Cited by 401Meta-analysis and systematic reviewsStatistical Methods in Clinical TrialsDelphi Technique in Research

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GetReal in network meta-analysis: a review of the methodology

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Efthimiou, Orestis, Debray, Thomas P. A., van Valkenhoef, Gert, Trelle, Sven, Panayidou, Klea, Moons, Karel G. M., Reitsma, Johannes B., Shang, Aijing, Salanti, Georgia, on behalf of GetReal Methods Review Group·2016·Research Synthesis Methods

DOI 10.1002/jrsm.1195

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Abstract

Pairwise meta‐analysis is an established statistical tool for synthesizing evidence from multiple trials, but it is informative only about the relative efficacy of two specific interventions. The usefulness of pairwise meta‐analysis is thus limited in real‐life medical practice, where many competing interventions may be available for a certain condition and studies informing some of the pairwise comparisons may be lacking. This commonly encountered scenario has led to the development of network meta‐analysis (NMA). In the last decade, several applications, methodological developments, and empirical studies in NMA have been published, and the area is thriving as its relevance to public health is increasingly recognized. This article presents a review of the relevant literature on NMA methodology aiming to pinpoint the developments that have appeared in the field. Copyright © 2016 John Wiley & Sons, Ltd.

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Authors: Efthimiou, O., Debray, T. P. A., van Valkenhoef, G., Trelle, S., Panayidou, K., Moons, K. G. M., Reitsma, J. B., Shang, A., Salanti, G., & on behalf of GetReal Methods Review Group
Affiliations: University of Ioannina (GR)
University Medical Center Utrecht (NL)
Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen The Netherlands
University of Bern (CH)
F. Hoffmann-La Roche AG (CH)
Corresponding author: Efthimiou, Orestis
ORCID: Efthimiou, Orestis
Debray, Thomas P. A.
Trelle, Sven
Moons, Karel G. M.
Reitsma, Johannes B.
Salanti, Georgia
Venue: Research Synthesis Methods
Publisher: Wiley
Published: 2016-01-11
Volume: 7
Issue: 3
Pages: 236-263
ISSN: 1759-2879 (ISSN-L)
1759-2887
DOI: 10.1002/jrsm.1195
OpenAlex: W2237437504
Semantic Scholar: 5a3c19f9f2a50dce244ece8903463aa0b3cd9464
Cited by: 401
References: 187
Citations by year: 2026: 30 · 2025: 55 · 2024: 57 · 2023: 56 · 2022: 47 · 2021: 37 · 2020: 35 · 2019: 26 · 2018: 28 · 2017: 17 · 2016: 10
FWCI: 9.22
Type: journal article
Language: en
Open access: green
pure.amsterdamumc.nl
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Research Synthesis Methods (publishedVersion)
PubMed (publishedVersion)
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BORIS (University Library Bern) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion)
Open Access CRIS of the University of Bern
Funders: Innovative Medicines Initiative Joint Undertaking (115546)
European Union's Seventh Framework Programme (FP7/2007-2013)
Topics: Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Social Sciences › Sociology and Political Science › Delphi Technique in Research
Keywords: network meta-analysis, comparative effectiveness, evidence synthesis, method development
MeSH terms: Network Meta-Analysis as Topic, Clinical Trials as Topic, Computer Simulation, Humans, Placebos, Regression Analysis, Research Design, Software, Statistics as Topic, Models, Statistical, Databases, Bibliographic

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GetReal in network meta-analysis: a review of the methodology

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