Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system
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A handheld and biocompatible mass spectrometry system provides nondestructive molecular diagnosis of cancer tissue samples.
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Perception-based approaches have been used to classify various disease conditions on the basis of patterns in DNA methylation, volatile organic compounds, small metabolites, and imaging data.
“Perception-based approaches have been used to classify various disease conditions on the basis of different patterns in methylation of DNA sequencing13, volatile organic compounds using electronic noses14, small metabolites using mass spectrometry15, and image analysis of pathology, computerized tomography scans and magnetic resonance imaging data16,17.”
From Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning (2022) · cites this paper as [15]
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Regression shrinkage and selection via the lasso
Tibshirani, R. (1996) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1996.tb02080.x · Cited by 51,482 · see citing works
Stummer, W., Pichlmeier, U., Meinel, T., Wiestler, O. D., Zanella, F., & Reulen, H.-J. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70665-9 · Cited by 3,423 · see citing works
GLIOMA EXTENT OF RESECTION AND ITS IMPACT ON PATIENT OUTCOME
Sanai, N., & Berger, M. S. (2008) · Neurosurgery · doi:10.1227/01.neu.0000318159.21731.cf · Cited by 1,323 · see citing works
Norris, J. L., & Caprioli, R. M. (2013) · Chemical Reviews · doi:10.1021/cr3004295 · Cited by 692 · see citing works
What does one minute of operating room time cost?
Macario, A. (2010) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2010.02.003 · Cited by 658 · see citing works
Mass Spectrometric Imaging for Biomedical Tissue Analysis
Chughtai, K., & Heeren, R. M. A. (2010) · Chemical Reviews · doi:10.1021/cr100012c · Cited by 652 · see citing works
Intraoperative brain cancer detection with Raman spectroscopy in humans
Jermyn, M., Mok, K., Mercier, J., Desroches, J., Pichette, J., Saint-Arnaud, K., Bernstein, L., Guiot, M., Petrecca, K., & Leblond, F. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa2384 · Cited by 619 · see citing works
Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry
Balog, J., Sasi-Szabó, L., Kinross, J. K., Lewis, M. R., Muirhead, L. J., Veselkov, K., Mirnezami, R., Dezsö, B., Damjanovich, L., Darzi, A. W., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005623 · Cited by 611 · see citing works
Orringer, D. A., Pandian, B., Niknafs, Y. S., Hollon, T. C., Szczepanski, J. M., Lewis, S., Garrard, M. R., Hervey‐Jumper, S. L., Garton, H. J. L., Maher, C. O., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0027 · Cited by 570 · see citing works
Mass spectrometry imaging under ambient conditions
Wu, C., Dill, A. L., Eberlin, L. S., Cooks, R. G., & Ifa, D. R. (2012) · Mass Spectrometry Reviews · doi:10.1002/mas.21360 · Cited by 487 · see citing works
Self-citationMino-Kenudson, M. A., Chirieac, L. R., Law, K., Hornick, J. L., Lindeman, N. I., Mark, E. J., Cohen, D., Johnson, B. E., Janne, P. A., Iafrate, A. J., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2845 · Cited by 424 · see citing works
Personalized genomic analyses for cancer mutation discovery and interpretation
Jones, S., Anagnostou, V., Lytle, K., Parpart-Li, S. T., Nesselbush, M. C., Riley, D. R. J., Shukla, M., Chesnick, B., Kadan, M., Papp, E., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa7161 · Cited by 413 · see citing works
Kertész, V., & Berkel, G. J. V. (2009) · Journal of Mass Spectrometry · doi:10.1002/jms.1709 · Cited by 349 · see citing works
In Vivo, In Situ Tissue Analysis Using Rapid Evaporative Ionization Mass Spectrometry
Schäfer, K., Dénes, J., Albrecht, K., Szaniszló, T., Balog, J., Skoumal, R., Katona, M., Tóth, M., Balogh, L., & Takáts, Z. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200902546 · Cited by 334 · see citing works
Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry
Laskin, J., Heath, B. S., Roach, P. J., Cazares, L. H., & Semmes, O. J. (2011) · Analytical Chemistry · doi:10.1021/ac2021322 · Cited by 334 · see citing works
