Outcomes of prolonged exposure therapy for veterans with posttraumatic stress disorder
Abstract
Prolonged Exposure (PE) is an evidenced-based psychotherapy for posttraumatic stress disorder (PTSD) that is being disseminated nationally within the U.S. Department of Veterans Affairs (VA) with promising initial results. Empirical evidence, however, regarding the effectiveness of PE for treatment of PTSD in military veterans is limited. Building on previous treatment outcome research, the current study investigated the effectiveness of PE in a diverse veteran sample. One-hundred fifteen veterans were enrolled in PE at an urban VA medical center and its surrounding outpatient clinics. PTSD and depression symptoms as well as quality of life were measured before and after treatment. Several baseline patient characteristics were examined as predictors of treatment response. Eighty-four participants completed treatment. Participants experienced a 42% reduction in PTSD symptoms, a 31% reduction in depression symptoms, and an increase in quality of life following PE. Veterans not prescribed psychotropic medication reported greater PTSD symptom reduction than veterans prescribed such medication. The implications of these results for treatment programs targeting PTSD in veterans are discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A substantial proportion of patients maintain clinically significant residual symptoms and/or continue to meet diagnostic criteria for PTSD following PE.
“a substantial proportion of patients maintain clinically significant residual symptoms and/or continue to meet diagnostic criteria for PTSD following PE (Bradley et al., 2005; Goodson et al., 2013).”
From Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial (2018) · cites this paper as Goodson et al., 2013
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910 · see citing works
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,385 · see citing works
Psychometric properties of the PTSD checklist (PCL)
Blanchard, E. B., Jones-Alexander, J., Buckley, T. C., & Forneris, C. A. (1996) · Behaviour Research and Therapy · doi:10.1016/0005-7967(96)00033-2 · Cited by 3,997 · see citing works
Mild traumatic brain injury in U.S. soldiers returning from Iraq
Hoge, C. W., McGurk, D., Thomas, J. L., Cox, A. L., Engel, C. C., & Castro, C. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa072972 · Cited by 2,775 · see citing works
A Multidimensional Meta-Analysis of Psychotherapy for PTSD
Bradley, R., Greene, J., Russ, E., Dutra, L., & Westen, D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.214 · Cited by 1,938 · see citing works
(1990) · Choice Reviews Online · doi:10.5860/choice.27-6366 · Cited by 1,627 · see citing works
A meta-analytic review of prolonged exposure for posttraumatic stress disorder
Powers, M. B., Halpern, J. M., Ferenschak, M. P., Gillihan, S. J., & Foa, E. B. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.007 · Cited by 1,005 · see citing works
Foa, E. B., Hembree, E. A., Cahill, S. P., Rauch, S. A. M., Riggs, D. S., Feeny, N. C., & Yadin, E. (2005) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.73.5.953 · Cited by 931 · see citing works
Bisson, J. I., Ehlers, A., Matthews, R., Pilling, S., Richards, D., & Turner, S. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.021402 · Cited by 900 · see citing works
Seal, K. H., Metzler, T. J., Gima, K. S., Bertenthal, D., Maguen, S., & Marmar, C. R. (2009) · American Journal of Public Health · doi:10.2105/ajph.2008.150284 · Cited by 830 · see citing works
Schnurr, P. P., Friedman, M. J., Engel, C. C., Foa, E. B., Shea, M. T., Chow, B. K., Resick, P. A., Thurston, V., Orsillo, S. M., Haug, R., et al. (2007) · JAMA · doi:10.1001/jama.297.8.820 · Cited by 813 · cited 2× · see citing works
“Our findings are consistent with previous research demonstrating the effectiveness of exposure therapy in general, and PE specifically, in veteran populations (Cooper & Clum, 1989; Glynn et al., 1999, Rauch et al., 2009; Schnurr et al., 2007; Tuerk et al., 2011).”
