The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells
Abstract
We review what is presently known about structure, cellular distribution, biochemical characteristics, and function of a new family of human cell-surface receptors referred to as immunoglobulin-like transcripts (ILTs), leukocyte Ig-like receptors (LIRs), or monocyte/macrophage Ig-like receptors (MIRs). These receptors are genetically, structurally, and functionally related to a group of natural killer (NK) cell receptors for HLA class I molecules known as killer cell Ig-like receptors (KIRs). Distinct ILT/LIR/MIR isotypes are differentially expressed on lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes; at least some of them recognize HLA class I molecules. Whereas some isotypes either inhibit or induce cell activation, others may be secreted as soluble receptors. ILT/LIR/MIR receptors may allow all immune cells to monitor class I expression on other cells and to respond in its absence, just as NK cells do. In addition, they may contribute to homeostasis by establishing activation thresholds that can be overcome only by relevant triggering stimuli and not by bystander cells. J. Leukoc. Biol. 66: 375–381; 1999.
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Cites
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 1×
“In another approach, soluble class I tetramers complexed either with influenza- or HIV-derived viral peptides and conjugated with streptavidin-phycoerythrin [41] have been studied for their binding to cells transiently expressing ILTs.”
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Cited by
Plasticity in the organization and sequences of human KIR/ILT gene families
Wilson, M. J., Torkar, M., Haude, A., Milne, S., Jones, T., Sheer, D., Beck, S., & Trowsdale, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080588597 · Cited by 624
NATURAL KILLER CELL DEVELOPMENTAL PATHWAYS: A Question of Balance
Di Santo, J. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090700 · Cited by 448
Human leukocyte immunoglobulin-like receptors in health and disease
Redondo-García, S., Barritt, C., Papagregoriou, C., Yeboah, M., Frendeus, B., Cragg, M. S., & Roghanian, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1282874 · Cited by 53
Human inhibitory and activating Ig-like receptors which modulate the function of myeloid cells
Dietrich, J., Nakajima, H., & Colonna, M. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00294-x · Cited by 53
Self-citationLeukocyte immunoglobulin-like receptor subfamily B: therapeutic targets in cancer
Deng, M., Chen, H., Liu, X., Huang, R., He, Y., Yoo, B., Xie, J., John, S., Zhang, N., An, Z., et al. (2021) · Antibody Therapeutics · doi:10.1093/abt/tbab002 · Cited by 53
Metadata
- Authors
- Colonna, M., Nakajima, H., Navarro, F., & López-Botet, M.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-09-01
- Volume
- 66
- Issue
- 3
- Pages
- 375-381
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W1828168755
- Cited by
- 191
- References
- 1
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Colonna, M., Nakajima, H., Navarro, F., & López-Botet, M. (1999). A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. Journal of Leukocyte Biology. https://doi.org/10.1002/jlb.66.3.375
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