Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences
Open accessAbstract
The amyloid precursor protein (APP) has been associated with Alzheimer's disease (AD) because APP is processed into the beta-peptide that accumulates in amyloid plaques, and APP gene mutations can cause early onset AD. Inflammation is also associated with AD as exemplified by increased expression of interleukin-1 (IL-1) in microglia in affected areas of the AD brain. Here we demonstrate that IL-1alpha and IL-1beta increase APP synthesis by up to 6-fold in primary human astrocytes and by 15-fold in human astrocytoma cells without changing the steady-state levels of APP mRNA. A 90-nucleotide sequence in the APP gene 5'-untranslated region (5'-UTR) conferred translational regulation by IL-1alpha and IL-1beta to a chloramphenicol acetyltransferase (CAT) reporter gene. Steady-state levels of transfected APP(5'-UTR)/CAT mRNAs were unchanged, whereas both base-line and IL-1-dependent CAT protein synthesis were increased. This APP mRNA translational enhancer maps from +55 to +144 nucleotides from the 5'-cap site and is homologous to related translational control elements in the 5'-UTR of the light and and heavy ferritin genes. Enhanced translation of APP mRNA provides a mechanism by which IL-1 influences the pathogenesis of AD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inflammatory proteins such as interleukin-1β, tumor necrosis factor-α, and interferon-γ can alter APP expression, APP processing, or Aβ transport.
“Because inflammatory proteins (e.g., interleukin-1β, tumor necrosis factor–α, and interferon-γ) can alter APP expression, APP processing, or Aβ transport (47–50), the inflammatory changes caused by the deletion of Abi3 locus may have contributed to the increase in APP protein level and subsequently Aβ accumulation.”
From Deletion of <i>Abi3</i> gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis (2021) · cites this paper as [49]
Cites
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619 · see citing works
Biologic basis for interleukin-1 in disease.
Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 3,380 · see citing works
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works
On Finding All Suboptimal Foldings of an RNA Molecule
Zuker, M. (1989) · Science · doi:10.1126/science.2468181 · Cited by 2,023 · see citing works
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works
Amyloid β-peptide is produced by cultured cells during normal metabolism
Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921 · see citing works
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works
Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757 · see citing works
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611 · see citing works
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159 · see citing works
Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 893 · see citing works
Self-citationGingras, A., Kennedy, S. G., O'Leary, M., Sonenberg, N., & Hay, N. (1998) · Genes & Development · doi:10.1101/gad.12.4.502 · Cited by 885 · see citing works
Ma, J., Yee, A., Brewer, H. B., Das, S., & Potter, H. (1994) · Nature · doi:10.1038/372092a0 · Cited by 871 · see citing works
Self-citationInterleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847 · see citing works
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830 · see citing works
Complement activation by beta-amyloid in Alzheimer disease.
Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works
Self-citationScavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727 · see citing works
β-Amyloid-mediated vasoactivity and vascular endothelial damage
Thomas, T., Thomas, G., McLendon, C., Sutton, T., & Mullan, M. (1996) · Nature · doi:10.1038/380168a0 · Cited by 703 · see citing works
The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)
Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C. L., & Beyreuther, K. T. (1996) · Science · doi:10.1126/science.271.5254.1406 · Cited by 677 · see citing works
Johnson‐Wood, K., Lee, M., Motter, R. N., Hu, K., Gordon, G., Barbour, R., Khan, K., Gordon, M. N., Tan, H. T., Games, D., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1550 · Cited by 634 · see citing works
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., DONNELLY, R. J., Jacobsen, J. S., Vitek, M. P., & Gajdusek, D. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7606 · Cited by 591 · see citing works
Selkoe, D. J., Podlisny, M. B., Joachim, C. L., Vickers, E., Lee, G. S., Fritz, L. C., & Oltersdorf, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7341 · Cited by 579 · see citing works
Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.
Busciglio, J., Gabuzda, D. H., Matsudaira, P., & Yankner, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2092 · Cited by 569 · see citing works
Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas‐Kramarski, R., JAFFE, E. A., Gandy, S., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10075 · Cited by 558 · see citing works
Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers.
