miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation

Many roads to maturity: microRNA biogenesis pathways and their regulation

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Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

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Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

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A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis

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Vertebrate MicroRNA Genes

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Microglia: Dynamic Mediators of Synapse Development and Plasticity

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Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

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Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

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CNS inflammation and neurodegeneration

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Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production

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A Novel Regulator of Macrophage Activation: miR-223 in Obesity-Associated Adipose Tissue Inflammation

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Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

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Macrophage polarization and meta-inflammation

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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

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Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells

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MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation

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An update on environmental mastitis: Challenging perceptions

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An Evolutionarily Conserved Mechanism for MicroRNA-223 Expression Revealed by MicroRNA Gene Profiling

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miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis

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Inducible MicroRNA-223 Down-Regulation Promotes TLR-Triggered IL-6 and IL-1β Production in Macrophages by Targeting STAT3

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Exosomal microRNA signatures in multiple sclerosis reflect disease status

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MicroRNAs in Immune Response and Macrophage Polarization

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The Role of NLRP3 and IL-1β in the Pathogenesis of Inflammatory Bowel Disease

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Platelet-Secreted MicroRNA-223 Promotes Endothelial Cell Apoptosis Induced by Advanced Glycation End Products via Targeting the Insulin-like Growth Factor 1 Receptor

Pan, Y., Liang, H., Liu, H., Li, D., Chen, X., Li, L., Zhang, C., & Zen, K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301790 · Cited by 238 · see citing works

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

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Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate

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MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection

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Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response

Li, J., Tan, M., Xiang, Q., Zhou, Z., & Yan, H. (2017) · Thrombosis Research · doi:10.1016/j.thromres.2017.04.016 · Cited by 197 · see citing works

MicroRNAs in rheumatoid arthritis: From pathogenesis to clinical impact

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Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis

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The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans

Liu, L., Dong, Y., Ye, M., Jin, S. K., Yang, J., Joosse, M. E., Sun, Y., Zhang, J., Lazarev, M. G., Brant, S. R., et al. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw219 · Cited by 189 · see citing works

Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Wang, H., Chao, K., Ng, S. C., Bai, A. H. C., Yu, Q., Yu, J. Q., Li, M., Cui, Y., Chen, M., Hu, J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-0901-8 · Cited by 186 · see citing works

Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization

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Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice

Neudecker, V., Brodsky, K. S., Clambey, E. T., Schmidt, E. P., Packard, T. A., Davenport, B., Standiford, T. J., Weng, T., Fletcher, A. A., Barthel, L., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5360 · Cited by 179 · see citing works

Epithelial-mesenchymal transition and inflammation at the site of the primary tumor

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Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1

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A potential role of microvesicle-containing miR-223/142 in lung inflammation

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Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

Zardo, G., Ciolfi, A., Vian, L., Starnes, L. M., Billi, M., Racanicchi, S., Maresca, C., Fazi, F., Travaglini, L., Noguera, N. I., et al. (2012) · Blood · doi:10.1182/blood-2011-08-371344 · Cited by 145 · see citing works

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation

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Circulating and Fecal microRNAs as Biomarkers for Inflammatory Bowel Diseases

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MicroRNA-223 Antagonizes Angiogenesis by Targeting β1 Integrin and Preventing Growth Factor Signaling in Endothelial Cells

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Circulating Plasma Extracellular Microvesicle MicroRNA Cargo and Endothelial Dysfunction in Children with Obstructive Sleep Apnea

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MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation

Zhou, W., Pal, A. S., Hsu, A. Y.-H., Gurol, T., Zhu, X., Wirbisky-Hershberger, S. E., Freeman, J. L., Kasinski, A. L., & Deng, Q. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.058 · Cited by 117 · see citing works

miRNA-223 at the crossroads of inflammation and cancer

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MicroRNA-223 Regulates the Differentiation and Function of Intestinal Dendritic Cells and Macrophages by Targeting C/EBPβ

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Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury

Feng, Z., Qi, S., Zhang, Y., Qi, Z., Yan, L., Zhou, J., He, F., Li, Q., Yang, Y., Chen, Q., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.549 · Cited by 103 · see citing works

