The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury
Abstract
Extracts of injured rat brain contained molecules that shared biological and physicochemical properties with interleukin‐1 (IL‐1). Brain IL‐1‐like activity increased following brain injury in parallel with the increase in astrocyte and fibroblast mitogenic activity. After 3 days postlesion, it reached about 20 times the basal (noninjured) level. Monoclonal antibodies to human IL‐1 inhibited this brain IL‐1‐like activity. One of the cellular sources of brain IL‐1‐like activity seems to be astroglial cells. Primary cultures of purified rat brain astrocytes secreted into the culture medium more IL‐1 activity than comparable numbers of peripheral blood monocytes. Brain IL‐1, as well as authentic monocyte IL‐1, appear to act on brain glial cells, promoting thymidine incorporation into purified astrocytes in culture.
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Cites
Interleukin 1 of the central nervous system is produced by ameboid microglia.
Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B. (1986) · The Journal of experimental medicine · doi:10.1084/jem.164.2.594 · Cited by 859
Cited by
Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion
Taupin, V., Toulmond, S., Serrano, A., Benavides, J., & Zavala, F. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90008-m · Cited by 512
Hefti, F., Hartikka, J., & Knusel, B. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90118-8 · Cited by 466
Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat
Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460
Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
Balasingam, V, Tejada-Berges, T., Wright, E., Bouckova, R., & Yong, V. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00846.1994 · Cited by 342
Rogers, J. T., Leiter, L. M., McPhee, J., Cahill, C. M., Zhan, S.-S., Potter, H., & Nilsson, L. N. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6421 · Cited by 290
Metadata
- Authors
- Nieto‐Sampedro, M., & Berman, M. A.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 1987-01
- Volume
- 17
- Issue
- 3
- Pages
- 214-219
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1974505155
- Cited by
- 177
- References
- 1
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nieto‐Sampedro, M., & Berman, M. A. (1987). Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.490170303
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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