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Multimodal nonlinear optical microscopy

Open access
Yue, S., Slipchenko, M.N., Cheng, J.‐X.·2011·Laser & Photonics Reviews

Abstract

Because each nonlinear optical (NLO) imaging modality is sensitive to specific molecules or structures, multimodal NLO imaging capitalizes the potential of NLO microscopy for studies of complex biological tissues. The coupling of multiphoton fluorescence, second‐harmonic generation, and coherent anti‐Stokes Raman scattering (CARS) has allowed investigation of a broad range of biological questions concerning lipid metabolism, cancer development, cardiovascular disease, and skin biology. Moreover, recent research shows the great potential of using a CARS microscope as a platform to develop more advanced NLO modalities such as electronic‐resonance‐enhanced four‐wave mixing, stimulated Raman scattering, and pump‐probe microscopy. This article reviews the various approaches developed for realization of multimodal NLO imaging as well as developments of new NLO modalities on a CARS microscope. Applications to various aspects of biological and biomedical research are discussed.

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Crossref · 10.1002/lpor.201000027

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Metadata

Authors
Yue, S., Slipchenko, M. N., & Cheng, J. ‐.
Venue
Laser & Photonics Reviews
Publisher
Wiley
Published
2011-03-04
Volume
5
Issue
4
Pages
496-512
ISSN
  • 1863-8880 (ISSN-L)
  • 1863-8899
OpenAlex
W2163829398
Cited by
180
References
7
FWCI
5.21
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Multimodal nonlinear optical microscopy. https://app.cochat.ai/papers/10.1002/lpor.201000027
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Yue, S., Slipchenko, M. N., & Cheng, J. ‐. (2011). Multimodal nonlinear optical microscopy. Laser & Photonics Reviews. https://doi.org/10.1002/lpor.201000027

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