Kut, C., Chaichana, K. L., Xi, J., Raza, S. M., Ye, X., McVeigh, E. R., Rodríguez, F. J., Quiñones‐Hinojosa, A., & Li, X. D. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010611 · Cited by 318 · see citing works
Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors
Eberlin, L. S., Norton, I. H., Orringer, D. A., Dunn, I. F., Liu, X., Ide, J. L., Jarmusch, A. K., Ligon, K. L., Jolesz, F. A., Golby, A. J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215687110 · Cited by 289 · see citing works
Self-citationCalligaris, D., Caragacianu, D. L., Liu, X., Norton, I. H., Thompson, C. J., Richardson, A. L., Golshan, M. A., Easterling, M. L., Santagata, S., Dillon, D. A. R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408129111 · Cited by 246 · see citing works
Buchholz, T. A., Somerfield, M. R., Griggs, J. J., El‐Eid, S. E., Hammond, M. E., Lyman, G. H., Mason, G., & Newman, L. A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.1572 · Cited by 207 · see citing works
Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS
Jarmusch, A. K., Pirro, V., Baird, Z., Hattab, E. M., Cohen‐Gadol, A., & Cooks, R. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523306113 · Cited by 206 · see citing works
Ambient Ionization Mass Spectrometry for Cancer Diagnosis and Surgical Margin Evaluation
Ifa, D. R., & Eberlin, L. S. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.237172 · Cited by 177 · see citing works
Self-citationBiocompatibility: Meeting a Key Functional Requirement of Next-Generation Medical Devices
Helmus, M. N., Gibbons, D. F., & Cebon, D. (2008) · Toxicologic Pathology · doi:10.1177/0192623307310949 · Cited by 170 · see citing works
Analysis of Long-term Survivors After Surgical Resection for Pancreatic Cancer
Han, S., Jang, J., Kim, S., Kim, W. H., Lee, K. U., & Park, Y.-H. (2006) · Pancreas · doi:10.1097/01.mpa.0000202953.87740.93 · Cited by 162 · see citing works
Guenther, S., Muirhead, L. J., Speller, A. V. M., Golf, O., Strittmatter, N., Ramakrishnan, R., Goldin, R. D., Jones, E. A., Veselkov, K., Nicholson, J. K., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2258 · Cited by 159 · see citing works
In vivo Real-Time Mass Spectrometry for Guided Surgery Application
Fatou, B., Saudemont, P., Leblanc, É., Vinatier, D., Mesdag, V., Wisztorski, M., Focşa, C., Salzet, M., Ziskind, M., & Fournier, I. (2016) · Scientific Reports · doi:10.1038/srep25919 · Cited by 148 · see citing works
Pagnotti, V. S., Chubatyi, N. D., & McEwen, C. N. (2011) · Analytical Chemistry · doi:10.1021/ac200556z · Cited by 143 · see citing works
A framework for a personalized surgical approach to ovarian cancer
Nick, A. M., Coleman, R. L., Ramirez, P. T., & Sood, A. K. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.26 · Cited by 131 · see citing works
Sans, M., Gharpure, K. M., Tibshirani, R. J., Zhang, J., Li, L., Liu, J., Young, J. H., Dood, R. L., Sood, A. K., & Eberlin, L. S. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3044 · Cited by 126 · see citing works
Self-citationAutomation of a Surface Sampling Probe/Electrospray Mass Spectrometry System
Kertész, V., Ford, M. J., & Berkel, G. J. V. (2005) · Analytical Chemistry · doi:10.1021/ac0510742 · Cited by 115 · see citing works
Schäfer, K., Szaniszló, T., Günther, S., Balog, J., Dénes, J., Keserű, M., Dezsö, B., Tóth, M., Spengler, B., & Takáts, Z. (2011) · Analytical Chemistry · doi:10.1021/ac102613m · Cited by 100 · see citing works
Visualizing life with ambient mass spectrometry
Hsu, C., & Dorrestein, P. C. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.07.005 · Cited by 81 · see citing works
Cardiolipins Are Biomarkers of Mitochondria-Rich Thyroid Oncocytic Tumors
Zhang, J., Yu, W., Ryu, S. W., Lin, J. Q., Buentello, G., Tibshirani, R. J., Suliburk, J. W., & Eberlin, L. S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1545 · Cited by 79 · see citing works
Self-citationProtein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype
Kang, H. S., Lee, S. C., Park, Y. S., Jeon, Y. E., Lee, J. H., Jung, S., Park, I. H., Jang, S. H., Park, H. M., Yoo, C. W., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-465 · Cited by 76 · see citing works