Tokunaga, K., Nakamura, Y., Sakata, K., Fujimori, K., Ohkubo, M., Sawada, K., & Sakiyama, S. (1987) · PubMed · Cited by 537 · see citing works
Ameboid microglia as effectors of inflammation in the central nervous system
Giulian, D. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180123 · Cited by 482 · see citing works
Nonsteroidal anti-inflammatory drugs in Alzheimer's disease
Rich, J. B., Rasmusson, D. X., Folstein, M. F., Carson, K. A., Kawas, C., & Brandt, J. (1995) · Neurology · doi:10.1212/wnl.45.1.51 · Cited by 446 · see citing works
Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.
(1994) · PubMed Central · Cited by 441 · see citing works
βA4 amyloid protein deposition in brain after head trauma
Roberts, G., Gentleman, S., Lynch, A., & Graham, D. I. (1991) · The Lancet · doi:10.1016/0140-6736(91)92724-g · Cited by 440 · see citing works
Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., & Roses, A. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117407 · Cited by 404 · see citing works
Formation of β-amyloid protein deposits in brains of transgenic mice
Quon, D. H., Wang, Y., Catalano, R., Scardina, J. M., Murakami, K., & Cordell, B. (1991) · Nature · doi:10.1038/352239a0 · Cited by 397 · see citing works
Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage
Siman, R. G., Card, J. P., Nelson, R. B., & Davis, L. G. (1989) · Neuron · doi:10.1016/0896-6273(89)90252-3 · Cited by 344 · see citing works
Evans, K. C., Berger, E. P., Cho, C. G., Weisgraber, K. H., & Lansbury, P. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.763 · Cited by 333 · see citing works
Rouault, T. A., Stout, C. D., Kaptain, S., Harford, J. B., & Klausner, R. D. (1991) · Cell · doi:10.1016/0092-8674(91)90312-m · Cited by 296 · see citing works
Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?
Andersen, K., Launer, L. J., Ott, A., Hoes, A. W., Breteler, M. M. B., & Albert Hofman, D. (1995) · Neurology · doi:10.1212/wnl.45.8.1441 · Cited by 284 · see citing works
Sheng, J. G., Ito, K., Skinner, R. D., Mrak, R. E., Rovnaghi, C. R., van Eldik, L. J., & Griffin, W. S. T. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00104-2 · Cited by 269 · see citing works
Rogers, J. T., Bridges, K. R., Durmowicz, G. P., Glass, J., Auron, P. E., & Munro, H. N. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77341-9 · Cited by 260 · see citing works
Self-citationForloni, G., Demicheli, F., Giorgi, S., Bendotti, C., & Angeretti, N. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90202-m · Cited by 255 · see citing works
Ferritin Synthesis in Inflammation: I. PATHOGENESIS OF IMPAIRED IRON RELEASE
Konijn, A. M., & Hershko, C. (1977) · British Journal of Haematology · doi:10.1111/j.1365-2141.1977.tb08806.x · Cited by 247 · see citing works
Chandra, T., Stackhouse, R., Kidd, V. J., Robson, K., & Woo, S. L. C. (1983) · Biochemistry · doi:10.1021/bi00291a001 · Cited by 198 · see citing works
Cohen, M. L., Golde, T. E., Usiak, M., Younkin, L. H., & Younkin, S. G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1227 · Cited by 186 · see citing works
Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury
Nieto‐Sampedro, M., & Berman, M. A. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490170303 · Cited by 177 · see citing works
Das, S., & Potter, H. (1995) · Neuron · doi:10.1016/0896-6273(95)90300-3 · Cited by 166 · see citing works
Self-citationPantopoulos, K., Mueller, S., Atzberger, A., Ansorge, W. J., Stremmel, W., & Hentze, M. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9802 · Cited by 163 · see citing works
Leedman, P. J., Stein, A. R., Chin, W. W., & Rogers, J. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.12017 · Cited by 154 · see citing works
Self-citationRogers, J. (1996) · Blood · doi:10.1182/blood.v87.6.2525.bloodjournal8762525 · Cited by 154 · see citing works
Self-citationPhosphorylation and Activation of both Iron Regulatory Proteins 1 and 2 in HL-60 Cells
Schalinske, K. L., & Eisenstein, R. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.7168 · Cited by 125 · see citing works
Gray, C. W., & Patel, A. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90037-p · Cited by 113 · see citing works
Zaidi, S. H. E., & Malter, J. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17292 · Cited by 110 · see citing works
Moir, R. D., Lynch, T., Bush, A. I., Whyte, S., Henry, A., Portbury, S. D., Multhaup, G., Small, D. H., Tanzi, R. E., Beyreuther, K. T., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5013 · Cited by 103 · see citing works
Interleukin-1: a gene expression system regulated at multiple levels.
