Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins
Open accessAbstract
Depressive disorders have been shown to be highly influenced by environmental pathogenic factors, some of which are believed to exert stress on human brain functioning via epigenetic modifications. Previous genome-wide methylomic studies on depression have suggested that, along with differential DNA methylation, affected co-twins of monozygotic (MZ) pairs have increased DNA methylation variability, probably in line with theories of epigenetic stochasticity. Nevertheless, the potential biological roots of this variability remain largely unexplored. The current study aimed to evaluate whether DNA methylation differences within MZ twin pairs were related to differences in their psychopathological status. Data from the Illumina Infinium HumanMethylation450 Beadchip was used to evaluate peripheral blood DNA methylation of 34 twins (17 MZ pairs). Two analytical strategies were used to identify (a) differentially methylated probes (DMPs) and (b) variably methylated probes (VMPs). Most DMPs were located in genes previously related to neuropsychiatric phenotypes. Remarkably, one of these DMPs (cg01122889) was located in the WDR26 gene, the DNA sequence of which has been implicated in major depressive disorder from genome-wide association studies. Expression of WDR26 has also been proposed as a biomarker of depression in human blood. Complementarily, VMPs were located in genes such as CACNA1C, IGF2 and the p38 MAP kinase MAPK11, showing enrichment for biological processes such as glucocorticoid signaling. These results expand on previous research to indicate that both differential methylation and differential variability have a role in the etiology and clinical manifestation of depression, and provide clues on specific genomic loci of potential interest in the epigenetics of depression.
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
The brief symptom inventory: an introductory report.
Derogatis, L. R., & Melisaratos, N. (1983) · Psychological Medicine · doi:10.1017/s0033291700048017 · Cited by 6,650 · see citing works
Cytoscape 2.8: new features for data integration and network visualization
Smoot, M. E., Ono, K., Ruscheinski, J., Wang, P., & Ideker, T. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq675 · Cited by 4,770 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Roux, P. P., & Blenis, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.320-344.2004 · Cited by 2,494 · see citing works
Reactome: a database of reactions, pathways and biological processes
Croft, D., O'Kelly, G., Wu, G., Haw, R., Gillespie, M., Matthews, L., Caudy, M., Garapati, P., Gopinath, G., Jassal, B., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1018 · Cited by 1,751 · see citing works
High density DNA methylation array with single CpG site resolution
Bibikova, M., Barnes, B., Tsan, C., Ho, V., Klotzle, B., Le, J. M., Delano, D., Zhang, L., Schroth, G. P., Gunderson, K. L., et al. (2011) · Genomics · doi:10.1016/j.ygeno.2011.07.007 · Cited by 1,727 · see citing works
Brain on stress: how the social environment gets under the skin
McEwen, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121254109 · Cited by 1,200 · see citing works
A mega-analysis of genome-wide association studies for major depressive disorder
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works
Classical twin studies and beyond
Boomsma, D., Busjahn, A., & Peltonen, L. (2002) · Nature Reviews Genetics · doi:10.1038/nrg932 · Cited by 1,105 · see citing works
Increased methylation variation in epigenetic domains across cancer types
Hansen, K. D., Timp, W., Bravo, H. C., Sabunciyan, S., Langmead, B., McDonald, O. G., Wen, B., Wu, H., Liu, Y., Diep, D. H., et al. (2011) · Nature Genetics · doi:10.1038/ng.865 · Cited by 1,053 · see citing works
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007 · see citing works
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
Sandoval, J., Heyn, H., Moran, S., Serra-Musach, J., Pujana, M. A., Bibikova, M., & Esteller, M. (2011) · Epigenetics · doi:10.4161/epi.6.6.16196 · Cited by 990 · see citing works
Heim, C., & Binder, E. B. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.032 · Cited by 986 · see citing works
Major Depression and Generalized Anxiety Disorder: Same Genes, (Partly) Different Environments?
Kendler, K. S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820090044008 · Cited by 773 · see citing works
McKusick's Online Mendelian Inheritance in Man (OMIM(R))
Amberger, J., Bocchini, C. A., Scott, A. F., & Hamosh, A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn665 · Cited by 717 · see citing works
Dynamic DNA methylation across diverse human cell lines and tissuesPreprint
Varley, K. E., Gertz, J., Bowling, K. M., Parker, S. L., Reddy, T. E., Pauli, F., Cross, M. K., Williams, B. A., Stamatoyannopoulos, J. A., Crawford, G. E., et al. (2013) · Genome Research · doi:10.1101/gr.147942.112 · Cited by 693 · see citing works
DNA methylation profiles in monozygotic and dizygotic twins
Kaminsky, Z. A., Tang, T., Wang, S.-C., Ptak, C., Oh, G., Wong, A. H. C., Feldcamp, L. A., Virtanen, C., Halfvarson, J., Tysk, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.286 · Cited by 662 · see citing works
Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r43 · Cited by 630 · see citing works
Genome-Wide Dna Methylation Profiling Using Infinium ® Assay
Bibikova, M. V., Le, J. M., Barnes, B., Saedinia-Melnyk, S., Zhou, L., Shen, R., & Gunderson, K. L. (2009) · Epigenomics · doi:10.2217/epi.09.14 · Cited by 592 · see citing works
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
Timp, W., & Feinberg, A. (2013) · Nature Reviews. Cancer · doi:10.1038/nrc3486 · Cited by 586 · see citing works
Feinberg, A. P., & Irizarry, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906183107 · Cited by 524 · see citing works
(2002) · PubMed · Cited by 518 · see citing works
Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460 · see citing works
Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats
McGowan, P. O., Suderman, M., Sasaki, A., Huang, T. C. T., Hallett, M., Meaney, M. J., & Szyf, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014739 · Cited by 452 · see citing works
Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., Maclean, A. W., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2010.109 · Cited by 444 · see citing works
Symptoms of Anxiety and Symptoms of Depression
Kendler, K. S. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800170073010 · Cited by 442 · see citing works
Phenotypic differences in genetically identical organisms: the epigenetic perspective.
