Nonviral methods for siRNA delivery

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.

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RNAi-mediated gene silencing in non-human primates

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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Transvascular delivery of small interfering RNA to the central nervous system

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Interfering with disease: a progress report on siRNA-based therapeutics

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

Morrissey, D. V., Lockridge, J. A., Shaw, L., Blanchard, K. S., Jensen, K., Breen, W., Hartsough, K. C., Machemer, L., Radka, S. F., Jadhav, V., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1122 · Cited by 1,168 · see citing works

Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection,

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RNA interference targeting Fas protects mice from fulminant hepatitis

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RNAi therapeutics: a potential new class of pharmaceutical drugs

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Strategies for silencing human disease using RNA interference

Kim, D. H., & Rossi, J. J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2006 · Cited by 1,078 · see citing works

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

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Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras

McNamara, J. O., Andrechek, E. R., Wang, Y., Viles, K. D., Rempel, R. E., Gilboa, E., Sullenger, B. A., & Giangrande, P. H. (2006) · Nature Biotechnology · doi:10.1038/nbt1223 · Cited by 1,005 · see citing works

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

Wolfrum, C., Shi, S., Jayaprakash, K. N., Jayaraman, M., Wang, G., Pandey, R. K., Rajeev, K. G., Nakayama, T., Charrise, K., Ndungo, E. M., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1339 · Cited by 974 · see citing works

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

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RNAi therapeutics: Principles, prospects and challenges

Aagaard, L., & Rossi, J. J. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.005 · Cited by 895 · see citing works

Inhibition of respiratory viruses by nasally administered siRNA

Bitko, V., Musiyenko, A., Shulyayeva, O., & Barik, S. (2004) · Nature Medicine · doi:10.1038/nm1164 · Cited by 725 · see citing works

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

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In vivo imaging of siRNA delivery and silencing in tumors

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Lipid-based Nanoparticles for Nucleic Acid Delivery

Li, W., & Szoka, F. C. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9180-5 · Cited by 642 · see citing works

RNA Interference in Vitro and in Vivo Using a Novel Chitosan/siRNA Nanoparticle System

Howard, K. A., Rahbek, U. L., Liu, X., Damgaard, C. K., Glud, S. Z., Andersen, M. Ø., Hovgaard, M. B., Schmitz, A., Nyengaard, J. R., Besenbacher, F., et al. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.04.010 · Cited by 586 · see citing works

Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma

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Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging

Tomalia, D. A., Reyna, L. A., & Svenson, S. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350061 · Cited by 496 · see citing works

Gene Silencing by Systemic Delivery of Synthetic siRNAs in Adult Mice

Sørensen, D. R., Leirdal, M., & Sioud, M. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00181-5 · Cited by 469 · see citing works

Nonviral delivery of synthetic siRNAs in vivo

Akhtar, S., & Benter, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33494 · Cited by 464 · see citing works

Inhibition of influenza virus production in virus-infected mice by RNA interference

Ge, Q., Filip, L., Bai, A., Nguyen, T., Eisen, H. N., & Chen, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402486101 · Cited by 444 · see citing works

Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model.

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Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

Li, B.-J., Tang, Q., Cheng, D., Qin, C., Xie, F. Y., Wei, Q., Xu, J., Liu, Y., Zheng, B.-J., Woodle, M. C., et al. (2005) · Nature Medicine · doi:10.1038/nm1280 · Cited by 433 · see citing works

PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner

Ishida, T., Wang, X., Shimizu, T., Nawata, K., & Kiwada, H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.015 · Cited by 382 · see citing works

RNA interference: From gene silencing to gene-specific therapeutics

Leung, R. K. M., & Whittaker, P. A. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.03.004 · Cited by 382 · see citing works

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA

Heidel, J. D., Yu, Z., Liu, J. Y.-C., Rele, S. M., Liang, Y., Zeidan, R. K., Kornbrust, D. J., & Davis, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701458104 · Cited by 382 · see citing works

siRNA relieves chronic neuropathic pain

Dorn, G. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh044 · Cited by 380 · see citing works

A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics

Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., & Muramatsu, T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2682 · Cited by 373 · see citing works

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo

Takeshita, F., Minakuchi, Y., Nagahara, S., Honma, K., Sasaki, H., Hirai, K., Teratani, T., Namatame, N., Yamamoto, Y., Hanai, K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501753102 · Cited by 352 · see citing works