Auron, P. E., & Webb, A. C. (1995) · PubMed · Cited by 94 · see citing works
Iron Levels Modulate α‐Secretase Cleavage of Amyloid Precursor Protein
Bodovitz, S., Falduto, M. T., Frail, D. E., & Klein, W. L. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64010307.x · Cited by 86 · see citing works
Blom, M. A. A., van Twillert, M. G. H., de Vries, S. C., Engels, F., Finch, C. E., Veerhuis, R., & Eikelenboom, P. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01204-3 · Cited by 79 · see citing works
LeBlanc, A. C., Chen, H. Y., AUTILIO‐GAMBETTI, L., & Gambetti, P. L. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80861-v · Cited by 76 · see citing works
Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.
Holtzman, D. M., Bayney, R. M., Li, Y. W., Khosrovi, H., Berger, C. N., Epstein, C. J., & Mobley, W. C. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05094.x · Cited by 68 · see citing works
Alternative polyadenylation of the amyloid protein precursor mRNA regulates translation.
de Sauvage, F. J., Kruys, V., Marinx, O., Huez, G. A., & Octave, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05382.x · Cited by 57 · see citing works
Rogers, J. T., Andriotakis, J., Lacroix, L., Durmowicz, G. P., Kasschau, K., & Bridges, K. R. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.13.2678 · Cited by 55 · see citing works
Self-citationThe predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2.
Nostrand, W. E. V., Farrow, J. S., Wagner, S. L., Bhasin, R., Goldgaber, D., Cotman, C. W., & Cunningham, D. D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10302 · Cited by 52 · see citing works
A specific structural interaction of Alzheimer's peptide Aβ1–42 with α1-antichymotrypsin
Janciauskiene, S. M., Eriksson, S., & Wright, H. T. (1996) · Nature Structural & Molecular Biology · doi:10.1038/nsb0896-668 · Cited by 51 · see citing works
HB-GAM is a cytokine present in Alzheimerʼs and Downʼs syndrome lesions
Wısnıewskı, T., Lalowski, M. M., Baumann, M., Rauvala, H., Raulo, E., Nolo, R. M., & Frangione, B. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00068 · Cited by 43 · see citing works
Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains
Johnston, J. A., Norgren, S., Ravid, R., Wasco, W., Winblad, B. G., Lannfelt, L., & Cowburn, R. F. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00161-1 · Cited by 28 · see citing works
Machein, U., Lieb, K., Hüll, M., & Fiebich, B. L. (1995) · Neuroreport · doi:10.1097/00001756-199511270-00004 · Cited by 27 · see citing works
Neve, R. L., Valletta, J. S., Li, Y., Ventosa-Michelman, M., Holtzman, D. M., & Mobley, W. C. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00007-1 · Cited by 19 · see citing works
A new quantitative solution hybridisation-RNase protection assay for APP and APLP2 mRNA
Johnston, J. A., Norgren, S., Annerén, G., Cowburn, R. F., & Lannfelt, L. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00160-x · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · see citing works
“The APP transgene includes the 5 untranslated region, which contains a putative interleukin-1 (IL-1 ) translational enhancer element (Rogers et al., 1999).”