Wong, A., Gottesman, I., & Petronis, A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi116 · Cited by 438 · see citing works
The continuing value of twin studies in the omics era
van Dongen, J., Slagboom, P., Draisma, H., Martin, N. G., & Boomsma, D. (2012) · Nature reviews genetics · doi:10.1038/nrg3243 · Cited by 398 · see citing works
Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index
Feinberg, A. P., Irizarry, R. A., Fradin, D. D., Aryee, M. J., Murakami, P. N., Aspelund, T., Eiríksdóttir, G., Harris, T. B., Launer, L. J., Gudnason, V. G., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001262 · Cited by 335 · see citing works
A human B cell methylome at 100−base pair resolution
Rauch, T. A., Wu, X., Zhong, X., Riggs, A. D., & Pfeifer, G. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812399106 · Cited by 333 · see citing works
Wong, C. C. Y., Meaburn, E. L., Ronald, A., Price, T. S., Jeffries, A. R., Schalkwyk, L. C., Plomin, R., & Mill, J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.41 · Cited by 327 · see citing works
Kendler, K. S. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830050025004 · Cited by 323 · see citing works
The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells
Provençal, N., Suderman, M. J., Guillemin, C., Massart, R., Ruggiero, A., Wang, D., Bennett, A. J., Pierre, P. J., Friedman, D. P., Côté, S. M., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1470-12.2012 · Cited by 312 · see citing works
The role of DNA methylation in stress-related psychiatric disorders
Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309 · see citing works
Gertz, J., Varley, K. E., Reddy, T. E., Bowling, K. M., Pauli, F., Parker, S. L., Kucera, K. S., Willard, H. F., & Myers, R. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002228 · Cited by 304 · see citing works
MethHC: a database of DNA methylation and gene expression in human cancer
Huang, W.-Y., Hsu, S., Huang, H., Sun, Y.-M., Chou, C., Weng, S.-L., & Huang, H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1151 · Cited by 296 · see citing works
Zeller, C., Dai, W., Steele, N. L., Siddiq, A., Walley, A. J., Wilhelm-Benartzi, C. S., Rizzo, S., van der Zee, A. G. J., Plumb, J. A., & Brown, R. E. (2012) · Oncogene · doi:10.1038/onc.2011.611 · Cited by 285 · see citing works
Spiteri, E., Konopka, G., Coppola, G., Bomar, J. M., Oldham, M. C., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B., & Geschwind, D. H. (2007) · The American Journal of Human Genetics · doi:10.1086/522237 · Cited by 281 · see citing works
DNA Methylation Signatures within the Human Brain
Ladd‐Acosta, C., Pevsner, J., Sabunciyan, S., Yolken, R. H., Webster, M. J., Dinkins, T., Callinan, P. A., Fan, J., Potash, J. B., & Feinberg, A. P. (2007) · The American Journal of Human Genetics · doi:10.1086/524110 · Cited by 277 · see citing works
Gene–environment interactions: early life stress and risk for depressive and anxiety disorders
Nugent, N. R., Tyrka, A. R., Carpenter, L. L., & Price, L. H. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2151-x · Cited by 269 · see citing works
Bruchas, M. R., Schindler, A. G., Shankar, H., Messinger, D. I., Miyatake, M., Land, B. B., Lemos, J. C., Hagan, C. E., Neumaier, J. F., Quintana, A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.011 · Cited by 266 · see citing works
DNA methylation: A mechanism for embedding early life experiences in the genome
Szyf, M., & Bick, J. (2013) · Child Development · doi:10.1111/j.1467-8624.2012.01793.x · Cited by 251 · see citing works
Zbozinek, T. D., Rose, R. D., Wolitzky-Taylor, K. B., Sherbourne, C. D., Sullivan, G., Stein, M. B., Roy‐Byrne, P., & Craske, M. G. (2012) · Depression and Anxiety · doi:10.1002/da.22026 · Cited by 246 · see citing works
On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”
Tylee, D. S., Kawaguchi, D. M., & Glatt, S. J. (2013) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32150 · Cited by 243 · see citing works
Regulated Noise in the Epigenetic Landscape of Development and Disease
Pujadas, E., & Feinberg, A. P. (2012) · Cell · doi:10.1016/j.cell.2012.02.045 · Cited by 234 · see citing works
What is the genetic relationship between anxiety and depression?
