Inhibition by all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages
Abstract
Besides their growth-inhibiting and differentiation-inducing properties, retinoids have been shown to exert immunomodulatory and anti-inflammatory functions by mechanisms that are not well understood. Tumor necrosis factor-alpha (TNF), a cytokine produced by mononuclear phagocytes, has been shown to be an important mediator of endotoxin-induced septic shock, cachexia, bone resorption, and inflammation. Nitric oxide may also have a role in septic shock, hypotension, and vasodilatation. In this study, we examined the effects of retinoids on the production of TNF and nitric oxide by murine peritoneal macrophages. Of the various retinoids studied, all-trans-retinoic acid (RA) was most potent; it almost completely inhibited the production of TNF by macrophages activated with endotoxin and interferon-gamma. The inhibitory effect was dependent on the dose and duration of RA exposure to macrophages. RA also blocked phorbol ester-induced TNF production in a macrophage cell line (RAW 264.7). Besides TNF, the retinoid suppressed the production of nitric oxide from activated peritoneal macrophages. The importance of these results in relation to controlling various harmful effects of cytokines released by activated macrophages is discussed.
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ATRA appears to possess an inherent anti-inflammatory function independent of Aβ.
“However, ATRA appears to possess an inherent anti-inflammatory function independent of A (Mehta et al., 1994;Datta et al., 2001).”
From Retinoic Acid Attenuates β-Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model (2008) · cites this paper as Mehta et al., 1994
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,089 · see citing works
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615 · see citing works
Human tumor necrosis factor. Production, purification, and characterization.
Aggarwal, B. B., Kohr, W. J., Hass, P. E., Moffat, B., Spencer, S. A., Henzel, W. J., Bringman, T. S., Nedwin, G. E., Goeddel, D. V., & Harkins, R. N. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89560-6 · Cited by 917 · see citing works
Self-citationEffect of nitric oxide synthase inhibitors on hypotension in patients with septic shock
Petros, A., BENNETT, D. B., & Vallance, P. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)92376-d · Cited by 860 · see citing works
Smith, M. A., Parkinson, D. R., Cheson, B. D., & Friedman, M. A. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.5.839 · Cited by 485 · see citing works
Sherry, B. A., & Cerami, A. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.4.1269 · Cited by 429 · see citing works
Modulation of cytokine production by transforming growth factor-beta.
Chantry, D., Turner, M., Abney, E. R., & Feldmann, M. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.12.4295 · Cited by 323 · see citing works
Inhibition by Retinoic Acid of Collagenase Production in Rheumatoid Synovial Cells
Brinckerhoff, C., McMillan, R. M., Dayer, J., & Harris, E. D. (1980) · New England Journal of Medicine · doi:10.1056/nejm198008213030805 · Cited by 163 · see citing works
Davis, B. H., Kramer, R. T., & Davidson, N. O. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114943 · Cited by 148 · see citing works
Brinckerhoff, C., Coffey, J. W., & Sullivan, A. C. (1983) · Science · doi:10.1126/science.6308759 · Cited by 121 · see citing works
Lancaster, J. R. (1992) · Cited by 116 · see citing works
Culture and properties of cells derived from Kaposi sarcoma
Corbeil, J., Evans, L., Vasak, E., et al. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.9.2972 · Cited by 80 · see citing works
Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines.
Estrov, Z. E., Kurzrock, R., Pócsik, É., Pathak, S., Kantarjian, H. M., Zipf, T. F., Harris, D., Talpaz, M., & Aggarwal, B. B. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.3.763 · Cited by 72 · see citing works
Self-citationScheibe, R. J., & Wagner, J. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37086-3 · Cited by 60 · see citing works
Retinoic acid upregulates interleukin-2 receptors on activated human thymocytes
Sidell, N., & Ramsdell, F. (1988) · Cellular Immunology · doi:10.1016/0008-8749(88)90183-9 · Cited by 53 · see citing works
Goldman, R. (1984) · Journal of Cellular Physiology · doi:10.1002/jcp.1041200113 · Cited by 37 · see citing works
Mehta, K., Claringbold, P., & Lopez‐Berestein, G. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.11.3902 · Cited by 18 · see citing works
Self-citationMehta, K., Turpin, J. A., & Lopez‐Berestein, G. (1987) · Journal of Leukocyte Biology · doi:10.1002/jlb.41.4.341 · Cited by 18 · see citing works
Self-citationCachectin: A Monokine Implicated as a Mediator of Cachexia and Shock
Beutler, B., & CERAMI, N. (1987) · Elsevier eBooks · doi:10.1016/b978-0-12-432014-7.50012-7 · Cited by 15 · see citing works
TNF and viruses: multiple interrelationships.
Rubin, B. Y. (1992) · PubMed · Cited by 10 · see citing works
Mehta, K., Claringbold, P., & Lopez‐Berestein, G. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.11.4206 · Cited by 6 · see citing works
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Ding, Y., Qiao, A., Wang, Z., Goodwin, J. S., Lee, E.-S., Block, M. L., Allsbrook, M., McDonald, M. P., & Fan, G.-H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3153-08.2008 · Cited by 269 · see citing works
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease
Seo, E.-J., Fischer, N., & Efferth, T. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.030 · Cited by 265 · see citing works
Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases
Oliveira, L. D. M., Teixeira, F. M. E., & Sato, M. N. (2018) · Mediators of Inflammation · doi:10.1155/2018/3067126 · Cited by 267 · see citing works
Retinoic acid in the immune system
Pino‐Lagos, K., Benson, M. J., & Noelle, R. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.017 · Cited by 138 · see citing works
Wang, X., Allen, C., & Ballow, M. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-006-9068-5 · Cited by 107 · see citing works
- Authors
- Mehta, K., McQueen, T., Tucker, S., Pandita, R., & Aggarwal, B. B.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Mehta, Kapil
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-03-01
- Volume
- 55
- Issue
- 3
- Pages
- 336-342
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W1845759512
- Cited by
- 132
- References
- 22
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Leukocyte Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (NCI CA 16672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- all-trans retinoic acid, retinoids, TNF-α, nitric oxide, peritoneal macrophages, endotoxin, interferon-gamma, septic shock, immunomodulation, anti-inflammatory activity, RAW 264.7 macrophages, phorbol ester
- MeSH terms
- Animals, Cells, Cultured, Endotoxins, Interferon-gamma, Macrophage Activation, Mice, Inbred ICR, Nitric Oxide, Tretinoin, Tumor Necrosis Factor-alpha, Macrophages, Peritoneal, Mice
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