ResultTreating the Trauma of Rape: Cognitive Behavioral Therapy for PTSD
Ellis, E. M. (1999) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1999.53.1.126 · Cited by 734 · see citing works
Asmundson, G. J., Coons, M. J., Taylor, S., & Katz, J. (2002) · The Canadian Journal of Psychiatry · doi:10.1177/070674370204701004 · Cited by 695 · see citing works
Taylor, S. J., Thordarson, D. S., Maxfield, L., Fedoroff, I. C., Lovell, K., & Ogrodniczuk, J. S. (2003) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.71.2.330 · Cited by 563 · see citing works
Kang, H. K. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwf187 · Cited by 524 · see citing works
Karlin, B. E., Ruzek, J. I., Chard, K. M., Eftekhari, A., Monson, C. M., Hembree, E. A., Resick, P. A., & Foa, E. B. (2010) · Journal of Traumatic Stress · doi:10.1002/jts.20588 · Cited by 486 · see citing works
Do patients drop out prematurely from exposure therapy for PTSD?
Hembree, E. A., Foa, E. B., Dorfan, N. M., Street, G. P., Kowalski, J., & Tu, X. (2003) · Journal of Traumatic Stress · doi:10.1023/b:jots.0000004078.93012.7d · Cited by 451 · see citing works
Neuropsychological Outcomes of Army Personnel Following Deployment to the Iraq War
Vasterling, J. J., Proctor, S. P., Amoroso, P. J., Kane, R., Heeren, T., & White, R. F. (2006) · JAMA · doi:10.1001/jama.296.5.519 · Cited by 412 · see citing works
Cloitre, M., Chase Stovall-McClough, K., Miranda, R., & Chemtob, C. M. (2004) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.72.3.411 · Cited by 333 · see citing works
Change in posttraumatic stress disorder symptoms: Do clinicians and patients agree?
Monson, C. M., Gradus, J. L., Young‐Xu, Y., Schnurr, P. P., Price, J. L., & Schumm, J. A. (2008) · Psychological Assessment · doi:10.1037/1040-3590.20.2.131 · Cited by 317 · see citing works
Chronic posttraumatic stress disorder and chronic pain in Vietnam combat veterans
Beckham, J. C., Crawford, A. L., Feldman, M. E., Kirby, A. C., Hertzberg, M. A., Davidson, J. R. T., & Moore, S. D. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00129-3 · Cited by 306 · see citing works
Imaginal flooding as a supplementary treatment for PTSD in combat veterans: A controlled study
Cooper, N. A., & Clum, G. A. (1989) · Behavior Therapy · doi:10.1016/s0005-7894(89)80057-7 · Cited by 293 · see citing works
Placebo effects: clinical aspects and neurobiology
Oken, B. S. (2008) · Brain · doi:10.1093/brain/awn116 · Cited by 237 · see citing works
Rizvi, S. L., Vogt, D. S., & Resick, P. A. (2009) · Behaviour Research and Therapy · doi:10.1016/j.brat.2009.06.003 · Cited by 216 · see citing works
Tuerk, P. W., Yoder, M. S., Grubaugh, A. L., Myrick, H., Hamner, M. B., & Acierno, R. E. (2010) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2010.11.002 · Cited by 208 · see citing works
Otto, M. W., Smits, J. A. J., & Reese, H. E. (2005) · Clinical Psychology Science and Practice · doi:10.1093/clipsy.bpi009 · Cited by 204 · see citing works
Glynn, S. M., Eth, S., Randolph, E. T., Foy, D. W., Urbaitis, M., Boxer, L., Paz, G. G., Leong, G. B., Firman, G., Salk, J. D., et al. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.2.243 · Cited by 198 · see citing works
Prolonged exposure for PTSD in a Veterans Health Administration PTSD clinic
Rauch, S. A. M., Defever, E., Favorite, T., Duroe, A., Garrity, C., Martis, B., & Liberzon, I. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20380 · Cited by 171 · see citing works
Disability Compensation Seeking Among Veterans Evaluated for Posttraumatic Stress Disorder
Frueh, B. C., Elhai, J. D., Gold, P. B., Monnier, J., Magruder, K. M., Keane, T. M., & Arana, G. W. (2002) · Psychiatric Services · doi:10.1176/appi.ps.54.1.84 · Cited by 122 · see citing works