Hettema, J. M. (2008) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30171 · Cited by 207 · see citing works
Kaneko, M., Koike, H., Saito, R., Kitamura, Y., Okuma, Y., & Nomura, Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2422-09.2010 · Cited by 201 · see citing works
Yuen, R. K. C., Peñaherrera, M. S., von Dadelszen, P., McFadden, D. E., & Robinson, W. P. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.63 · Cited by 197 · see citing works
Iwamoto, K., Bundo, M., Ueda, J., Oldham, M. C., Ukai, W., Hashimoto, E., Saito, T., Geschwind, D. H., & Kato, T. (2011) · Genome Research · doi:10.1101/gr.112755.110 · Cited by 189 · see citing works
Dong, C., Wong, M.-L., & Licinio, J. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.92 · Cited by 182 · see citing works
Uddin, M., Koenen, K. C., Aiello, A. E., Wildman, D. E., de los Santos, R., & Galea, S. (2011) · Psychological Medicine · doi:10.1017/s0033291710001674 · Cited by 174 · see citing works
DNA Methylation, Behavior and Early Life Adversity
Moshe Szyf, A. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2013.06.004 · Cited by 142 · see citing works
Kendler, K. S., Myers, J., MAES, H. H. M., & Keyes, C. L. M. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9466-1 · Cited by 136 · see citing works
Genome-wide Methylomic Analysis of Monozygotic Twins Discordant for Adolescent Depression
Dempster, E. L., Wong, C. C. Y., Lester, K. J., Burrage, J., Gregory, A. M., Mill, J. S., & Eley, T. C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.013 · Cited by 132 · see citing works
Teschendorff, A. E., & Widschwendter, M. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts170 · Cited by 120 · see citing works
Evidence for disruption of sphingolipid metabolism in schizophrenia
Narayan, S., Head, S. R., Gilmartin, T. J., Dean, B., & Thomas, E. A. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21822 · Cited by 114 · see citing works
Epigenomics reveals a functional genome anatomy and a new approach to common disease
Feinberg, A. P. (2010) · Nature Biotechnology · doi:10.1038/nbt1010-1049 · Cited by 113 · see citing works
Phipson, B., & Oshlack, A. (2014) · Genome Biology · doi:10.1186/s13059-014-0465-4 · Cited by 112 · see citing works
Versican V1 Isoform Induces Neuronal Differentiation and Promotes Neurite Outgrowth
Wu, Y., Sheng, W., Chen, L., Dong, H., Lee, V., Lu, F., Wong, C. S., Lu, W.-Y., & Yang, B. B. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0667 · Cited by 107 · see citing works
PAJER, K. A., Andrus, B. M., Gardner, W. P., Lourie, A., Strange, B., Campo, J. V., Bridge, J. A., Blizinsky, K. D., Dennis, K., Vedell, P. T., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.26 · Cited by 105 · see citing works
Significance analysis and statistical dissection of variably methylated regions
Jaffe, A. E., Feinberg, A. P., Irizarry, R. A., & Leek, J. T. (2011) · Biostatistics · doi:10.1093/biostatistics/kxr013 · Cited by 100 · see citing works
Byrne, E. M., Carrillo‐Roa, T., Henders, A. K., Bowdler, L. M., McRae, A. F., Heath, A. C., Martin, N. G., Montgomery, G. W., Krause, L., & Wray, N. R. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.45 · Cited by 100 · see citing works
Haque, F. N., Gottesman, I. I., & Wong, A. H. C. (2009) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30206 · Cited by 99 · see citing works
Mosing, M. A., Gordon, S. D., Medland, S. E., Statham, D. J., Nelson, E. C., Heath, A. C., Martin, N. G., & Wray, N. R. (2009) · Depression and Anxiety · doi:10.1002/da.20611 · Cited by 99 · see citing works
Hypermethylation in the ZBTB20 gene is associated with major depressive disorder
Davies, M. N., Krause, L., Bell, J. T., Gao, F., Ward, K. J., Wu, H., Lu, H., Liu, Y., Tsai, P.-C., Collier, D. A., et al. (2014) · Genome biology · doi:10.1186/gb-2014-15-4-r56 · Cited by 96 · see citing works
Psychometric Properties of the Spanish Version of the BSI
Ruipérez, M. A., Ibáñez, M. I., Lorente, E., Moro, M., & Ortet, G. (2001) · European Journal of Psychological Assessment · doi:10.1027//1015-5759.17.3.241 · Cited by 88 · see citing works
Epigenetic layers and players underlying neurodevelopment
LaSalle, J. M., Powell, W. T., & Yasui, D. H. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.05.001 · Cited by 85 · see citing works
Nieratschker, V., Massart, R., Gilles, M., Luoni, A., Suderman, M. J., Krumm, B., Meier, S., Witt, S. H., Nöthen, M. M., Suomi, S. J., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.75 · Cited by 84 · see citing works
Chang, S.-C., Koenen, K. C., Galea, S., Aiello, A. E., Soliven, R., Wildman, D. E., & Uddin, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039184 · Cited by 81 · see citing works
Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress
Luo, Y., Xu, Y., Cao, W.-Y., Zhong, X., Duan, J., Wang, X., Hu, Z., Li, F., Zhang, J.-Y., Zhou, M., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.011 · Cited by 76 · see citing works
Cline, B. H., Steinbusch, H. W. M., Malin, D., Revishchin, A. V., Gv, P., Cespuglio, R., & Strekalova, T. V. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-110 · Cited by 74 · see citing works