Transcriptome MicroRNA Profiling of Bovine Mammary Glands Infected with Staphylococcus aureus

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Expression of innate immune genes, proteins and microRNAs in lung tissue of pigs infected experimentally with influenza virus (H1N2)

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FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4

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Bioinformatics analysis of microRNA and putative target genes in bovine mammary tissue infected with Streptococcus uberis

Naeem, A., Zhong, K., Moisá, S. J., Drackley, J. K., Moyes, K. M., & Loor, J. J. (2012) · Journal of Dairy Science · doi:10.3168/jds.2011-5173 · Cited by 98 · see citing works

Genome-wide microRNA profiling of bovine milk-derived exosomes infected with Staphylococcus aureus

Cai, M., He, H., Jia, X., Chen, S., Wang, J., Shi, Y., Liu, B., Xiao, W., & Lai, S. (2018) · Cell Stress and Chaperones · doi:10.1007/s12192-018-0876-3 · Cited by 97 · see citing works

Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production

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MicroRNAs as biomarkers for clinical studies

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Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis

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Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients

Ogando, J., Tardáguila, M., Díaz-Alderete, A., Usategui, A., Miranda-Ramos, V., Martínez-Herrera, D. J., de la Fuente, L., García-León, M. J., Moreno, M. C., Escudero, S. S., et al. (2016) · Scientific Reports · doi:10.1038/srep20223 · Cited by 87 · see citing works

Epigenetic Mechanisms of Inflammasome Regulation

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Circulating serum miR-223-3p and miR-16-5p as possible biomarkers of early rheumatoid arthritis

Dunaeva, M., Blom, J., Thurlings, R. M., & Pruijn, G. J. M. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13156 · Cited by 85 · see citing works

Long noncoding RNA GAS5 promotes microglial inflammatory response in Parkinson's disease by regulating NLRP3 pathway through sponging miR-223-3p

Xu, W. G., Zhang, L., Geng, Y., Liu, Y., & Zhang, N. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106614 · Cited by 85 · see citing works

SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Li, G., Xia, Z., Liu, Y., Meng, F., Wu, X., Fang, Y., Zhang, C., & Liu, D. (2018) · Bioscience Reports · doi:10.1042/bsr20180541 · Cited by 84 · see citing works

Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation

Markopoulos, G. S., Roupakia, E., Marcu, K. B., & Kolettas, E. (2019) · Cells · doi:10.3390/cells8101143 · Cited by 83 · see citing works

Viral enteritis in calves.

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Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis

Zhang, Y., Wang, Y., Zhang, L., Xia, L., Zheng, M., Zeng, Z., Liu, Y., Yarovinsky, T. O., Ostriker, A. C., Fan, X., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316951 · Cited by 79 · see citing works

Long non‐coding RNA MEG3 inhibits M2 macrophage polarization by activating TRAF6 via microRNA‐223 down‐regulation in viral myocarditis

Xue, Y., Zhang, S., Zheng, C., Li, Y., Zhang, L., Su, Q. Y., Hao, Y., Wang, S., & Li, X. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15720 · Cited by 74 · see citing works

Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs

Yang, E. J., Lee, W., Ku, S., Song, K., & Bae, J. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.02.026 · Cited by 70 · see citing works

Circulating MicroRNA223 is a New Biomarker for Inflammatory Bowel Disease

Wang, H., Zhang, S., Yu, Q., Yang, G., Guo, J., Li, M., Zeng, Z., He, Y., Chen, B., & Chen, M. (2016) · Medicine · doi:10.1097/md.0000000000002703 · Cited by 70 · see citing works

Genome-Wide Transcriptional and Post-transcriptional Regulation of Innate Immune and Defense Responses of Bovine Mammary Gland to Staphylococcus aureus

Fang, L., Hou, Y., An, J., Li, B., Song, M., Wang, X. Q., Sørensen, P. B., Dong, Y., Liu, C., Wang, Y., et al. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00193 · Cited by 70 · see citing works

The Potential Therapeutic Role of miR-223 in Bovine Endometritis by Targeting the NLRP3 Inflammasome

