Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?
Abstract
The presence and cellular localization of interleukin-1 beta immunoreactivity (irIL-1) in and around the brain was investigated using immunocytochemistry on Bouin's fixed vibratome brain sections of control and endotoxin-treated rats. Peripheral administration of endotoxin resulted in the appearance of irIL-1 in cells in the meninges, choroid plexus, brain blood vessels and in non-neuronal cells in the brain parenchyma. Using monoclonal and polyclonal antibodies to macrophage and astrocyte antigens, the endotoxin-induced irIL-1 positive cells could be identified as macrophages in the meninges and choroid plexus (ED2), perivascular cells (ED2) and ramified microglial cells (GSA-I-B4 isolectin). Our data demonstrate a pathway for the induction of non-specific sickness symptoms in response to endotoxin.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
Hickey, W. F., & Kimura, H. (1988) · Science · doi:10.1126/science.3276004 · Cited by 1,466 · see citing works
Stress and immunity: An integrated view of relationships between the brain and the immune system
Dantzer, R., & Kelley, K. W. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90345-7 · Cited by 534 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Immune-neuro-endocrine interactions: facts and hypotheses.
BESEDOVSKY, H. O., & REY, A. D. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-64 · Cited by 1,564 · see citing works
Control of brain development, function, and behavior by the microbiome
Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093 · see citing works
Cytokine-induced sickness behavior: where do we stand?
Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862 · see citing works
Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity
Dantzer, R. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.040 · Cited by 743 · see citing works
Cytokines and their relationship to the symptoms and outcome of cancer
Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2507 · Cited by 652 · see citing works
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works
The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders
Knezevic, E., Nenic, K., Milanovic, V., & Knezevic, N. N. (2023) · Cells · doi:10.3390/cells12232726 · Cited by 564 · see citing works
“IL-1 beta promotes proinflammatory genes and proteins in the brain [106–108], as well as IL-1 beta-induced sickness behavior in rodents, resulting in social withdrawal, loss of appetite, decreased motor activity, and a decrease in cognitive function [109] (see Table 1).”
BackgroundVagal immune-to-brain communication: a visceral chemosensory pathway
Goehler, L. E., Gaykema, R. P. A., Hansen, M. K., Anderson, K., Maier, S. F., & Watkins, L. R. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00219-8 · Cited by 525 · see citing works
Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat
Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460 · see citing works
Walker, A. K., Budac, D. P., Bisulco, S., Lee, A. W., Smith, R. A., Beenders, B., Kelley, K. W., & Dantzer, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.71 · Cited by 432 · see citing works
Dantzer, R., Konsman, J.-P., Bluthé, R.-M., & Kelley, K. W. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00220-4 · Cited by 400 · see citing works
Immune and neuroendocrine mechanisms of stress vulnerability and resilience
Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374 · see citing works
Cytokine, sickness behavior, and depression
Dantzer, R. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.003 · Cited by 340 · see citing works
Maier, S. F. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00032-1 · Cited by 300 · see citing works
Tilders, F. J. H., DeRuk, R. H., Van Dam, A.-M., Vincent, V. A. M., Schotanus, K., & Persoons, J. H. A. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90010-8 · Cited by 277 · see citing works
Molecular Basis of Sickness Behavior<sup>a</sup>
DANTZER, R., BLUTHÉ, R., GHEUSI, G., CREMONA, S., LAYÉ, S., PARNET, P., & KELLEY, K. W. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08321.x · Cited by 249 · see citing works
Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
Rothwell, N. J., Luheshi, G., & Toulmond, S. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02033-0 · Cited by 233 · see citing works
Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin
Maier, S. F., Wiertelak, E. P., Martin, D., & Watkins, L. R. (1993) · Brain Research · doi:10.1016/0006-8993(93)91446-y · Cited by 210 · see citing works
Molecular links between endocrine, nervous and immune system during chronic stress
Zefferino, R., Di Gioia, S., & Conese, M. (2021) · Brain and Behavior · doi:10.1002/brb3.1960 · Cited by 204 · see citing works
How and why do T cells and their derived cytokines affect the injured and healthy brain?
Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.39 · Cited by 199 · see citing works
Gut microbiota composition is associated with temperament traits in infants
Aatsinki, A.-K., Lahti, L., Uusitupa, H.-M., Munukka, E., Keskitalo, A., Nolvi, S., O'Mahony, S., Pietilä, S., Elo, L. L., Eerola, E., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.035 · Cited by 148 · see citing works
Nguyen, K. T., Deak, T., Will, M. J., Hansen, M. K., Hunsaker, B. N., Fleshner, M., Watkins, L. R., & Maier, S. F. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02443-9 · Cited by 143 · see citing works
Neuroendocrine Regulation of Brain Cytokines After Psychological Stress
Johnson, J. D., Barnard, D. F., Kulp, A. C., & Mehta, D. M. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00053 · Cited by 135 · see citing works
Goujon, E., Parnet, P., Layé, S., Combe, C., & Dantzer, R. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00242-k · Cited by 128 · see citing works
KAPCALA, L. P., CHAUTARD, T., & ESKAY, R. L. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44699.x · Cited by 103 · see citing works
Lyons, A., McQuillan, K., Deighan, B. F., O’Reilly, J.-A., Downer, E. J., Murphy, A. C., Watson, M., Piazza, A., O’Connell, F., Griffin, R., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.060 · Cited by 98 · see citing works
Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation
Rummel, C., Inoue, W., Poole, S., & Luheshi, G. N. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.98 · Cited by 88 · see citing works
Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00398 · Cited by 85 · see citing works
Self-citationCoelho, A.-M., Fioramonti, J., & Bueno, L. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00269-0 · Cited by 31 · see citing works
- Authors
- van Dam, A.-M., Brouns, M., Louisse, S., & Berkenbosch, F.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Berkenbosch, Frank
- ORCID
- Brouns, Madeleine
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1992-08
- Volume
- 588
- Issue
- 2
- Pages
- 291-296
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2029078097
- Cited by
- 333
- References
- 2
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 7
- FWCI
- 17.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- IL-1β, macrophages, ramified microglia, endotoxin, sickness behavior, meninges, choroid plexus, perivascular cells, cerebral vasculature, astrocytes, neuroinflammation
- MeSH terms
- Animals, Brain, Endotoxins, Immunohistochemistry, Interleukin-1, Macrophages, Male, Neuroglia, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
