The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Biological tissue imaging with time‐of‐flight secondary ion mass spectrometry and cluster ion sources
Open accessAbstract
Time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) using liquid metal ion guns (LMIGs) is now sensitive enough to produce molecular‐ion images directly from biological tissue samples. Primary cluster ions strike a spot on the sample to produce a mass spectrum. An image of this sample is achieved by rastering the irradiated point over the sample surface. The use of secondary ion mass spectrometry for mapping biological tissue surfaces provides unique analytical capabilities; in particular, it enables in a single acquisition a large variety of biological compounds to be localised on a micrometer scale and scrutinised for colocalisations. Without any treatment of the sample, this method is fully compatible with subsequent and complementary analyses like fluorescence microscopy, histochemical staining, or even matrix‐assisted laser desorption/ionisation imaging. Basic physical concepts, required instrumentation (ion source and mass analyzer), sample preparation methods, image acquisition, image processing, and emerging biological applications will be described and discussed. Copyright © 2005 John Wiley & Sons, Ltd.
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Cites
Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
Caprioli, R. M., Farmer, T. B., & Gile, J. (1997) · Analytical Chemistry · doi:10.1021/ac970888i · Cited by 2,234
Cited by
McDonnell, L. A., & Heeren, R. M. A. (2007) · Mass Spectrometry Reviews · doi:10.1002/mas.20124 · Cited by 1,082
Cluster secondary ion mass spectrometry of polymers and related materials
Mahoney, C. M. (2010) · Mass Spectrometry Reviews · doi:10.1002/mas.20233 · Cited by 293
Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Becker, J. S., Zoriy, M., Matusch, A., Wu, B., Salber, D., Palm, C., & Becker, J. S. (2010) · Mass Spectrometry Reviews · doi:10.1002/mas.20239 · Cited by 287
Abiotic synthesis of amino acids in the recesses of the oceanic lithosphere
Ménez, B., Pisapia, C., Andreani, M., Jamme, F., Vanbellingen, Q. P., Brunelle, A., Richard, L., Dumas, P., & Réfrégiers, M. (2018) · Nature · doi:10.1038/s41586-018-0684-z · Cited by 249
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Metadata
- Authors
- Brunelle, A., Touboul, D., & Laprévote, O.
- Venue
- Journal of Mass Spectrometry
- Publisher
- Wiley
- Published
- 2005-08
- Volume
- 40
- Issue
- 8
- Pages
- 985-999
- ISSN
- 1076-5174 (ISSN-L)
- 1096-9888
- OpenAlex
- W2081216971
- Cited by
- 241
- References
- 1
- FWCI
- 20.11
- Type
- journal article
- Language
- en
- Open access
- green
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