Cited by 268Pain Mechanisms and TreatmentsStress Responses and CortisolChild Abuse and Trauma

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Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms

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Burke, Nikita N., Finn, David P., McGuire, Brian E., Roche, Michelle·2017·Journal of Neuroscience Research

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Abstract

A wealth of research over the past 2 decades has expanded our understanding of the impact of early‐life adversity on physiological function and, consequently, health and wellbeing in later life. Early‐life adversity increases the risk of developing a number of disorders, such as chronic pain, fibromyalgia, and irritable bowel syndrome. Although much of the research has examined the impact of physical maltreatment, an increasing number of studies have been published over the past few years examining the effect of childhood psychological stress and trauma on the development of various types of chronic pain conditions. We review the clinical and preclinical data examining the link among early‐life psychological stress, altered nociceptive behavior, and chronic pain in later life. Evidence supporting a role for certain key neurobiological substrates, including the hypothalamic‐pituitary‐adrenal axis; monoaminergic, opioidergic, endocannabinoid and immune systems; and epigenetic mechanisms in the association between early‐life psychological stress and chronic pain, is provided. Greater understanding of the impact of early‐life stress may inform the development of personalized treatments for chronic pain in later life and strategies to prevent its onset in susceptible individuals. © 2016 Wiley Periodicals, Inc.

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Ganguly P, 2015, Broken or maladaptive?, Altered trajectories in neuroinflammation and behavior after early life adversity. Dev Cogn Neurosci, 11, 18

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Authors: Burke, N. N., Finn, D. P., McGuire, B. E., & Roche, M.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Roche, Michelle
ORCID: Burke, Nikita N.
Finn, David P.
McGuire, Brian E.
Roche, Michelle
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2016-07-12
Volume: 95
Issue: 6
Pages: 1257-1270
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.23802
OpenAlex: W2482083953
Cited by: 268
References: 157
Citations by year: 2026: 27 · 2025: 24 · 2024: 27 · 2023: 39 · 2022: 33 · 2021: 27 · 2020: 31 · 2019: 35 · 2018: 14 · 2017: 10 · 2016: 1
FWCI: 2.35
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
University of Galway Research Repository (submittedVersion, cc-by)
Funders: Science Foundation Ireland (#11/RFP/NES/3175, 10/IN.1/B2976)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: chronic pain, childhood trauma, childhood adversity, nociception, hypothalamic-pituitary-adrenal axis, monoaminergic systems, opioid system, endocannabinoid system, immune system, epigenetics, fibromyalgia, irritable bowel syndrome, pain prevention, personalized pain treatment
MeSH terms: Animals, Child, Humans, Neurobiology, Stress, Psychological, Causality, Adult Survivors of Child Abuse, Translational Research, Biomedical, Chronic Pain

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Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms

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