Kim, S., Mo, J., Han, S. B., Choi, S. Y., Han, S. B., Moon, B.-K., Rhyu, I. J., Sun, W., & Kim, H. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.027 · Cited by 74 · see citing works
The Impact of Environmental Experiences on Symptoms of Anxiety and Depression Across the Life Span
Kendler, K. S., Eaves, L. J., Loken, E. K., Pedersen, N. L., Middeldorp, C. M., Reynolds, C. A., Boomsma, D. I., Lichtenstein, P., Silberg, J. L., & Gardner, C. O. (2011) · Psychological Science · doi:10.1177/0956797611417255 · Cited by 72 · see citing works
Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation
Leung, L. C., Urbančič, V., Baudet, M., Dwivedy, A., Bayley, T. G., Lee, A. C., Harris, W. A., & Holt, C. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3290 · Cited by 69 · see citing works
Mechanisms underlying synaptic vulnerability and degeneration in neurodegenerative disease
Gillingwater, T. H., & Wishart, T. M. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12014 · Cited by 66 · see citing works
DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons
Oh, G., Wang, S.-C., Pal, M., Chen, Z. F., Khare, T., Tochigi, M., Ng, C., Yang, Y. A., Kwan, A., Kaminsky, Z. A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.016 · Cited by 66 · see citing works
Protocadherin α (PCDHA) as a novel susceptibility gene for autism
Anitha, A., Thanseem, I., Nakamura, K., Yamada, K., Iwayama, Y., Toyota, T., Iwata, Y., Suzuki, K., Sugiyama, T., Tsujii, M., et al. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120058 · Cited by 64 · see citing works
Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine
Feinberg, A. P. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12224 · Cited by 63 · see citing works
WDR26: A novel Gβ‐like protein, suppresses MAPK signaling pathway
Zhu, Y., Wang, Y., Xia, C., Li, D., Li, Y., Zeng, W., Yuan, W., Liu, H., Zhu, C., Wu, X., et al. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20175 · Cited by 56 · see citing works
Nakamura, K., Aizawa, K., Nakabayashi, K., Kato, N., Yamauchi, J., Hata, K., & Tanoue, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054036 · Cited by 49 · see citing works
Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia
Pantazopoulos, H., Boyer-Boiteau, A., Holbrook, E. H., Jang, W., Hahn, C.-G., Arnold, S. E., & Berretta, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.08.013 · Cited by 47 · see citing works
Ubiquitin-proteasome dependent degradation of GABAAα1 in autism spectrum disorder
Crider, A., Pandya, C. D., Peter, D., Ahmed, A. O., & Pillai, A. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-45 · Cited by 45 · see citing works
Structural Variation of Chondroitin Sulfate and Its Roles in the Central Nervous System
Maeda, N. (2010) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152410790780136 · Cited by 43 · see citing works
Mohrmann, I., Gillessen‐Kaesbach, G., Siebert, R., Caliebe, A., & Hellenbroich, Y. (2011) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2011.04.006 · Cited by 43 · see citing works
Oh, J.-E., Chambwe, N., Klein, S., Gal, J., Andrews, S., Gleason, G., Shaknovich, R., Melnick, A., Campagne, F., & Toth, M. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.130 · Cited by 43 · see citing works
Zygosity and chorionicity in triplet pregnancies: new data
Guilherme, R., Drunat, S., Delezoide, A., Oury, J., & Luton, D. (2008) · Human Reproduction · doi:10.1093/humrep/den364 · Cited by 39 · see citing works
Carter, C. J. (2013) · Pathogens and Disease · doi:10.1111/2049-632x.12077 · Cited by 38 · see citing works
Gene expression profiling in hypothalamus of immobilization-stressed mouse using cDNA microarray
Lee, H.-C., Chang, D., Yeom, M., Kim, G.-H., Choi, K., Shim, I., Lee, H., & Hahm, D. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.11.016 · Cited by 32 · see citing works
Correlation Between Decrease in Protein Levels of Ubiquitin Ligase HRD1 and Amyloid-β Production
Saito, R., Kaneko, M., Okuma, Y., & Nomura, Y. (2010) · Journal of Pharmacological Sciences · doi:10.1254/jphs.10118sc · Cited by 32 · see citing works
Huang, K.-C., Yang, K.-C., Lin, H., Tsao, T. T.-H., Lee, W., Lee, S., & Kao, C. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-s5-s10 · Cited by 30 · see citing works
Klausmeyer, A., Conrad, R., Faissner, A., & Wiese, S. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22531 · Cited by 24 · see citing works
Karanges, E. A., Kashem, M., Sarker, R., Ahmed, E. U., Ahmed, S., van Nieuwenhuijzen, P. V., Kemp, A., & McGregor, I. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00086 · Cited by 24 · see citing works
Hrd1 Facilitates Tau Degradation and Promotes Neuron Survival
Shen, Y., Sun, A. M., Fang, S., Feng, L., Li, Q., Hou, H., Liu, C. L., Wang, H. P., Shen, J., Luo, J., et al. (2012) · Current Molecular Medicine · doi:10.2174/156652412798889009 · Cited by 21 · see citing works
The Utility of Twins for Epigenetic Analysis
Saffery, R., Morley, R., & Foley, D. (2012) · Springer eBooks · doi:10.1007/978-94-007-2495-2_10 · Cited by 5 · see citing works
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- First MB Structured Clinical Interview for DSM-IV Axis I Disorders: SCID - I: Clinician Version: Administration Booklet American Psychiatric Press: Washington, DC, USA 1997
