Fluid vulnerability theory as a framework for understanding the association between posttraumatic stress disorder and suicide: a narrative review
Abstract
Suicide is a persistent issue in the United States and across the globe. A large body of published research shows that posttraumatic stress disorder (PTSD) increases the risk of suicidal ideation, suicidal behaviors, and death by suicide. However, the existing literature examining why that association might pertain is widely dispersed across disciplines (e.g., psychology, nursing) and lacks an integrative theoretical framework, making it difficult to conceptualize the current state of science in this area. Therefore, the primary aims of this narrative review were to (a) provide a comprehensive and interdisciplinary critique of the current state of knowledge regarding mechanisms that underlie the association between PTSD and suicide and (b) organize that knowledge according to a specified theoretical framework. The framework guiding this review is "fluid vulnerability theory," a diathesis-stress model of suicide that emphasizes the dynamic nature of suicide risk across cognitive, emotional, behavioral, and physiological domains. A summary of the findings, including patterns that emerged, gaps that remain, and recommendations for the advancement of science and practice in this area are addressed in this narrative review.
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Hyperarousal is a key diagnostic feature of both PTSD and the suicide crisis.
“Given that hyperarousal is a key diagnostic feature of both PTSD and the suicide crisis (Rogers et al., 2017; Rugo-Cook et al., 2021)”
From Clinical indicators of the suicide crisis and response to ketamine (2025) · cites this paper as Rugo-Cook et al., 2021
Traumatic stress has been linked to short and long-term suicide risk and has been shown to decrease in relation to ketamine administration.
“Traumatic stress has also been linked to short and long-term suicide risk (Rugo-Cook et al., 2021) and has been shown to decrease in relation to ketamine administration (Feder et al., 2014).”
From Clinical indicators of the suicide crisis and response to ketamine (2025) · cites this paper as Rugo-Cook et al., 2021
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Clinical indicators of the suicide crisis and response to ketamine
Ballard, E. D., Neely, L., Waldman, L., Greenstein, D., & Zarate, C. A. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.11.080 · Cited by 5 · see citing works
- Authors
- Rugo‐Cook, K. F., Kerig, P. K., Crowell, S. E., & Bryan, C. J.
- Affiliations
- Department of Psychology University of Utah Salt Lake City Utah USA
- University of Utah (US)
- The Ohio State University Wexner Medical Center (US)
- Venue
- Journal of Traumatic Stress
- Publisher
- Wiley
- Published
- 2021-12
- Volume
- 34
- Issue
- 6
- Pages
- 1080-1098
- ISSN
- 0894-9867 (ISSN-L)
- 1573-6598
- OpenAlex
- W4200006326
- Cited by
- 25
- References
- 137
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 2
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Traumatic Stress (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- post-traumatic stress disorder, suicide, diathesis-stress model, suicidal ideation, suicide risk factors, dynamic vulnerability
- MeSH terms
- Disease Susceptibility, Humans, Risk Factors, Stress Disorders, Post-Traumatic, Suicide, United States, Suicidal Ideation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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