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Cited by 182Viral Infections and Immunology ResearchNeonatal and Maternal InfectionsLiterature Analysis and Criticism

Specific Association of Human Parechovirus Type 3 with Sepsis and Fever in Young Infants, as Identified by Direct Typing of Cerebrospinal Fluid Samples

Harvala, H., Robertson, I., Chieochansin, T., McWilliam Leitch, E. C., Templeton, K., Simmonds, P.·2009·The Journal of Infectious Diseases
DOI 10.1086/599094
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Abstract

BACKGROUND: Human parechoviruses (HPeVs), along with human enteroviruses (HEVs), are associated with neonatal sepsis and meningitis. We determined the relative importance of these viruses and the specific HPeV types involved in the development of central nervous system-associated disease. METHODS: A total of 1575 cerebrospinal fluid (CSF) samples obtained during 2006-2008 were screened for HPeV by means of nested polymerase chain reaction. All samples for which results were positive were typed by sequencing of viral protein (VP) 3/VP1. Screening for HEV was performed in parallel, as was detection of HPeV in respiratory and fecal surveillance samples, to identify virus types circulating in the general population. RESULTS: HPeV was detected in 14 CSF samples obtained exclusively from young infants (age, <3 months) with sepsis or pyrexia. The frequency of detection of HPeVs varied greatly by year, with the highest frequency (7.2%) noted in 2008 exceeding that of HEVs. Direct typing of CSF samples revealed that all infections were caused by HPeV type 3, a finding that is in contrast to the predominant circulation of HPeV1 in contemporary respiratory and fecal surveillance samples. CONCLUSION: HPeV was a significant cause of severe sepsis and fever with central nervous system involvement in young infants, rivaling enteroviruses. The specific targeting of young infants by HPeV type 3 may reflect a difference in tissue tropism between virus types or a lack of protection of young infants by maternal antibody consequent to the recent emergence of HPeV.

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Crossref · 10.1086/599094

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  • Sepsis-like syndrome has been reported in 40-80% of HPeV (especially type 3) infections and 10-30% of EV infections in young infants.

    “Sepsis-like syndrome has been reported in 40–80% of HPeV (especially type 3) infections and 10–30% of EV infections in young infants (21–27).”

    From Epidemiology of pediatric meningitis and encephalitis in Japan: a cross-sectional study (2024) · cites this paper as [27]

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Authors
Harvala, H., Robertson, I., Chieochansin, T., McWilliam Leitch, E. C., Templeton, K., & Simmonds, P.
Affiliations
  • Edinburgh Royal Infirmary (GB)
  • University of Edinburgh (GB)
  • Chulalongkorn University (TH)
Corresponding author
Harvala, H.
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2009-06-15
Volume
199
Issue
12
Pages
1753-1760
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/599094
OpenAlex
W2038214228
Cited by
182
References
35
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 12 · 2018: 8 · 2017: 15 · 2016: 13 · 2015: 11 · 2014: 18 · 2013: 19 · 2012: 21
FWCI
10.26
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Literature Analysis and Criticism
Keywords
human parechovirus type 3, parechovirus, human enteroviruses, neonatal sepsis, infant fever, cerebrospinal fluid, central nervous system infection, virus typing, tissue tropism, maternal antibodies, emerging viruses, viral surveillance
MeSH terms
Adolescent, Adult, Aged, Child, Child, Preschool, Feces, Female, Fever, Humans, Infant, Male, Meningitis, Viral, Middle Aged, Phylogeny, Picornaviridae Infections, Time Factors, Age Distribution, Sepsis, Parechovirus, Young Adult

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