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Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150 · see citing works
Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders
Sutherland, H. G. E., & Griffiths, L. R. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13053 · Cited by 134 · see citing works
Major depression and the biological hallmarks of aging
Lorenzo, E. C., Kuchel, G. A., Kuo, C., Moffitt, T. E., & Diniz, B. S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101805 · Cited by 129 · see citing works
What do DNA methylation studies tell us about depression? A systematic review
Li, M., D’Arcy, C., Li, X., Zhang, T., Joober, R., & Meng, X. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0412-y · Cited by 125 · see citing works
Epigenetic Modifications of Major Depressive Disorder
Saavedra, K., Molina-Márquez, A., Saavedra, N., Zambrano, T., & Salazar, L. A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081279 · Cited by 124 · see citing works
Origins of human disease: the chrono-epigenetic perspective
Oh, E. S., & Petronis, A. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00348-6 · Cited by 108 · see citing works
Peng, H., Zhu, Y., Strachan, E., Fowler, E., Bacus, T., Roy-Byrne, P., Goldberg, J., Vaccarino, V., & Zhao, J. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000604 · Cited by 99 · see citing works
Li, C., Miles, T. P., Shen, L., Shen, Y., Liu, T., Zhang, M., Li, S., & Huang, C. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.116 · Cited by 88 · see citing works
Diez años de investigación traslacional colaborativa en enfermedades mentales: el CIBERSAM
Salagre, E., Arango, C., Artigas, F., Ayuso‐Mateos, J. L., Bernardo, M., Castro‐Fornieles, J., Bobes, J., Desco, M., Fañanás, L., González-Pinto, A. M., et al. (2018) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2018.10.001 · Cited by 88 · see citing works
Self-citationJarić, I., Rocks, D., Cham, H., Herchek, A., & Kundaković, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00074 · Cited by 86 · see citing works
DNA Methylation and Psychiatric Disorders
Liu, C., Jiao, C., Wang, K., & Yuan, N. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.01.006 · Cited by 85 · see citing works
Progress in Epigenetics of Depression
Peña, C. J., & Nestler, E. J. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2017.12.011 · Cited by 84 · see citing works
Neurophysiological Changes Induced by Chronic Toxoplasma gondii Infection
Tedford, E., & McConkey, G. A. (2017) · Pathogens · doi:10.3390/pathogens6020019 · Cited by 82 · see citing works
Epigenetic dysregulation of protocadherins in human disease
Hajj, N. E., Dittrich, M. T., & Haaf, T. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.07.007 · Cited by 76 · see citing works
Depression and suicide risk prediction models using blood-derived multi-omics data
Bhak, Y., Jeong, H.-O., Cho, Y. S., Jeon, S., Cho, J., Gim, J., Jeon, Y., Blažytė, A., Park, S. G., Kim, H., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0595-2 · Cited by 74 · see citing works
Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders
Byrne, E. M., Zhu, Z., Qi, T., Skene, N., Bryois, J., Pardiñas, A. F., Stahl, E. A., Smoller, J. W., Rietschel, M., Owen, M. J., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0705-9 · Cited by 72 · see citing works
Epigenome-wide association study of depression symptomatology in elderly monozygotic twins
Starnawska, A., Tan, Q., Soerensen, M., McGue, M. K., Mors, O. N., Børglum, A. D., Christensen, K., Nyegaard, M., & Christiansen, L. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0548-9 · Cited by 70 · see citing works
Zhu, Y., Strachan, E., Fowler, E., Bacus, T., Roy-Byrne, P., & Zhao, J. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0550-2 · Cited by 66 · see citing works
Chen, Y.-C., Sudre, G. P., Sharp, W. S., Donovan, F. X., Chandrasekharappa, S. C., Hansen, N. F., Elnitski, L. L., & Shaw, P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.45 · Cited by 61 · see citing works
Epigenome-wide association study of DNA methylation in panic disorder
Shimada-Sugimoto, M., Otowa, T., Miyagawa, T., Umekage, T., Kawamura, Y., Bundo, M., Iwamoto, K., Tochigi, M., Kasai, K., Kaiya, H., et al. (2017) · Clinical Epigenetics · doi:10.1186/s13148-016-0307-1 · Cited by 61 · see citing works
Grassi, D., Franz, H., Vezzali, R., Bovio, P. P., Heidrich, S., Dehghanian, F., Lagunas, N., Belzung, C., KRIEGLSTEIN, K. G., & Vogel, T. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx095 · Cited by 58 · see citing works
Pardo, M., Cheng, Y., Sitbon, Y. H., Lowell, J. A., Grieco, S. F., Worthen, R. J., Desse, S. I., & Barreda-Diaz, A. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.10.012 · Cited by 57 · see citing works
An epigenome-wide association study of early-onset major depression in monozygotic twins
Roberson‐Nay, R., Lapato, D. M., Wolen, A. R., Lancaster, E. E., Webb, B. T., Verhulst, B., Hettema, J. M., & York, T. P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00984-2 · Cited by 65 · see citing works
DNA methylation analysis from saliva samples for epidemiological studies