BackgroundLee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works
History and progress of hypotheses and clinical trials for Alzheimer’s disease
Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723 · see citing works
Chin-Chan, M., Navarro-Yepes, J., & Quintanilla‐Vega, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00124 · Cited by 712 · see citing works
Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
Belaidi, A. A., & Bush, A. I. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13425 · Cited by 580 · see citing works
Inflammatory processes in Alzheimer's disease
Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works
The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
Shaftel, S. S., Griffin, W. S. T., & O'Banion, M. K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-7 · Cited by 565 · see citing works
Rogers, J. T., Randall, J. D., Cahill, C. M., Eder, P. S., Huang, X., Gunshin, H., Leiter, L., McPhee, J., Sarang, S. S., Utsuki, T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207435200 · Cited by 551 · see citing works
Self-citationStriking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Masaldan, S., Bush, A. I., Devos, D., Rolland, A., & Moreau, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.033 · Cited by 485 · see citing works
Kozłowski, H., Janicka-Kłos, A., Brasuń, J., Gaggelli, E., Valensin, D., & Valensin, G. (2009) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2009.05.011 · Cited by 467 · see citing works
The role of astrocytes in amyloid production and Alzheimer's disease
Frost, G. R., & Li, Y. (2017) · Open Biology · doi:10.1098/rsob.170228 · Cited by 435 · see citing works
Alzheimer’s disease pathogenesis and therapeutic interventions
Parihar, M. S., & Hemnani, T. (2004) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2003.12.007 · Cited by 434 · see citing works
Neuroinflammatory processes in Alzheimer’s disease
Heneka, M. T., O’Banion, M. K., Terwel, D., & Kummer, M. P. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0438-z · Cited by 433 · see citing works
Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., Miller, J.-N. H., Johnson, R. E., & O’Banion, M. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31450 · Cited by 433 · see citing works
Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms
Sastre, M., Klockgether, T., & Heneka, M. T. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.014 · Cited by 426 · see citing works
Neuroinflammation in Alzheimer's disease and prion disease
Eikelenboom, P., Bate, C., van Gool, W. A., Hoozemans, J. J. M., Rozemüller, A. J. M., Veerhuis, R., & Williams, A. (2002) · Glia · doi:10.1002/glia.10146 · Cited by 402 · see citing works
Ghosh, S., Wu, M. D., Shaftel, S. S., Kyrkanides, S., LaFerla, F. M., Olschowka, J. A., & O'Banion, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4361-12.2013 · Cited by 390 · see citing works
The Janus face of glial-derived S100B: Beneficial and detrimental functions in the brain
Eldik, L. J. V., & Wainwright, M. S. (2003) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2003-00230 · Cited by 384 · see citing works
Blasko, I., Stampfer‐Kountchev, M., Robatscher, P., Veerhuis, R., Eikelenboom, P., & Grubeck‐Loebenstein, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00101.x · Cited by 374 · see citing works
Zhao, J. J., O’Connor, T., & Vassar, R. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-150 · Cited by 370 · see citing works
The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease
Miranda, S., Opazo, C., Larrondo, L. F., Muñoz, F. J., Ruiz, F., Leighton, F., & Inestrosa, N. C. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00015-0 · Cited by 369 · see citing works
Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., LEUVEN, F. V., & Heneka, M. T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09796.2003 · Cited by 359 · see citing works
Calderón‐Garcidueñas, L., Maronpot, R. R., Torres‐Jardón, R., Henríquez-Roldán, C. F., Schoonhoven, R., Acuña-Ayala, H., Villarreal-Calderón, A., Nakamura, J., Fernando, R. A., Reed, W., et al. (2003) · Toxicologic Pathology · doi:10.1080/01926230390226645 · Cited by 350 · see citing works
Perry, T., Lahiri, D. K., Sambamurti, K., Chen, D., Mattson, M. P., Egan, J. M., & Greig, N. H. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10611 · Cited by 347 · see citing works
Patel, N. S., Paris, D., Mathura, V. S., Quadros, A., Crawford, F., & MULLAN, M. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-9 · Cited by 318 · see citing works
Neuroinflammation in Alzheimer&rsquo;s disease
Zhang, F., & Jiang, L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75546 · Cited by 276 · see citing works
Xia, M. Q., Bacskai, B. J., Knowles, R. B., Qin, S. X., & Hyman, B. T. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00285-x · Cited by 269 · see citing works
Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders
Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258 · see citing works