Design and validation of a clinical instrument for spectral diagnosis of cutaneous malignancy
Rajaram, N., Aramil, T. J., Lee, K., Reichenberg, J. S., Nguyen, T. H., & Tunnell, J. W. (2010) · Applied Optics · doi:10.1364/ao.49.000142 · Cited by 71 · see citing works
Prognostic implications of a positive bronchial resection margin
Massard, G., Doddoli, C., Gasser, B., Ducrocq, X., Kessler, R., Schumacher, C., Jung, G.-M., & Wihlm, J. (2000) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(00)00384-5 · Cited by 66 · see citing works
Data quality in tissue analysis using desorption electrospray ionization
Dill, A. L., Eberlin, L. S., Costa, A. B., Ifa, D. R., & Cooks, R. G. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5249-z · Cited by 64 · see citing works
Self-citationBronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation
Maygarden, S. J., Detterbeck, F. C., & Funkhouser, W. K. (2004) · Modern Pathology · doi:10.1038/modpathol.3800154 · Cited by 49 · see citing works
Chen, C., Lin, Z., Garimella, S., Zheng, L., Shi, R., Cooks, R. G., & Ouyang, Z. (2013) · Analytical Chemistry · doi:10.1021/ac4025279 · Cited by 32 · see citing works
Silicone Surface with Drug Nanodepots for Medical Devices
Mokkaphan, J., Banlunara, W., Palaga, T., Sombuntham, P., & Wanichwecharungruang, S. P. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am505566m · Cited by 25 · see citing works
Zhang, J., Yu, W., Suliburk, J. W., & Eberlin, L. S. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.258723 · Cited by 20 · see citing works
Self-citationPrognostic predictors of patients with carcinoma of the gastric cardia.
Zhang, M., Li, Z., Ma, Y., Zhu, G., Zhang, H., & Xue, Y. (2012) · PubMed · doi:10.5754/hge09356 · Cited by 18 · see citing works
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Advances in Solid Phase Microextraction and Perspective on Future Directions
Reyes‐Garcés, N., Gionfriddo, E., Gómez‐Ríos, G. A., Alam, M. N., Boyacı, E., Bojko, B., Singh, V., Grandy, J. J., & Pawliszyn, J. B. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04502 · Cited by 737 · see citing works
Ambient Ionization Mass Spectrometry: Recent Developments and Applications
Feider, C. L., Krieger, A. C., DeHoog, R. J., & Eberlin, L. S. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00807 · Cited by 499 · see citing works
Self-citationAnalytical Challenges and Recent Advances in Mass Spectrometry Based Lipidomics
Rustam, Y. H., & Reid, G. E. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04836 · Cited by 285 · see citing works
Liquid chromatography–tandem mass spectrometry for clinical diagnostics
Thomas, S. N., French, D., Jannetto, P. J., Rappold, B. A., & Clarke, W. A. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00175-x · Cited by 255 · see citing works
Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma
Huang, L., Wang, L., Hu, X., Chen, S., Tao, P., Su, H., Yang, J., Xu, W. L., Vedarethinam, V., Wu, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17347-6 · Cited by 238 · see citing works
5‐ALA in the management of malignant glioma
Stepp, H., & Stummer, W. (2018) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22933 · Cited by 234 · see citing works
Mass spectrometry-based proteomics as an emerging tool in clinical laboratories
Birhanu, A. G. (2023) · Clinical Proteomics · doi:10.1186/s12014-023-09424-x · Cited by 225 · see citing works
Kim, M., Chen, C., Wang, P., Mulvey, J. J., Yang, Y., Wun, C., Antman-Passig, M., Luo, H.-B., Cho, S., Long-Roche, K., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00860-y · Cited by 214 · see citing works
Zhang, W., Zhang, D., Chen, Q., Wu, J., Ouyang, Z., & Xia, Y. (2019) · Nature Communications · doi:10.1038/s41467-018-07963-8 · Cited by 190 · see citing works
Phelps, D. L., Balog, J., Gildea, L., Bodai, Z., Savage, A., El-Bahrawy, M. A., Speller, A. V. M., Rosini, F., Kudo, H., McKenzie, J. S., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0048-3 · Cited by 160 · see citing works
Ambient Ionization Mass Spectrometry Today and Tomorrow: Embracing Challenges and Opportunities