Nishitani, S., Parets, S. E., Haas, B. W., & Smith, A. K. (2018) · Epigenetics · doi:10.1080/15592294.2018.1461295 · Cited by 50 · see citing works
The importance of epigenetics in diagnostics and treatment of major depressive disorder
Czarny, P., Białek, K., Ziółkowska, S., Strycharz, J., Barszczewska, G., & Sliwinski, T. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030167 · Cited by 37 · see citing works
Global Deep-Sea Biodiversity Research Trends Highlighted by Science Mapping Approach
Costa, C., Fanelli, E., Marini, S., Danovaro, R., & Aguzzi, J. (2020) · Frontiers in Marine Science · doi:10.3389/fmars.2020.00384 · Cited by 41 · see citing works
Epigenetic mechanisms in atrial fibrillation: New insights and future directions
Tao, H., Shi, K., Yang, J., & Li, J. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2015.08.006 · Cited by 40 · see citing works
Xiu, J., Li, J., Liu, Z., Wei, H., Zhu, C., Han, R., Liu, Z., Zhu, W., Shen, Y., & Xu, Q. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201967119 · Cited by 40 · see citing works
A comprehensive regional analysis of genome-wide expression profiles for major depressive disorder
Forero, D. A., Guio-Vega, G. P., & González‐Giraldo, Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.061 · Cited by 38 · see citing works
Zwamborn, R. A. J., Snijders, C., An, N., Thomson, A. C., Rutten, B. P. F., & de Nijs, L. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.005 · Cited by 39 · see citing works
Schmidt, M., Lax, E., Zhou, R., Cheishvili, D., Ruder, A. M., Ludiro, A., Lapert, F., Macedo da Cruz, A., Sandrini, P., Calzoni, T., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-018-0348-7 · Cited by 37 · see citing works
DNA Methylation in Major Depressive Disorder
Pishva, E., Rutten, B. P. F., & van den Hove, D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_10 · Cited by 34 · see citing works
Role of DNA Methylation in Mediating Genetic Risk of Psychiatric Disorders
Starnawska, A., & Demontis, D. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.596821 · Cited by 34 · see citing works
A MIR4646 associated methylation locus is hypomethylated in adolescent depression
Boström, A. E., Ciuculete, D.-M., Attwood, M., Krattinger, R., Nikontovic, L., Titova, O. E., Kullak-Ublick, G. A., Mwinyi, J., & Schiöth, H. B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.05.017 · Cited by 33 · see citing works
Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain
Tóth, M. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-030220-022920 · Cited by 32 · see citing works
Ciuculete, D. M., Boström, A. E. D., Tuunainen, A., Sohrabi, F., Kular, L., Jagodic, M., Voisin, S. A. C., Mwinyi, J., & Schiöth, H. B. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.03.008 · Cited by 29 · see citing works
Epigenome-wide DNA methylation in obsessive-compulsive disorder
Schiele, M. A., Lipovsek, J., Schlosser, P., Soutschek, M., Schratt, G. M., Zaudig, M., Berberich, G., Köttgen, A., & Domschke, K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01996-w · Cited by 31 · see citing works
Walker, R. M., Christoforou, A., McCartney, D. L., Morris, S. W., Kennedy, N. A., Morten, P., Anderson, S. M., Torrance, H. S., Macdonald, A., Sussmann, J. E., et al. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0171-z · Cited by 30 · see citing works
Starnawska, A., Hansen, C. S., Sparsø, T., Mazin, W., Olsen, L., Bertalan, M., Buil, A., Bybjerg‐Grauholm, J., Bækvad‐Hansen, M., HOUGAARD, D. M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.181 · Cited by 28 · see citing works
Palma-Gudiel, H., Peralta, V., Deuschle, M., Navarro, V., & Fañanás, L. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.002 · Cited by 28 · see citing works
Self-citationTherapeutic response to paroxetine in major depressive disorder predicted by DNA Methylation
Takeuchi, N., Nonen, S., Kato, M., Wakeno, M., Takekita, Y., Kinoshita, T., & Kugawa, F. (2017) · Neuropsychobiology · doi:10.1159/000480512 · Cited by 26 · see citing works
DNA methylation in stress and depression: from biomarker to therapeutics
Sales, A. J., Guimarães, F. S., & Joca, S. R. L. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.18 · Cited by 27 · see citing works
Heterogeneity in major depressive disorder: The need for biomarker-based personalized treatments
Suseelan, S., & Pinna, G. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.09.001 · Cited by 26 · see citing works
Ciuculete, D. M., Voisin, S. A. C., Kular, L., Welihinda, N., Jonsson, J., Jagodic, M., Mwinyi, J., & Schiöth, H. B. (2019) · Epigenetics · doi:10.1080/15592294.2019.1700628 · Cited by 26 · see citing works
Walker, R. M., Sussmann, J. E., Whalley, H. C., Ryan, N., Porteous, D. J., McIntosh, A. M., & Evans, K. L. (2016) · Bipolar Disorders · doi:10.1111/bdi.12415 · Cited by 24 · see citing works
Chiarella, J., Tremblay, R. E., Moshe Szyf, A., Provençal, N., & Booij, L. (2015) · Twin Research and Human Genetics · doi:10.1017/thg.2015.84 · Cited by 24 · see citing works
Distinct epigenetic signatures between adult-onset and late-onset depression
Yamagata, H., Ogihara, H., Matsuo, K., Uchida, S., Kobayashi, A., Seki, T., Kobayashi, M., Harada, K., Chen, C., Miyata, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81758-8 · Cited by 23 · see citing works
