Cited by 42Monoclonal and Polyclonal Antibodies ResearchBiosimilars and Bioanalytical MethodsRadiopharmaceutical Chemistry and Applications

Assessments of antibody biodistribution

Glassman, Patrick M., Abuqayyas, Lubna, Balthasar, Joseph P.·2015·The Journal of Clinical Pharmacology

Abstract

Monoclonal antibody (mAb) therapeutics are in use for several disease conditions, and have generally shown excellent clinical benefit, in large part due to their high specificity and affinity for target proteins. As this therapeutic class continues to grow in size, improved understanding of the mechanisms controlling mAb biodistribution and protein binding may be expected to allow better prediction of safety and efficacy. Due to the large size and polarity of antibodies, rates of mAb distribution and elimination are typically much slower than those reported for small molecule drugs. Additionally, high affinity interaction with target proteins will often influence mAb pharmacokinetics, leading to complex, nonlinear tissue distribution and elimination. In this report, we summarize key determinants of mAb disposition, methods for assessing antibody exposure and protein binding, and model‐based approaches that may be utilized to predict mAb pharmacokinetics.

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Crossref · 10.1002/jcph.365

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91 of 91 references verified0 citation errors · 0 not checkable

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  • Because blood capillaries only allow substances with less than 16 kDa to reach systemic circulation, s.c. or i.m. administered mAbs presumably enter the circulation through lymphatic fluid drainage.

    “Since blood capillaries only allow substances with less than 16 kDa to reach systemic circulation, s.c. or i.m. administered mAbs presumably enter the circulation through lymphatic fluid drainage.19”
  • The primary mechanism of antibody diffusion in tissues is through convective transport through paracellular pores in vascular endothelial cell membranes.

    “The primary mechanism of antibody diffusion in tissues is through the convective transport through paracellular pores in vascular endothelial cell membranes.19”

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Authors
Glassman, P. M., Abuqayyas, L., & Balthasar, J. P.
Affiliations
  • University at Buffalo, State University of New York (US)
  • Amgen (United States) (US)
Corresponding author
Balthasar, Joseph P.
Venue
The Journal of Clinical Pharmacology
Publisher
Wiley
Published
2015-02-23
Volume
55
Issue
S3
Pages
S29-38
ISSN
  • 0021-9754 (ISSN-L)
  • 0091-2700
  • 1552-4604
OpenAlex
W1905868842
Cited by
42
References
91
Citations by year
2025: 6 · 2024: 1 · 2023: 4 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 1 · 2015: 1
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Life Sciences › Immunology and Microbiology › Immunology › Biosimilars and Bioanalytical Methods
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
Keywords
therapeutic monoclonal antibodies, antibody biodistribution, pharmacokinetics, protein binding, tissue distribution, elimination kinetics, nonlinear pharmacokinetics, model-based prediction
MeSH terms
Animals, Antibodies, Monoclonal, Humans, Models, Biological, Tissue Distribution

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