Kuo, T.-H., Dutkiewicz, E. P., Pei, J., & Hsu, C. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05454 · Cited by 158 · see citing works
He, J., Sun, C., Li, T., Luo, Z., Huang, L., Song, X., Li, X., & Abliz, Z. (2018) · Advanced Science · doi:10.1002/advs.201800250 · Cited by 157 · see citing works
Applications of Tandem Mass Spectrometry (MS/MS) in Protein Analysis for Biomedical Research
Neagu, A.-N., Jayathirtha, M., Baxter, E., Donnelly, M., Petre, B. A., & Darie, C. C. (2022) · Molecules · doi:10.3390/molecules27082411 · Cited by 144 · see citing works
AND-gate contrast agents for enhanced fluorescence-guided surgery
Widen, J. C., Tholen, M., Yim, J. J., Antaris, A., Casey, K. M., Rogalla, S., Klaassen, A., Sorger, J., & Bogyo, M. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00616-6 · Cited by 142 · see citing works
Multimodal Imaging Mass Spectrometry: Next Generation Molecular Mapping in Biology and Medicine
Neumann, E. K., Djambazova, K. V., Caprioli, R. M., & Spraggins, J. M. (2020) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00232 · Cited by 132 · see citing works
Saudemont, P., Quanico, J. P., Robin, Y. M., Baud, A., Balog, J., Fatou, B., Tierny, D., Pascal, Q., Minier, K., Pottier, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.09.009 · Cited by 116 · see citing works
Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer
Sans, M., Zhang, J., Lin, J. Q., Feider, C. L., Giese, N., Breen, M., Sebastian, K., Liu, J., Sood, A. K., & Eberlin, L. S. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.299289 · Cited by 109 · see citing works
Self-citationIntra-operative spectroscopic assessment of surgical margins during breast conserving surgery
Shipp, D. W., Rakha, E. A., Koloydenko, A. A., Macmillan, R. D., Ellis, I. O., & Notingher, I. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1002-2 · Cited by 107 · see citing works
A Multifunctional Platinum Nanoreactor for Point-of-Care Metabolic Analysis
Huang, L., Gurav, D. D., Wu, S., Xu, W. L., Vedarethinam, V., Yang, J., Su, H., Wan, X., Fang, Y., Shen, B., et al. (2019) · Matter · doi:10.1016/j.matt.2019.08.014 · Cited by 107 · see citing works
Self-citationEmpowering Clinical Diagnostics with Mass Spectrometry
Banerjee, S. (2020) · ACS Omega · doi:10.1021/acsomega.9b03764 · Cited by 107 · see citing works
In Situ DESI-MSI Lipidomic Profiles of Breast Cancer Molecular Subtypes and Precursor Lesions
Santoro, A. L., Drummond, R. D., da Silva, I. T., Ferreira, S. S., Juliano, L., Vendramini, P. H., Lemos, M. B. D. C., Eberlin, M. N., & de Andrade, V. P. (2020) · Cancer Research · doi:10.1158/0008-5472.can-18-3574 · Cited by 103 · see citing works
Artificial Intelligence and Mapping a New Direction in Laboratory Medicine: A Review
Herman, D. S., Rhoads, D. D., Schulz, W. L., & Durant, T. J. S. (2021) · Clinical Chemistry · doi:10.1093/clinchem/hvab165 · Cited by 89 · see citing works
Son, A., Kim, W., Park, J., Park, Y., Lee, W., Lee, S., & Kim, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189880 · Cited by 85 · see citing works
Surgical margins in head and neck cancer: Intra- and postoperative considerations
Robbins, K. T., Triantafyllou, A. G., Suarez, C. M., López, F., Hunt, J. L., Strojan, P., Williams, M. D., Braakhuis, B. J. M., de Bree, R., Hinni, M. L., et al. (2018) · Auris Nasus Larynx · doi:10.1016/j.anl.2018.08.011 · Cited by 85 · see citing works
Instrumentation at the Leading Edge of Proteomics
Peters-Clarke, T. M., Coon, J. J., & Riley, N. M. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c04497 · Cited by 84 · see citing works
Jin, Z., Yue, Q., Duan, W., Sui, A., Zhao, B., Deng, Y., Zhai, Y., Zhang, Y., Sun, T., Zhang, G., et al. (2022) · Advanced Science · doi:10.1002/advs.202104935 · Cited by 83 · see citing works
Seddiki, K., Saudemont, P., Precioso, F., Ogrinc, N., Wisztorski, M., Salzet, M., Fournier, I., & Droit, A. (2020) · Nature Communications · doi:10.1038/s41467-020-19354-z · Cited by 82 · see citing works
Review—Electrochemistry's Potential to Reach the Ultimate Sensitivity in Measurement Science
Goines, S., & Dick, J. E. (2020) · Journal of The Electrochemical Society · doi:10.1149/2.0052003jes · Cited by 81 · see citing works
