Cited by 242Organ Transplantation Techniques and OutcomesNutrition and Health in AgingLiver Disease Diagnosis and Treatment

Impact of quality as well as quantity of skeletal muscle on outcomes after liver transplantation

Hamaguchi, Yuhei, Kaido, Toshimi, Okumura, Shinya, Fujimoto, Yasuhiro, Ogawa, Kohei, Mori, Akira, Hammad, Ahmed, Tamai, Yumiko +2 more·2014·Liver Transplantation

Abstract

Intramuscular fat accumulation has come to be associated with loss of muscle strength and function, one of the components of sarcopenia. However, the impact of preoperative quality of skeletal muscle on outcomes after living donor liver transplantation (LDLT) is unclear. The present study evaluated the intramuscular adipose tissue content (IMAC) and psoas muscle mass index (PMI) in 200 adult patients undergoing LDLT at our institution between January 2008 and October 2013. Correlations of IMAC with other factors, overall survival rates in patients classified according to IMAC or PMI, and risk factors for poor survival after LDLT were analyzed. IMAC was significantly correlated with age (r = 0.229, P = 0.03) and PMI (r = -0.236, P = 0.02) in males and with age (r = 0.349, P < 0.001) and branched-chain amino acid (BCAA)-to-tyrosine ratio (r = -0.250, P = 0.01) in females. The overall survival rates in patients with high IMAC or low PMI were significantly lower than those for patients with normal IMAC or PMI (P < 0.001, P < 0.001, respectively). Multivariate analysis showed that high IMAC [odds ratio (OR) = 3.898, 95% confidence interval (CI) = 2.025-7.757, P < 0.001] and low PMI (OR = 3.635, 95% CI = 1.896-7.174, P < 0.001) were independent risk factors for death after LDLT. In conclusion, high IMAC and low PMI were closely involved with posttransplant mortality. Preoperative quality and quantity of skeletal muscle could be incorporated into new selection criteria for LDLT. Perioperative nutritional therapy and rehabilitation could be important for good outcomes after LDLT.

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Crossref · 10.1002/lt.23970

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Authors
Hamaguchi, Y., Kaido, T., Okumura, S., Fujimoto, Y., Ogawa, K., Mori, A., Hammad, A., Tamai, Y., Inagaki, N., & Uemoto, S.
Affiliations
Kyoto University (JP)
Corresponding author
Kaido, Toshimi
Venue
Liver Transplantation
Published
2014-11
Volume
20
Issue
11
Pages
1413-1419
ISSN
1527-6465 (ISSN-L)
OpenAlex
W1699364310
Cited by
242
References
30
Citations by year
2026: 10 · 2025: 12 · 2024: 9 · 2023: 26 · 2022: 24 · 2021: 28 · 2020: 26 · 2019: 28 · 2018: 21 · 2017: 20 · 2016: 26 · 2015: 10 · 2014: 1
FWCI
18.83
Type
journal article
Language
en
Open access
closed
Locations
  • Liver Transplantation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords
living donor liver transplantation, intramuscular fat, psoas muscle mass index, sarcopenia, skeletal muscle quality, postoperative mortality, overall survival, preoperative nutritional assessment, donor selection criteria, rehabilitation
MeSH terms
Adipose Tissue, Adolescent, Adult, Aged, Female, Humans, Japan, Liver Diseases, Male, Middle Aged, Retrospective Studies, Risk Factors, Liver Transplantation, Psoas Muscles, Muscle, Skeletal, Young Adult, Sarcopenia

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