Zhao, G., Jiang, K., Yang, Y.-P., Zhang, T., Wu, H., Shaukat, A., Qiu, C.-W., & Deng, G.-Z. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01916 · Cited by 69 · see citing works

Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate

Liu, Z., Wang, J., Cheng, H., Ke, X., Sun, L., Zhang, Q. C., & Wang, H. (2018) · Cell · doi:10.1016/j.cell.2018.05.031 · Cited by 69 · see citing works

MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells

Zeng, Y., Zhang, X., Kang, K., Chen, J., Wu, Z., Huang, J., Lu, W., Chen, Y., Zhang, J., Wang, Z., et al. (2016) · Scientific Reports · doi:10.1038/srep24900 · Cited by 68 · see citing works

Online Hemodiafiltration Inhibits Inflammation-Related Endothelial Dysfunction and Vascular Calcification of Uremic Patients Modulating miR-223 Expression in Plasma Extracellular Vesicles

Cavallari, C., Dellepiane, S., Fonsato, V., Medica, D., Marengo, M., MIGLIORI, M., Quercia, A. D., Pitino, A., Formica, M., Panichi, V., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800747 · Cited by 66 · see citing works

Icariin alleviates rheumatoid arthritis via regulating miR-223-3p/NLRP3 signalling axis

Wu, Z., Luo, J. F., Shi, X., Zhang, S.-X., Zhu, X., & Guo, J. (2020) · Autoimmunity · doi:10.1080/08916934.2020.1836488 · Cited by 65 · see citing works

Differential expression of microRNAs in Marek's disease virus-transformed T-lymphoma cell lines

Yao, Y., Zhao, Y., Smith, L. P., Lawrie, C. H., Saunders, N. J. S. G., Watson, M., & Nair, V. (2009) · Journal of General Virology · doi:10.1099/vir.0.009902-0 · Cited by 64 · see citing works

miR‐223 promotes regenerative myeloid cell phenotype and function in the demyelinated central nervous system

Galloway, D. A., Blandford, S. N., Berry, T., Williams, J. B., Stefanelli, M., Ploughman, M., & Moore, C. S. (2019) · Glia · doi:10.1002/glia.23576 · Cited by 64 · see citing works

MicroRNA-223-3p modulates dendritic cell function and ameliorates experimental autoimmune myocarditis by targeting the NLRP3 inflammasome

Chen, L., Hou, X., Zhang, M., Zheng, Y., Zheng, X., Yang, Q., Li, J., Gu, N., Zhang, M., Sun, Y., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.10.027 · Cited by 64 · see citing works

Downregulation of miR-223 Expression Is an Early Event during Mammary Transformation and Confers Resistance to CDK4/6 Inhibitors in Luminal Breast Cancer

Citron, F., Segatto, I., Vinciguerra, G. L. R., Musco, L., Russo, F., Mungo, G., D’Andrea, S., Mattevi, M. C., Perin, T., Schiappacassi, M., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1793 · Cited by 64 · see citing works

Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors

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Bone Marrow–Derived MicroRNA‐223 Works as an Endocrine Genetic Signal in Vascular Endothelial Cells and Participates in Vascular Injury From Kawasaki Disease

Chu, M., Wu, R., Qin, S., Hua, W., Shan, Z., Rong, X., Zeng, J., Hong, L., Sun, Y., Liu, Y., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004878 · Cited by 62 · see citing works

MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients

Valmiki, S., Ahuja, V., & Paul, J. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i29.5324 · Cited by 62 · see citing works

MicroRNA‑223 attenuates LPS‑induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4/NF‑κB signaling pathway via RHOB

Yan, Y., Lu, K., Ye, T., & Zhang, Z. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4075 · Cited by 62 · see citing works

Kruppel‐like factor 6 and miR‐223 signaling axis regulates macrophage‐mediated inflammation

Kim, G., Ng, H. P., Patel, N., & Mahabeleshwar, G. H. (2019) · The FASEB Journal · doi:10.1096/fj.201900867rr · Cited by 61 · see citing works

Emerging roles of DROSHA beyond primary microRNA processing

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MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice

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