Blasko, I., Veerhuis, R., Stampfer-Kountchev, M., Saurwein-Teissl, M., Eikelenboom, P., & Grubeck-Loebenstein, B. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0321 · Cited by 258 · see citing works
Michaud, J.-P., Hallé, M., Lampron, A., Thériault, P., Préfontaine, P., Filali, M., Tribout-Jover, P., Lanteigne, A.-M., Jodoin, R., Cluff, C. W., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215165110 · Cited by 251 · see citing works
Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
Frankola, K. A., Greig, N. H., Luo, W., & Tweedie, D. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794653751 · Cited by 252 · see citing works
Griffin, W. S. T., & Mrak, R. E. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.2.233 · Cited by 248 · see citing works
Bates, K. A., Verdile, G., Li, Q.-X., Ames, D., Hudson, P., Masters, C. L., & Martins, R. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.96 · Cited by 247 · see citing works
Szczepanik, A. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00404-5 · Cited by 243 · see citing works
Wu, Z., Ni, J., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A. W., Ibbett, P., & Nakanishi, H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.002 · Cited by 239 · see citing works
MicroRNA-101 Regulates Amyloid Precursor Protein Expression in Hippocampal Neurons
Vilardo, E., Barbato, C., Ciotti, M., Cogoni, C., & Ruberti, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.112664 · Cited by 238 · see citing works
Iron and neurodegenerative disorders
Thompson, K. J., Shoham, S., & Connor, J. R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00510-x · Cited by 235 · see citing works
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
Mancuso, R., Fryatt, G., Cleal, M., Obst, J., Pipi, E., Monzón-Sandoval, J., Ribe, E., Winchester, L., Webber, C., Nevado, A., et al. (2019) · Brain · doi:10.1093/brain/awz241 · Cited by 235 · see citing works
Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production
Kim, S. H., Smith, C. J., & Eldik, L. J. V. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00126-x · Cited by 234 · see citing works
Current drug targets for Alzheimer's disease treatment
Lahiri, D. K., Farlow, M. R., Greig, N. H., & Sambamurti, K. (2002) · Drug Development Research · doi:10.1002/ddr.10081 · Cited by 220 · see citing works
Translational pathophysiology: a novel molecular mechanism of human disease
Cazzola, M., & Skoda, R. C. (2000) · Blood · doi:10.1182/blood.v95.11.3280 · Cited by 222 · see citing works
Metabolism of amyloid-β peptide and Alzheimer's disease
Iwata, N., Higuchi, M., & Saido, T. C. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.03.010 · Cited by 216 · see citing works
Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks
Domingues, C., Silva, O. A. B. D. C. E., & Henriques, A. G. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170317113606 · Cited by 212 · see citing works
Li, Y., Liu, L., Kang, J., Sheng, J. G., Barger, S. W., Mrak, R. E., & Griffin, W. S. T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00149.2000 · Cited by 209 · see citing works
Metals ions and neurodegeneration
Molina‐Holgado, F., Hider, R. C., Gaeta, A., Williams, R., & Francis, P. T. (2007) · BioMetals · doi:10.1007/s10534-006-9033-z · Cited by 207 · see citing works
Shaw, K. T. Y., Utsuki, T., Rogers, J. T., Yu, Q., Sambamurti, K., Brossi, A. R., Ge, Y., Lahiri, D. K., & Greig, N. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131152998 · Cited by 206 · see citing works
Self-citationMicroRNAs can regulate human APP levels
Patel, N., Hoang, D. M., Miller, N., Ansaloni, S., Huang, Q., Rogers, J. T., Lee, J. C., & Saunders, A. J. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-10 · Cited by 205 · see citing works
Self-citationLong, J. M., Ray, B., & Lahiri, D. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.366336 · Cited by 198 · see citing works
Brain Iron Toxicity: Differential Responses of Astrocytes, Neurons, and Endothelial Cells
Lockman, J. A., Lockman, P. R., Geldenhuys, W. J., Allen, D. D., & der Schyf, C. J. V. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9290-4 · Cited by 190 · see citing works
Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms
Rommy von Bernhardi, M., & Eugenín, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4082 · Cited by 189 · see citing works
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
Sambamurti, K., Greig, N. H., & Lahiri, D. K. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:1:1:1 · Cited by 184 · see citing works
Ashok, A., Rai, N. K., Tripathi, S., & Bandyopadhyay, S. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfu208 · Cited by 177 · see citing works
The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease
Jiang, Q., Heneka, M. T., & Landreth, G. E. (2008) · CNS Drugs · doi:10.2165/00023210-200822010-00001 · Cited by 174 · see citing works
Sly, L. M., KRZESICKI, R. F., Brashler, J. R., Buhl, A.-L., McKinley, D. D., Carter, D. B., & Chin, J. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00730-4 · Cited by 174 · see citing works
Interactions between APP secretases and inflammatory mediators