Kopta, S. M., & Lowry, J. L. (2002) · Psychotherapy Research · doi:10.1093/ptr/12.4.413 · Cited by 116 · see citing works
Prolonged Exposure Therapy for Older Veterans With Posttraumatic Stress Disorder: A Pilot Study
Thorp, S. R., Stein, M. B., Jeste, D. V., Patterson, T. L., & Wetherell, J. L. (2012) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3182435ee9 · Cited by 85 · see citing works
Effectiveness studies: advantages and disadvantages
Möller, H. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.2/hmoeller · Cited by 69 · see citing works
Ready, D. J., Thomas, K. R., Worley, V., Burridge, A. B., Harvey, L. A. C., Baltzell, D., & ROTHBAUM, B. O. (2008) · Journal of Traumatic Stress · doi:10.1002/jts.20326 · Cited by 64 · see citing works
Fontana, A., & Rosenheck, R. A. (1998) · Journal of Nervous and Mental Disease · doi:10.1097/00005053-199804000-00004 · Cited by 55 · see citing works
Avoiding Treatment Failures in the Anxiety Disorders
(2010) · doi:10.1007/978-1-4419-0612-0 · Cited by 41 · see citing works
Laffaye, C., Rosen, C. S., Schnurr, P. P., & Friedman, M. J. (2007) · Military Medicine · doi:10.7205/milmed.172.10.1039 · Cited by 29 · see citing works
Smits, J. A. J., Reese, H. E., Powers, M. B., & Otto, M. W. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0612-0_5 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Post-traumatic stress disorder.
Yehuda, R., Hoge, C. W., McFarlane, A. C., Vermetten, E., Lanius, R. A., Nievergelt, C. M., Hobfoll, S. E., Koenen, K. C., Neylan, T. C., & Hyman, S. E. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.57 · Cited by 870 · see citing works
Flanagan, J. C., Sippel, L. M., Wahlquist, A., Moran-Santa Maria, M. M., & Back, S. E. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.12.014 · Cited by 117 · see citing works
Stephenson, K. R., Simpson, T. L., Martinez, M. E., & Kearney, D. J. (2017) · Journal of Clinical Psychology · doi:10.1002/jclp.22323 · Cited by 89 · see citing works
Killeen, T. K., Back, S. E., & Brady, K. T. (2015) · Drug and Alcohol Review · doi:10.1111/dar.12229 · Cited by 52 · see citing works
Mohr, D. C., Rosen, C. S., Schnurr, P. P., Orazem, R. J., Noorbaloochi, S., Clothier, B. A., Eftekhari, A., Bernardy, N. C., Chard, K. M., Crowley, J. J., et al. (2018) · Psychiatric Services · doi:10.1176/appi.ps.201700432 · Cited by 26 · see citing works
Åkerblom, S., Perrin, S., Fischer, M. R., & McCracken, L. M. (2022) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2021-0100 · Cited by 9 · see citing works
- Authors
- Goodson, J. T., Lefkowitz, C. M., Helstrom, A. W., & Gawrysiak, M. J.
- Affiliations
- Philadelphia VA Medical Center (US)
- Corresponding author
- Goodson, Jason T.
- Venue
- Journal of Traumatic Stress
- Publisher
- Wiley
- Published
- 2013-08
- Volume
- 26
- Issue
- 4
- Pages
- 419-425
- ISSN
- 0894-9867 (ISSN-L)
- 1573-6598
- OpenAlex
- W1897337326
- Cited by
- 88
- References
- 38
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 12 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 10 · 2014: 4 · 2013: 1
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Traumatic Stress (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- prolonged exposure therapy, post-traumatic stress disorder, military veterans, treatment outcomes, depressive symptoms, quality of life, predictors of treatment response, psychotropic drugs, Department of Veterans Affairs
- MeSH terms
- Adult, Aged, Depression, Female, Humans, Implosive Therapy, Male, Middle Aged, Psychiatric Status Rating Scales, Psychotropic Drugs, Quality of Life, Surveys and Questionnaires, Stress Disorders, Post-Traumatic, United States, Veterans, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review