King, M. E., Zhang, J., Lin, J. Q., Garza, K. Y., DeHoog, R. J., Feider, C. L., Bensussan, A., Sans, M., Krieger, A. C., Badal, S., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104411118 · Cited by 81 · see citing works
Self-citationElectrochemical imaging of cells and tissues
Lin, T., Rapino, S., Girault, H. H., & Lesch, A. S. (2018) · Chemical Science · doi:10.1039/c8sc01035h · Cited by 80 · see citing works
Ogrinc, N., Saudemont, P., Balog, J., Robin, Y. M., Gimeno, J., Pascal, Q., Tierny, D., Takáts, Z., Salzet, M., & Fournier, I. (2019) · Nature Protocols · doi:10.1038/s41596-019-0217-8 · Cited by 78 · see citing works
Mass spectrometry imaging to detect lipid biomarkers and disease signatures in cancer
Holzlechner, M., Eugenín, E. A., & Prideaux, B. (2019) · Cancer Reports · doi:10.1002/cnr2.1229 · Cited by 76 · see citing works
Vanadium Core–Shell Nanorods Inspect Metabolic Changes of Diabetic Retinopathy
Vedarethinam, V., Huang, L., Zhang, M., Su, H., Hu, H., Xia, H., Liu, Y., Wu, B., Wan, X., Shen, J., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002791 · Cited by 75 · see citing works
Direct sampling mass spectrometry for clinical analysis
Pu, F., Chiang, S., Zhang, W., & Ouyang, Z. (2018) · The Analyst · doi:10.1039/c8an01722k · Cited by 75 · see citing works
Keating, M. F., Zhang, J., Feider, C. L., Retailleau, S., Reid, R., Antaris, A. L., Hart, B. R., Tan, G., Milner, T. E., Miller, K. R., et al. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02037 · Cited by 74 · see citing works
Self-citationRecent advances in on-site mass spectrometry analysis for clinical applications
Zhou, X., Zhang, W., & Ouyang, Z. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116548 · Cited by 73 · see citing works
Applications of Mass Spectrometry for Clinical Diagnostics: The Influence of Turnaround Time
Swiner, D. J., Jackson, S., Burris, B. J., & Badu-Tawiah, A. K. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04901 · Cited by 73 · see citing works
Soudah, T., Zoabi, A., & Margulis, K. (2021) · Mass Spectrometry Reviews · doi:10.1002/mas.21736 · Cited by 71 · see citing works
Harnessing Tumor Evolution to Circumvent Resistance
McNamara, K. L., & Curtis, C. N. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.05.007 · Cited by 66 · see citing works
Mass Spectrometry-Based Intraoperative Tumor Diagnostics
Hänel, L., Kwiatkowski, M., Heikaus, L., & Schlüter, H. (2019) · Future Science OA · doi:10.4155/fsoa-2018-0087 · Cited by 66 · see citing works
Bojko, B., Looby, N., Olkowicz, M., Roszkowska, A., Kupcewicz, B., dos Santos, P. R., Ramadan, K. Z., Keshavjee, S. H., Waddell, T. K., Gómez‐Ríos, G. A., et al. (2020) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2020.08.011 · Cited by 65 · see citing works
Wide-field quantitative micro-elastography of human breast tissue
Allen, W. M., Kennedy, K. M., Fang, Q., Chin, L., Curatolo, A., Watts, L., Zilkens, R., Chin, S. L., Dessauvagie, B. F., Latham, B. I., et al. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.001082 · Cited by 65 · see citing works
Vijayalakshmi, K., Shankar, V., Bain, R. M., Nolley, R., Sonn, G. A., Kao, C., Zhao, H., Tibshirani, R. J., Zare, R. N., & Brooks, J. D. (2019) · International Journal of Cancer · doi:10.1002/ijc.32843 · Cited by 64 · see citing works
Tang, F., Guo, C., Ma, X., Zhang, J., Su, Y., Tian, R., Shi, R., Xia, Y., Wang, X., & Ouyang, Z. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04675 · Cited by 57 · see citing works
Self-citationZhang, J., Li, S. Q., Lin, J. Q., Yu, W., & Eberlin, L. S. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-2522 · Cited by 57 · see citing works
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Ogrinc, N., Kruszewski, A., Chaillou, P., Saudemont, P., Lagadec, C. H., Salzet, M., Christian Duriez, A., & Fournier, I. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c01692 · Cited by 55 · see citing works
Emerging role of clinical mass spectrometry in pathology
Fung, A. W. S., Sugumar, V., Ren, A. H., & Kulasingam, V. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2019-206269 · Cited by 53 · see citing works
Woolman, M., Kuzan-Fischer, C. M., Ferry, I., Kiyota, T., Luu, B., Wu, M., Muñoz, D. G., Das, S., Aman, A. M., Taylor, M. D., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3411 · Cited by 52 · see citing works
