Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus: Parechovirus and HHV-6 in infants
Abstract
Human parechovirus (HPeV) and human herpes virus-6 (HHV-6) are acquired commonly in infancy and associated with central nervous system infection. The prevalence of HPeV and HHV-6 in the cerebrospinal fluid (CSF) of infants tested for enterovirus (EV) and herpes-simplex virus (HSV) is unknown. All stored CSF samples from EV or HSV testing in infants less than 6 months of age at Children's Hospital Colorado between January 1, 2010 and December 31, 2011 were tested for HPeV, HHV-6, EV, and HSV by PCR. Clinical characteristics and epidemiological data were collected using retrospective electronic chart review. Of 239 infants tested, 29 cases of EV (12.1%), 7 cases of HPeV (2.9%), 5 cases of HHV-6 (2.1%), and 5 cases of HSV (2.1%) were identified with no bacterial co-infections. HPeV cases occurred between July and October in infants with median age of 24 days. Infants with HPeV had a median maximum temperature of 39 °C, median fever duration of 3 days and median peripheral white blood cell count of 5.2 × 10(3)/μL. HHV-6 cases occurred in infants with median age of 61 days without seasonality. Five percent of infants less than 6 months of age undergoing testing for EV or HSV have HPeV or HHV-6 in the CSF. Targeting testing of HPeV towards febrile infants less than 2 months of age with leukopenia in the late summer to early fall, and HHV-6 towards older infants may increase diagnostic yield. The clinical and fiscal impact of testing infants for HPeV and HHV-6 needs to be determined.
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HPeV is less well studied, but it has been suggested that with further data these infants may be able to be managed similarly to those who are positive for EV.
“HPeV is less well studied, but it has been suggested that with further data these infants may be able to be managed similarly to those who are positive for EV (16, 18).”
From Retrospective Evaluation of Infants Aged 1 to 60 Days with Residual Cerebrospinal Fluid (CSF) Tested Using the FilmArray Meningitis/Encephalitis (ME) Panel (2018) · cites this paper as [16]
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- Authors
- Messacar, K., Breazeale, G., Wei, Q., Robinson, C. C., & Dominguez, S. R.
- Affiliations
- Department of Pediatrics; Section of Hospital Medicine and Infectious Diseases; Aurora Colorado
- Children's Hospital Colorado (US)
- Department of Pathology and Laboratory Medicine; Aurora Colorado
- Corresponding author
- Messacar, Kevin
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2015-02-03
- Volume
- 87
- Issue
- 5
- Pages
- 829-835
- ISSN
- 0146-6615 (ISSN-L)
- OpenAlex
- W1848118686
- Cited by
- 34
- References
- 18
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 1 · 2015: 2
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1 TR001082)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- human parechovirus, human herpesvirus 6, cerebrospinal fluid, infants, central nervous system infection, enterovirus, herpes simplex virus, febrile infants, leukopenia, seasonal variation, diagnostic yield, viral prevalence
- MeSH terms
- Cerebrospinal Fluid, Colorado, Enterovirus Infections, Enterovirus, Female, Herpesviridae Infections, Humans, Infant, Infant, Newborn, Male, Seasons, Temperature, Herpesvirus 6, Human, Prevalence, Polymerase Chain Reaction, Simplexvirus, Encephalitis, Viral, Parechovirus
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