Cited by 83Ultrasound and Hyperthermia ApplicationsNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

Ultrasonic-activated micellar drug delivery for cancer treatment

Open access
Husseini, Ghaleb A., Pitt, William G.·2009·Journal of Pharmaceutical Sciences

Abstract

The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective nanocarrier allows for the delivery of a high concentration of potent medications to targeted tissue while minimizing the side effect of the agent to the rest of the body. Polymeric micelles have been shown to encapsulate therapeutic agents and maintain their structural integrity at lower concentrations. Ultrasound is currently being used in drug delivery as well as diagnostics, and has many advantages that elevate its importance in drug delivery. The technique is noninvasive, thus no surgery is needed; the ultrasonic waves can be easily controlled by advanced electronic technology so that they can be focused on the desired target volume. Additionally, the physics of ultrasound are widely used and well understood; thus ultrasonic application can be tailored towards a particular drug delivery system. In this article, we review the recent progress made in research that utilizes both polymeric micelles and ultrasonic power in drug delivery.

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  • Several works have been reported on increasing drug delivery under ultrasound because of improved tissue penetration, correlation the features of cell membrane perturbation, and drug release.

    “Several works have been reported thus far on increasing drug delivery under ultrasound because of improved tissue penetration, correlation the features of cell membrane perturbation, and drug release [202,203,204,205].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [204]

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Research works printed but not linked: 5

  1. [36]Leroux JC 2007 Injectable nanocarriers for biodetoxification Nature Nanotechnology 2 11 679 684 18654405
  2. [61]Batrakova E Li S Li Y Alkhov VY Elmquist W Kabanov AV 2004 Distribution kinetics of micelle-forming bock copolymer pluronic 185 J Control Release 100 389 397 15567504
  3. [62]Rapoport N Munshi N Pitt WG 3rd International Symposium on Polymer Therapeutics London 1998 32
  4. [64]Rapoport N Pitina L Munshi N Pitt WG 8th International Symposium on Recent Advances in Drug Delivery Systems Salt Lake City, Utah 1997 260 261
  5. [89]Rapoport N Christensen DA Fain HD Barrows L Gao Z 2004 Ultrasound-triggered drug targeting of tumors in vitro and in vivo Ultrasoincs 42 943 950 15047411

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Authors
Husseini, G. A., & Pitt, W. G.
Affiliations
Brigham Young University (US)
Corresponding author
Husseini, Ghaleb A.
Venue
Journal of Pharmaceutical Sciences
Publisher
Elsevier BV
Published
2009-03
Volume
98
Issue
3
Pages
795-811
ISSN
0022-3549 (ISSN-L)
OpenAlex
W2094567694
Cited by
83
References
148
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 5
FWCI
0.31
Type
journal article
Language
en
Open access
Locations
  • Journal of Pharmaceutical Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace at AUS (American University of Sharjah) (acceptedVersion)
  • DSpace at AUS (American University of Sharjah) (submittedVersion)
Funders
National Cancer Institute (CA98138, R01CA098138)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
polymeric micelles, micellar drug delivery, cancer therapy, nanocarriers, targeted drug delivery, drug encapsulation
MeSH terms
Animals, Drug Therapy, Humans, Micelles, Surface-Active Agents, Ultrasonics, Drug Delivery Systems

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