Advances in imaging mass spectrometry for biomedical and clinical research
Djambazova, K. V., Ardenne, J. M. V., & Spraggins, J. M. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117344 · Cited by 51 · see citing works
Applications of ambient ionization mass spectrometry in 2022: An annual review
Rankin‐Turner, S., Sears, P., & Heaney, L. M. (2023) · Analytical Science Advances · doi:10.1002/ansa.202300004 · Cited by 49 · see citing works
In situ DESI-MSI Lipidomic Profiles of Mucosal Margin of Oral Squamous Cell Carcinoma
Yang, X., Song, X., Zhang, X., Shankar, V., Wang, S., Yang, Y. T., Chen, S., Zhang, L., Ni, Y., Zare, R. N., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103529 · Cited by 48 · see citing works
Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis
Wang, J., Pursell, M. E., DeVor, A., Awoyemi, O., Valentine, S. J., & Li, P. (2022) · PROTEOMICS · doi:10.1002/pmic.202200112 · Cited by 48 · see citing works
Cancer Surgery 2.0: Guidance by Real-Time Molecular Technologies
Ogrinc, N., Saudemont, P., Takáts, Z., Salzet, M., & Fournier, I. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.04.001 · Cited by 48 · see citing works
Yan, R., Chen, J., Wang, J., Rao, J., Du, X., Liu, Y., Zhang, L. W., Qiu, L., Liu, B., Zhao, Y., et al. (2018) · Small · doi:10.1002/smll.201802745 · Cited by 46 · see citing works
Genangeli, M., Heeren, R. M. A., & Siegel, T. P. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-02148-8 · Cited by 46 · see citing works
Miniature mass spectrometers and their potential for clinical point‐of‐care analysis
Zhai, Y., Fu, X., & Xu, W. L. (2023) · Mass Spectrometry Reviews · doi:10.1002/mas.21867 · Cited by 45 · see citing works
Mass spectrometry-based non-targeted metabolic profiling for disease detection: Recent developments
Zang, X., Monge, M. E., & Fernández, F. M. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.05.030 · Cited by 44 · see citing works
Lin, L., Chen, C., Huang, Y.-C., Chung, H., Lin, C.-W., Chen, K., Peng, Y., Ding, S., Wang, M., Shen, T., et al. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.11.014 · Cited by 44 · see citing works
Booth, M. A., Gowers, S. A. N., Leong, C. L., Rogers, M. L., Samper, I. C., Wickham, A. P., & Boutelle, M. G. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04224 · Cited by 43 · see citing works
Zhang, J., Sans, M., Garza, K. Y., & Eberlin, L. S. (2020) · Mass Spectrometry Reviews · doi:10.1002/mas.21664 · Cited by 42 · see citing works
Self-citationNIR‐II Fluorescence imaging for cerebrovascular diseases
Ren, F. Z., Jiang, Z., Han, M., Zhang, H., Yun, B., Zhu, H., & Li, Z. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200128 · Cited by 42 · see citing works
Rapid automated diagnosis of primary hepatic tumour by mass spectrometry and artificial intelligence
Giordano, S., Takeda, S., Donadon, M., Saiki, H., Brunelli, L., Pastorelli, R., Cimino, M., Soldani, C., Franceschini, B., Tommaso, L. D., et al. (2020) · Liver International · doi:10.1111/liv.14604 · Cited by 41 · see citing works
Brown, H. M., Alfaro, C. M., Pirro, V., Dey, M., Hattab, E. M., Cohen‐Gadol, A., & Cooks, R. G. (2020) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfaa233 · Cited by 41 · see citing works
Zhang, J., Sans, M., DeHoog, R. J., Garza, K. Y., King, M. E., Feider, C. L., Bensussan, A., Keating, M. F., Lin, J. Q., Povilaitis, S. C., et al. (2021) · Clinical Chemistry · doi:10.1093/clinchem/hvab098 · Cited by 41 · see citing works
Self-citationUrken, M. L., Yun, J., Saturno, M. P., Greenberg, L. A., Chai, R. L., Sharif, K. F., & Brandwein‐Weber, M. (2023) · Oral Oncology · doi:10.1016/j.oraloncology.2023.106445 · Cited by 40 · see citing works
Brown, H. M., Pirro, V., & Cooks, R. G. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2017.281923 · Cited by 39 · see citing works
To target Tau pathologies, we must embrace and reconstruct their complexities
Limorenko, G., & Lashuel, H. A. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105536 · Cited by 39 · see citing works
