The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
Open accessAbstract
A wealth of research over the past 2 decades has expanded our understanding of the impact of early‐life adversity on physiological function and, consequently, health and wellbeing in later life. Early‐life adversity increases the risk of developing a number of disorders, such as chronic pain, fibromyalgia, and irritable bowel syndrome. Although much of the research has examined the impact of physical maltreatment, an increasing number of studies have been published over the past few years examining the effect of childhood psychological stress and trauma on the development of various types of chronic pain conditions. We review the clinical and preclinical data examining the link among early‐life psychological stress, altered nociceptive behavior, and chronic pain in later life. Evidence supporting a role for certain key neurobiological substrates, including the hypothalamic‐pituitary‐adrenal axis; monoaminergic, opioidergic, endocannabinoid and immune systems; and epigenetic mechanisms in the association between early‐life psychological stress and chronic pain, is provided. Greater understanding of the impact of early‐life stress may inform the development of personalized treatments for chronic pain in later life and strategies to prevent its onset in susceptible individuals. © 2016 Wiley Periodicals, Inc.
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“there is a wealth of evidence that symptoms of depression, anxiety, and emotional distress contribute strongly (more strongly than pain intensity, in many studies) to key long-term outcomes of persistent pain such as physical disability 35, 43–46, work disability 47, healthcare costs 48, 49, mortality 50–53, and suicide 22, 54, 55.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [49]
In the citing paper
“As such, physiological alterations associated with ELAb may contribute to the development of stress-related functional pain syndromes,(17) and affective impairment in adulthood,(20,21) both of which predominately affect women.(22,23)”
In the citing paper
“However, dysregulation of allostatic systems can manifest as either hypo- or hyper- responsiveness to stress later in life,(14–16) with consequent impairment in endogenous pain regulation.(17–19)”
In the citing paper
“and may explain, in part, why women with ELAb are at risk for pain disorders.(17,19)”
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The path to healthy ageing in China: a Peking University–Lancet Commission
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Evaluating psychosocial contributions to chronic pain outcomes
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Metadata
- Authors
- Burke, N. N., Finn, D. P., McGuire, B. E., & Roche, M.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Roche, Michelle
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2016-07-12
- Volume
- 95
- Issue
- 6
- Pages
- 1257-1270
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W2482083953
- Cited by
- 268
- References
- 157
- Citations by year
- 2026: 27 · 2025: 24 · 2024: 27 · 2023: 39 · 2022: 33 · 2021: 27 · 2020: 31 · 2019: 35 · 2018: 14 · 2017: 10 · 2016: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- University of Galway Research Repository (submittedVersion, cc-by)
- Funders
- Science Foundation Ireland (#11/RFP/NES/3175, 10/IN.1/B2976)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- chronic pain, childhood trauma, childhood adversity, nociception, hypothalamic-pituitary-adrenal axis, monoaminergic systems, opioid system, endocannabinoid system, immune system, epigenetics, fibromyalgia, irritable bowel syndrome, pain prevention, personalized pain treatment
- MeSH terms
- Animals, Child, Humans, Neurobiology, Stress, Psychological, Causality, Adult Survivors of Child Abuse, Translational Research, Biomedical, Chronic Pain
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