Radiolabeled Multimeric Cyclic RGD Peptides as Integrin α v β 3 Targeted Radiotracers for Tumor Imaging

Liu, S. (2006) · Molecular Pharmaceutics · doi:10.1021/mp060049x · Cited by 339 · see citing works

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

Minakuchi, Y. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh093 · Cited by 336 · see citing works

Focal Adhesion Kinase Targeting UsingIn vivoShort Interfering RNA Delivery in Neutral Liposomes for Ovarian Carcinoma Therapy

Halder, J., Kamat, A. A., Landen, C. N., Han, L. Y., Lutgendorf, S. K., Lin, Y. G., Merritt, W. M., Jennings, N. B., Chávez‐Reyes, A., Coleman, R. L., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0021 · Cited by 297 · see citing works

Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.

Verma, U. N., Surabhi, R. M., Schmaltieg, A., Becerra, C. R., & Gaynor, R. B. (2003) · PubMed · Cited by 294 · see citing works

Targeted Delivery of Antisense Oligodeoxynucleotide and Small Interference RNA into Lung Cancer Cells

Li, S., & Huang, L. (2006) · Molecular Pharmaceutics · doi:10.1021/mp060039w · Cited by 282 · see citing works

Anisamide‐targeted stealth liposomes: A potent carrier for targeting doxorubicin to human prostate cancer cells

Banerjee‬‬‬‬‬‬‬‬‬, R., Tyagi, P., Li, S., & Huang, L. (2004) · International Journal of Cancer · doi:10.1002/ijc.20452 · Cited by 274 · see citing works

Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides

Meade, B. R., & Dowdy, S. F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.004 · Cited by 274 · see citing works

Gene transfer with modified polyethylenimines

Kichler, A. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.507 · Cited by 266 · see citing works

Anti-RhoA and Anti-RhoC siRNAs Inhibit the Proliferation and Invasiveness of MDA-MB-231 Breast Cancer Cells in Vitro and in Vivo

Pillé, J.-Y., Denoyelle, C., Varet, J., Bertrand, J., Soria, J., Opolon, P., Lu, H., Pritchard, L. L., Vannier, J., Malvy, C., et al. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.08.029 · Cited by 264 · see citing works

Postexposure Protection of Guinea Pigs against a Lethal Ebola Virus Challenge Is Conferred by RNA Interference

Geisbert, T. W., Hensley, L. E., Kagan, E., Yu, E. Z., Geisbert, J. B., Daddario-DiCaprio, K. M., Fritz, E. A., Jahrling, P. B., McClintock, K., Phelps, J. R., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/504267 · Cited by 254 · see citing works

Cholesteryl Oligoarginine Delivering Vascular Endothelial Growth Factor siRNA Effectively Inhibits Tumor Growth in Colon Adenocarcinoma

Kim, W. J., Christensen, L. V., Jo, S., Yockman, J. W., Jeong, J. H., Kim, Y., & Kim, S. W. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.03.022 · Cited by 251 · see citing works

Small Interfering RNA Targeting Heme Oxygenase-1 Enhances Ischemia-Reperfusion-induced Lung Apoptosis

Zhang, X., Shan, P., Jiang, D., Noble, P. W., Abraham, N. G., Kappas, A., & Lee, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312941200 · Cited by 241 · see citing works

Therapeutic potential of RNA interference against cancer

Takeshita, F., & Ochiya, T. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00234.x · Cited by 239 · see citing works

An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor

Chono, S., Li, S., Conwell, C. C., & Huang, L. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.07.006 · Cited by 237 · see citing works

Delivery Vehicles for Small Interfering RNA In Vivo

de Fougerolles, A. R. (2008) · Human Gene Therapy · doi:10.1089/hum.2008.928 · Cited by 228 · see citing works

Non-viral is superior to viral gene delivery

Li, S.-D., & Huang, L. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.09.004 · Cited by 225 · see citing works

Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat

Tan, P.-H., Yang, L.-C., Hc, S., Lan, K.-C., & Cheng, J.-T. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302376 · Cited by 222 · see citing works

Toxicogenomics of non-viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity

Akhtar, S., & Benter, I. F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.010 · Cited by 219 · see citing works

Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid

Semple, S. C., Harasym, T. O., Clow, K. A., Ansell, S. M., Klimuk, S. K., & Hope, M. J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.078113 · Cited by 211 · see citing works

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

Thakker, D. R., Natt, F., Hüsken, D., Maier, R., Müller, M., van der Putten, H., Hoyer, D., & Cryan, J. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406214101 · Cited by 211 · see citing works

Tat-Conjugated PAMAM Dendrimers as Delivery Agents for Antisense and siRNA Oligonucleotides

Kang, H. M., DeLong, R. K., Fisher, M. H., & Juliano, R. L. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-8330-5 · Cited by 197 · see citing works

Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA

Li, S., Chono, S., & Huang, L. (2008) · Molecular Therapy · doi:10.1038/mt.2008.51 · Cited by 195 · see citing works

Materializing the Potential of Small Interfering RNA via a Tumor-Targeting Nanodelivery System

Pirollo, K. F., Rait, A. S., Zhou, Q., Hwang, S. H., Dagata, J. A., Zon, G., Hogrefe, R. I., Palchik, G. A., & Chang, E. H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4535 · Cited by 195 · see citing works

Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration

Tsubouchi, A., Sakakura, J., Yagi, R., Mazaki, Y., SCHAEFER, E. M., Yano, H., & Sabe, H. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202117 · Cited by 177 · see citing works

shRNA and siRNA delivery to the brain

Pardridge, W. M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.008 · Cited by 176 · see citing works

Harnessing in vivo siRNA delivery for drug discovery and therapeutic development

Xie, F. Y., Woodle, M. C., & Lu, P. Y. (2006) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03668-8 · Cited by 175 · see citing works

Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo

Chien, P.-Y., Wang, J., Carbonaro, D., Lei, S., Miller, B., Sheikh, S., Ali, S. M., Ahmad, M. U., & Ahmad, I. (2004) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700793 · Cited by 152 · see citing works

Toxicogenomics of Non-viral Vectors for Gene Therapy: A Microarray Study of Lipofectin- and Oligofectamine-induced Gene Expression Changes in Human Epithelial Cells

Omidi, Y., Hollins, A. J., Benboubetra, M., Drayton, R. M., Benter, I. F., & Akhtar, S. (2003) · Journal of drug targeting · doi:10.1080/10611860310001636908 · Cited by 152 · see citing works

Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

Makimura, H., Mizuno, T. M., Mastaitis, J. W., Agami, R., & Mobbs, C. V. (2002) · BMC Neuroscience · doi:10.1186/1471-2202-3-18 · Cited by 150 · see citing works

Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles

Li, S., Chono, S., & Huang, L. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.11.002 · Cited by 147 · see citing works

Applications of RNA Interference in Mammalian Systems

Martin, S. E., & Caplen, N. J. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.8.080706.092424 · Cited by 137 · see citing works

Sustained Polymeric Delivery of Gene Silencing Antisense ODNs, siRNA, DNAzymes and Ribozymes:In VitroandIn VivoStudies

Khan, A., Benboubetra, M., Sayyed, P. Z., Ng, K. W., Fox, S. P., Beck, G., Benter, I. F., & Akhtar, S. (2004) · Journal of drug targeting · doi:10.1080/10611860400003858 · Cited by 134 · see citing works

Delivery Systems for the Direct Application of siRNAs to Induce RNA Interference (RNAi) In Vivo

Aigner, A. M. (2006) · BioMed Research International · doi:10.1155/jbb/2006/71659 · Cited by 130 · see citing works

RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis.

Nakamura, H., Siddiqui, S. S., Shen, X., Malik, A. B., Pulido, J. S., Kumar, N. M., & Yue, B. Y. J. T. (2004) · PubMed · Cited by 130 · see citing works

Surface‐Modified LPD Nanoparticles for Tumor Targeting

Li, S., & Huang, L. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1348.001 · Cited by 123 · see citing works

Erbin Suppresses the MAP Kinase Pathway

Huang, Y. Z., Zang, M., Xiong, W., Luo, Z., & Mei, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205413200 · Cited by 120 · see citing works

Nanomedicine: Techniques, Potentials, and Ethical Implications

Ebbesen, M., & Jensen, T. G. (2006) · Journal of Biomedicine and Biotechnology · doi:10.1155/jbb/2006/51516 · Cited by 117 · see citing works

Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity

Hollins, A. J., Omidi, Y., Benter, I. F., & Akhtar, S. (2007) · Journal of drug targeting · doi:10.1080/10611860601151860 · Cited by 116 · see citing works

RNAi-Induced Gene Silencing by Local Electroporation in Targeting Brain Region

Akaneya, Y., Jiang, B., & Tsumoto, T. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00161.2004 · Cited by 115 · see citing works

Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules

Sebestyén, M. G., Budker, V. G., Budker, T., Subbotin, V. M., Zhang, G., Monahan, S. D., Lewis, D. L., Wong, S. C., Hagstrom, J. E., & Wolff, J. A. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.921 · Cited by 108 · see citing works

Computer-assisted Hydrodynamic Gene Delivery

Suda, T., Suda, K., & Liu, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.66 · Cited by 107 · see citing works

Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery

Golzio, M., Mazzolini, L., Moller, P., Rols, M., & Teissié, J. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302405 · Cited by 107 · see citing works

PAMAM Dendrimers as Delivery Agents for Antisense Oligonucleotides

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Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer

Pal, A., Ahmad, A., Khan, S., Sakabe, I., Zhang, C., Kasid, U. N., & Ahmad, I. (2005) · International Journal of Oncology · doi:10.3892/ijo.26.4.1087 · Cited by 104 · see citing works

Targeted Delivery Systems of Small Interfering RNA by Systemic Administration

Kawakami, S., & Hashida, M. (2007) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.22.142 · Cited by 104 · see citing works

Non-viral siRNA delivery to the lung

Thomas, M., Lu, J. J.-Q., Chen, J., & Klibanov, A. M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.003 · Cited by 95 · see citing works

Systemic siRNA delivery via hydrodynamic intravascular injection

Lewis, D. L., & Wolff, J. A. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.002 · Cited by 82 · see citing works

Sequence‐specific gene silencing in murine muscle induced by electroporation‐mediated transfer of short interfering RNA

Kishida, T., Asada, H., Gojo, S., Ohashi, S., Shin‐Ya, M., Yasutomi, K., Terauchi, R., Takahashi, K. A., Kubo, T., Imanishi, J., et al. (2003) · The Journal of Gene Medicine · doi:10.1002/jgm.456 · Cited by 78 · see citing works

Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice

Massaro, D. J., MASSARO, G. D., & Clerch, L. B. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00067.2004 · Cited by 74 · see citing works

The Design and Exogenous Delivery of siRNA for Post-transcriptional Gene Silencing

Gilmore, I. R., Fox, S. P., Hollins, A. J., Sohail, M. F., & Akhtar, S. (2004) · Journal of drug targeting · doi:10.1080/10611860400006257 · Cited by 73 · see citing works

Attenuation of α2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood

Shishkina, G. T., Kalinina, T., & Dygalo, N. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.015 · Cited by 59 · see citing works

siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo

Hérard, A., Besret, L., Dubois, A., Dauguet, J., Delzescaux, T., Hantraye, P., Bonvento, G., & Moya, K. L. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.020 · Cited by 57 · see citing works

Development of new RNAi therapeutics.

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Specific β1-adrenergic receptor silencing with small interfering RNA lowers high blood pressure and improves cardiac function in myocardial ischemia

Arnold, A., Tang, Y., Qian, K., Shen, L., Valencia, V., Phillips, M. I., & Zhang, Y. C. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000254374.73241.ab · Cited by 47 · see citing works

Intracellular Delivery of Oligonucleotide Conjugates and Dendrimer Complexes

Juliano, R. L. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1348.011 · Cited by 46 · see citing works

RNA interference: potential therapeutic targets

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Lipid-Protamine-DNA-Mediated Antigen Delivery

Vangasseri, D., Han, S., & Huang, L. (2005) · Current Drug Delivery · doi:10.2174/156720105774370168 · Cited by 31 · see citing works

RNA Interference in Mice

Kühn, R., Streif, S., & Wurst, W. (2007) · Springer eBooks · doi:10.1007/978-3-540-35109-2_7 · Cited by 30 · see citing works

Interaction of oligonucleotide-conjugates with the dipeptide transporter system in CACO-2 cells

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siRNA vs. shRNA: Similarities and differences

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Insect Molecular Biology and Biochemistry

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