Grieco, S. F., Cheng, Y., Eldar-Finkelman, H., Jope, R. S., & Beurel, E. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.08.008 · Cited by 22 · see citing works
Palma‐Gudiel, H., Córdova‐Palomera, A., Navarro, V., & Fañanás, L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.017 · Cited by 21 · see citing works
Self-citationCarmel, M., Michaelovsky, E., Weinberger, R., Frisch, A., Mekori‐Domachevsky, E., Gothelf, D., & Weizman, A. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2020.1747113 · Cited by 19 · see citing works
Baker, M. R., Lee, A. S., & Rajadhyaksha, A. M. (2023) · Channels · doi:10.1080/19336950.2023.2176984 · Cited by 19 · see citing works
Kébir, O., Chaumette, B., & Krebs, M. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0138-2 · Cited by 19 · see citing works
Self-citationCórdova‐Palomera, A., Palma‐Gudiel, H., Forés-Martos, J., Tabarés‐Seisdedos, R., & Fañanás, L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207754 · Cited by 18 · see citing works
Self-citationEpigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics
Gatta, E., Saudagar, V., Auta, J., Grayson, D. R., & Guidotti, A. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.08.002 · Cited by 17 · see citing works
WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression levels in H9c2 cells
Jiang, L., Wang, H., Chen, G., Feng, Y., Zou, J., Liu, M., Liu, K., Wang, N., Zhang, H., Wang, K., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.015 · Cited by 16 · see citing works
Liu, J., Zhang, Z., Xu, J., Song, X., Yuan, W., Miao, M., Liang, H., & Du, J. (2019) · Epigenomics · doi:10.2217/epi-2019-0004 · Cited by 16 · see citing works
CIBERSAM: Ten years of collaborative translational research in mental disorders
Salagre, E., Arango, C., Artigas, F., Ayuso‐Mateos, J. L., Bernardo, M., Castro‐Fornieles, J., Bobes, J., Desco, M., Fañanás, L., González-Pinto, A. M., et al. (2019) · Revista de Psiquiatría y Salud Mental (English Edition) · doi:10.1016/j.rpsmen.2018.10.001 · Cited by 16 · see citing works
Self-citationMusazzi, L., Paoli, C., Misztak, P., & Mazzini, G. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220201084536 · Cited by 15 · see citing works
Roberson‐Nay, R., Wolen, A. R., Lapato, D. M., Lancaster, E. E., Webb, B. T., Verhulst, B., Hettema, J. M., & York, T. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/422345 · Cited by 14 · see citing works
Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation
Castro-Castro, A., Muriel, O., del Pozo, M. Á., & Bustelo, X. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166715 · Cited by 13 · see citing works
Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder
Fernández-Pereira, C., Penedo, M. A., Baltanás, T. R., Pérez-Márquez, T., Alves-Villar, M., Martínez, R. F., Veiga, C., Salgado‐Barreira, Á., Prieto-González, J. M., Ortolano, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015254 · Cited by 12 · see citing works
Introduction to Epigenetics in Psychiatry
Lee, R. S., & Avramopoulos, D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00001-2 · Cited by 13 · see citing works
The placental gateway of maternal transgenerational epigenetic inheritance
Sailasree, P., Srivastava, S., & Mishra, R. K. (2017) · Journal of Genetics · doi:10.1007/s12041-017-0788-5 · Cited by 12 · see citing works
An epigenome-wide methylation study of healthy individuals with or without depressive symptoms
Shimada, M., Otowa, T., Miyagawa, T., Umekage, T., Kawamura, Y., Bundo, M., Iwamoto, K., Ikegame, T., Tochigi, M., Kasai, K., et al. (2018) · Journal of Human Genetics · doi:10.1038/s10038-017-0382-y · Cited by 11 · see citing works
MTHFR gene methylation is associated with perceived stress in healthy young adults
Jiménez, K. M., Pereira‐Morales, A. J., & Forero, D. A. (2018) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000196 · Cited by 10 · see citing works
Brain and Blood Biomarkers of Major Depressive Disorder
Zallar, L. J., & Dupont, M. B. (2026) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.4613 · Cited by 12 · see citing works
Neuropeptides as the Shared Genetic Crosstalks Linking Periodontitis and Major Depression Disorder
Sun, C., Han, J., Bai, Y., Zhong, Z., Song, Y., & Sun, Y. (2021) · Disease Markers · doi:10.1155/2021/3683189 · Cited by 9 · see citing works
Kader, F., Ghai, M., & Zhou, M. M. (2020) · Forensic Science International · doi:10.1016/j.forsciint.2020.110372 · Cited by 8 · see citing works
GID complex regulates the differentiation of neural stem cells by destabilizing TET2
Xia, M., Yan, R., Wang, W., Zhang, M., Miao, Z., Wan, B., & Xu, X. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1007-9 · Cited by 6 · see citing works
The DNA Methylome: An Interface Between the Environment, Immunity, and Ageing
McEwen, L. M., Goodman, S. J., Kobor, M. S., & Jones, M. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-43365-3_3 · Cited by 6 · see citing works
Hein, S. D., Thomas, T., Naumova, O. Y., Luthar, S. S., & Grigorenko, E. L. (2018) · Developmental Psychobiology · doi:10.1002/dev.21789 · Cited by 6 · see citing works
The Promise of Epigenetic Editing for Treating Brain Disorders