Qi, Y., Yang, L., Liu, B., Liu, L., Liu, Y., Zheng, Q., Liu, D., & Luo, J. (2021) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2021.120400 · Cited by 38 · see citing works
Koumpa, F. S., Xylas, D., Konopka, M., Galea, D., Veselkov, K., Antoniou, A., Mehta, A., & Mirnezami, R. (2019) · Gastroenterology Research and Practice · doi:10.1155/2019/5180895 · Cited by 37 · see citing works
Dabaj, I., Ferey, J., Marguet, F., Gilard, V., Basset, C., Bahri, Y., Bréhin, A., Vanhulle, C., Leturcq, F., Marret, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81090-1 · Cited by 37 · see citing works
Ma, Y., & Yates, J. R. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1500902 · Cited by 36 · see citing works
Zhang, W., Chiang, S., Li, Z., Chen, Q., Xia, Y., & Ouyang, Z. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201900011 · Cited by 36 · see citing works
Rapid Analysis and Authentication of Meat Using the MasSpec Pen Technology
Gatmaitan, A. N., Lin, J. Q., Zhang, J., & Eberlin, L. S. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07830 · Cited by 36 · see citing works
Self-citationSu, P., Chen, X., Smith, A. J., Espenship, M. F., Samayoa‐Oviedo, H. Y., Wilson, S. M., Ranjbar, H. G., Larriba‐Andaluz, C., & Laskin, J. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02092 · Cited by 36 · see citing works
Recent review on selected xenobiotics and their impacts on gut microbiome and metabolome
Jin, Y., Chi, J., LoMonaco, K., Boon, A., & Gu, H. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117155 · Cited by 35 · see citing works
Trimpin, S. (2018) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.8269 · Cited by 33 · see citing works
Allen, W. M., Foo, K. Y., Zilkens, R., Kennedy, K. M., Fang, Q., Chin, L., Dessauvagie, B. F., Latham, B. I., Saunders, C. M., & Kennedy, B. F. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.006331 · Cited by 33 · see citing works
Portable Instrumentation for Ambient Ionization and Miniature Mass Spectrometers
Smith, B. L., Hankinson, T., & Maher, S. (2024) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061522-040824 · Cited by 32 · see citing works
Brown, H. M., Pu, F., Dey, M., Miller, J. B., Shah, M. V., Shapiro, S., Ouyang, Z., Cohen‐Gadol, A., & Cooks, R. G. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-02198-y · Cited by 31 · see citing works
Woolman, M., Qiu, J., Kuzan-Fischer, C. M., Ferry, I., Dara, D., Katz, L., Daud, F., Wu, M., Ventura, M., Bernards, N., et al. (2020) · Chemical Science · doi:10.1039/d0sc02241a · Cited by 31 · see citing works
Current methods in translational cancer research
Lee, M. W., Miljanic, M., Triplett, T., Ramírez, C., Aung, K. L., Eckhardt, S., & Capasso, A. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09931-5 · Cited by 31 · see citing works
Applications of ambient ionization mass spectrometry in 2021: An annual review
Rankin‐Turner, S., Reynolds, J. C., Turner, M. A., & Heaney, L. M. (2022) · Analytical Science Advances · doi:10.1002/ansa.202100067 · Cited by 31 · see citing works
Wang, X., Zhang, J., Zheng, K., Du, Q., Wang, G., Huang, J., Zhou, Y., Li, Y., Jin, H., & He, J. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.02.010 · Cited by 30 · see citing works
Self-citationWheeler, K., Gosmanov, C., Sandoval, M. J., Yang, Z., & McCall, L. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117713 · Cited by 29 · see citing works
Advancements in Ambient Ionisation Mass Spectrometry in 2024: An Annual Review
Henderson, A., Heaney, L. M., & Rankin‐Turner, S. (2025) · Analytical Science Advances · doi:10.1002/ansa.70007 · Cited by 29 · see citing works
Ogrinc, N., Attencourt, C., Colin, É., Boudahi, A., Tebbakha, R., Salzet, M., Testelin, S., Dakpé, S., & Fournier, I. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.827360 · Cited by 29 · see citing works
Towards real-time intraoperative tissue interrogation for REIMS-guided glioma surgery
Hese, L. V., Vleeschouwer, S. D., Theys, T., Larivière, E., Solie, L., Sciot, R., Siegel, T. P., Rex, S., Heeren, R. M. A., & Cuypers, E. (2022) · Journal of Mass Spectrometry and Advances in the Clinical Lab · doi:10.1016/j.jmsacl.2022.04.004 · Cited by 29 · see citing works
Portable Multiplex Optical Assays
