The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Neurospheres: Insights into neural stem cell biology
Abstract
Neural stem cells (NSC) are a tissue‐specific subtype of self‐renewing and multipotent cells that can give rise to all neural populations. In this review, the importance of maintaining cell–cell contacts in the study of NSC is highlighted, and data obtained from some crucial single‐cell studies is compared to results obtained from neurospheres, where aggregates of NSC are grown in suspension. In particular, results that indicate how this culture system may be well suited to analyze NSC plasticity, cell–cell, and cell–extracellular matrix (ECM) interactions are pointed out, and the hypothesis that cell–cell and cell–ECM contacts may be essential for NSC maintenance, survival, and proliferation is highlighted. Finally, it is suggested that neurospheres might play a role in the study of context‐dependent behavior of NSC in niches by providing a system where NSC can be challenged chemically or biologically and analyzed in vitro, in a time‐ and context‐dependent manner. © 2004 Wiley‐Liss, Inc.
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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
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Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
Taking Cell-Matrix Adhesions to the Third Dimension
Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Defining the Epithelial Stem Cell Niche in Skin
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Adaptation of core mechanisms to generate cell polarity
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Cited by
Three-dimensional in vitro cell culture models in drug discovery and drug repositioning
Langhans, S. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00006 · Cited by 1,522
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
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Neural stem cell systems: physiological players or in vitro entities?
Conti, L., & Cattaneo, E. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2761 · Cited by 320
Metadata
- Authors
- Campos, L. S.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2004-10-25
- Volume
- 78
- Issue
- 6
- Pages
- 761-769
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1982227030
- Cited by
- 167
- References
- 8
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
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