Sastre, M., Walter, J., & Gentleman, S. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-25 · Cited by 172 · see citing works
Chami, L., & Checler, F. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-52 · Cited by 168 · see citing works
Schliebs, R. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6962-9 · Cited by 167 · see citing works
Ting, K. K., Brew, B. J., & Guillemin, G. J. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-36 · Cited by 166 · see citing works
Mandel, S., Amit, T., Bar-Am, O., & Youdim, M. B. H. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.001 · Cited by 164 · see citing works
Song, C., Li, X., Leonard, B. E., & Horrobin, D. F. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300217-jlr200 · Cited by 161 · see citing works
Increased production of inflammatory cytokines in mild cognitive impairment
Magaki, S., Mueller, C., DICKSON, C., & Kirsch, W. M. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.015 · Cited by 156 · see citing works
Rogers, J. T., Bush, A. I., Cho, H.-H., Smith, D. H., Thomson, A. M., Friedlich, A. L., Lahiri, D. K., Leedman, P. J., Huang, X., & Cahill, C. M. (2008) · Biochemical Society Transactions · doi:10.1042/bst0361282 · Cited by 148 · see citing works
Self-citationIron and iron management proteins in neurobiology
Connor, J. R., Menzies, S. L., Burdo, J. R., & Boyer, P. J. (2001) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00303-4 · Cited by 173 · see citing works
Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease
Moore, A. H., & O’Banion, M. K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00162-x · Cited by 146 · see citing works
Regulated Intramembrane Proteolysis of the Interleukin-1 Receptor II by α-, β-, and γ-Secretase
Kuhn, P., Marjaux, E., Imhof, A., Strooper, B. D., Haass, C., & Lichtenthaler, S. F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700356200 · Cited by 144 · see citing works
Long, J. M., Maloney, B., Rogers, J. T., & Lahiri, D. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0266-3 · Cited by 141 · see citing works
Self-citationQin, K., Yang, Y., Mastrangelo, P., & Westaway, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108744200 · Cited by 140 · see citing works
Glial cell dysregulation: a new perspective on Alzheimer disease
Rommy von Bernhardi, M. (2007) · Neurotoxicity Research · doi:10.1007/bf03033906 · Cited by 138 · see citing works
Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration
Fujioka, M., Taoka, T., Matsuo, Y., Mishima, K., Ogoshi, K., Kondo, Y., Tsuda, M., Fujiwara, M., Asano, T., Sakaki, T., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10751 · Cited by 138 · see citing works
Nilsson, L. N. G., Bales, K. R., DiCarlo, G., Gordon, M. N., Morgan, D., Paul, S. M., & Potter, H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01444.2001 · Cited by 137 · see citing works
Self-citationLahiri, D. K., Chen, D., Maloney, B., Holloway, H. W., Yu, Q.-S., Utsuki, T., Giordano, T., Sambamurti, K., & Greig, N. H. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.112102 · Cited by 134 · see citing works
Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery
Cervellati, C., Trentini, A., Pecorelli, A., & Valacchi, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8076 · Cited by 137 · see citing works
Oshiro, S., Morioka, M. S., & Kikuchi, M. (2011) · Advances in Pharmacological Sciences · doi:10.1155/2011/378278 · Cited by 134 · see citing works
Alzheimer's Mechanisms in Ischemic Brain Degeneration
Pluta, R. M., Ułamek, M., & Jabłoński, M. (2009) · The Anatomical Record · doi:10.1002/ar.21018 · Cited by 132 · see citing works
Amit, T., Avramovich‐Tirosh, Y., Youdim, M. B. H., & Mandel, S. (2008) · The FASEB Journal · doi:10.1096/fj.07-8627rev · Cited by 126 · see citing works
Alasmari, F., Alshammari, M. A., Alasmari, A. F., Alanazi, W. A., & Alhazzani, K. (2018) · BioMed Research International · doi:10.1155/2018/3087475 · Cited by 125 · see citing works
Veerhuis, R., Van Breemen, M. J., Hoozemans, J. J., Morbin, M., Ouladhadj, J., Tagliavini, F., & Eikelenboom, P. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0624-7 · Cited by 123 · see citing works
Synergistic protection of PC12 cells from β-amyloid toxicity by resveratrol and catechin
Conte, A., Pellegrini, S., & Tagliazucchi, D. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.08.001 · Cited by 124 · see citing works
Padmanabhan, J., Levy, M. M., Dickson, D. W., & Potter, H. (2006) · Brain · doi:10.1093/brain/awl255 · Cited by 123 · see citing works
Self-citationRay, B., Long, J. M., Sokol, D. K., & Lahiri, D. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020405 · Cited by 119 · see citing works
Ullah, F., Liang, A., Rangel, A., Gyengési, E., Niedermayer, G., & Münch, G. W. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1939-4 · Cited by 119 · see citing works
COYLE, J. T., & Schwarcz, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.90 · Cited by 113 · see citing works
The molecular basis of the prevention of Alzheimer's disease through healthy nutrition.
