2018: 60 · 2017: 57 · 2016: 57 · 2015: 42 · 2014: 8
FWCI: 5.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AI087630, AI104706, AI007511)
Asthma and Allergy foundation of America
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: NLRP3 inflammasome, inflammasome activation, inflammasome priming, caspase-1, pyroptosis, innate immunity, damage-associated molecular patterns, pathogen-associated molecular patterns
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Cell Survival, Humans, Cell Death, Adaptive Immunity, Inflammasomes

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Mechanism of NLRP3 inflammasome activation

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