Coskun, A. F., Topkaya, S. N., Yetisen, A. K., & Çetin, A. E. (2018) · Advanced Optical Materials · doi:10.1002/adom.201801109 · Cited by 29 · see citing works
Delineating the tumor margin with intraoperative surface-enhanced Raman spectroscopy
Jiang, C., Wang, Y., Song, W., & Lu, L. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-01577-9 · Cited by 29 · see citing works
Methods for Assessing Surface Cleanliness
(2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816081-7.00003-6 · Cited by 28 · see citing works
Biological mass spectrometry enables spatiotemporal ‘omics: From tissues to cells to organelles
Pade, L. R., Stepler, K. E., Portero, E. P., DeLaney, K., & Nemes, P. (2023) · Mass Spectrometry Reviews · doi:10.1002/mas.21824 · Cited by 28 · see citing works
Trimpin, S., Pophristic, M., Adeniji‐Adele, A., Tomsho, J. W., & McEwen, C. N. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03378 · Cited by 28 · see citing works
Use of Mass Spectrometry to Screen Glycan Early Markers in Hepatocellular Carcinoma
de Oliveira, R. M., Ricart, C. A. O., & Martins, A. M. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2017.00328 · Cited by 27 · see citing works
Fundamental Studies of New Ionization Technologies and Insights from IMS-MS
Trimpin, S., Inutan, E. D., Karki, S., Elia, E. A., Zhang, W., Weidner, S. M., Marshall, D. D., Hoang, K., Lee, C., Davis, E. T. J., et al. (2019) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-019-02194-7 · Cited by 27 · see citing works
Meisenbichler, C., Kluibenschedl, F., & Müller, T. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02615 · Cited by 27 · see citing works
Povilaitis, S. C., Chakraborty, A. D., Kirkpatrick, L., Downey, R. D., Hauger, S. B., & Eberlin, L. S. (2022) · Clinical Chemistry · doi:10.1093/clinchem/hvac147 · Cited by 27 · see citing works
Self-citationStromal vapors for real-time molecular guidance of breast-conserving surgery
Vaysse, P., Kooreman, L. F. S., Engelen, S. M. E., Kremer, B., Damink, S. W. M. O., Heeren, R. M. A., Smidt, M. L., & Siegel, T. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-77102-1 · Cited by 27 · see citing works
Manoli, E., Mason, S., Ford, L., Adebesin, A., Bodai, Z., Darzi, A. W., Kinross, J. K., & Takáts, Z. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00270 · Cited by 27 · see citing works
Insights and prospects for ion mobility-mass spectrometry in clinical chemistry
Koomen, D. C., May, J. C., & MCLEAN, J. A. J. (2022) · Expert Review of Proteomics · doi:10.1080/14789450.2022.2026218 · Cited by 26 · see citing works
Mass Spectrometry Imaging Spatial Tissue Analysis toward Personalized Medicine
Gonçalves, J. P. L., Bollwein, C., & Schwamborn, K. (2022) · Life · doi:10.3390/life12071037 · Cited by 26 · see citing works
- Authors
- Zhang, J., Rector, J., Lin, J. Q., Young, J. H., Sans, M., Katta, N., Giese, N., Yu, W., Nagi, C., Suliburk, J., Liu, J., Bensussan, A., DeHoog, R. J., Garza, K. Y., Ludolph, B., Sorace, A. G., Syed, A., Zahedivash, A., Milner, T. E., & Eberlin, L. S.
- Affiliations
- The University of Texas at Austin (US)
- Baylor College of Medicine (US)
- The University of Texas MD Anderson Cancer Center (US)
- Department of Chemistry, University of Texas at Austin, Austin, TX 78712, USA.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-09-06
- Volume
- 9
- Issue
- 406
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5830136
- OpenAlex
- W2753124759
- Cited by
- 406
- References
- 41
- Citations by year
- 2026: 29 · 2025: 33 · 2024: 40 · 2023: 50 · 2022: 44 · 2021: 52 · 2020: 50 · 2019: 64 · 2018: 37 · 2017: 6
- FWCI
- 21.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Cancer Institute (award310081, R00CA190783)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Keywords
- nondestructive tissue analysis, cancer diagnosis, tumor markers, molecular profiling, histopathology, thyroid tumors, breast cancer, ovarian cancer, intraoperative diagnosis, mouse tumor model
- MeSH terms
- Animals, Disease Models, Animal, Female, Humans, Intraoperative Care, Mice, Nude, Neoplasms, Organ Specificity, Mass Spectrometry, Molecular Diagnostic Techniques, Principal Component Analysis
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