Network meta‐analysis for indirect treatment comparisons
Abstract
I present methods for assessing the relative effectiveness of two treatments when they have not been compared directly in a randomized trial but have each been compared to other treatments. These network meta‐analysis techniques allow estimation of both heterogeneity in the effect of any given treatment and inconsistency (‘incoherence’) in the evidence from different pairs of treatments. A simple estimation procedure using linear mixed models is given and used in a meta‐analysis of treatments for acute myocardial infarction. Copyright © 2002 John Wiley & Sons, Ltd.
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A recent review of published ecological meta-analyses revealed that the majority of them are produced in a handful of countries around the world, exacerbating academic inequality.
“A recent review of published ecological meta-analyses revealed that the majority of them are produced in a handful of countries around the world, exacerbating academic inequality 74 .”
From Meta-analysis and the science of research synthesis (2018) · cites this paper as [74]
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- Authors
- Lumley, T.
- Affiliations
- University of Washington (US)
- Corresponding author
- Lumley, Thomas
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 2002-07-26
- Volume
- 21
- Issue
- 16
- Pages
- 2313-2324
- ISSN
- 0277-6715 (ISSN-L)
- 1097-0258
- OpenAlex
- W2133531206
- Cited by
- 1,206
- References
- 21
- Citations by year
- 2026: 32 · 2025: 58 · 2024: 52 · 2023: 54 · 2022: 80 · 2021: 76 · 2020: 91 · 2019: 54 · 2018: 68 · 2017: 67 · 2016: 70 · 2015: 81 · 2014: 93 · 2013: 71 · 2012: 73
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Statistics in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Social Sciences › Sociology and Political Science › Delphi Technique in Research
- Keywords
- network meta-analysis, indirect treatment comparison, treatment effect heterogeneity, linear mixed models, acute myocardial infarction
- MeSH terms
- Fibrinolytic Agents, Humans, Myocardial Infarction, Tissue Plasminogen Activator, Recombinant Proteins, Meta-Analysis as Topic, Models, Statistical, Thrombolytic Therapy, Angioplasty
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