Steele, M. L., Stuchbury, G., & Münch, G. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.002 · Cited by 127 · see citing works
Song, C., Manku, M. S., & Horrobin, D. F. (2008) · Journal of Nutrition · doi:10.1093/jn/138.5.954 · Cited by 108 · see citing works
Mrak, R. E., & Griffin, W. S. T. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.679 · Cited by 108 · see citing works
Cahill, C. M., Lahiri, D. K., Huang, X., & Rogers, J. T. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.12.001 · Cited by 107 · see citing works
Self-citationCellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease
Masaldan, S., Belaidi, A. A., Ayton, S., & Bush, A. I. (2019) · Pharmaceuticals · doi:10.3390/ph12020093 · Cited by 103 · see citing works
Hu, J., & Eldik, L. J. V. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01804-1 · Cited by 101 · see citing works
Greig, N. H., Mattson, M. P., Perry, T., Chan, S. L., Giordano, T., Sambamurti, K., Rogers, J. T., Ovadia, H., & Lahiri, D. K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.018 · Cited by 98 · see citing works
Self-citationNillert, N., Pannangrong, W., Welbat, J. U., Chaijaroonkhanarak, W., Sripanidkulchai, K., & Sripanidkulchai, B. (2017) · Nutrients · doi:10.3390/nu9010024 · Cited by 99 · see citing works
Mechanisms by which metals promote events connected to neurodegenerative diseases
Campbell, A., Smith, M. A., Sayre, L. M., Bondy, S. C., & Perry, G. L. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00455-5 · Cited by 96 · see citing works
Interleukins, Inflammation, and Mechanisms of Alzheimer's Disease
Weisman, D., Hakimian, E., & Ho, G. J. (2006) · Vitamins & Hormones · doi:10.1016/s0083-6729(06)74020-1 · Cited by 95 · see citing works
Brain Iron Metabolism and Neurodegenerative Disorders
Sipe, J. C., Lee, P. L., & Beutler, E. (2002) · Developmental Neuroscience · doi:10.1159/000065701 · Cited by 94 · see citing works
Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease
Ray, B., Maloney, B., Sambamurti, K., Karnati, H. K., Nelson, P. T., Greig, N. H., & Lahiri, D. K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0709-x · Cited by 91 · see citing works
Unregulated inflammation shortens human functional longevity
Brod, S. A. (2000) · Inflammation Research · doi:10.1007/s000110050632 · Cited by 91 · see citing works
Aminopyridazines inhibit β-amyloid-induced glial activation and neuronal damage in vivo
Craft, J. M., Watterson, D. M., Frautschy, S. A., & Eldik, L. J. V. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.01.006 · Cited by 91 · see citing works
Szczepanik, A. M., Rampe, D., & Ringheim, G. E. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00240.x · Cited by 87 · see citing works
Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories
Doherty, G. H. (2011) · Neuroscience Bulletin · doi:10.1007/s12264-011-1530-6 · Cited by 87 · see citing works
Potter, H. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00308-6 · Cited by 87 · see citing works
Self-citation
- Authors
- Rogers, J. T., Leiter, L. M., McPhee, J., Cahill, C. M., Zhan, S.-S., Potter, H., & Nilsson, L. N. G.
- Affiliations
- Brigham and Women's Hospital (US)
- Massachusetts General Hospital (US)
- University of South Florida (US)
- Corresponding author
- Rogers, Jack T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 274
- Issue
- 10
- Pages
- 6421-6431
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2149650428
- Cited by
- 290
- References
- 66
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 9 · 2013: 7 · 2012: 13
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (6872302)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR29I32717)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- amyloid precursor protein, Alzheimer's disease, interleukin-1, translational regulation, 5' untranslated region, translational enhancer, astrocytes, astrocytoma cells, IL-1α, IL-1β, inflammation, ferritin gene, mRNA translation
- MeSH terms
- Alzheimer Disease, Astrocytes, Base Sequence, Cells, Cultured, Humans, Interleukin-1, Molecular Sequence Data, RNA, Messenger, Transfection, Protein Biosynthesis, Up-Regulation, Amyloid beta-Protein Precursor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review