González-Molina, L. A., Dolga, A. M., Rots, M. G., & Sarno, F. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_4 · Cited by 5 · see citing works
Becker, M., Abaev, K., Pinhasov, A., & Ornoy, A. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113866 · Cited by 5 · see citing works
Premature aging in serious mental illness
Diniz, B. S., Fries, G. R., Kuo, C.-L., Xu, M., & Lenze, E. J. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02322-4 · Cited by 4 · see citing works
Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods
Lei, C., Chen, Z., Ma, C., Xie, L., Wu, D., Chen, J., & Chen, J. (2026) · Chinese Medicine · doi:10.1186/s13020-025-01320-w · Cited by 5 · see citing works
Baker, E. C., Earnhardt-San, A. L., Cilkiz, K. Z., Littlejohn, B. P., Cardoso, R. C., Ghaffari, N., Long, C. R., Riggs, P. K., Randel, R. D., Welsh, T. H., et al. (2023) · Biology · doi:10.3390/biology12020252 · Cited by 4 · see citing works
Islam, F., Lisoway, A. J., Oh, E., Fiori, L., Magarbeh, L., Elsheikh, S., Kim, H. K., Kloiber, S., Kennedy, J. L., Frey, B., et al. (2023) · Pharmacopsychiatry · doi:10.1055/a-2313-9979 · Cited by 4 · see citing works
Zaina, S., & Lund, G. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0673-y · Cited by 4 · see citing works
The Role of Epigenetic Factors in the Development of Depressive Disorders
Mustafin, R. N., Enikeeva, R. F., Davydova, Y. D., & Хуснутдинова, Э. К. (2018) · Russian Journal of Genetics · doi:10.1134/s1022795418120104 · Cited by 4 · see citing works
Epigenetics of Major Depressive Disorder
Wang, K. Z., Dada, O. O., Bani‐Fatemi, A., Tasmim, S., Monda, M., Graff, A., & Luca, V. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-58131-8.00002-1 · Cited by 4 · see citing works
Ketamine treatment effects on DNA methylation and Epigenetic Biomarkers of agingPreprint
Dawson, K., Carangan, A. M. J. M., Klunder, J., Carreras-Gallo, N., Sehgal, R., Megilligan, S., Askins, B. C., Perkins, N., Mendez, T. L., Smith, R. C., et al. (2024) · medRxiv · doi:10.1101/2024.09.10.24313258 · Cited by 4 · see citing works
MDDOmics: multi-omics resource of major depressive disorder
Zhao, Y.-C., Xiang, J., Shi, X., Jia, P., Zhang, Y., & Li, M. (2024) · Database J. Biol. Databases Curation · doi:10.1093/database/baae042 · Cited by 4 · see citing works
Epigenetics and Genetics of Development
Lussier, A. A., Islam, S. A., & Kobor, M. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804036-2.00007-8 · Cited by 3 · see citing works
Eissenberg, J. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823928-5.00035-9 · Cited by 3 · see citing works
Ye, S.-H., Zhao, Y., Liu, Z., Luo, C.-P., Xiong, J., Zhan, J., Li, Y., Wei, B., Chen, C., & Yang, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1354999 · Cited by 3 · see citing works
Epigenetic biomarkers in neuropsychiatric disorders
Lin, C.-C., & Huang, T. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00003-4 · Cited by 3 · see citing works
Dawson, K. L., Carangan, A. M. J. M., Klunder, J., Carreras-Gallo, N., Sehgal, R., Megilligan, S., Askins, B. C., Perkins, N., Mendez, T. L., Smith, R. M., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03683-y · Cited by 2 · see citing works
Technologies for Deciphering Epigenomic DNA Patterns
Morán, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_24 · Cited by 2 · see citing works
Challenges in Analyzing Functional Epigenetic Data in Perspective of Adolescent Psychiatric Health
Manu, D. M., Mwinyi, J., & Schiöth, H. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105856 · Cited by 2 · see citing works
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Czarny, P. L., Białek, K. I., Ziółkowska, S., Talarowska, M. E., & Śliwiński, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00029-5 · Cited by 2 · see citing works
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Morelli, G., Valle, F. D., & Orlando, V. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-24930-3_11 · Cited by 1 · see citing works
- Authors
- Córdova-Palomera, A., Fatjó-Vilas, M., Gastó, C., Navarro, V, Krebs, M.-O., & Fañanás, L.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Inserm (FR)
- Corresponding author
- Fañanás, L
- Venue
- Translational Psychiatry
- Published
- 2015-04-28
- Volume
- 5
- Issue
- 4
- Pages
- e557-e557
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC4462612
- OpenAlex
- W2076363539
- Cited by
- 117
- References
- 96
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 12 · 2018: 19 · 2017: 20 · 2016: 10 · 2015: 4 · 2014: 1
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministerio de Ciencia e Innovación (PIM2010ERN-00642, SAF2008-05674-C03-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, DNA methylation, monozygotic twins, differential methylation, WDR26, CACNA1C, insulin-like growth factor II, MAPK11, glucocorticoid signaling, major depressive disorder, peripheral blood DNA
- MeSH terms
- Adult, Major Depressive Disorder, Depressive Disorder, Female, Humans, Insulin-Like Growth Factor II, Male, Middle Aged, Proteins, Twins, Monozygotic, DNA Methylation, Calcium Channels, L-Type, Epigenesis, Genetic, Mitogen-Activated Protein Kinase 11, Adaptor Proteins, Signal Transducing, Young Adult
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