Ultrasonic-activated micellar drug delivery for cancer treatment
Open accessAbstract
The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective nanocarrier allows for the delivery of a high concentration of potent medications to targeted tissue while minimizing the side effect of the agent to the rest of the body. Polymeric micelles have been shown to encapsulate therapeutic agents and maintain their structural integrity at lower concentrations. Ultrasound is currently being used in drug delivery as well as diagnostics, and has many advantages that elevate its importance in drug delivery. The technique is noninvasive, thus no surgery is needed; the ultrasonic waves can be easily controlled by advanced electronic technology so that they can be focused on the desired target volume. Additionally, the physics of ultrasound are widely used and well understood; thus ultrasonic application can be tailored towards a particular drug delivery system. In this article, we review the recent progress made in research that utilizes both polymeric micelles and ultrasonic power in drug delivery.
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Several works have been reported on increasing drug delivery under ultrasound because of improved tissue penetration, correlation the features of cell membrane perturbation, and drug release.
“Several works have been reported thus far on increasing drug delivery under ultrasound because of improved tissue penetration, correlation the features of cell membrane perturbation, and drug release [202,203,204,205].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [204]
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High-resolution scanning electron microscopic evaluation of cell-membrane porosity by ultrasound.
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Plasma Membrane Disruption Underlies Injury of the Corneal Endothelium by Ultrasound
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Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas
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Micelles in Anticancer Drug Delivery
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Induction of apoptotic cell DNA fragmentation in human cells after treatment with hyperthermia
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Sequestration and Ultrasound-Induced Release of Doxorubicin from Stabilized Pluronic P105 Micelles
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Self-citationNonthermal issues: Cavitation—Its nature, detection and measurement
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Polymeric contrast agent with targeting potential
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Thresholds for hemorrhages in mouse skin and intestine induced by lithotripter shock waves
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Ultrasonic enhancement of antibiotic action on several species of bacteria.
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Reducing bacterial resistance to antibiotics with ultrasound
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Self-citationInvestigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
Husseini, G. A., Runyan, C. M., & Pitt, W. G. (2002) · BMC Cancer · doi:10.1186/1471-2407-2-20 · Cited by 53 · see citing works
Self-citationAnti-GAD antibody targeted non-viral gene delivery to islet beta cells
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Treatment of bacterial biofilms on polymeric biomaterials using antibiotics and ultrasound
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Self-citationIntracellular uptake of Pluronic copolymer: effects of the aggregation state
Muniruzzaman, M., Marin, A., Luo, Y., Prestwich, G. D., Pitt, W. G., Husseini, G. A., & Rapoport, N. Y. (2002) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(01)00329-0 · Cited by 46 · see citing works
Self-citationThermally reversible polymer gels for biohybrid artificial pancreas
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Self-citationNecrotic dna degradation mimics apoptotic nucleosomal fragmentation comet tail length
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Ultrasonically induced gas bubble production in agar based gels: Part I, experimental investigation
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Long-circulating poly(ethylene glycol)-coated emulsions to target solid tumors
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The role of insonation intensity in acoustic-enhanced antibiotic treatment of bacterial biofilms
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Thresholds for nonthermal bioeffects: Theoretical and experimental basis for a threshold index
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Flagged first, then by citations
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Cited by
Sorted by citations
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Recent Advances in Nanomicelles Delivery Systems.
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Ultrasonically triggered drug delivery: Breaking the barrier
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Self-citation
- Authors
- Husseini, G. A., & Pitt, W. G.
- Affiliations
- Brigham Young University (US)
- Corresponding author
- Husseini, Ghaleb A.
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 98
- Issue
- 3
- Pages
- 795-811
- ISSN
- 0022-3549 (ISSN-L)
- PMC
- PMC2635419
- OpenAlex
- W2094567694
- Cited by
- 83
- References
- 148
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 5
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace at AUS (American University of Sharjah) (acceptedVersion)
- DSpace at AUS (American University of Sharjah) (submittedVersion)
- Funders
- National Cancer Institute (CA98138, R01CA098138)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- polymeric micelles, micellar drug delivery, cancer therapy, nanocarriers, targeted drug delivery, drug encapsulation
- MeSH terms
- Animals, Drug Therapy, Humans, Micelles, Surface-Active Agents, Ultrasonics, Drug Delivery Systems
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